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Items: 1 to 50 of 66

1.

Profiling of Epigenetic Features in Clinical Samples Reveals Novel Widespread Changes in Cancer.

Noberini R, Restellini C, Savoia EO, Raimondi F, Ghiani L, Jodice MG, Bertalot G, Bonizzi G, Capra M, Maffini FA, Tagliabue M, Ansarin M, Lupia M, Giordano M, Osti D, Pelicci G, Chiocca S, Bonaldi T.

Cancers (Basel). 2019 May 24;11(5). pii: E723. doi: 10.3390/cancers11050723.

2.

A T Cell Suppressive Circuitry Mediated by CD39 and Regulated by ShcC/Rai Is Induced in Astrocytes by Encephalitogenic T Cells.

Ulivieri C, De Tommaso D, Finetti F, Ortensi B, Pelicci G, D'Elios MM, Ballerini C, Baldari CT.

Front Immunol. 2019 May 10;10:1041. doi: 10.3389/fimmu.2019.01041. eCollection 2019.

3.

Clinical Significance of Extracellular Vesicles in Plasma from Glioblastoma Patients.

Osti D, Del Bene M, Rappa G, Santos M, Matafora V, Richichi C, Faletti S, Beznoussenko GV, Mironov A, Bachi A, Fornasari L, Bongetta D, Gaetani P, DiMeco F, Lorico A, Pelicci G.

Clin Cancer Res. 2019 Jan 1;25(1):266-276. doi: 10.1158/1078-0432.CCR-18-1941. Epub 2018 Oct 4.

PMID:
30287549
4.

Extensive and systematic rewiring of histone post-translational modifications in cancer model systems.

Noberini R, Osti D, Miccolo C, Richichi C, Lupia M, Corleone G, Hong SP, Colombo P, Pollo B, Fornasari L, Pruneri G, Magnani L, Cavallaro U, Chiocca S, Minucci S, Pelicci G, Bonaldi T.

Nucleic Acids Res. 2018 May 4;46(8):3817-3832. doi: 10.1093/nar/gky224.

5.

The Shc protein RAI promotes an adaptive cell survival program in hypoxic neuroblastoma cells.

Criscuoli M, Filippi I, Osti D, Aldinucci C, Guerrini G, Pelicci G, Carraro F, Naldini A.

J Cell Physiol. 2018 May;233(5):4282-4293. doi: 10.1002/jcp.26247. Epub 2017 Nov 24.

PMID:
29057481
6.

Mutations targeting the coagulation pathway are enriched in brain metastases.

Richichi C, Fornasari L, Melloni GEM, Brescia P, Patanè M, Del Bene M, Mustafa DAM, Kros JM, Pollo B, Pruneri G, Sciandivasci A, Munzone E, DiMeco F, Pelicci PG, Riva L, Pelicci G.

Sci Rep. 2017 Jul 26;7(1):6573. doi: 10.1038/s41598-017-06811-x.

7.

PAT-H-MS coupled with laser microdissection to study histone post-translational modifications in selected cell populations from pathology samples.

Noberini R, Longuespée R, Richichi C, Pruneri G, Kriegsmann M, Pelicci G, Bonaldi T.

Clin Epigenetics. 2017 Jul 11;9:69. doi: 10.1186/s13148-017-0369-8. eCollection 2017.

8.

Correction: The Adaptor Protein Rai/ShcC Promotes Astrocyte-Dependent Inflammation during Experimental Autoimmune Encephalomyelitis.

Ulivieri C, Savino MT, Luccarini I, Fanigliulo E, Aldinucci A, Bonechi E, Benagiano M, Ortensi B, Pelicci G, D'Elios MM, Ballerini C, Baldari CT.

J Immunol. 2016 Nov 15;197(10):4178. No abstract available.

9.

Tumor-initiating cell frequency is relevant for glioblastoma aggressiveness.

Richichi C, Osti D, Del Bene M, Fornasari L, Patanè M, Pollo B, DiMeco F, Pelicci G.

Oncotarget. 2016 Nov 1;7(44):71491-71503. doi: 10.18632/oncotarget.11600.

10.

The Adaptor Protein Rai/ShcC Promotes Astrocyte-Dependent Inflammation during Experimental Autoimmune Encephalomyelitis.

Ulivieri C, Savino MT, Luccarini I, Fanigliulo E, Aldinucci A, Bonechi E, Benagiano M, Ortensi B, Pelicci G, D'Elios MM, Ballerini C, Baldari CT.

J Immunol. 2016 Jul 15;197(2):480-90. doi: 10.4049/jimmunol.1502063. Epub 2016 Jun 10. Erratum in: J Immunol. 2016 Nov 15;197(10 ):4178.

11.

Extracellular vesicle-mediated transfer of CLIC1 protein is a novel mechanism for the regulation of glioblastoma growth.

Setti M, Osti D, Richichi C, Ortensi B, Del Bene M, Fornasari L, Beznoussenko G, Mironov A, Rappa G, Cuomo A, Faretta M, Bonaldi T, Lorico A, Pelicci G.

Oncotarget. 2015 Oct 13;6(31):31413-27. doi: 10.18632/oncotarget.5105.

12.

Functional role of CLIC1 ion channel in glioblastoma-derived stem/progenitor cells.

Setti M, Savalli N, Osti D, Richichi C, Angelini M, Brescia P, Fornasari L, Carro MS, Mazzanti M, Pelicci G.

J Natl Cancer Inst. 2013 Nov 6;105(21):1644-55. doi: 10.1093/jnci/djt278. Epub 2013 Oct 10.

13.

Marker-independent method for isolating slow-dividing cancer stem cells in human glioblastoma.

Richichi C, Brescia P, Alberizzi V, Fornasari L, Pelicci G.

Neoplasia. 2013 Jul;15(7):840-7.

14.

Outcome and clinico-biological characteristics of advanced breast cancer patients with surgically resected brain metastases: a multidisciplinary approach.

Munzone E, Casali C, Aurilio G, Botteri E, Perin A, Pelicci G, Brescia P, Sciandivasci A, Adamoli L, Viale G, Dimeco F.

Ecancermedicalscience. 2013 Apr 18;7:309. doi: 10.3332/ecancer.2013.309. Print 2013.

15.

Cancer stem cell contribution to glioblastoma invasiveness.

Ortensi B, Setti M, Osti D, Pelicci G.

Stem Cell Res Ther. 2013 Feb 28;4(1):18. doi: 10.1186/scrt166. Review.

16.

The Shc family protein adaptor, Rai, acts as a negative regulator of Th17 and Th1 cell development.

Savino MT, Ulivieri C, Emmi G, Prisco D, De Falco G, Ortensi B, Beccastrini E, Emmi L, Pelicci G, D'Elios MM, Baldari CT.

J Leukoc Biol. 2013 Apr;93(4):549-59. doi: 10.1189/jlb.0712331. Epub 2013 Jan 23.

PMID:
23345394
17.

CD133 is essential for glioblastoma stem cell maintenance.

Brescia P, Ortensi B, Fornasari L, Levi D, Broggi G, Pelicci G.

Stem Cells. 2013 May;31(5):857-69. doi: 10.1002/stem.1317.

18.

Current strategies for identification of glioma stem cells: adequate or unsatisfactory?

Brescia P, Richichi C, Pelicci G.

J Oncol. 2012;2012:376894. doi: 10.1155/2012/376894. Epub 2012 May 23.

19.

Rai is a new regulator of neural progenitor migration and glioblastoma invasion.

Ortensi B, Osti D, Pellegatta S, Pisati F, Brescia P, Fornasari L, Levi D, Gaetani P, Colombo P, Ferri A, Nicolis S, Finocchiaro G, Pelicci G.

Stem Cells. 2012 May;30(5):817-32. doi: 10.1002/stem.1056.

20.

The Shc family protein adaptor, Rai, negatively regulates T cell antigen receptor signaling by inhibiting ZAP-70 recruitment and activation.

Ferro M, Savino MT, Ortensi B, Finetti F, Genovese L, Masi G, Ulivieri C, Benati D, Pelicci G, Baldari CT.

PLoS One. 2011;6(12):e29899. doi: 10.1371/journal.pone.0029899. Epub 2011 Dec 29.

21.

Design, recruitment, logistics, and data management of the GEHA (Genetics of Healthy Ageing) project.

Skytthe A, Valensin S, Jeune B, Cevenini E, Balard F, Beekman M, Bezrukov V, Blanche H, Bolund L, Broczek K, Carru C, Christensen K, Christiansen L, Collerton JC, Cotichini R, de Craen AJ, Dato S, Davies K, De Benedictis G, Deiana L, Flachsbart F, Gampe J, Gilbault C, Gonos ES, Haimes E, Hervonen A, Hurme MA, Janiszewska D, Jylhä M, Kirkwood TB, Kristensen P, Laiho P, Leon A, Marchisio A, Masciulli R, Nebel A, Passarino G, Pelicci G, Peltonen L, Perola M, Poulain M, Rea IM, Remacle J, Robine JM, Schreiber S, Scurti M, Sevini F, Sikora E, Skouteri A, Slagboom PE, Spazzafumo L, Stazi MA, Toccaceli V, Toussaint O, Törnwall O, Vaupel JW, Voutetakis K, Franceschi C; GEHA consortium.

Exp Gerontol. 2011 Nov;46(11):934-45. doi: 10.1016/j.exger.2011.08.005. Epub 2011 Aug 16.

22.

Human glioblastoma tumours and neural cancer stem cells express the chemokine CX3CL1 and its receptor CX3CR1.

Erreni M, Solinas G, Brescia P, Osti D, Zunino F, Colombo P, Destro A, Roncalli M, Mantovani A, Draghi R, Levi D, Rodriguez Y Baena R, Gaetani P, Pelicci G, Allavena P.

Eur J Cancer. 2010 Dec;46(18):3383-92. doi: 10.1016/j.ejca.2010.07.022. Epub 2010 Aug 19.

PMID:
20728344
23.

Rai acts as a negative regulator of autoimmunity by inhibiting antigen receptor signaling and lymphocyte activation.

Savino MT, Ortensi B, Ferro M, Ulivieri C, Fanigliulo D, Paccagnini E, Lazzi S, Osti D, Pelicci G, Baldari CT.

J Immunol. 2009 Jan 1;182(1):301-8.

24.

Expression of the Rai (Shc C) adaptor protein in the human enteric nervous system.

Villanacci V, Bassotti G, Ortensi B, Fisogni S, Cathomas G, Maurer CA, Galletti A, Salerni B, Pelicci G.

Neurogastroenterol Motil. 2008 Mar;20(3):206-12. Epub 2007 Sep 27.

PMID:
17919311
25.

Lack of changes in the PI3K/AKT survival pathway in the spinal cord motor neurons of a mouse model of familial amyotrophic lateral sclerosis.

Peviani M, Cheroni C, Troglio F, Quarto M, Pelicci G, Bendotti C.

Mol Cell Neurosci. 2007 Apr;34(4):592-602. Epub 2007 Jan 11.

PMID:
17303436
26.

Cathepsin D expression is decreased in Alzheimer's disease fibroblasts.

Urbanelli L, Emiliani C, Massini C, Persichetti E, Orlacchio A, Pelicci G, Sorbi S, Hasilik A, Bernardi G, Orlacchio A.

Neurobiol Aging. 2008 Jan;29(1):12-22. Epub 2006 Oct 17.

PMID:
17049675
27.

RAI(ShcC/N-Shc)-dependent recruitment of GAB 1 to RET oncoproteins potentiates PI 3-K signalling in thyroid tumors.

De Falco V, Guarino V, Malorni L, Cirafici AM, Troglio F, Erreni M, Pelicci G, Santoro M, Melillo RM.

Oncogene. 2005 Sep 15;24(41):6303-13.

PMID:
15940252
28.

The Rai (Shc C) adaptor protein regulates the neuronal stress response and protects against cerebral ischemia.

Troglio F, Echart C, Gobbi A, Pawson T, Pelicci PG, De Simoni MG, Pelicci G.

Proc Natl Acad Sci U S A. 2004 Oct 26;101(43):15476-81. Epub 2004 Oct 19.

29.

Up-regulation of glycohydrolases in Alzheimer's Disease fibroblasts correlates with Ras activation.

Emiliani C, Urbanelli L, Racanicchi L, Orlacchio A, Pelicci G, Sorbi S, Bernardi G, Orlacchio A.

J Biol Chem. 2003 Oct 3;278(40):38453-60. Epub 2003 Jul 23.

30.

The neuron-specific Rai (ShcC) adaptor protein inhibits apoptosis by coupling Ret to the phosphatidylinositol 3-kinase/Akt signaling pathway.

Pelicci G, Troglio F, Bodini A, Melillo RM, Pettirossi V, Coda L, De Giuseppe A, Santoro M, Pelicci PG.

Mol Cell Biol. 2002 Oct;22(20):7351-63.

31.

Tyrosine phosphorylation of the beta-amyloid precursor protein cytoplasmic tail promotes interaction with Shc.

Tarr PE, Roncarati R, Pelicci G, Pelicci PG, D'Adamio L.

J Biol Chem. 2002 May 10;277(19):16798-804. Epub 2002 Mar 4.

32.

Shc signaling in differentiating neural progenitor cells.

Conti L, Sipione S, Magrassi L, Bonfanti L, Rigamonti D, Pettirossi V, Peschanski M, Haddad B, Pelicci P, Milanesi G, Pelicci G, Cattaneo E.

Nat Neurosci. 2001 Jun;4(6):579-86.

PMID:
11369938
33.

The p66shc adaptor protein controls oxidative stress response and life span in mammals.

Migliaccio E, Giorgio M, Mele S, Pelicci G, Reboldi P, Pandolfi PP, Lanfrancone L, Pelicci PG.

Nature. 1999 Nov 18;402(6759):309-13.

PMID:
10580504
34.

Polyomavirus large T antigen induces alterations in cytoplasmic signalling pathways involving Shc activation.

Gottifredi V, Pelicci G, Munarriz E, Maione R, Pelicci PG, Amati P.

J Virol. 1999 Feb;73(2):1427-37.

35.

Eps15R is a tyrosine kinase substrate with characteristics of a docking protein possibly involved in coated pits-mediated internalization.

Coda L, Salcini AE, Confalonieri S, Pelicci G, Sorkina T, Sorkin A, Pelicci PG, Di Fiore PP.

J Biol Chem. 1998 Jan 30;273(5):3003-12.

36.

Modified phage peptide libraries as a tool to study specificity of phosphorylation and recognition of tyrosine containing peptides.

Dente L, Vetriani C, Zucconi A, Pelicci G, Lanfrancone L, Pelicci PG, Cesareni G.

J Mol Biol. 1997 Jun 27;269(5):694-703.

PMID:
9223634
37.

Identification of Shc docking site on Ret tyrosine kinase.

Arighi E, Alberti L, Torriti F, Ghizzoni S, Rizzetti MG, Pelicci G, Pasini B, Bongarzone I, Piutti C, Pierotti MA, Borrello MG.

Oncogene. 1997 Feb 20;14(7):773-82.

38.

Opposite effects of the p52shc/p46shc and p66shc splicing isoforms on the EGF receptor-MAP kinase-fos signalling pathway.

Migliaccio E, Mele S, Salcini AE, Pelicci G, Lai KM, Superti-Furga G, Pawson T, Di Fiore PP, Lanfrancone L, Pelicci PG.

EMBO J. 1997 Feb 17;16(4):706-16.

39.

A family of Shc related proteins with conserved PTB, CH1 and SH2 regions.

Pelicci G, Dente L, De Giuseppe A, Verducci-Galletti B, Giuli S, Mele S, Vetriani C, Giorgio M, Pandolfi PP, Cesareni G, Pelicci PG.

Oncogene. 1996 Aug 1;13(3):633-41.

PMID:
8760305
40.

Not all Shc's roads lead to Ras.

Bonfini L, Migliaccio E, Pelicci G, Lanfrancone L, Pelicci PG.

Trends Biochem Sci. 1996 Jul;21(7):257-61. Review.

PMID:
8755247
41.

Sch proteins are localized on endoplasmic reticulum membranes and are redistributed after tyrosine kinase receptor activation.

Lotti LV, Lanfrancone L, Migliaccio E, Zompetta C, Pelicci G, Salcini AE, Falini B, Pelicci PG, Torrisi MR.

Mol Cell Biol. 1996 May;16(5):1946-54.

42.

Constitutive phosphorylation of Shc proteins in human tumors.

Pelicci G, Lanfrancone L, Salcini AE, Romano A, Mele S, Grazia Borrello M, Segatto O, Di Fiore PP, Pelicci PG.

Oncogene. 1995 Sep 7;11(5):899-907.

PMID:
7675449
43.

The motogenic and mitogenic responses to HGF are amplified by the Shc adaptor protein.

Pelicci G, Giordano S, Zhen Z, Salcini AE, Lanfrancone L, Bardelli A, Panayotou G, Waterfield MD, Ponzetto C, Pelicci PG, et al.

Oncogene. 1995 Apr 20;10(8):1631-8.

PMID:
7731718
44.

Inhibition of CD4/p56lck signaling by a dominant negative mutant of the Shc adaptor protein.

Baldari CT, Pelicci G, Di Somma MM, Milia E, Giuli S, Pelicci PG, Telford JL.

Oncogene. 1995 Mar 16;10(6):1141-7. Erratum in: Oncogene 1995 Dec 7;11(11):2451.

PMID:
7700640
45.

Overexpression of Shc proteins potentiates the proliferative response to the granulocyte-macrophage colony-stimulating factor and recruitment of Grb2/SoS and Grb2/p140 complexes to the beta receptor subunit.

Lanfrancone L, Pelicci G, Brizzi MF, Aronica MG, Casciari C, Giuli S, Pegoraro L, Pawson T, Pelicci PG, Arouica MG.

Oncogene. 1995 Mar 2;10(5):907-17. Erratum in: Oncogene 1995 Aug 3;11(3):607.

PMID:
7898932
46.

Signalling properties of FLT4, a proteolytically processed receptor tyrosine kinase related to two VEGF receptors.

Pajusola K, Aprelikova O, Pelicci G, Weich H, Claesson-Welsh L, Alitalo K.

Oncogene. 1994 Dec;9(12):3545-55.

PMID:
7970715
47.

Formation of Shc-Grb2 complexes is necessary to induce neoplastic transformation by overexpression of Shc proteins.

Salcini AE, McGlade J, Pelicci G, Nicoletti I, Pawson T, Pelicci PG.

Oncogene. 1994 Oct;9(10):2827-36.

PMID:
8084588
48.

Chromosome locations of genes encoding human signal transduction adapter proteins, Nck (NCK), Shc (SHC1), and Grb2 (GRB2).

Huebner K, Kastury K, Druck T, Salcini AE, Lanfrancone L, Pelicci G, Lowenstein E, Li W, Park SH, Cannizzaro L, et al.

Genomics. 1994 Jul 15;22(2):281-7.

PMID:
7806213
49.
50.

The oncogenic versions of the Ret and Trk tyrosine kinases bind Shc and Grb2 adaptor proteins.

Borrello MG, Pelicci G, Arighi E, De Filippis L, Greco A, Bongarzone I, Rizzetti M, Pelicci PG, Pierotti MA.

Oncogene. 1994 Jun;9(6):1661-8.

PMID:
8183561

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