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Items: 1 to 50 of 71

1.

Anti-inflammatory microenvironment of esophageal adenocarcinomas negatively impacts survival.

Karstens KF, Kempski J, Giannou AD, Pelczar P, Steglich B, Steurer S, Freiwald E, Woestemeier A, Konczalla L, Tachezy M, Reeh M, Bockhorn M, Perez D, Mann O, Lohse AW, Roesch T, Izbicki JR, Gagliani N, Huber S.

Cancer Immunol Immunother. 2020 Feb 25. doi: 10.1007/s00262-020-02517-8. [Epub ahead of print]

PMID:
32100077
2.

Palmitoylation of BMPR1a regulates neural stem cell fate.

Wegleiter T, Buthey K, Gonzalez-Bohorquez D, Hruzova M, Bin Imtiaz MK, Abegg A, Mebert I, Molteni A, Kollegger D, Pelczar P, Jessberger S.

Proc Natl Acad Sci U S A. 2019 Dec 17;116(51):25688-25696. doi: 10.1073/pnas.1912671116. Epub 2019 Nov 26.

3.

Topical application of human-derived Ig isotypes for the control of acute respiratory infection evaluated in a human CD89-expressing mouse model.

Koernig S, Campbell IK, Mackenzie-Kludas C, Schaub A, Loetscher M, Ching Ng W, Zehnder R, Pelczar P, Sanli I, Alhamdoosh M, Ng M, Brown LE, Käsermann F, Vonarburg C, Zuercher AW.

Mucosal Immunol. 2019 Jul;12(4):1013-1024. doi: 10.1038/s41385-019-0167-z. Epub 2019 May 19.

PMID:
31105268
4.

Fate-Mapping of GM-CSF Expression Identifies a Discrete Subset of Inflammation-Driving T Helper Cells Regulated by Cytokines IL-23 and IL-1β.

Komuczki J, Tuzlak S, Friebel E, Hartwig T, Spath S, Rosenstiel P, Waisman A, Opitz L, Oukka M, Schreiner B, Pelczar P, Becher B.

Immunity. 2019 May 21;50(5):1289-1304.e6. doi: 10.1016/j.immuni.2019.04.006. Epub 2019 May 9.

PMID:
31079916
5.

Maternal overnutrition programs hedonic and metabolic phenotypes across generations through sperm tsRNAs.

Sarker G, Sun W, Rosenkranz D, Pelczar P, Opitz L, Efthymiou V, Wolfrum C, Peleg-Raibstein D.

Proc Natl Acad Sci U S A. 2019 May 21;116(21):10547-10556. doi: 10.1073/pnas.1820810116. Epub 2019 May 6.

6.

Quantitative RyR1 reduction and loss of calcium sensitivity of RyR1Q1970fsX16+A4329D cause cores and loss of muscle strength.

Elbaz M, Ruiz A, Bachmann C, Eckhardt J, Pelczar P, Venturi E, Lindsay C, Wilson AD, Alhussni A, Humberstone T, Pietrangelo L, Boncompagni S, Sitsapesan R, Treves S, Zorzato F.

Hum Mol Genet. 2019 Sep 15;28(18):2987-2999. doi: 10.1093/hmg/ddz092.

PMID:
31044239
7.

Extrinsic and intrinsic apoptosis activate pannexin-1 to drive NLRP3 inflammasome assembly.

Chen KW, Demarco B, Heilig R, Shkarina K, Boettcher A, Farady CJ, Pelczar P, Broz P.

EMBO J. 2019 May 15;38(10). pii: e101638. doi: 10.15252/embj.2019101638. Epub 2019 Mar 22.

PMID:
30902848
8.

The transcription factor Duxbl mediates elimination of pre-T cells that fail β-selection.

Klein F, Mitrovic M, Roux J, Engdahl C, von Muenchow L, Alberti-Servera L, Fehling HJ, Pelczar P, Rolink A, Tsapogas P.

J Exp Med. 2019 Mar 4;216(3):638-655. doi: 10.1084/jem.20181444. Epub 2019 Feb 14.

9.

Quantitative reduction of RyR1 protein caused by a single-allele frameshift mutation in RYR1 ex36 impairs the strength of adult skeletal muscle fibres.

Elbaz M, Ruiz A, Eckhardt J, Pelczar P, Muntoni F, Boncompagni S, Treves S, Zorzato F.

Hum Mol Genet. 2019 Jun 1;28(11):1872-1884. doi: 10.1093/hmg/ddz025.

PMID:
30689883
10.

Primed Track, high-fidelity lineage tracing in mouse pre-implantation embryos using primed conversion of photoconvertible proteins.

Welling M, Mohr MA, Ponti A, Rullan Sabater L, Boni A, Kawamura YK, Liberali P, Peters AH, Pelczar P, Pantazis P.

Elife. 2019 Jan 21;8. pii: e44491. doi: 10.7554/eLife.44491.

11.

Alterations in sperm long RNA contribute to the epigenetic inheritance of the effects of postnatal trauma.

Gapp K, van Steenwyk G, Germain PL, Matsushima W, Rudolph KLM, Manuella F, Roszkowski M, Vernaz G, Ghosh T, Pelczar P, Mansuy IM, Miska EA.

Mol Psychiatry. 2018 Oct 30. doi: 10.1038/s41380-018-0271-6. [Epub ahead of print]

PMID:
30374190
12.

Transgenerational transmission of hedonic behaviors and metabolic phenotypes induced by maternal overnutrition.

Sarker G, Berrens R, von Arx J, Pelczar P, Reik W, Wolfrum C, Peleg-Raibstein D.

Transl Psychiatry. 2018 Oct 12;8(1):195. doi: 10.1038/s41398-018-0243-2.

13.

A Transgenic MMTV-Flippase Mouse Line for Molecular Engineering in Mammary Gland and Breast Cancer Mouse Models.

Lüönd F, Bill R, Vettiger A, Oller H, Pelczar P, Christofori G.

J Mammary Gland Biol Neoplasia. 2019 Mar;24(1):39-45. doi: 10.1007/s10911-018-9412-4. Epub 2018 Sep 12.

PMID:
30209717
14.

Publisher Correction: Cold-induced epigenetic programming of the sperm enhances brown adipose tissue activity in the offspring.

Sun W, Dong H, Becker AS, Dapito DH, Modica S, Grandl G, Opitz L, Efthymiou V, Straub LG, Sarker G, Balaz M, Balazova L, Perdikari A, Kiehlmann E, Bacanovic S, Zellweger C, Peleg-Raibstein D, Pelczar P, Reik W, Burger IA, von Meyenn F, Wolfrum C.

Nat Med. 2018 Nov;24(11):1777. doi: 10.1038/s41591-018-0163-y.

PMID:
30087436
15.

Author Correction: Cold-induced epigenetic programming of the sperm enhances brown adipose tissue activity in the offspring.

Sun W, Dong H, Becker AS, Dapito DH, Modica S, Grandl G, Opitz L, Efthymiou V, Straub LG, Sarker G, Balaz M, Balazova L, Perdikari A, Kiehlmann E, Bacanovic S, Zellweger C, Peleg-Raibstein D, Pelczar P, Reik W, Burger IA, von Meyenn F, Wolfrum C.

Nat Med. 2018 Nov;24(11):1776. doi: 10.1038/s41591-018-0162-z.

PMID:
30087435
16.

TRPC1 regulates brown adipose tissue activity in a PPARγ-dependent manner.

Wolfrum C, Kiehlmann E, Pelczar P.

Am J Physiol Endocrinol Metab. 2018 Nov 1;315(5):E825-E832. doi: 10.1152/ajpendo.00170.2017. Epub 2018 Jul 10.

17.

Cold-induced epigenetic programming of the sperm enhances brown adipose tissue activity in the offspring.

Sun W, Dong H, Becker AS, Dapito DH, Modica S, Grandl G, Opitz L, Efthymiou V, Straub LG, Sarker G, Balaz M, Balazova L, Perdikari A, Kiehlmann E, Bacanovic S, Zellweger C, Peleg-Raibstein D, Pelczar P, Reik W, Burger IA, von Meyenn F, Wolfrum C.

Nat Med. 2018 Sep;24(9):1372-1383. doi: 10.1038/s41591-018-0102-y. Epub 2018 Jul 9. Erratum in: Nat Med. 2018 Aug 7;:. Nat Med. 2018 Aug 7;:.

PMID:
29988127
18.

Regulation of IL-22BP in psoriasis.

Voglis S, Moos S, Kloos L, Wanke F, Zayoud M, Pelczar P, Giannou AD, Pezer S, Albers M, Luessi F, Huber S, Schäkel K, Kurschus FC.

Sci Rep. 2018 Mar 23;8(1):5085. doi: 10.1038/s41598-018-23510-3.

19.

LPS targets host guanylate-binding proteins to the bacterial outer membrane for non-canonical inflammasome activation.

Santos JC, Dick MS, Lagrange B, Degrandi D, Pfeffer K, Yamamoto M, Meunier E, Pelczar P, Henry T, Broz P.

EMBO J. 2018 Mar 15;37(6). pii: e98089. doi: 10.15252/embj.201798089. Epub 2018 Feb 19.

20.

Corrigendum: Pramel7 mediates ground-state pluripotency through proteasomal-epigenetic combined pathways.

Graf U, Casanova EA, Wyck S, Dalcher D, Gatti M, Vollenweider E, Okoniewski MJ, Weber FA, Patel SS, Schmid MW, Li J, Sharif J, Wanner GA, Koseki H, Wong J, Pelczar P, Penengo L, Santoro R, Cinelli P.

Nat Cell Biol. 2017 Jul 28;19(8):1003. doi: 10.1038/ncb3572.

PMID:
28752849
21.

Pramel7 mediates ground-state pluripotency through proteasomal-epigenetic combined pathways.

Graf U, Casanova EA, Wyck S, Dalcher D, Gatti M, Vollenweider E, Okoniewski MJ, Weber FA, Patel SS, Schmid MW, Li J, Sharif J, Wanner GA, Koseki H, Wong J, Pelczar P, Penengo L, Santoro R, Cinelli P.

Nat Cell Biol. 2017 Jul;19(7):763-773. doi: 10.1038/ncb3554. Epub 2017 Jun 12. Erratum in: Nat Cell Biol. 2017 Jul 28;19(8):1003.

PMID:
28604677
22.

Regulated expression of amyloidogenic immunoglobulin light chains in mice.

Nuvolone M, Sorce S, Pelczar P, Rushing E, Lavatelli F, Rognoni P, Valentini V, Palladini G, Merlini G, Aguzzi A.

Amyloid. 2017 Mar;24(sup1):52-53. doi: 10.1080/13506129.2017.1289914. No abstract available.

PMID:
28434289
23.

Dysregulation of the Cytokine GM-CSF Induces Spontaneous Phagocyte Invasion and Immunopathology in the Central Nervous System.

Spath S, Komuczki J, Hermann M, Pelczar P, Mair F, Schreiner B, Becher B.

Immunity. 2017 Feb 21;46(2):245-260. doi: 10.1016/j.immuni.2017.01.007.

24.

Protease resistance of infectious prions is suppressed by removal of a single atom in the cellular prion protein.

Leske H, Hornemann S, Herrmann US, Zhu C, Dametto P, Li B, Laferriere F, Polymenidou M, Pelczar P, Reimann RR, Schwarz P, Rushing EJ, Wüthrich K, Aguzzi A.

PLoS One. 2017 Feb 16;12(2):e0170503. doi: 10.1371/journal.pone.0170503. eCollection 2017.

25.

TH17 cells express ST2 and are controlled by the alarmin IL-33 in the small intestine.

Pascual-Reguant A, Bayat Sarmadi J, Baumann C, Noster R, Cirera-Salinas D, Curato C, Pelczar P, Huber S, Zielinski CE, Löhning M, Hauser AE, Esplugues E.

Mucosal Immunol. 2017 Nov;10(6):1431-1442. doi: 10.1038/mi.2017.5. Epub 2017 Feb 15.

PMID:
28198366
26.

Modeling the ferrochelatase c.315-48C modifier mutation for erythropoietic protoporphyria (EPP) in mice.

Barman-Aksözen J, C Wiek P, Bansode VB, Koentgen F, Trüb J, Pelczar P, Cinelli P, Schneider-Yin X, Schümperli D, Minder EI.

Dis Model Mech. 2017 Mar 1;10(3):225-233. doi: 10.1242/dmm.027755. Epub 2017 Jan 12.

27.

IL-10 Receptor Signaling Is Essential for TR1 Cell Function In Vivo.

Brockmann L, Gagliani N, Steglich B, Giannou AD, Kempski J, Pelczar P, Geffken M, Mfarrej B, Huber F, Herkel J, Wan YY, Esplugues E, Battaglia M, Krebs CF, Flavell RA, Huber S.

J Immunol. 2017 Feb 1;198(3):1130-1141. doi: 10.4049/jimmunol.1601045. Epub 2016 Dec 21.

28.

A pathogenic role for T cell-derived IL-22BP in inflammatory bowel disease.

Pelczar P, Witkowski M, Perez LG, Kempski J, Hammel AG, Brockmann L, Kleinschmidt D, Wende S, Haueis C, Bedke T, Witkowski M, Krasemann S, Steurer S, Booth CJ, Busch P, König A, Rauch U, Benten D, Izbicki JR, Rösch T, Lohse AW, Strowig T, Gagliani N, Flavell RA, Huber S.

Science. 2016 Oct 21;354(6310):358-362.

PMID:
27846573
29.

Strictly co-isogenic C57BL/6J-Prnp-/- mice: A rigorous resource for prion science.

Nuvolone M, Hermann M, Sorce S, Russo G, Tiberi C, Schwarz P, Minikel E, Sanoudou D, Pelczar P, Aguzzi A.

J Exp Med. 2016 Mar 7;213(3):313-27. doi: 10.1084/jem.20151610. Epub 2016 Feb 29.

30.

IL-23 prevents IL-13-dependent tissue repair associated with Ly6C(lo) monocytes in Entamoeba histolytica-induced liver damage.

Noll J, Helk E, Fehling H, Bernin H, Marggraff C, Jacobs T, Huber S, Pelczar P, Ernst T, Ittrich H, Otto B, Mittrücker HW, Hölscher C, Tacke F, Bruchhaus I, Tannich E, Lotter H.

J Hepatol. 2016 May;64(5):1147-1157. doi: 10.1016/j.jhep.2016.01.013. Epub 2016 Jan 22.

31.

Continuous Histone Replacement by Hira Is Essential for Normal Transcriptional Regulation and De Novo DNA Methylation during Mouse Oogenesis.

Nashun B, Hill PW, Smallwood SA, Dharmalingam G, Amouroux R, Clark SJ, Sharma V, Ndjetehe E, Pelczar P, Festenstein RJ, Kelsey G, Hajkova P.

Mol Cell. 2015 Nov 19;60(4):611-25. doi: 10.1016/j.molcel.2015.10.010. Epub 2015 Nov 5.

32.

The Cytokine GM-CSF Drives the Inflammatory Signature of CCR2+ Monocytes and Licenses Autoimmunity.

Croxford AL, Lanzinger M, Hartmann FJ, Schreiner B, Mair F, Pelczar P, Clausen BE, Jung S, Greter M, Becher B.

Immunity. 2015 Sep 15;43(3):502-14. doi: 10.1016/j.immuni.2015.08.010. Epub 2015 Sep 1.

33.

Functional validation of mouse tyrosinase non-coding regulatory DNA elements by CRISPR-Cas9-mediated mutagenesis.

Seruggia D, Fernández A, Cantero M, Pelczar P, Montoliu L.

Nucleic Acids Res. 2015 May 26;43(10):4855-67. doi: 10.1093/nar/gkv375. Epub 2015 Apr 20.

34.

Neurodegeneration and unfolded-protein response in mice expressing a membrane-tethered flexible tail of PrP.

Dametto P, Lakkaraju AK, Bridel C, Villiger L, O'Connor T, Herrmann US, Pelczar P, Rülicke T, McHugh D, Adili A, Aguzzi A.

PLoS One. 2015 Feb 6;10(2):e0117412. doi: 10.1371/journal.pone.0117412. eCollection 2015.

35.

Mouse genome engineering using designer nucleases.

Hermann M, Cermak T, Voytas DF, Pelczar P.

J Vis Exp. 2014 Apr 2;(86). doi: 10.3791/50930.

36.

Implication of sperm RNAs in transgenerational inheritance of the effects of early trauma in mice.

Gapp K, Jawaid A, Sarkies P, Bohacek J, Pelczar P, Prados J, Farinelli L, Miska E, Mansuy IM.

Nat Neurosci. 2014 May;17(5):667-9. doi: 10.1038/nn.3695. Epub 2014 Apr 13.

37.

Heritable and inducible gene knockdown in astrocytes or neurons in vivo by a combined lentiviral and RNAi approach.

Heitz F, Johansson T, Baumgärtel K, Gecaj R, Pelczar P, Mansuy IM.

Front Cell Neurosci. 2014 Mar 19;8:62. doi: 10.3389/fncel.2014.00062. eCollection 2014.

38.

Binary recombinase systems for high-resolution conditional mutagenesis.

Hermann M, Stillhard P, Wildner H, Seruggia D, Kapp V, Sánchez-Iranzo H, Mercader N, Montoliu L, Zeilhofer HU, Pelczar P.

Nucleic Acids Res. 2014 Apr;42(6):3894-907. doi: 10.1093/nar/gkt1361. Epub 2014 Jan 9.

39.

Stroma-derived interleukin-34 controls the development and maintenance of langerhans cells and the maintenance of microglia.

Greter M, Lelios I, Pelczar P, Hoeffel G, Price J, Leboeuf M, Kündig TM, Frei K, Ginhoux F, Merad M, Becher B.

Immunity. 2012 Dec 14;37(6):1050-1060. doi: 10.1016/j.immuni.2012.11.001. Epub 2012 Nov 21.

40.

Hyperactive self-inactivating piggyBac for transposase-enhanced pronuclear microinjection transgenesis.

Marh J, Stoytcheva Z, Urschitz J, Sugawara A, Yamashiro H, Owens JB, Stoytchev I, Pelczar P, Yanagimachi R, Moisyadi S.

Proc Natl Acad Sci U S A. 2012 Nov 20;109(47):19184-9. doi: 10.1073/pnas.1216473109. Epub 2012 Oct 23.

41.

Inactivation of Patched1 in mice leads to development of gastrointestinal stromal-like tumors that express Pdgfrα but not kit.

Pelczar P, Zibat A, van Dop WA, Heijmans J, Bleckmann A, Gruber W, Nitzki F, Uhmann A, Guijarro MV, Hernando E, Dittmann K, Wienands J, Dressel R, Wojnowski L, Binder C, Taguchi T, Beissbarth T, Hogendoorn PC, Antonescu CR, Rubin BP, Schulz-Schaeffer W, Aberger F, van den Brink GR, Hahn H.

Gastroenterology. 2013 Jan;144(1):134-144.e6. doi: 10.1053/j.gastro.2012.09.061. Epub 2012 Oct 3.

42.

Evaluation of OPEN zinc finger nucleases for direct gene targeting of the ROSA26 locus in mouse embryos.

Hermann M, Maeder ML, Rector K, Ruiz J, Becher B, Bürki K, Khayter C, Aguzzi A, Joung JK, Buch T, Pelczar P.

PLoS One. 2012;7(9):e41796. doi: 10.1371/journal.pone.0041796. Epub 2012 Sep 6.

43.

Is BAC transgenesis obsolete? State of the art in the era of designer nucleases.

Beil J, Fairbairn L, Pelczar P, Buch T.

J Biomed Biotechnol. 2012;2012:308414. doi: 10.1155/2012/308414. Epub 2012 Jul 30.

44.

Pramel7 mediates LIF/STAT3-dependent self-renewal in embryonic stem cells.

Casanova EA, Shakhova O, Patel SS, Asner IN, Pelczar P, Weber FA, Graf U, Sommer L, Bürki K, Cinelli P.

Stem Cells. 2011 Mar;29(3):474-85. doi: 10.1002/stem.588.

45.

Specific proteolytic cleavage of agrin regulates maturation of the neuromuscular junction.

Bolliger MF, Zurlinden A, Lüscher D, Bütikofer L, Shakhova O, Francolini M, Kozlov SV, Cinelli P, Stephan A, Kistler AD, Rülicke T, Pelczar P, Ledermann B, Fumagalli G, Gloor SM, Kunz B, Sonderegger P.

J Cell Sci. 2010 Nov 15;123(Pt 22):3944-55. doi: 10.1242/jcs.072090. Epub 2010 Oct 27.

46.

Helper-independent piggyBac plasmids for gene delivery approaches: strategies for avoiding potential genotoxic effects.

Urschitz J, Kawasumi M, Owens J, Morozumi K, Yamashiro H, Stoytchev I, Marh J, Dee JA, Kawamoto K, Coates CJ, Kaminski JM, Pelczar P, Yanagimachi R, Moisyadi S.

Proc Natl Acad Sci U S A. 2010 May 4;107(18):8117-22. doi: 10.1073/pnas.1003674107. Epub 2010 Apr 19.

47.

A novel three-dimensional culture system allows prolonged culture of functional human granulosa cells and mimics the ovarian environment.

Kossowska-Tomaszczuk K, Pelczar P, Güven S, Kowalski J, Volpi E, De Geyter C, Scherberich A.

Tissue Eng Part A. 2010 Jun;16(6):2063-73. doi: 10.1089/ten.TEA.2009.0684.

48.

Genetic vasectomy-overexpression of Prm1-EGFP fusion protein in elongating spermatids causes dominant male sterility in mice.

Haueter S, Kawasumi M, Asner I, Brykczynska U, Cinelli P, Moisyadi S, Bürki K, Peters AH, Pelczar P.

Genesis. 2010 Mar;48(3):151-60. doi: 10.1002/dvg.20598.

49.

Localization of the germination protein GerD to the inner membrane in Bacillus subtilis spores.

Pelczar PL, Setlow P.

J Bacteriol. 2008 Aug;190(16):5635-41. doi: 10.1128/JB.00670-08. Epub 2008 Jun 13.

50.

High survival and developmental rates of vitrified mouse zygotes following polar body biopsy.

Macas E, Merki-Feld GS, Xie M, Stiller R, Pelczar P, Imthurn B.

Reprod Biomed Online. 2008 Feb;16(2):271-5.

PMID:
18284885

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