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Items: 1 to 50 of 457

1.

PREP1 tumor suppressor protects the late-replicating DNA by controlling its replication timing and symmetry.

Palmigiano A, Santaniello F, Cerutti A, Penkov D, Purushothaman D, Makhija E, Luzi L, di Fagagna FD, Pelicci PG, Shivashankar V, Dellino GI, Blasi F.

Sci Rep. 2018 Feb 16;8(1):3198. doi: 10.1038/s41598-018-21363-4.

2.

p66Shc deficiency enhances CXCR4 and CCR7 recycling in CLL B cells by facilitating their dephosphorylation-dependent release from β-arrestin at early endosomes.

Patrussi L, Capitani N, Cattaneo F, Manganaro N, Gamberucci A, Frezzato F, Martini V, Visentin A, Pelicci PG, D'Elios MM, Trentin L, Semenzato G, Baldari CT.

Oncogene. 2018 Mar;37(11):1534-1550. doi: 10.1038/s41388-017-0066-2. Epub 2018 Jan 12.

PMID:
29326436
3.

The E3 ubiquitin ligase WWP1 sustains the growth of acute myeloid leukaemia.

Sanarico AG, Ronchini C, Croce A, Memmi EM, Cammarata UA, De Antoni A, Lavorgna S, Divona M, Giacò L, Melloni GEM, Brendolan A, Simonetti G, Martinelli G, Mancuso P, Bertolini F, Coco FL, Melino G, Pelicci PG, Bernassola F.

Leukemia. 2018 Apr;32(4):911-919. doi: 10.1038/leu.2017.342. Epub 2017 Dec 6.

4.

Erratum. Deletion of p66Shc Longevity Gene Protects Against Experimental Diabetic Glomerulopathy by Preventing Diabetes-Induced Oxidative Stress. Diabetes 2006;55:1642-1650.

Menini S, Amadio L, Oddi G, Ricci C, Pesce C, Pugliese F, Giorgio M, Migliaccio E, Pelicci P, Iacobini C, Pugliese G.

Diabetes. 2018 Jan;67(1):165. doi: 10.2337/db18-er01a. Epub 2017 Oct 24. No abstract available.

5.

Tumour-derived PGD2 and NKp30-B7H6 engagement drives an immunosuppressive ILC2-MDSC axis.

Trabanelli S, Chevalier MF, Martinez-Usatorre A, Gomez-Cadena A, Salomé B, Lecciso M, Salvestrini V, Verdeil G, Racle J, Papayannidis C, Morita H, Pizzitola I, Grandclément C, Bohner P, Bruni E, Girotra M, Pallavi R, Falvo P, Leibundgut EO, Baerlocher GM, Carlo-Stella C, Taurino D, Santoro A, Spinelli O, Rambaldi A, Giarin E, Basso G, Tresoldi C, Ciceri F, Gfeller D, Akdis CA, Mazzarella L, Minucci S, Pelicci PG, Marcenaro E, McKenzie ANJ, Vanhecke D, Coukos G, Mavilio D, Curti A, Derré L, Jandus C.

Nat Commun. 2017 Sep 19;8(1):593. doi: 10.1038/s41467-017-00678-2.

6.

Interrogating open issues in cancer medicine with patient-derived xenografts.

Byrne AT, Alférez DG, Amant F, Annibali D, Arribas J, Biankin AV, Bruna A, Budinská E, Caldas C, Chang DK, Clarke RB, Clevers H, Coukos G, Dangles-Marie V, Eckhardt SG, Gonzalez-Suarez E, Hermans E, Hidalgo M, Jarzabek MA, de Jong S, Jonkers J, Kemper K, Lanfrancone L, Mælandsmo GM, Marangoni E, Marine JC, Medico E, Norum JH, Palmer HG, Peeper DS, Pelicci PG, Piris-Gimenez A, Roman-Roman S, Rueda OM, Seoane J, Serra V, Soucek L, Vanhecke D, Villanueva A, Vinolo E, Bertotti A, Trusolino L.

Nat Rev Cancer. 2017 Sep 15;17(10):632. doi: 10.1038/nrc.2017.85. [Epub ahead of print]

PMID:
28912576
7.

Glucose and Lactate Miniaturized Biosensors for SECM-Based High-Spatial Resolution Analysis: A Comparative Study.

Soldà A, Valenti G, Marcaccio M, Giorgio M, Pelicci PG, Paolucci F, Rapino S.

ACS Sens. 2017 Sep 22;2(9):1310-1318. doi: 10.1021/acssensors.7b00324. Epub 2017 Aug 24.

PMID:
28836760
8.

Mutations targeting the coagulation pathway are enriched in brain metastases.

Richichi C, Fornasari L, Melloni GEM, Brescia P, Patanè M, Del Bene M, Mustafa DAM, Kros JM, Pollo B, Pruneri G, Sciandivasci A, Munzone E, DiMeco F, Pelicci PG, Riva L, Pelicci G.

Sci Rep. 2017 Jul 26;7(1):6573. doi: 10.1038/s41598-017-06811-x.

9.

Transcriptional activation of RagD GTPase controls mTORC1 and promotes cancer growth.

Di Malta C, Siciliano D, Calcagni A, Monfregola J, Punzi S, Pastore N, Eastes AN, Davis O, De Cegli R, Zampelli A, Di Giovannantonio LG, Nusco E, Platt N, Guida A, Ogmundsdottir MH, Lanfrancone L, Perera RM, Zoncu R, Pelicci PG, Settembre C, Ballabio A.

Science. 2017 Jun 16;356(6343):1188-1192. doi: 10.1126/science.aag2553.

10.

A harmonized and efficient clinical research environment would benefit patients and enhance European competitiveness. Commentary.

Amato A, Aringhieri E, Boccia S, Buccella F, Gorini B, Gramaglia D, Masetti R, Rossi P, Pelicci PG.

Ann Ist Super Sanita. 2017 Apr-Jun;53(2):104-107. doi: 10.4415/ANN_17_02_05.

11.

A knowledge-based framework for the discovery of cancer-predisposing variants using large-scale sequencing breast cancer data.

Melloni GEM, Mazzarella L, Bernard L, Bodini M, Russo A, Luzi L, Pelicci PG, Riva L.

Breast Cancer Res. 2017 May 31;19(1):63. doi: 10.1186/s13058-017-0854-1.

12.

Interrogating open issues in cancer precision medicine with patient-derived xenografts.

Byrne AT, Alférez DG, Amant F, Annibali D, Arribas J, Biankin AV, Bruna A, Budinská E, Caldas C, Chang DK, Clarke RB, Clevers H, Coukos G, Dangles-Marie V, Eckhardt SG, Gonzalez-Suarez E, Hermans E, Hidalgo M, Jarzabek MA, de Jong S, Jonkers J, Kemper K, Lanfrancone L, Mælandsmo GM, Marangoni E, Marine JC, Medico E, Norum JH, Palmer HG, Peeper DS, Pelicci PG, Piris-Gimenez A, Roman-Roman S, Rueda OM, Seoane J, Serra V, Soucek L, Vanhecke D, Villanueva A, Vinolo E, Bertotti A, Trusolino L.

Nat Rev Cancer. 2017 Apr;17(4):254-268. doi: 10.1038/nrc.2016.140. Epub 2017 Jan 20. Review. Erratum in: Nat Rev Cancer. 2017 Sep 15;:.

PMID:
28104906
13.

PML-RARA-associated cooperating mutations belong to a transcriptional network that is deregulated in myeloid leukemias.

Ronchini C, Brozzi A, Riva L, Luzi L, Gruszka AM, Melloni GEM, Scanziani E, Dharmalingam G, Mutarelli M, Belcastro V, Lavorgna S, Rossi V, Spinelli O, Biondi A, Rambaldi A, Lo-Coco F, di Bernardo D, Pelicci PG.

Leukemia. 2017 Sep;31(9):1975-1986. doi: 10.1038/leu.2016.386. Epub 2016 Dec 27.

PMID:
28025581
14.

miR-494-3p is a novel tumor driver of lung carcinogenesis.

Faversani A, Amatori S, Augello C, Colombo F, Porretti L, Fanelli M, Ferrero S, Palleschi A, Pelicci PG, Belloni E, Ercoli G, Degrassi A, Baccarin M, Altieri DC, Vaira V, Bosari S.

Oncotarget. 2017 Jan 31;8(5):7231-7247. doi: 10.18632/oncotarget.13933.

15.

From the maximum tolerable to the minimum effective treatment: The Umberto Veronesi's life commitment to breast cancer care.

Curigliano G, Cardoso F, Costa A, Galimberti V, Goldhirsch A, Pelicci PG, Veronesi P, Viale G, Orecchia R.

Breast. 2017 Feb;31:241-243. doi: 10.1016/j.breast.2016.11.013. Epub 2016 Nov 19. No abstract available.

PMID:
27876474
16.

Molecular mechanisms of asymmetric divisions in mammary stem cells.

Santoro A, Vlachou T, Carminati M, Pelicci PG, Mapelli M.

EMBO Rep. 2016 Dec;17(12):1700-1720. Epub 2016 Nov 21. Review.

17.

RNAi screens identify CHD4 as an essential gene in breast cancer growth.

D'Alesio C, Punzi S, Cicalese A, Fornasari L, Furia L, Riva L, Carugo A, Curigliano G, Criscitiello C, Pruneri G, Pelicci PG, Faretta M, Bossi D, Lanfrancone L.

Oncotarget. 2016 Dec 6;7(49):80901-80915. doi: 10.18632/oncotarget.12646.

18.

Maintenance of leukemic cell identity by the activity of the Polycomb complex PRC1 in mice.

Rossi A, Ferrari KJ, Piunti A, Jammula S, Chiacchiera F, Mazzarella L, Scelfo A, Pelicci PG, Pasini D.

Sci Adv. 2016 Oct 7;2(10):e1600972. eCollection 2016 Oct.

19.

In Vivo Functional Platform Targeting Patient-Derived Xenografts Identifies WDR5-Myc Association as a Critical Determinant of Pancreatic Cancer.

Carugo A, Genovese G, Seth S, Nezi L, Rose JL, Bossi D, Cicalese A, Shah PK, Viale A, Pettazzoni PF, Akdemir KC, Bristow CA, Robinson FS, Tepper J, Sanchez N, Gupta S, Estecio MR, Giuliani V, Dellino GI, Riva L, Yao W, Di Francesco ME, Green T, D'Alesio C, Corti D, Kang Y, Jones P, Wang H, Fleming JB, Maitra A, Pelicci PG, Chin L, DePinho RA, Lanfrancone L, Heffernan TP, Draetta GF.

Cell Rep. 2016 Jun 28;16(1):133-147. doi: 10.1016/j.celrep.2016.05.063. Epub 2016 Jun 16.

20.

In Vivo Genetic Screens of Patient-Derived Tumors Revealed Unexpected Frailty of the Transformed Phenotype.

Bossi D, Cicalese A, Dellino GI, Luzi L, Riva L, D'Alesio C, Diaferia GR, Carugo A, Cavallaro E, Piccioni R, Barberis M, Mazzarol G, Testori A, Punzi S, Pallavicini I, Tosti G, Giacó L, Melloni G, Heffernan TP, Natoli G, Draetta GF, Minucci S, Pelicci P, Lanfrancone L.

Cancer Discov. 2016 Jun;6(6):650-63. doi: 10.1158/2159-8290.CD-15-1200. Epub 2016 May 13.

21.

NGF controls APP cleavage by downregulating APP phosphorylation at Thr668: relevance for Alzheimer's disease.

Triaca V, Sposato V, Bolasco G, Ciotti MT, Pelicci P, Bruni AC, Cupidi C, Maletta R, Feligioni M, Nisticò R, Canu N, Calissano P.

Aging Cell. 2016 Aug;15(4):661-72. doi: 10.1111/acel.12473. Epub 2016 Apr 13.

22.

p46Shc Inhibits Thiolase and Lipid Oxidation in Mitochondria.

Tomilov A, Tomilova N, Shan Y, Hagopian K, Bettaieb A, Kim K, Pelicci PG, Haj F, Ramsey J, Cortopassi G.

J Biol Chem. 2016 Jun 10;291(24):12575-85. doi: 10.1074/jbc.M115.695577. Epub 2016 Apr 8.

23.

PML is required for telomere stability in non-neoplastic human cells.

Marchesini M, Matocci R, Tasselli L, Cambiaghi V, Orleth A, Furia L, Marinelli C, Lombardi S, Sammarelli G, Aversa F, Minucci S, Faretta M, Pelicci PG, Grignani F.

Oncogene. 2016 Apr 7;35(14):1876. doi: 10.1038/onc.2015.312. No abstract available.

PMID:
27052595
24.

Cyclophilin D counteracts P53-mediated growth arrest and promotes Ras tumorigenesis.

Bigi A, Beltrami E, Trinei M, Stendardo M, Pelicci PG, Giorgio M.

Oncogene. 2016 Sep 29;35(39):5132-43. doi: 10.1038/onc.2016.42. Epub 2016 Mar 14.

PMID:
26973251
25.

P66SHC deletion improves fertility and progeric phenotype of late-generation TERC-deficient mice but not their short lifespan.

Giorgio M, Stendardo M, Migliaccio E, Pelicci PG.

Aging Cell. 2016 Jun;15(3):446-54. doi: 10.1111/acel.12448. Epub 2016 Mar 10.

26.

Cell cycle-dependent resolution of DNA double-strand breaks.

Ambrosio S, Di Palo G, Napolitano G, Amente S, Dellino GI, Faretta M, Pelicci PG, Lania L, Majello B.

Oncotarget. 2016 Jan 26;7(4):4949-60. doi: 10.18632/oncotarget.6644.

27.

Alliance Against Cancer, the network of Italian cancer centers bridging research and care.

De Paoli P, Ciliberto G, Ferrarini M, Pelicci P, Dellabona P, De Lorenzo F, Mantovani A, Musto P, Opocher G, Picci P, Ricciardi W, De Maria R.

J Transl Med. 2015 Nov 14;13:360. doi: 10.1186/s12967-015-0711-x.

28.

In vitro and in vivo single-agent efficacy of checkpoint kinase inhibition in acute lymphoblastic leukemia.

Iacobucci I, Di Rorà AG, Falzacappa MV, Agostinelli C, Derenzini E, Ferrari A, Papayannidis C, Lonetti A, Righi S, Imbrogno E, Pomella S, Venturi C, Guadagnuolo V, Cattina F, Ottaviani E, Abbenante MC, Vitale A, Elia L, Russo D, Zinzani PL, Pileri S, Pelicci PG, Martinelli G.

J Hematol Oncol. 2015 Nov 5;8:125. doi: 10.1186/s13045-015-0206-5.

29.

Peak shape clustering reveals biological insights.

Cremona MA, Sangalli LM, Vantini S, Dellino GI, Pelicci PG, Secchi P, Riva L.

BMC Bioinformatics. 2015 Oct 28;16:349. doi: 10.1186/s12859-015-0787-6.

30.

Calcite single crystals as hosts for atomic-scale entrapment and slow release of drugs.

Magnabosco G, Di Giosia M, Polishchuk I, Weber E, Fermani S, Bottoni A, Zerbetto F, Pelicci PG, Pokroy B, Rapino S, Falini G, Calvaresi M.

Adv Healthc Mater. 2015 Sep 16;4(13):1899. doi: 10.1002/adhm.201500631. No abstract available.

PMID:
26379220
31.

Maintaining epithelial stemness with p63.

Melino G, Memmi EM, Pelicci PG, Bernassola F.

Sci Signal. 2015 Jul 28;8(387):re9. doi: 10.1126/scisignal.aaa1033. Review.

PMID:
26221054
32.

PML is required for telomere stability in non-neoplastic human cells.

Marchesini M, Matocci R, Tasselli L, Cambiaghi V, Orleth A, Furia L, Marinelli C, Lombardi S, Sammarelli G, Aversa F, Minucci S, Faretta M, Pelicci PG, Grignani F.

Oncogene. 2016 Apr 7;35(14):1811-21. doi: 10.1038/onc.2015.246. Epub 2015 Jun 29. Erratum in: Oncogene. 2016 Apr 7;35(14):1876.

33.

PML/RARα-Regulated miR-181a/b Cluster Targets the Tumor Suppressor RASSF1A in Acute Promyelocytic Leukemia.

Bräuer-Hartmann D, Hartmann JU, Wurm AA, Gerloff D, Katzerke C, Verga Falzacappa MV, Pelicci PG, Müller-Tidow C, Tenen DG, Niederwieser D, Behre G.

Cancer Res. 2015 Aug 15;75(16):3411-24. doi: 10.1158/0008-5472.CAN-14-3521. Epub 2015 Jun 3.

34.

Calcite Single Crystals as Hosts for Atomic-Scale Entrapment and Slow Release of Drugs.

Magnabosco G, Di Giosia M, Polishchuk I, Weber E, Fermani S, Bottoni A, Zerbetto F, Pelicci PG, Pokroy B, Rapino S, Falini G, Calvaresi M.

Adv Healthc Mater. 2015 Jul 15;4(10):1510-6. doi: 10.1002/adhm.201500170. Epub 2015 Jun 1. Erratum in: Adv Healthc Mater. 2015 Sep 16;4(13):1899.

PMID:
26033854
35.

Redox-Mediated Suberoylanilide Hydroxamic Acid Sensitivity in Breast Cancer.

Chiaradonna F, Barozzi I, Miccolo C, Bucci G, Palorini R, Fornasari L, Botrugno OA, Pruneri G, Masullo M, Passafaro A, Galimberti VE, Fantin VR, Richon VM, Pece S, Viale G, Di Fiore PP, Draetta G, Pelicci PG, Minucci S, Chiocca S.

Antioxid Redox Signal. 2015 Jul 1;23(1):15-29. doi: 10.1089/ars.2014.6189. Epub 2015 May 27.

36.

Whole exome sequencing identifies driver mutations in asymptomatic computed tomography-detected lung cancers with normal karyotype.

Belloni E, Veronesi G, Rotta L, Volorio S, Sardella D, Bernard L, Pece S, Di Fiore PP, Fumagalli C, Barberis M, Spaggiari L, Pelicci PG, Riva L.

Cancer Genet. 2015 Apr;208(4):152-5. doi: 10.1016/j.cancergen.2015.02.004. Epub 2015 Feb 20.

PMID:
25850996
37.

Modelling the p53/p66Shc Aging Pathway in the Shortest Living Vertebrate Nothobranchius Furzeri.

Priami C, De Michele G, Cotelli F, Cellerino A, Giorgio M, Pelicci PG, Migliaccio E.

Aging Dis. 2015 Mar 10;6(2):95-108. doi: 10.14336/AD.2014.0228. eCollection 2015 Mar. Review.

38.

p63 Sustains self-renewal of mammary cancer stem cells through regulation of Sonic Hedgehog signaling.

Memmi EM, Sanarico AG, Giacobbe A, Peschiaroli A, Frezza V, Cicalese A, Pisati F, Tosoni D, Zhou H, Tonon G, Antonov A, Melino G, Pelicci PG, Bernassola F.

Proc Natl Acad Sci U S A. 2015 Mar 17;112(11):3499-504. doi: 10.1073/pnas.1500762112. Epub 2015 Mar 4.

39.

DOTS-Finder: a comprehensive tool for assessing driver genes in cancer genomes.

Melloni GE, Ogier AG, de Pretis S, Mazzarella L, Pelizzola M, Pelicci PG, Riva L.

Genome Med. 2014 Jun 10;6(6):44. doi: 10.1186/gm563. eCollection 2014.

40.

The Combination of the PARP Inhibitor Rucaparib and 5FU Is an Effective Strategy for Treating Acute Leukemias.

Falzacappa MV, Ronchini C, Faretta M, Iacobucci I, Di Rorà AG, Martinelli G, Meyer LH, Debatin KM, Orecchioni S, Bertolini F, Pelicci PG.

Mol Cancer Ther. 2015 Apr;14(4):889-98. doi: 10.1158/1535-7163.MCT-14-0276. Epub 2015 Feb 9.

41.

The hidden genomic landscape of acute myeloid leukemia: subclonal structure revealed by undetected mutations.

Bodini M, Ronchini C, Giacò L, Russo A, Melloni GE, Luzi L, Sardella D, Volorio S, Hasan SK, Ottone T, Lavorgna S, Lo-Coco F, Candoni A, Fanin R, Toffoletti E, Iacobucci I, Martinelli G, Cignetti A, Tarella C, Bernard L, Pelicci PG, Riva L.

Blood. 2015 Jan 22;125(4):600-5. doi: 10.1182/blood-2014-05-576157. Epub 2014 Dec 12. Review.

42.

The genomic and epigenomic landscapes of AML.

Mazzarella L, Riva L, Luzi L, Ronchini C, Pelicci PG.

Semin Hematol. 2014 Oct;51(4):259-72. doi: 10.1053/j.seminhematol.2014.08.007. Epub 2014 Aug 26.

PMID:
25311739
43.

Confocal microscopy for high-resolution and high-content analysis of the cell cycle.

Furia L, Pelicci P, Faretta M.

Curr Protoc Cytom. 2014 Oct 1;70:7.42.1-14. doi: 10.1002/0471142956.cy0742s70. Review.

PMID:
25271962
44.

High-resolution cytometry for high-content cell cycle analysis.

Furia L, Pelicci P, Faretta M.

Curr Protoc Cytom. 2014 Oct 1;70:7.41.1-15. doi: 10.1002/0471142956.cy0741s70. Review.

PMID:
25271961
45.

Gender-dependent resiliency to stressful and metabolic challenges following prenatal exposure to high-fat diet in the p66(Shc-/-) mouse.

Bellisario V, Berry A, Capoccia S, Raggi C, Panetta P, Branchi I, Piccaro G, Giorgio M, Pelicci PG, Cirulli F.

Front Behav Neurosci. 2014 Aug 22;8:285. doi: 10.3389/fnbeh.2014.00285. eCollection 2014.

46.

PAT-ChIP coupled with laser microdissection allows the study of chromatin in selected cell populations from paraffin-embedded patient samples.

Amatori S, Ballarini M, Faversani A, Belloni E, Fusar F, Bosari S, Pelicci PG, Minucci S, Fanelli M.

Epigenetics Chromatin. 2014 Aug 5;7:18. doi: 10.1186/1756-8935-7-18. eCollection 2014.

47.

Report from the Melanoma Independent Board First Melanoma MIB Conference, 21-22 October 2013.

Testori A, Ascierto P, Chiarion Sileni V, De Lorenzo F, Pelicci P, Rossi C.

Ecancermedicalscience. 2014 Jun 30;8:440. doi: 10.3332/ecancer.2014.440. eCollection 2014.

48.

Cinnamic anilides as new mitochondrial permeability transition pore inhibitors endowed with ischemia-reperfusion injury protective effect in vivo.

Fancelli D, Abate A, Amici R, Bernardi P, Ballarini M, Cappa A, Carenzi G, Colombo A, Contursi C, Di Lisa F, Dondio G, Gagliardi S, Milanesi E, Minucci S, Pain G, Pelicci PG, Saccani A, Storto M, Thaler F, Varasi M, Villa M, Plyte S.

J Med Chem. 2014 Jun 26;57(12):5333-47. doi: 10.1021/jm500547c. Epub 2014 Jun 11.

PMID:
24918261
49.

An intrabody specific for the nucleophosmin carboxy-terminal mutant and fused to a nuclear localization sequence binds its antigen but fails to relocate it in the nucleus.

Martinelli C, Colombo E, Piccini D, Sironi C, Pelicci PG, de Marco A.

Biotechnol Rep (Amst). 2014 May 27;3:27-33. doi: 10.1016/j.btre.2014.05.008. eCollection 2014 Sep.

50.

Next-generation sequencing and DNA replication in human cells: the future has arrived.

Dellino GI, Pelicci PG.

Future Oncol. 2014 Mar;10(4):683-93. doi: 10.2217/fon.13.182. Review.

PMID:
24754597

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