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Items: 1 to 50 of 73

1.

Multivariate Control of Transcript to Protein Variability in Single Mammalian Cells.

Popovic D, Koch B, Kueblbeck M, Ellenberg J, Pelkmans L.

Cell Syst. 2018 Oct 24;7(4):398-411.e6. doi: 10.1016/j.cels.2018.09.001. Epub 2018 Oct 17.

PMID:
30342881
2.

Multiplexed protein maps link subcellular organization to cellular states.

Gut G, Herrmann MD, Pelkmans L.

Science. 2018 Aug 3;361(6401). pii: eaar7042. doi: 10.1126/science.aar7042.

PMID:
30072512
3.

Hypertonic Stress Causes Cytoplasmic Translocation of Neuronal, but Not Astrocytic, FUS due to Impaired Transportin Function.

Hock EM, Maniecka Z, Hruska-Plochan M, Reber S, Laferrière F, Sahadevan M K S, Ederle H, Gittings L, Pelkmans L, Dupuis L, Lashley T, Ruepp MD, Dormann D, Polymenidou M.

Cell Rep. 2018 Jul 24;24(4):987-1000.e7. doi: 10.1016/j.celrep.2018.06.094.

4.

Kinase-controlled phase transition of membraneless organelles in mitosis.

Rai AK, Chen JX, Selbach M, Pelkmans L.

Nature. 2018 Jul;559(7713):211-216. doi: 10.1038/s41586-018-0279-8. Epub 2018 Jul 4.

PMID:
29973724
5.

Large-scale image-based profiling of single-cell phenotypes in arrayed CRISPR-Cas9 gene perturbation screens.

de Groot R, Lüthi J, Lindsay H, Holtackers R, Pelkmans L.

Mol Syst Biol. 2018 Jan 23;14(1):e8064. doi: 10.15252/msb.20178064.

6.

Modifiers of prion protein biogenesis and recycling identified by a highly parallel endocytosis kinetics assay.

Ballmer BA, Moos R, Liberali P, Pelkmans L, Hornemann S, Aguzzi A.

J Biol Chem. 2017 May 19;292(20):8356-8368. doi: 10.1074/jbc.M116.773283. Epub 2017 Mar 24.

7.

Elevated serum IgG4 levels in diagnosis and treatment response in patients with idiopathic retroperitoneal fibrosis.

Pelkmans LG, Hendriksz TR, Westenend PJ, Vermeer HJ, van Bommel EFH.

Clin Rheumatol. 2017 Apr;36(4):903-912. doi: 10.1007/s10067-017-3542-8. Epub 2017 Jan 19.

PMID:
28105551
8.

Post-transcriptional control of executioner caspases by RNA-binding proteins.

Subasic D, Stoeger T, Eisenring S, Matia-González AM, Imig J, Zheng X, Xiong L, Gisler P, Eberhard R, Holtackers R, Gerber AP, Pelkmans L, Hengartner MO.

Genes Dev. 2016 Oct 1;30(19):2213-2225.

9.

A Systems Survey of Progressive Host-Cell Reorganization during Rotavirus Infection.

Green VA, Pelkmans L.

Cell Host Microbe. 2016 Jul 13;20(1):107-20. doi: 10.1016/j.chom.2016.06.005.

10.

IgG/IgM antiphospholipid antibodies present in the classification criteria for the antiphospholipid syndrome: a critical review of their association with thrombosis.

Kelchtermans H, Pelkmans L, de Laat B, Devreese KM.

J Thromb Haemost. 2016 Aug;14(8):1530-48. doi: 10.1111/jth.13379. Epub 2016 Aug 11. Review.

11.

Simultaneous measurement of thrombin generation and fibrin formation in whole blood under flow conditions.

Kelchtermans H, Pelkmans L, Bouwhuis A, Schurgers E, Lindhout T, Huskens D, Miszta A, Hemker HC, Lancé MD, de Laat B.

Thromb Haemost. 2016 Jul 4;116(1):134-45. doi: 10.1160/TH15-10-0801. Epub 2016 Apr 14.

PMID:
27074907
12.

Passive Noise Filtering by Cellular Compartmentalization.

Stoeger T, Battich N, Pelkmans L.

Cell. 2016 Mar 10;164(6):1151-1161. doi: 10.1016/j.cell.2016.02.005. Review.

13.

Control of Transcript Variability in Single Mammalian Cells.

Battich N, Stoeger T, Pelkmans L.

Cell. 2015 Dec 17;163(7):1596-610. doi: 10.1016/j.cell.2015.11.018.

14.

Differences in the mechanism of blood clot formation and nanostructure in infants and children compared with adults.

Ignjatovic V, Pelkmans L, Kelchtermans H, Al Dieri R, Hemker C, Kremers R, Bloemen S, Karlaftis V, Attard C, de Laat B, Monagle P.

Thromb Res. 2015 Dec;136(6):1303-9. doi: 10.1016/j.thromres.2015.10.034. Epub 2015 Oct 26.

PMID:
26522267
15.

Hypoxia Induces a Prothrombotic State Independently of the Physical Activity.

Ninivaggi M, de Laat M, Lancé MM, Kicken CH, Pelkmans L, Bloemen S, Dirks ML, van Loon LJ, Govers-Riemslag JW, Lindhout T, Konings J, de Laat B.

PLoS One. 2015 Oct 30;10(10):e0141797. doi: 10.1371/journal.pone.0141797. eCollection 2015.

16.

Thrombin Generating Capacity and Phenotypic Association in ABO Blood Groups.

Kremers RM, Mohamed AB, Pelkmans L, Hindawi S, Hemker HC, de Laat HB, Huskens D, Al Dieri R.

PLoS One. 2015 Oct 28;10(10):e0141491. doi: 10.1371/journal.pone.0141491. eCollection 2015.

17.

Trajectories of cell-cycle progression from fixed cell populations.

Gut G, Tadmor MD, Pe'er D, Pelkmans L, Liberali P.

Nat Methods. 2015 Oct;12(10):951-4. doi: 10.1038/nmeth.3545. Epub 2015 Aug 24.

18.

Sumoylation regulates EXO1 stability and processing of DNA damage.

Bologna S, Altmannova V, Valtorta E, Koenig C, Liberali P, Gentili C, Anrather D, Ammerer G, Pelkmans L, Krejci L, Ferrari S.

Cell Cycle. 2015 Aug 3;14(15):2439-50. doi: 10.1080/15384101.2015.1060381. Epub 2015 Jun 17.

19.

Computer vision for image-based transcriptomics.

Stoeger T, Battich N, Herrmann MD, Yakimovich Y, Pelkmans L.

Methods. 2015 Sep 1;85:44-53. doi: 10.1016/j.ymeth.2015.05.016. Epub 2015 May 23.

20.

Cell-intrinsic adaptation of lipid composition to local crowding drives social behaviour.

Frechin M, Stoeger T, Daetwyler S, Gehin C, Battich N, Damm EM, Stergiou L, Riezman H, Pelkmans L.

Nature. 2015 Jul 2;523(7558):88-91. doi: 10.1038/nature14429. Epub 2015 May 25.

PMID:
26009010
21.

Wnt directs the endosomal flux of LDL-derived cholesterol and lipid droplet homeostasis.

Scott CC, Vossio S, Vacca F, Snijder B, Larios J, Schaad O, Guex N, Kuznetsov D, Martin O, Chambon M, Turcatti G, Pelkmans L, Gruenberg J.

EMBO Rep. 2015 Jun;16(6):741-52. doi: 10.15252/embr.201540081. Epub 2015 Apr 7.

22.

Simultaneous analysis of large-scale RNAi screens for pathogen entry.

Rämö P, Drewek A, Arrieumerlou C, Beerenwinkel N, Ben-Tekaya H, Cardel B, Casanova A, Conde-Alvarez R, Cossart P, Csúcs G, Eicher S, Emmenlauer M, Greber U, Hardt WD, Helenius A, Kasper C, Kaufmann A, Kreibich S, Kühbacher A, Kunszt P, Low SH, Mercer J, Mudrak D, Muntwiler S, Pelkmans L, Pizarro-Cerdá J, Podvinec M, Pujadas E, Rinn B, Rouilly V, Schmich F, Siebourg-Polster J, Snijder B, Stebler M, Studer G, Szczurek E, Truttmann M, von Mering C, Vonderheit A, Yakimovich A, Bühlmann P, Dehio C.

BMC Genomics. 2014 Dec 22;15:1162. doi: 10.1186/1471-2164-15-1162.

23.

Single-cell and multivariate approaches in genetic perturbation screens.

Liberali P, Snijder B, Pelkmans L.

Nat Rev Genet. 2015 Jan;16(1):18-32. doi: 10.1038/nrg3768. Epub 2014 Dec 2. Review.

PMID:
25446316
24.

Thrombin-dependent Incorporation of von Willebrand Factor into a Fibrin Network.

Miszta A, Pelkmans L, Lindhout T, Krishnamoorthy G, de Groot PG, Hemker CH, Heemskerk JW, Kelchtermans H, de Laat B.

J Biol Chem. 2014 Dec 26;289(52):35979-86. doi: 10.1074/jbc.M114.591677. Epub 2014 Nov 7.

25.

Coronavirus cell entry occurs through the endo-/lysosomal pathway in a proteolysis-dependent manner.

Burkard C, Verheije MH, Wicht O, van Kasteren SI, van Kuppeveld FJ, Haagmans BL, Pelkmans L, Rottier PJ, Bosch BJ, de Haan CA.

PLoS Pathog. 2014 Nov 6;10(11):e1004502. doi: 10.1371/journal.ppat.1004502. eCollection 2014 Nov. Erratum in: PLoS Pathog. 2015 Feb;11(2):e1004709.

26.

Thrombin generation in the presence of platelets is sensitive to the activation status of von Willebrand factor.

Pelkmans L, Miszta A, Al Dieri R, de Laat B, Kelchtermans H.

Thromb Haemost. 2015 Jan;113(1):209-11. doi: 10.1160/TH14-03-0285. Epub 2014 Oct 2. No abstract available.

PMID:
25274249
27.

A hierarchical map of regulatory genetic interactions in membrane trafficking.

Liberali P, Snijder B, Pelkmans L.

Cell. 2014 Jun 5;157(6):1473-87. doi: 10.1016/j.cell.2014.04.029.

28.

Large scale RNAi reveals the requirement of nuclear envelope breakdown for nuclear import of human papillomaviruses.

Aydin I, Weber S, Snijder B, Samperio Ventayol P, Kühbacher A, Becker M, Day PM, Schiller JT, Kann M, Pelkmans L, Helenius A, Schelhaas M.

PLoS Pathog. 2014 May 29;10(5):e1004162. doi: 10.1371/journal.ppat.1004162. eCollection 2014 May.

29.

Specific inhibition of diverse pathogens in human cells by synthetic microRNA-like oligonucleotides inferred from RNAi screens.

Franceschini A, Meier R, Casanova A, Kreibich S, Daga N, Andritschke D, Dilling S, Rämö P, Emmenlauer M, Kaufmann A, Conde-Álvarez R, Low SH, Pelkmans L, Helenius A, Hardt WD, Dehio C, von Mering C.

Proc Natl Acad Sci U S A. 2014 Mar 25;111(12):4548-53. doi: 10.1073/pnas.1402353111. Epub 2014 Mar 10.

30.

Image-based transcriptomics in thousands of single human cells at single-molecule resolution.

Battich N, Stoeger T, Pelkmans L.

Nat Methods. 2013 Nov;10(11):1127-33. doi: 10.1038/nmeth.2657. Epub 2013 Oct 6.

PMID:
24097269
31.

Predicting functional gene interactions with the hierarchical interaction score.

Snijder B, Liberali P, Frechin M, Stoeger T, Pelkmans L.

Nat Methods. 2013 Nov;10(11):1089-92. doi: 10.1038/nmeth.2655. Epub 2013 Oct 6.

PMID:
24097268
32.

Variability in exposure of epitope G40-R43 of domain i in commercial anti-beta2-glycoprotein I IgG ELISAs.

Pelkmans L, Kelchtermans H, de Groot PG, Zuily S, Regnault V, Wahl D, Pengo V, de Laat B.

PLoS One. 2013 Aug 12;8(8):e71402. doi: 10.1371/journal.pone.0071402. eCollection 2013.

33.

Annexin A5 anticoagulant activity in children with systemic lupus erythematosus and the association with antibodies to domain I of β2-glycoprotein I.

Wahezi DM, Ilowite NT, Wu XX, Pelkmans L, Laat B, Schanberg LE, Rand JH; Atherosclerosis Prevention in Pediatric Lupus Erythematosus Investigators.

Lupus. 2013 Jun;22(7):702-11. doi: 10.1177/0961203313490241. Epub 2013 May 20.

34.

Cardiac remodeling during and after renin-angiotensin system stimulation in Cyp1a1-Ren2 transgenic rats.

Heijnen BF, Pelkmans LP, Danser AH, Garrelds IM, Mullins JJ, De Mey JG, Struijker-Boudier HA, Janssen BJ.

J Renin Angiotensin Aldosterone Syst. 2014 Mar;15(1):69-81. doi: 10.1177/1470320313480537. Epub 2013 Mar 5.

PMID:
23462119
35.

Dual specificity kinase DYRK3 couples stress granule condensation/dissolution to mTORC1 signaling.

Wippich F, Bodenmiller B, Trajkovska MG, Wanka S, Aebersold R, Pelkmans L.

Cell. 2013 Feb 14;152(4):791-805. doi: 10.1016/j.cell.2013.01.033.

36.

Integrin-mediated signaling induced by simian virus 40 leads to transient uncoupling of cortical actin and the plasma membrane.

Stergiou L, Bauer M, Mair W, Bausch-Fluck D, Drayman N, Wollscheid B, Oppenheim A, Pelkmans L.

PLoS One. 2013;8(2):e55799. doi: 10.1371/journal.pone.0055799. Epub 2013 Feb 7.

37.

Long-term safety and efficacy of a tamoxifen-based treatment strategy for idiopathic retroperitoneal fibrosis.

van Bommel EF, Pelkmans LG, van Damme H, Hendriksz TR.

Eur J Intern Med. 2013 Jul;24(5):444-50. doi: 10.1016/j.ejim.2012.11.010. Epub 2012 Dec 13.

PMID:
23246124
38.

Towards quantitative cell biology.

Liberali P, Pelkmans L.

Nat Cell Biol. 2012 Dec;14(12):1233. doi: 10.1038/ncb2648.

PMID:
23196839
39.

RNAi screening reveals proteasome- and Cullin3-dependent stages in vaccinia virus infection.

Mercer J, Snijder B, Sacher R, Burkard C, Bleck CK, Stahlberg H, Pelkmans L, Helenius A.

Cell Rep. 2012 Oct 25;2(4):1036-47. doi: 10.1016/j.celrep.2012.09.003. Epub 2012 Oct 19.

40.

Antibodies against domain I of β2-glycoprotein I: the one and only?

Pelkmans L, de Laat B.

Lupus. 2012 Jun;21(7):769-72. doi: 10.1177/0961203312437439. Review.

PMID:
22635228
41.

Cell Biology. Using cell-to-cell variability--a new era in molecular biology.

Pelkmans L.

Science. 2012 Apr 27;336(6080):425-6. doi: 10.1126/science.1222161. No abstract available.

PMID:
22539709
42.

Single-cell analysis of population context advances RNAi screening at multiple levels.

Snijder B, Sacher R, Rämö P, Liberali P, Mench K, Wolfrum N, Burleigh L, Scott CC, Verheije MH, Mercer J, Moese S, Heger T, Theusner K, Jurgeit A, Lamparter D, Balistreri G, Schelhaas M, De Haan CA, Marjomäki V, Hyypiä T, Rottier PJ, Sodeik B, Marsh M, Gruenberg J, Amara A, Greber U, Helenius A, Pelkmans L.

Mol Syst Biol. 2012 Apr 24;8:579. doi: 10.1038/msb.2012.9.

43.

Value of acute-phase reactants in monitoring disease activity and treatment response in idiopathic retroperitoneal fibrosis.

Pelkmans LG, Aarnoudse AJ, Hendriksz TR, van Bommel EF.

Nephrol Dial Transplant. 2012 Jul;27(7):2819-25. doi: 10.1093/ndt/gfr779. Epub 2012 Jan 23.

PMID:
22273666
44.

RNAi screen of Salmonella invasion shows role of COPI in membrane targeting of cholesterol and Cdc42.

Misselwitz B, Dilling S, Vonaesch P, Sacher R, Snijder B, Schlumberger M, Rout S, Stark M, von Mering C, Pelkmans L, Hardt WD.

Mol Syst Biol. 2011 Mar 15;7:474. doi: 10.1038/msb.2011.7.

45.

Origins of regulated cell-to-cell variability.

Snijder B, Pelkmans L.

Nat Rev Mol Cell Biol. 2011 Feb;12(2):119-25. doi: 10.1038/nrm3044. Epub 2011 Jan 12. Review.

PMID:
21224886
46.

Evaluation of methods for detection of fluorescence labeled subcellular objects in microscope images.

Ruusuvuori P, Aijö T, Chowdhury S, Garmendia-Torres C, Selinummi J, Birbaumer M, Dudley AM, Pelkmans L, Yli-Harja O.

BMC Bioinformatics. 2010 May 13;11:248. doi: 10.1186/1471-2105-11-248.

47.

Why the debate about land use change should not only focus on biofuels.

Gorissen L, Buytaert V, Cuypers D, Dauwe T, Pelkmans L.

Environ Sci Technol. 2010 Jun 1;44(11):4046-9. doi: 10.1021/es903036u. No abstract available.

PMID:
20441199
48.

CellClassifier: supervised learning of cellular phenotypes.

Rämö P, Sacher R, Snijder B, Begemann B, Pelkmans L.

Bioinformatics. 2009 Nov 15;25(22):3028-30. doi: 10.1093/bioinformatics/btp524. Epub 2009 Sep 2.

PMID:
19729371
49.

Population context determines cell-to-cell variability in endocytosis and virus infection.

Snijder B, Sacher R, Rämö P, Damm EM, Liberali P, Pelkmans L.

Nature. 2009 Sep 24;461(7263):520-3. doi: 10.1038/nature08282. Epub 2009 Aug 26.

PMID:
19710653
50.

Systems biology of virus infection in mammalian cells.

Pelkmans L.

Curr Opin Microbiol. 2009 Aug;12(4):429-31. doi: 10.1016/j.mib.2009.06.017. Epub 2009 Jul 22. No abstract available.

PMID:
19631577

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