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Items: 1 to 50 of 73

1.

Inhibition of mTOR by apigenin in UVB-irradiated keratinocytes: A new implication of skin cancer prevention.

Bridgeman BB, Wang P, Ye B, Pelling JC, Volpert OV, Tong X.

Cell Signal. 2016 May;28(5):460-468. doi: 10.1016/j.cellsig.2016.02.008. Epub 2016 Feb 12.

2.

Chemopreventive apigenin controls UVB-induced cutaneous proliferation and angiogenesis through HuR and thrombospondin-1.

Tong X, Mirzoeva S, Veliceasa D, Bridgeman BB, Fitchev P, Cornwell ML, Crawford SE, Pelling JC, Volpert OV.

Oncotarget. 2014 Nov 30;5(22):11413-27.

3.

Apigenin inhibits TGF-β-induced VEGF expression in human prostate carcinoma cells via a Smad2/3- and Src-dependent mechanism.

Mirzoeva S, Franzen CA, Pelling JC.

Mol Carcinog. 2014 Aug;53(8):598-609. doi: 10.1002/mc.22005. Epub 2013 Jan 28.

PMID:
23359392
4.

Targeting the PI3K/Akt/mTOR axis by apigenin for cancer prevention.

Tong X, Pelling JC.

Anticancer Agents Med Chem. 2013 Sep;13(7):971-8. Review.

5.

The desmosomal armadillo protein plakoglobin regulates prostate cancer cell adhesion and motility through vitronectin-dependent Src signaling.

Franzen CA, Todorović V, Desai BV, Mirzoeva S, Yang XJ, Green KJ, Pelling JC.

PLoS One. 2012;7(7):e42132. doi: 10.1371/journal.pone.0042132. Epub 2012 Jul 30.

6.

UVB radiation-induced β-catenin signaling is enhanced by COX-2 expression in keratinocytes.

Smith KA, Tong X, Abu-Yousif AO, Mikulec CC, Gottardi CJ, Fischer SM, Pelling JC.

Mol Carcinog. 2012 Sep;51(9):734-45. doi: 10.1002/mc.20840. Epub 2011 Aug 18.

7.

Apigenin, a chemopreventive bioflavonoid, induces AMP-activated protein kinase activation in human keratinocytes.

Tong X, Smith KA, Pelling JC.

Mol Carcinog. 2012 Mar;51(3):268-79. doi: 10.1002/mc.20793. Epub 2011 May 2.

PMID:
21538580
8.

Apigenin down-regulates the hypoxia response genes: HIF-1α, GLUT-1, and VEGF in human pancreatic cancer cells.

Melstrom LG, Salabat MR, Ding XZ, Strouch MJ, Grippo PJ, Mirzoeva S, Pelling JC, Bentrem DJ.

J Surg Res. 2011 May 15;167(2):173-81. doi: 10.1016/j.jss.2010.10.041. Epub 2010 Nov 27.

PMID:
21227456
9.

The chemopreventive bioflavonoid apigenin inhibits prostate cancer cell motility through the focal adhesion kinase/Src signaling mechanism.

Franzen CA, Amargo E, Todorović V, Desai BV, Huda S, Mirzoeva S, Chiu K, Grzybowski BA, Chew TL, Green KJ, Pelling JC.

Cancer Prev Res (Phila). 2009 Sep;2(9):830-41. doi: 10.1158/1940-6207.CAPR-09-0066. Epub 2009 Sep 8.

10.

Apigenin inhibits the GLUT-1 glucose transporter and the phosphoinositide 3-kinase/Akt pathway in human pancreatic cancer cells.

Melstrom LG, Salabat MR, Ding XZ, Milam BM, Strouch M, Pelling JC, Bentrem DJ.

Pancreas. 2008 Nov;37(4):426-31. doi: 10.1097/MPA.0b013e3181735ccb.

PMID:
18953257
11.
12.

Enhancement of UVB-induced apoptosis by apigenin in human keratinocytes and organotypic keratinocyte cultures.

Abu-Yousif AO, Smith KA, Getsios S, Green KJ, Van Dross RT, Pelling JC.

Cancer Res. 2008 Apr 15;68(8):3057-65. doi: 10.1158/0008-5472.CAN-07-2763.

13.

Geminin is overexpressed in human pancreatic cancer and downregulated by the bioflavanoid apigenin in pancreatic cancer cell lines.

Salabat MR, Melstrom LG, Strouch MJ, Ding XZ, Milam BM, Ujiki MB, Chen C, Pelling JC, Rao S, Grippo PJ, McGarry TJ, Bentrem DJ.

Mol Carcinog. 2008 Nov;47(11):835-44. doi: 10.1002/mc.20441.

PMID:
18404646
14.

Dietary genistein inhibits metastasis of human prostate cancer in mice.

Lakshman M, Xu L, Ananthanarayanan V, Cooper J, Takimoto CH, Helenowski I, Pelling JC, Bergan RC.

Cancer Res. 2008 Mar 15;68(6):2024-32. doi: 10.1158/0008-5472.CAN-07-1246.

15.

Inhibition of HIF-1 alpha and VEGF expression by the chemopreventive bioflavonoid apigenin is accompanied by Akt inhibition in human prostate carcinoma PC3-M cells.

Mirzoeva S, Kim ND, Chiu K, Franzen CA, Bergan RC, Pelling JC.

Mol Carcinog. 2008 Sep;47(9):686-700. doi: 10.1002/mc.20421.

PMID:
18240292
16.

Modulation of UVB-induced and basal cyclooxygenase-2 (COX-2) expression by apigenin in mouse keratinocytes: role of USF transcription factors.

Van Dross RT, Hong X, Essengue S, Fischer SM, Pelling JC.

Mol Carcinog. 2007 Apr;46(4):303-14.

PMID:
17186551
17.

Apigenin prevents UVB-induced cyclooxygenase 2 expression: coupled mRNA stabilization and translational inhibition.

Tong X, Van Dross RT, Abu-Yousif A, Morrison AR, Pelling JC.

Mol Cell Biol. 2007 Jan;27(1):283-96. Epub 2006 Oct 30.

18.

Do truncated cyclins contribute to aberrant cyclin expression in cancer?

Van Dross R, Browning PJ, Pelling JC.

Cell Cycle. 2006 Mar;5(5):472-7. Epub 2006 Mar 1. Review.

PMID:
16552186
20.

The chemopreventive bioflavonoid apigenin modulates signal transduction pathways in keratinocyte and colon carcinoma cell lines.

Van Dross R, Xue Y, Knudson A, Pelling JC.

J Nutr. 2003 Nov;133(11 Suppl 1):3800S-3804S. doi: 10.1093/jn/133.11.3800S.

PMID:
14608117
21.

Cyclic AMP activates B-Raf and ERK in cyst epithelial cells from autosomal-dominant polycystic kidneys.

Yamaguchi T, Nagao S, Wallace DP, Belibi FA, Cowley BD, Pelling JC, Grantham JJ.

Kidney Int. 2003 Jun;63(6):1983-94.

22.

Association of JNK1 with p21waf1 and p53: modulation of JNK1 activity.

Xue Y, Ramaswamy NT, Hong X, Pelling JC.

Mol Carcinog. 2003 Jan;36(1):38-44.

PMID:
12503078
24.
25.

Effects of the (-)-anti-11R,12S-dihydrodiol 13S,14R-epoxide of dibenzo.

Mahadevan B, Luch A, Seidel A, Pelling JC, Baird WM.

Carcinogenesis. 2001 Jan;22(1):161-9.

PMID:
11159755
26.

Effect of extracellular signal-regulated kinase on p53 accumulation in response to cisplatin.

Persons DL, Yazlovitskaya EM, Pelling JC.

J Biol Chem. 2000 Nov 17;275(46):35778-85.

27.

Cell-cycle arrest at G2/M and growth inhibition by apigenin in human colon carcinoma cell lines.

Wang W, Heideman L, Chung CS, Pelling JC, Koehler KJ, Birt DF.

Mol Carcinog. 2000 Jun;28(2):102-10.

PMID:
10900467
28.

cAMP stimulates the in vitro proliferation of renal cyst epithelial cells by activating the extracellular signal-regulated kinase pathway.

Yamaguchi T, Pelling JC, Ramaswamy NT, Eppler JW, Wallace DP, Nagao S, Rome LA, Sullivan LP, Grantham JJ.

Kidney Int. 2000 Apr;57(4):1460-71.

29.
33.

S-phase arrest in mouse keratinocytes exposed to multiple doses of ultraviolet B/A radiation.

Neades R, Cox L, Pelling JC.

Mol Carcinog. 1998 Nov;23(3):159-67.

PMID:
9833776
34.

Antioxidant action via p53-mediated apoptosis.

Liu M, Pelling JC, Ju J, Chu E, Brash DE.

Cancer Res. 1998 Apr 15;58(8):1723-9.

35.

Rapid activation of JNK1 in UV-B irradiated epidermal keratinocytes.

Ramaswamy NT, Ronai Z, Pelling JC.

Oncogene. 1998 Mar;16(11):1501-5.

36.

Induction of p21/WAF1 and G1 cell-cycle arrest by the chemopreventive agent apigenin.

Lepley DM, Pelling JC.

Mol Carcinog. 1997 Jun;19(2):74-82.

PMID:
9210954
37.

Dietary fat and energy modulation of biochemical events in tumor promotion.

Birt DF, Copenhaver J, Barnett T, Pelling JC, Luthra R.

Adv Exp Med Biol. 1997;400B:925-9. No abstract available.

PMID:
9547648
38.

The chemopreventive flavonoid apigenin induces G2/M arrest in keratinocytes.

Lepley DM, Li B, Birt DF, Pelling JC.

Carcinogenesis. 1996 Nov;17(11):2367-75.

PMID:
8968050
39.

Diet intervention for modifying cancer risk.

Birt DF, Pelling JC, Nair S, Lepley D.

Prog Clin Biol Res. 1996;395:223-34. Review.

PMID:
8895992
40.

Differential effects of UV-B and UV-C components of solar radiation on MAP kinase signal transduction pathways in epidermal keratinocytes.

Dhanwada KR, Dickens M, Neades R, Davis R, Pelling JC.

Oncogene. 1995 Nov 16;11(10):1947-53.

PMID:
7478512
41.

Relating aromatic hydrocarbon-induced DNA adducts and c-H-ras mutations in mouse skin papillomas: the role of apurinic sites.

Chakravarti D, Pelling JC, Cavalieri EL, Rogan EG.

Proc Natl Acad Sci U S A. 1995 Oct 24;92(22):10422-6.

42.

UV-B/A irradiation of mouse keratinocytes results in p53-mediated WAF1/CIP1 expression.

Liu M, Pelling JC.

Oncogene. 1995 May 18;10(10):1955-60.

PMID:
7761096
43.

Ha-ras p21-GTP levels remain constant during primary keratinocyte differentiation.

Betz NA, Pelling JC.

Mol Carcinog. 1995 Feb;12(2):66-76.

PMID:
7662118
44.

Dietary energy restriction and fat modulation of protein kinase C isoenzymes and phorbol ester binding in Sencar mouse epidermis.

Birt DF, Copenhaver J, Pelling JC, Anderson J.

Carcinogenesis. 1994 Dec;15(12):2727-32.

PMID:
8001228
45.
46.

Increase in p53 protein half-life in mouse keratinocytes following UV-B irradiation.

Liu M, Dhanwada KR, Birt DF, Hecht S, Pelling JC.

Carcinogenesis. 1994 Jun;15(6):1089-92.

PMID:
8020138
47.

Tumor cell surface beta 1-6 branched oligosaccharides and lung metastasis.

Lu Y, Pelling JC, Chaney WG.

Clin Exp Metastasis. 1994 Jan;12(1):47-54.

PMID:
8287620
48.

Sequencing analysis of Ha-, Ki-, and N-ras genes in rat urinary bladder tumors induced by N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide (FANFT) and sodium saccharin.

Masui T, Mann AM, Borgeson CD, Garland EM, Okamura T, Fujii H, Pelling JC, Cohen SM.

Teratog Carcinog Mutagen. 1993;13(5):225-33.

PMID:
7905676
49.

Protein kinase C is activated and diacylglycerol is elevated in epidermal cells from Sencar mice fed high fat diets.

Choe M, Kris ES, Luthra R, Copenhaver J, Pelling JC, Donnelly TE, Birt DF.

J Nutr. 1992 Dec;122(12):2322-9.

PMID:
1453216
50.

Inhibition of mouse skin tumorigenesis by dexamethasone occurs through a Ha-ras-independent mechanism.

Strawhecker JM, Pelling JC.

Carcinogenesis. 1992 Nov;13(11):2075-80.

PMID:
1423878

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