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Voluntary physical activity counteracts Chronic Heart Failure progression affecting both cardiac function and skeletal muscle in the transgenic Tgαq*44 mouse model.

Bardi E, Majerczak J, Zoladz JA, Tyrankiewicz U, Skorka T, Chlopicki S, Jablonska M, Bar A, Jasinski K, Buso A, Salvadego D, Nieckarz Z, Grassi B, Bottinelli R, Pellegrino MA.

Physiol Rep. 2019 Aug;7(13):e14161. doi: 10.14814/phy2.14161.


Diaphragm Atrophy and Weakness in the Absence of Mitochondrial Dysfunction in the Critically Ill.

van den Berg M, Hooijman PE, Beishuizen A, de Waard MC, Paul MA, Hartemink KJ, van Hees HWH, Lawlor MW, Brocca L, Bottinelli R, Pellegrino MA, Stienen GJM, Heunks LMA, Wüst RCI, Ottenheijm CAC.

Am J Respir Crit Care Med. 2017 Dec 15;196(12):1544-1558. doi: 10.1164/rccm.201703-0501OC.


Exercise training in Tgαq*44 mice during the progression of chronic heart failure: cardiac vs. peripheral (soleus muscle) impairments to oxidative metabolism.

Grassi B, Majerczak J, Bardi E, Buso A, Comelli M, Chlopicki S, Guzik M, Mavelli I, Nieckarz Z, Salvadego D, Tyrankiewicz U, Skórka T, Bottinelli R, Zoladz JA, Pellegrino MA.

J Appl Physiol (1985). 2017 Aug 1;123(2):326-336. doi: 10.1152/japplphysiol.00342.2017. Epub 2017 May 18.


Structure and function of human muscle fibres and muscle proteome in physically active older men.

Brocca L, McPhee JS, Longa E, Canepari M, Seynnes O, De Vito G, Pellegrino MA, Narici M, Bottinelli R.

J Physiol. 2017 Jul 15;595(14):4823-4844. doi: 10.1113/JP274148. Epub 2017 Jun 5.


Myosin content of single muscle fibers following short-term disuse and active recovery in young and old healthy men.

Hvid LG, Brocca L, Ørtenblad N, Suetta C, Aagaard P, Kjaer M, Bottinelli R, Pellegrino MA.

Exp Gerontol. 2017 Jan;87(Pt A):100-107. doi: 10.1016/j.exger.2016.10.009. Epub 2016 Oct 26.


FoxO-dependent atrogenes vary among catabolic conditions and play a key role in muscle atrophy induced by hindlimb suspension.

Brocca L, Toniolo L, Reggiani C, Bottinelli R, Sandri M, Pellegrino MA.

J Physiol. 2017 Feb 15;595(4):1143-1158. doi: 10.1113/JP273097. Epub 2016 Dec 12.


Human skeletal muscle fibre contractile properties and proteomic profile: adaptations to 3 weeks of unilateral lower limb suspension and active recovery.

Brocca L, Longa E, Cannavino J, Seynnes O, de Vito G, McPhee J, Narici M, Pellegrino MA, Bottinelli R.

J Physiol. 2015 Dec 15;593(24):5361-85. doi: 10.1113/JP271188.


Quantitative and qualitative adaptations of muscle fibers to glucocorticoids.

Minetto MA, Qaisar R, Agoni V, Motta G, Longa E, Miotti D, Pellegrino MA, Bottinelli R.

Muscle Nerve. 2015 Oct;52(4):631-9. doi: 10.1002/mus.24572. Epub 2015 Jun 30.


The role of alterations in mitochondrial dynamics and PGC-1α over-expression in fast muscle atrophy following hindlimb unloading.

Cannavino J, Brocca L, Sandri M, Grassi B, Bottinelli R, Pellegrino MA.

J Physiol. 2015 Apr 15;593(8):1981-95. doi: 10.1113/jphysiol.2014.286740. Epub 2015 Feb 4.


PGC1-α over-expression prevents metabolic alterations and soleus muscle atrophy in hindlimb unloaded mice.

Cannavino J, Brocca L, Sandri M, Bottinelli R, Pellegrino MA.

J Physiol. 2014 Oct 15;592(20):4575-89. doi: 10.1113/jphysiol.2014.275545. Epub 2014 Aug 15.


The time course of the adaptations of human muscle proteome to bed rest and the underlying mechanisms.

Brocca L, Cannavino J, Coletto L, Biolo G, Sandri M, Bottinelli R, Pellegrino MA.

J Physiol. 2012 Oct 15;590(20):5211-30. doi: 10.1113/jphysiol.2012.240267. Epub 2012 Jul 30.


Redox homeostasis, oxidative stress and disuse muscle atrophy.

Pellegrino MA, Desaphy JF, Brocca L, Pierno S, Camerino DC, Bottinelli R.

J Physiol. 2011 May 1;589(Pt 9):2147-60. doi: 10.1113/jphysiol.2010.203232. Epub 2011 Feb 14. Review.


Statin or fibrate chronic treatment modifies the proteomic profile of rat skeletal muscle.

Camerino GM, Pellegrino MA, Brocca L, Digennaro C, Camerino DC, Pierno S, Bottinelli R.

Biochem Pharmacol. 2011 Apr 15;81(8):1054-64. doi: 10.1016/j.bcp.2011.01.022. Epub 2011 Feb 15.


Neuromuscular electrical stimulation training induces atypical adaptations of the human skeletal muscle phenotype: a functional and proteomic analysis.

Gondin J, Brocca L, Bellinzona E, D'Antona G, Maffiuletti NA, Miotti D, Pellegrino MA, Bottinelli R.

J Appl Physiol (1985). 2011 Feb;110(2):433-50. doi: 10.1152/japplphysiol.00914.2010. Epub 2010 Dec 2.


Skeletal muscle fibre diversity and the underlying mechanisms.

Canepari M, Pellegrino MA, D'Antona G, Bottinelli R.

Acta Physiol (Oxf). 2010 Aug;199(4):465-76. doi: 10.1111/j.1748-1716.2010.02118.x. Epub 2010 Mar 24. Review.


Antioxidant treatment of hindlimb-unloaded mouse counteracts fiber type transition but not atrophy of disused muscles.

Desaphy JF, Pierno S, Liantonio A, Giannuzzi V, Digennaro C, Dinardo MM, Camerino GM, Ricciuti P, Brocca L, Pellegrino MA, Bottinelli R, Camerino DC.

Pharmacol Res. 2010 Jun;61(6):553-63. doi: 10.1016/j.phrs.2010.01.012. Epub 2010 Jan 29.


Myosin and actin content of human skeletal muscle fibers following 35 days bed rest.

Borina E, Pellegrino MA, D'Antona G, Bottinelli R.

Scand J Med Sci Sports. 2010 Feb;20(1):65-73. doi: 10.1111/j.1600-0838.2009.01029.x.


Single muscle fiber properties in aging and disuse.

Canepari M, Pellegrino MA, D'Antona G, Bottinelli R.

Scand J Med Sci Sports. 2010 Feb;20(1):10-9. doi: 10.1111/j.1600-0838.2009.00965.x. Epub 2009 Oct 14. Review.


Is oxidative stress a cause or consequence of disuse muscle atrophy in mice? A proteomic approach in hindlimb-unloaded mice.

Brocca L, Pellegrino MA, Desaphy JF, Pierno S, Camerino DC, Bottinelli R.

Exp Physiol. 2010 Feb;95(2):331-50. doi: 10.1113/expphysiol.2009.050245. Epub 2009 Oct 9.


Amino acid supplements improve native antioxidant enzyme expression in the skeletal muscle of diabetic mice.

Brocca L, D'Antona G, Bachi A, Pellegrino MA.

Am J Cardiol. 2008 Jun 2;101(11A):57E-62E. doi: 10.1016/j.amjcard.2008.03.002.


Amino acid supplementation counteracts metabolic and functional damage in the diabetic rat heart.

Pellegrino MA, Patrini C, Pasini E, Brocca L, Flati V, Corsetti G, D'Antona G.

Am J Cardiol. 2008 Jun 2;101(11A):49E-56E. doi: 10.1016/j.amjcard.2008.03.001.


Deterioration of contractile properties of muscle fibres in elderly subjects is modulated by the level of physical activity.

D'Antona G, Pellegrino MA, Carlizzi CN, Bottinelli R.

Eur J Appl Physiol. 2007 Jul;100(5):603-11. Epub 2007 Feb 2.


The human muscle proteome in aging.

Gelfi C, Vigano A, Ripamonti M, Pontoglio A, Begum S, Pellegrino MA, Grassi B, Bottinelli R, Wait R, Cerretelli P.

J Proteome Res. 2006 Jun;5(6):1344-53.


Neuromuscular adaptations to electrostimulation resistance training.

Maffiuletti NA, Zory R, Miotti D, Pellegrino MA, Jubeau M, Bottinelli R.

Am J Phys Med Rehabil. 2006 Feb;85(2):167-75.


Facioscapulohumeral muscular dystrophy in mice overexpressing FRG1.

Gabellini D, D'Antona G, Moggio M, Prelle A, Zecca C, Adami R, Angeletti B, Ciscato P, Pellegrino MA, Bottinelli R, Green MR, Tupler R.

Nature. 2006 Feb 23;439(7079):973-7. Epub 2005 Dec 11.


Skeletal muscle hypertrophy and structure and function of skeletal muscle fibres in male body builders.

D'Antona G, Lanfranconi F, Pellegrino MA, Brocca L, Adami R, Rossi R, Moro G, Miotti D, Canepari M, Bottinelli R.

J Physiol. 2006 Feb 1;570(Pt 3):611-27. Epub 2005 Dec 8.


What limits the velocity of fast-skeletal muscle contraction in mammals?

Nyitrai M, Rossi R, Adamek N, Pellegrino MA, Bottinelli R, Geeves MA.

J Mol Biol. 2006 Jan 20;355(3):432-42. Epub 2005 Nov 9.


Effects of voluntary wheel running and amino acid supplementation on skeletal muscle of mice.

Pellegrino MA, Brocca L, Dioguardi FS, Bottinelli R, D'Antona G.

Eur J Appl Physiol. 2005 Mar;93(5-6):655-64. Epub 2004 Nov 25.


Effects of resistance training on myosin function studied by the in vitro motility assay in young and older men.

Canepari M, Rossi R, Pellegrino MA, Orrell RW, Cobbold M, Harridge S, Bottinelli R.

J Appl Physiol (1985). 2005 Jun;98(6):2390-5. Epub 2005 Jan 27.


Human circulating AC133(+) stem cells restore dystrophin expression and ameliorate function in dystrophic skeletal muscle.

Torrente Y, Belicchi M, Sampaolesi M, Pisati F, Meregalli M, D'Antona G, Tonlorenzi R, Porretti L, Gavina M, Mamchaoui K, Pellegrino MA, Furling D, Mouly V, Butler-Browne GS, Bottinelli R, Cossu G, Bresolin N.

J Clin Invest. 2004 Jul;114(2):182-95.


Clenbuterol antagonizes glucocorticoid-induced atrophy and fibre type transformation in mice.

Pellegrino MA, D'Antona G, Bortolotto S, Boschi F, Pastoris O, Bottinelli R, Polla B, Reggiani C.

Exp Physiol. 2004 Jan;89(1):89-100.


Fast fibres in a large animal: fibre types, contractile properties and myosin expression in pig skeletal muscles.

Toniolo L, Patruno M, Maccatrozzo L, Pellegrino MA, Canepari M, Rossi R, D'Antona G, Bottinelli R, Reggiani C, Mascarello F.

J Exp Biol. 2004 May;207(Pt 11):1875-86.


The effect of ageing and immobilization on structure and function of human skeletal muscle fibres.

D'Antona G, Pellegrino MA, Adami R, Rossi R, Carlizzi CN, Canepari M, Saltin B, Bottinelli R.

J Physiol. 2003 Oct 15;552(Pt 2):499-511.


The mechanism of the force response to stretch in human skinned muscle fibres with different myosin isoforms.

Linari M, Bottinelli R, Pellegrino MA, Reconditi M, Reggiani C, Lombardi V.

J Physiol. 2004 Jan 15;554(Pt 2):335-52. Epub 2003 Oct 10. Erratum in: J Physiol. 2004 Mar 16;555(Pt 3):851.


Contractile effects of the exchange of cardiac troponin for fast skeletal troponin in rabbit psoas single myofibrils.

Piroddi N, Tesi C, Pellegrino MA, Tobacman LS, Homsher E, Poggesi C.

J Physiol. 2003 Nov 1;552(Pt 3):917-31. Epub 2003 Aug 22.


Cell therapy of alpha-sarcoglycan null dystrophic mice through intra-arterial delivery of mesoangioblasts.

Sampaolesi M, Torrente Y, Innocenzi A, Tonlorenzi R, D'Antona G, Pellegrino MA, Barresi R, Bresolin N, De Angelis MG, Campbell KP, Bottinelli R, Cossu G.

Science. 2003 Jul 25;301(5632):487-92. Epub 2003 Jul 10.


Orthologous myosin isoforms and scaling of shortening velocity with body size in mouse, rat, rabbit and human muscles.

Pellegrino MA, Canepari M, Rossi R, D'Antona G, Reggiani C, Bottinelli R.

J Physiol. 2003 Feb 1;546(Pt 3):677-89.


Contractile properties and myosin heavy chain isoform composition in single fibre of human laryngeal muscles.

D'Antona G, Megighian A, Bortolotto S, Pellegrino MA, Marchese-Ragona R, Staffieri A, Bottinelli R, Reggiani C.

J Muscle Res Cell Motil. 2002;23(3):187-95.


"Oxidative stress": effects of mild endurance training and testosterone treatment on rat gastrocnemius muscle.

Pansarasa O, D'Antona G, Gualea MR, Marzani B, Pellegrino MA, Marzatico F.

Eur J Appl Physiol. 2002 Oct;87(6):550-5. Epub 2002 Jul 13.


Circadian rhythm of hunger sensation in patients affected by dysthymic disorder.

Cugini P, Passynkova NR, Di Cristofano F, De Rosa R, De Francesco GP, Coda S, Pellegrino MA, D'Agostini-Costa C, Pandolfi C, Fontana S.

Clin Ter. 2002 Jan-Feb;153(1):25-30.


[Daily sensation of hunger, before and after phototherapy, in subjects with depression-type seasonal affective disorder].

Cugini P, Passynkova NR, Di Cristofano F, De Rosa R, De Francesco GP, Coda S, Pellegrino MA, D'Agostini-Costa C, Fontana S.

Clin Ter. 2001 Nov-Dec;152(6):353-62. Italian.


Differing ADP release rates from myosin heavy chain isoforms define the shortening velocity of skeletal muscle fibers.

Weiss S, Rossi R, Pellegrino MA, Bottinelli R, Geeves MA.

J Biol Chem. 2001 Dec 7;276(49):45902-8. Epub 2001 Oct 5.


Effects of the beta(2)-agonist clenbuterol on respiratory and limb muscles of weaning rats.

Polla B, Cappelli V, Morello F, Pellegrino MA, Boschi F, Pastoris O, Reggiani C.

Am J Physiol Regul Integr Comp Physiol. 2001 Mar;280(3):R862-9.


Functional diversity between orthologous myosins with minimal sequence diversity.

Canepari M, Rossi R, Pellegrino MA, Bottinelli R, Schiaffino S, Reggiani C.

J Muscle Res Cell Motil. 2000 May;21(4):375-82.


ATP consumption and efficiency of human single muscle fibers with different myosin isoform composition.

He ZH, Bottinelli R, Pellegrino MA, Ferenczi MA, Reggiani C.

Biophys J. 2000 Aug;79(2):945-61.


Profound misregulation of muscle-specific gene expression in facioscapulohumeral muscular dystrophy.

Tupler R, Perini G, Pellegrino MA, Green MR.

Proc Natl Acad Sci U S A. 1999 Oct 26;96(22):12650-4. Erratum in: Proc Natl Acad Sci U S A 2000 Feb 29;97(5):2397.


Speeds of actin translocation in vitro by myosins extracted from single rat muscle fibres of different types.

Canepari M, Rossi R, Pellegrino MA, Reggiani C, Bottinelli R.

Exp Physiol. 1999 Jul;84(4):803-6.


Thyroid hormone regulation of MHC isoform composition and myofibrillar ATPase activity in rat skeletal muscles.

Canepari M, Cappelli V, Pellegrino MA, Zanardi MC, Reggiani C.

Arch Physiol Biochem. 1998 Oct;106(4):308-15.


Specific contributions of various muscle fibre types to human muscle performance: an in vitro study.

Bottinelli R, Pellegrino MA, Canepari M, Rossi R, Reggiani C.

J Electromyogr Kinesiol. 1999 Apr;9(2):87-95.


Fibre types in skeletal muscles of chronic obstructive pulmonary disease patients related to respiratory function and exercise tolerance.

Satta A, Migliori GB, Spanevello A, Neri M, Bottinelli R, Canepari M, Pellegrino MA, Reggiani C.

Eur Respir J. 1997 Dec;10(12):2853-60.

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