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Items: 1 to 50 of 198

1.

Insights into the roles of CMK-1 and OGT-1 in interstimulus interval-dependent habituation in Caenorhabditis elegans.

Ardiel EL, McDiarmid TA, Timbers TA, Lee KCY, Safaei J, Pelech SL, Rankin CH.

Proc Biol Sci. 2018 Nov 14;285(1891). pii: 20182084. doi: 10.1098/rspb.2018.2084.

2.

Profiling of p5, a 24 Amino Acid Inhibitory Peptide Derived from the CDK5 Activator, p35 CDKR1 Against 70 Protein Kinases.

Binukumar BK, Pelech SL, Sutter C, Shukla V, Amin ND, Grant P, Bhaskar M, Skuntz S, Steiner J, Pant HC.

J Alzheimers Dis. 2016 Sep 6;54(2):525-33. doi: 10.3233/JAD-160458.

PMID:
27567857
3.

Registered report: RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth.

Bhargava A, Pelech S, Woodard B, Kerwin J, Maherali N; Reproducibility Project: Cancer Biology; Reproducibility Project Cancer Biology.

Elife. 2016 Feb 16;5. pii: e09976. doi: 10.7554/eLife.09976.

4.

Regulatory roles of conserved phosphorylation sites in the activation T-loop of the MAP kinase ERK1.

Lai S, Pelech S.

Mol Biol Cell. 2016 Mar 15;27(6):1040-50. doi: 10.1091/mbc.E15-07-0527. Epub 2016 Jan 28.

5.

Evolutionary Ancestry of Eukaryotic Protein Kinases and Choline Kinases.

Lai S, Safaei J, Pelech S.

J Biol Chem. 2016 Mar 4;291(10):5199-205. doi: 10.1074/jbc.M115.691428. Epub 2016 Jan 7.

6.

Determination of the Substrate Specificity of Protein Kinases with Peptide Micro- and Macroarrays.

Lai S, Winkler DF, Zhang H, Pelech S.

Methods Mol Biol. 2016;1360:183-202. doi: 10.1007/978-1-4939-3073-9_14.

PMID:
26501911
7.

Monitoring Protein Kinase Expression and Phosphorylation in Cell Lysates with Antibody Microarrays.

Zhang H, Shi X, Pelech S.

Methods Mol Biol. 2016;1360:107-22. doi: 10.1007/978-1-4939-3073-9_9.

PMID:
26501906
8.

Analysis of the Inhibitory Elements in the p5 Peptide Fragment of the CDK5 Activator, p35, CDKR1 Protein.

Binukumar BK, Shukla V, Amin ND, Bhaskar M, Skuntz S, Steiner J, Winkler D, Pelech SL, Pant HC.

J Alzheimers Dis. 2015;48(4):1009-17. doi: 10.3233/JAD-150412.

9.

Profiling signaling proteins in human spermatozoa: biomarker identification for sperm quality evaluation.

Silva JV, Freitas MJ, Correia BR, Korrodi-Gregório L, Patrício A, Pelech S, Fardilha M.

Fertil Steril. 2015 Oct;104(4):845-856.e8. doi: 10.1016/j.fertnstert.2015.06.039. Epub 2015 Jul 23.

PMID:
26209830
10.

Post-ovulatory aging of oocytes disrupts kinase signaling pathways and lysosome biogenesis.

McGinnis LK, Pelech S, Kinsey WH.

Mol Reprod Dev. 2014 Oct;81(10):928-45. doi: 10.1002/mrd.22413. Epub 2014 Sep 19.

11.

"Omics" of human sperm: profiling protein phosphatases.

Fardilha M, Ferreira M, Pelech S, Vieira S, Rebelo S, Korrodi-Gregorio L, Sousa M, Barros A, Silva V, da Cruz e Silva OA, da Cruz e Silva EF.

OMICS. 2013 Sep;17(9):460-72. doi: 10.1089/omi.2012.0119. Epub 2013 Jul 29.

12.

Using protein microarrays to study phosphorylation-mediated signal transduction.

Zhang H, Pelech S.

Semin Cell Dev Biol. 2012 Oct;23(8):872-82. doi: 10.1016/j.semcdb.2012.05.009. Epub 2012 Jun 15. Review.

PMID:
22706299
13.

Prediction of 492 human protein kinase substrate specificities.

Safaei J, Maňuch J, Gupta A, Stacho L, Pelech S.

Proteome Sci. 2011 Oct 14;9 Suppl 1:S6. doi: 10.1186/1477-5956-9-S1-S6.

14.

Phosphoproteomic analysis of Salmonella-infected cells identifies key kinase regulators and SopB-dependent host phosphorylation events.

Rogers LD, Brown NF, Fang Y, Pelech S, Foster LJ.

Sci Signal. 2011 Sep 20;4(191):rs9. doi: 10.1126/scisignal.2001668.

15.

Proteomic analyses of lung lysates from short-term exposure of Fischer 344 rats to cigarette smoke.

Carter CA, Misra M, Pelech S.

J Proteome Res. 2011 Aug 5;10(8):3720-31. doi: 10.1021/pr200345y. Epub 2011 Jun 16.

PMID:
21627322
16.

YB-1 evokes susceptibility to cancer through cytokinesis failure, mitotic dysfunction and HER2 amplification.

Davies AH, Barrett I, Pambid MR, Hu K, Stratford AL, Freeman S, Berquin IM, Pelech S, Hieter P, Maxwell C, Dunn SE.

Oncogene. 2011 Aug 25;30(34):3649-60. doi: 10.1038/onc.2011.82. Epub 2011 Mar 21.

17.

Protein phosphatase 1 complexes modulate sperm motility and present novel targets for male infertility.

Fardilha M, Esteves SL, Korrodi-Gregório L, Pelech S, da Cruz E Silva OA, da Cruz E Silva E.

Mol Hum Reprod. 2011 Aug;17(8):466-77. doi: 10.1093/molehr/gar004. Epub 2011 Jan 20. Review.

PMID:
21257602
18.
19.

Sparse combinatorial inference with an application in cancer biology.

Mukherjee S, Pelech S, Neve RM, Kuo WL, Ziyad S, Spellman PT, Gray JW, Speed TP.

Bioinformatics. 2009 Jan 15;25(2):265-71. doi: 10.1093/bioinformatics/btn611. Epub 2008 Nov 27.

20.

Protein signaling pathways in differentiation of neural stem cells.

Skalnikova H, Vodicka P, Pelech S, Motlik J, Gadher SJ, Kovarova H.

Proteomics. 2008 Nov;8(21):4547-59. doi: 10.1002/pmic.200800096.

PMID:
18837464
21.

Pertussis toxin induces angiogenesis in brain microvascular endothelial cells.

Lu C, Pelech S, Zhang H, Bond J, Spach K, Noubade R, Blankenhorn EP, Teuscher C.

J Neurosci Res. 2008 Sep;86(12):2624-40. doi: 10.1002/jnr.21716.

PMID:
18500752
22.

Antibody microarray analyses of signal transduction protein expression and phosphorylation during porcine oocyte maturation.

Pelech S, Jelinkova L, Susor A, Zhang H, Shi X, Pavlok A, Kubelka M, Kovarova H.

J Proteome Res. 2008 Jul;7(7):2860-71. doi: 10.1021/pr800082a. Epub 2008 May 17.

PMID:
18484764
23.

Biomarker identification for diagnosis of Alzheimer's disease.

Pelech S.

Expert Opin Med Diagn. 2008 May;2(5):577-91. doi: 10.1517/17530059.2.5.577.

PMID:
23495745
24.

Neuromuscular dysfunction in the mutant superoxide dismutase mouse model of amyotrophic lateral sclerosis.

Parkhouse WS, Cunningham L, McFee I, Miller JM, Whitney D, Pelech SL, Krieger C.

Amyotroph Lateral Scler. 2008;9(1):24-34. doi: 10.1080/17482960701725646.

PMID:
18273716
25.
26.

Protective up-regulation of CK2 by mutant huntingtin in cells co-expressing NMDA receptors.

Fan MM, Zhang H, Hayden MR, Pelech SL, Raymond LA.

J Neurochem. 2008 Feb;104(3):790-805. Epub 2007 Oct 30.

28.

Abeta treatment and P301L tau expression in an Alzheimer's disease tissue culture model act synergistically to promote aberrant cell cycle re-entry.

Hoerndli FJ, Pelech S, Papassotiropoulos A, Götz J.

Eur J Neurosci. 2007 Jul;26(1):60-72. Epub 2007 Jun 22.

PMID:
17587323
29.

Histological and proteomic analysis of reversible H-RasV12G expression in transgenic mouse skin.

Oh WJ, Rishi V, Pelech S, Vinson C.

Carcinogenesis. 2007 Oct;28(10):2244-52. Epub 2007 Jun 5.

PMID:
17551062
30.

Alpha-synuclein activates stress signaling protein kinases in THP-1 cells and microglia.

Klegeris A, Pelech S, Giasson BI, Maguire J, Zhang H, McGeer EG, McGeer PL.

Neurobiol Aging. 2008 May;29(5):739-52. Epub 2006 Dec 12.

PMID:
17166628
31.

Alpha-synuclein and its disease-causing mutants induce ICAM-1 and IL-6 in human astrocytes and astrocytoma cells.

Klegeris A, Giasson BI, Zhang H, Maguire J, Pelech S, McGeer PL.

FASEB J. 2006 Oct;20(12):2000-8.

PMID:
17012252
32.
33.

Phosphorylation of STAT3 serine-727 by cyclin-dependent kinase 1 is critical for nocodazole-induced mitotic arrest.

Shi X, Zhang H, Paddon H, Lee G, Cao X, Pelech S.

Biochemistry. 2006 May 9;45(18):5857-67.

PMID:
16669628
34.

Positive regulation of Raf1-MEK1/2-ERK1/2 signaling by protein serine/threonine phosphatase 2A holoenzymes.

Adams DG, Coffee RL Jr, Zhang H, Pelech S, Strack S, Wadzinski BE.

J Biol Chem. 2005 Dec 30;280(52):42644-54. Epub 2005 Oct 20.

35.

Nitroreductase-based therapy of prostate cancer, enhanced by raising expression of heat shock protein 70, acts through increased anti-tumour immunity.

Lipinski KS, Pelech S, Mountain A, Irvine AS, Kraaij R, Bangma CH, Mills KH, Todryk SM.

Cancer Immunol Immunother. 2006 Mar;55(3):347-54. Epub 2005 Jun 17.

PMID:
16075195
36.

Tumor cell pseudopodial protrusions. Localized signaling domains coordinating cytoskeleton remodeling, cell adhesion, glycolysis, RNA translocation, and protein translation.

Jia Z, Barbier L, Stuart H, Amraei M, Pelech S, Dennis JW, Metalnikov P, O'Donnell P, Nabi IR.

J Biol Chem. 2005 Aug 26;280(34):30564-73. Epub 2005 Jun 28.

37.

Antitumor immune responses mediated by adenoviral GDEPT using nitroreductase/CB1954 is enhanced by high-level coexpression of heat shock protein 70.

Djeha HA, Todryk SM, Pelech S, Wrighton CJ, Irvine AS, Mountain A, Lipinski KS.

Cancer Gene Ther. 2005 Jun;12(6):560-71.

PMID:
15665820
38.

Progressive changes in Met-dependent signaling in a human ovarian surface epithelial model of malignant transformation.

Wong AS, Roskelley CD, Pelech S, Miller D, Leung PC, Auersperg N.

Exp Cell Res. 2004 Sep 10;299(1):248-56.

PMID:
15302591
39.

B23/nucleophosmin serine 4 phosphorylation mediates mitotic functions of polo-like kinase 1.

Zhang H, Shi X, Paddon H, Hampong M, Dai W, Pelech S.

J Biol Chem. 2004 Aug 20;279(34):35726-34. Epub 2004 Jun 9.

40.

Tracking cell signaling protein expression and phosphorylation by innovative proteomic solutions.

Pelech S.

Curr Pharm Biotechnol. 2004 Feb;5(1):69-77. Review.

PMID:
14965210
43.
44.

Aberrant protein kinases and phosphoproteins in amyotrophic lateral sclerosis.

Krieger C, Hu JH, Pelech S.

Trends Pharmacol Sci. 2003 Oct;24(10):535-41. Review. No abstract available.

PMID:
14559406
45.

Cytokines and signal transduction pathways mediated by anthralin in alopecia areata-affected Dundee experimental balding rats.

Tang L, Cao L, Pelech S, Lui H, Shapiro J.

J Investig Dermatol Symp Proc. 2003 Jun;8(1):87-90. Review.

46.

Glycogen synthase kinase-3 regulates formation of long lamellipodia in human keratinocytes.

Koivisto L, Alavian K, Hakkinen L, Pelech S, McCulloch CA, Larjava H.

J Cell Sci. 2003 Sep 15;116(Pt 18):3749-60. Epub 2003 Jul 30.

47.

Adenosine triphosphate induces proliferation of human neural stem cells: Role of calcium and p70 ribosomal protein S6 kinase.

Ryu JK, Choi HB, Hatori K, Heisel RL, Pelech SL, McLarnon JG, Kim SU.

J Neurosci Res. 2003 May 1;72(3):352-62.

PMID:
12692902
48.

Protein kinase and protein phosphatase expression in amyotrophic lateral sclerosis spinal cord.

Hu JH, Zhang H, Wagey R, Krieger C, Pelech SL.

J Neurochem. 2003 Apr;85(2):432-42.

49.
50.

Kinetworks protein kinase multiblot analysis.

Pelech S, Sutter C, Zhang H.

Methods Mol Biol. 2003;218:99-111.

PMID:
12616715

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