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Items: 49


Targeting the autophagy in bone marrow stromal cells overcomes resistance to vorinostat in chronic lymphocytic leukemia.

Ding L, Zhang W, Yang L, Pelicano H, Zhou K, Yin R, Huang R, Zeng J.

Onco Targets Ther. 2018 Aug 24;11:5151-5170. doi: 10.2147/OTT.S170392. eCollection 2018.


Aberrant FGFR Tyrosine Kinase Signaling Enhances the Warburg Effect by Reprogramming LDH Isoform Expression and Activity in Prostate Cancer.

Liu J, Chen G, Liu Z, Liu S, Cai Z, You P, Ke Y, Lai L, Huang Y, Gao H, Zhao L, Pelicano H, Huang P, McKeehan WL, Wu CL, Wang C, Zhong W, Wang F.

Cancer Res. 2018 Aug 15;78(16):4459-4470. doi: 10.1158/0008-5472.CAN-17-3226. Epub 2018 Jun 11.


Increased Tumor Glycolysis Characterizes Immune Resistance to Adoptive T Cell Therapy.

Cascone T, McKenzie JA, Mbofung RM, Punt S, Wang Z, Xu C, Williams LJ, Wang Z, Bristow CA, Carugo A, Peoples MD, Li L, Karpinets T, Huang L, Malu S, Creasy C, Leahey SE, Chen J, Chen Y, Pelicano H, Bernatchez C, Gopal YNV, Heffernan TP, Hu J, Wang J, Amaria RN, Garraway LA, Huang P, Yang P, Wistuba II, Woodman SE, Roszik J, Davis RE, Davies MA, Heymach JV, Hwu P, Peng W.

Cell Metab. 2018 May 1;27(5):977-987.e4. doi: 10.1016/j.cmet.2018.02.024. Epub 2018 Apr 5.


Correction: Novel Role of NOX in Supporting Aerobic Glycolysis in Cancer Cells with Mitochondrial Dysfunction and as a Potential Target for Cancer Therapy.

Lu W, Hu Y, Chen G, Chen Z, Zhang H, Wang F, Feng L, Pelicano H, Wang H, Keating MJ, Liu J, McKeehan W, Wang H, Luo Y, Huang P.

PLoS Biol. 2017 Dec 11;15(12):e1002616. doi: 10.1371/journal.pbio.1002616. eCollection 2017 Dec.


Long non-coding RNA UICLM promotes colorectal cancer liver metastasis by acting as a ceRNA for microRNA-215 to regulate ZEB2 expression.

Chen DL, Lu YX, Zhang JX, Wei XL, Wang F, Zeng ZL, Pan ZZ, Yuan YF, Wang FH, Pelicano H, Chiao PJ, Huang P, Xie D, Li YH, Ju HQ, Xu RH.

Theranostics. 2017 Oct 17;7(19):4836-4849. doi: 10.7150/thno.20942. eCollection 2017.


Elimination of chronic lymphocytic leukemia cells in stromal microenvironment by targeting CPT with an antiangina drug perhexiline.

Liu PP, Liu J, Jiang WQ, Carew JS, Ogasawara MA, Pelicano H, Croce CM, Estrov Z, Xu RH, Keating MJ, Huang P.

Oncogene. 2016 Oct 27;35(43):5663-5673. doi: 10.1038/onc.2016.103. Epub 2016 Apr 11.


Targeting p53-deficient chronic lymphocytic leukemia cells in vitro and in vivo by ROS-mediated mechanism.

Liu J, Chen G, Pelicano H, Liao J, Huang J, Feng L, Keating MJ, Huang P.

Oncotarget. 2016 Nov 1;7(44):71378-71389. doi: 10.18632/oncotarget.12110.


Alterations of mitochondrial biogenesis in chronic lymphocytic leukemia cells with loss of p53.

Ogasawara MA, Liu J, Pelicano H, Hammoudi N, Croce CM, Keating MJ, Huang P.

Mitochondrion. 2016 Nov;31:33-39. doi: 10.1016/j.mito.2016.09.001. Epub 2016 Sep 17.


Long non-coding RNA XIST regulates gastric cancer progression by acting as a molecular sponge of miR-101 to modulate EZH2 expression.

Chen DL, Ju HQ, Lu YX, Chen LZ, Zeng ZL, Zhang DS, Luo HY, Wang F, Qiu MZ, Wang DS, Xu DZ, Zhou ZW, Pelicano H, Huang P, Xie D, Wang FH, Li YH, Xu RH.

J Exp Clin Cancer Res. 2016 Sep 13;35(1):142. doi: 10.1186/s13046-016-0420-1.


Redox Regulation of Stem-like Cells Though the CD44v-xCT Axis in Colorectal Cancer: Mechanisms and Therapeutic Implications.

Ju HQ, Lu YX, Chen DL, Tian T, Mo HY, Wei XL, Liao JW, Wang F, Zeng ZL, Pelicano H, Aguilar M, Jia WH, Xu RH.

Theranostics. 2016 May 23;6(8):1160-75. doi: 10.7150/thno.14848. eCollection 2016.


Effective elimination of chronic lymphocytic leukemia cells in the stromal microenvironment by a novel drug combination strategy using redox-mediated mechanisms.

Zhang W, Pelicano H, Yin R, Zeng J, Wen T, Ding L, Huang R.

Mol Med Rep. 2015 Nov;12(5):7374-88. doi: 10.3892/mmr.2015.4364. Epub 2015 Sep 25.


microRNA-217 inhibits tumor progression and metastasis by downregulating EZH2 and predicts favorable prognosis in gastric cancer.

Chen DL, Zhang DS, Lu YX, Chen LZ, Zeng ZL, He MM, Wang FH, Li YH, Zhang HZ, Pelicano H, Zhang W, Xu RH.

Oncotarget. 2015 May 10;6(13):10868-79.


Mitochondrial dysfunction in some triple-negative breast cancer cell lines: role of mTOR pathway and therapeutic potential.

Pelicano H, Zhang W, Liu J, Hammoudi N, Dai J, Xu RH, Pusztai L, Huang P.

Breast Cancer Res. 2014 Sep 11;16(5):434. doi: 10.1186/s13058-014-0434-6.


Identification of microRNA-214 as a negative regulator of colorectal cancer liver metastasis by way of regulation of fibroblast growth factor receptor 1 expression.

Chen DL, Wang ZQ, Zeng ZL, Wu WJ, Zhang DS, Luo HY, Wang F, Qiu MZ, Wang DS, Ren C, Wang FH, Chiao LJ, Pelicano H, Huang P, Li YH, Xu RH.

Hepatology. 2014 Aug;60(2):598-609. doi: 10.1002/hep.27118. Epub 2014 May 28.


Loss of p53 and altered miR15-a/16-1MCL-1 pathway in CLL: insights from TCL1-Tg:p53(-/-) mouse model and primary human leukemia cells.

Liu J, Chen G, Feng L, Zhang W, Pelicano H, Wang F, Ogasawara MA, Lu W, Amin HM, Croce CM, Keating MJ, Huang P.

Leukemia. 2014 Jan;28(1):118-28. doi: 10.1038/leu.2013.125. Epub 2013 Apr 23.


[Resistance of chronic lymphocytic leukemia cells in apoptosis: key role of stromal cells in maintaining the redox potential of CLL cells].

Zhang W, Feng L, Pelicano H, Huang P.

Med Sci (Paris). 2013 Jan;29(1):36-8. doi: 10.1051/medsci/2013291012. Epub 2013 Jan 25. French. No abstract available.


Novel role of NOX in supporting aerobic glycolysis in cancer cells with mitochondrial dysfunction and as a potential target for cancer therapy.

Lu W, Hu Y, Chen G, Chen Z, Zhang H, Wang F, Feng L, Pelicano H, Wang H, Keating MJ, Liu J, McKeehan W, Wang H, Luo Y, Huang P.

PLoS Biol. 2012;10(5):e1001326. doi: 10.1371/journal.pbio.1001326. Epub 2012 May 8. Erratum in: PLoS Biol. 2017 Dec 11;15(12 ):e1002616.


Antibody-induced nonapoptotic cell death in human lymphoma and leukemia cells is mediated through a novel reactive oxygen species-dependent pathway.

Honeychurch J, Alduaij W, Azizyan M, Cheadle EJ, Pelicano H, Ivanov A, Huang P, Cragg MS, Illidge TM.

Blood. 2012 Apr 12;119(15):3523-33. doi: 10.1182/blood-2011-12-395541. Epub 2012 Feb 21.


Stromal control of cystine metabolism promotes cancer cell survival in chronic lymphocytic leukaemia.

Zhang W, Trachootham D, Liu J, Chen G, Pelicano H, Garcia-Prieto C, Lu W, Burger JA, Croce CM, Plunkett W, Keating MJ, Huang P.

Nat Cell Biol. 2012 Feb 19;14(3):276-86. doi: 10.1038/ncb2432.


K-ras(G12V) transformation leads to mitochondrial dysfunction and a metabolic switch from oxidative phosphorylation to glycolysis.

Hu Y, Lu W, Chen G, Wang P, Chen Z, Zhou Y, Ogasawara M, Trachootham D, Feng L, Pelicano H, Chiao PJ, Keating MJ, Garcia-Manero G, Huang P.

Cell Res. 2012 Feb;22(2):399-412. doi: 10.1038/cr.2011.145. Epub 2011 Aug 30.


Cancer metabolism: is glutamine sweeter than glucose?

Lu W, Pelicano H, Huang P.

Cancer Cell. 2010 Sep 14;18(3):199-200. doi: 10.1016/j.ccr.2010.08.017. No abstract available.


Mitochondrial dysfunction and reactive oxygen species imbalance promote breast cancer cell motility through a CXCL14-mediated mechanism.

Pelicano H, Lu W, Zhou Y, Zhang W, Chen Z, Hu Y, Huang P.

Cancer Res. 2009 Mar 15;69(6):2375-83. doi: 10.1158/0008-5472.CAN-08-3359. Epub 2009 Mar 10.


Effective elimination of fludarabine-resistant CLL cells by PEITC through a redox-mediated mechanism.

Trachootham D, Zhang H, Zhang W, Feng L, Du M, Zhou Y, Chen Z, Pelicano H, Plunkett W, Wierda WG, Keating MJ, Huang P.

Blood. 2008 Sep 1;112(5):1912-22. doi: 10.1182/blood-2008-04-149815. Epub 2008 Jun 23.


Alterations of cellular redox state during NNK-induced malignant transformation and resistance to radiation.

Demizu Y, Sasaki R, Trachootham D, Pelicano H, Colacino JA, Liu J, Huang P.

Antioxid Redox Signal. 2008 May;10(5):951-61. doi: 10.1089/ars.2007.1871.


Novel action of paclitaxel against cancer cells: bystander effect mediated by reactive oxygen species.

Alexandre J, Hu Y, Lu W, Pelicano H, Huang P.

Cancer Res. 2007 Apr 15;67(8):3512-7.


Mitochondrial respiration defects in cancer cells cause activation of Akt survival pathway through a redox-mediated mechanism.

Pelicano H, Xu RH, Du M, Feng L, Sasaki R, Carew JS, Hu Y, Ramdas L, Hu L, Keating MJ, Zhang W, Plunkett W, Huang P.

J Cell Biol. 2006 Dec 18;175(6):913-23. Epub 2006 Dec 11.


Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by beta-phenylethyl isothiocyanate.

Trachootham D, Zhou Y, Zhang H, Demizu Y, Chen Z, Pelicano H, Chiao PJ, Achanta G, Arlinghaus RB, Liu J, Huang P.

Cancer Cell. 2006 Sep;10(3):241-52.


Glycolysis inhibition for anticancer treatment.

Pelicano H, Martin DS, Xu RH, Huang P.

Oncogene. 2006 Aug 7;25(34):4633-46. Review.


Simultaneous inhibition of PDK1/AKT and Fms-like tyrosine kinase 3 signaling by a small-molecule KP372-1 induces mitochondrial dysfunction and apoptosis in acute myelogenous leukemia.

Zeng Z, Samudio IJ, Zhang W, Estrov Z, Pelicano H, Harris D, Frolova O, Hail N Jr, Chen W, Kornblau SM, Huang P, Lu Y, Mills GB, Andreeff M, Konopleva M.

Cancer Res. 2006 Apr 1;66(7):3737-46.


Targeting Hsp90 by 17-AAG in leukemia cells: mechanisms for synergistic and antagonistic drug combinations with arsenic trioxide and Ara-C.

Pelicano H, Carew JS, McQueen TJ, Andreeff M, Plunkett W, Keating MJ, Huang P.

Leukemia. 2006 Apr;20(4):610-9.


A novel mechanism of action of methyl-2-cyano-3,12 dioxoolean-1,9 diene-28-oate: direct permeabilization of the inner mitochondrial membrane to inhibit electron transport and induce apoptosis.

Samudio I, Konopleva M, Pelicano H, Huang P, Frolova O, Bornmann W, Ying Y, Evans R, Contractor R, Andreeff M.

Mol Pharmacol. 2006 Apr;69(4):1182-93. Epub 2006 Jan 12.


OSW-1: a natural compound with potent anticancer activity and a novel mechanism of action.

Zhou Y, Garcia-Prieto C, Carney DA, Xu RH, Pelicano H, Kang Y, Yu W, Lou C, Kondo S, Liu J, Harris DM, Estrov Z, Keating MJ, Jin Z, Huang P.

J Natl Cancer Inst. 2005 Dec 7;97(23):1781-5.


Synergistic effect of targeting mTOR by rapamycin and depleting ATP by inhibition of glycolysis in lymphoma and leukemia cells.

Xu RH, Pelicano H, Zhang H, Giles FJ, Keating MJ, Huang P.

Leukemia. 2005 Dec;19(12):2153-8.


Novel role of p53 in maintaining mitochondrial genetic stability through interaction with DNA Pol gamma.

Achanta G, Sasaki R, Feng L, Carew JS, Lu W, Pelicano H, Keating MJ, Huang P.

EMBO J. 2005 Oct 5;24(19):3482-92. Epub 2005 Sep 15.


Inhibition of glycolysis in cancer cells: a novel strategy to overcome drug resistance associated with mitochondrial respiratory defect and hypoxia.

Xu RH, Pelicano H, Zhou Y, Carew JS, Feng L, Bhalla KN, Keating MJ, Huang P.

Cancer Res. 2005 Jan 15;65(2):613-21.


ROS stress in cancer cells and therapeutic implications.

Pelicano H, Carney D, Huang P.

Drug Resist Updat. 2004 Apr;7(2):97-110. Review.


Stabilization of p53 is a novel mechanism for proapoptotic function of NF-kappaB.

Fujioka S, Schmidt C, Sclabas GM, Li Z, Pelicano H, Peng B, Yao A, Niu J, Zhang W, Evans DB, Abbruzzese JL, Huang P, Chiao PJ.

J Biol Chem. 2004 Jun 25;279(26):27549-59. Epub 2004 Apr 21.


Hu1D10 induces apoptosis concurrent with activation of the AKT survival pathway in human chronic lymphocytic leukemia cells.

Mone AP, Huang P, Pelicano H, Cheney CM, Green JM, Tso JY, Johnson AJ, Jefferson S, Lin TS, Byrd JC.

Blood. 2004 Mar 1;103(5):1846-54. Epub 2003 Nov 20.


Inhibition of mitochondrial respiration: a novel strategy to enhance drug-induced apoptosis in human leukemia cells by a reactive oxygen species-mediated mechanism.

Pelicano H, Feng L, Zhou Y, Carew JS, Hileman EO, Plunkett W, Keating MJ, Huang P.

J Biol Chem. 2003 Sep 26;278(39):37832-9. Epub 2003 Jul 9.


The circadian gene Period2 plays an important role in tumor suppression and DNA damage response in vivo.

Fu L, Pelicano H, Liu J, Huang P, Lee C.

Cell. 2002 Oct 4;111(1):41-50. Erratum in: Cell 2002 Dec 27;111(7):1055.


Action of (E)-2'-deoxy-2'-(fluoromethylene)cytidine on DNA metabolism: incorporation, excision, and cellular response.

Zhou Y, Achanta G, Pelicano H, Gandhi V, Plunkett W, Huang P.

Mol Pharmacol. 2002 Jan;61(1):222-9.


Interaction of p53 and DNA-PK in response to nucleoside analogues: potential role as a sensor complex for DNA damage.

Achanta G, Pelicano H, Feng L, Plunkett W, Huang P.

Cancer Res. 2001 Dec 15;61(24):8723-9.


Role of p53 in cellular response to anticancer nucleoside analog-induced DNA damage.

Feng L, Achanta G, Pelicano H, Zhang W, Plunkett W, Huang P.

Int J Mol Med. 2000 Jun;5(6):597-604.


Excision of beta-D- and beta-L-nucleotide analogs from DNA by the human cytosolic 3'-to-5' exonuclease.

Pelicano H, Kukhanova M, Cheng YC.

Mol Pharmacol. 2000 May;57(5):1051-5.


Excision of beta-L- and beta-D-nucleotide analogs from DNA by p53 protein.

Kukhanova M, Liu TW, Pelicano H, Cheng YC.

Nucleosides Nucleotides Nucleic Acids. 2000 Jan-Feb;19(1-2):435-46.


Enzymatic properties of the unnatural beta-L-enantiomers of 2',3'-dideoxyadenosine and 2',3'-didehydro-2',3'-dideoxyadenosine.

Pélicano H, Pierra C, Eriksson S, Gosselin G, Imbach JL, Maury G.

J Med Chem. 1997 Nov 21;40(24):3969-73.


Study of the substrate-binding properties of bovine liver adenosine kinase and inhibition by fluorescent nucleoside analogues.

Pelicano H, Maury G, Elalaoui A, Shafiee M, Imbach JL, Goody RS, Divita G.

Eur J Biochem. 1997 Sep 15;248(3):930-7.


Equal inhibition of the replication of human immunodeficiency virus in human T-cell culture by ddA bis(SATE)phosphotriester and 3'-azido-2',3'-dideoxythymidine.

Perigaud C, Aubertin AM, Benzaria S, Pelicano H, Girardet JL, Maury G, Gosselin G, Kirn A, Imbach JL.

Biochem Pharmacol. 1994 Jul 5;48(1):11-14.


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