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Deployment of convalescent plasma for the prevention and treatment of COVID-19.

Bloch EM, Shoham S, Casadevall A, Sachais BS, Shaz B, Winters JL, van Buskirk C, Grossman BJ, Joyner M, Henderson JP, Pekosz A, Lau B, Wesolowski A, Katz L, Shan H, Auwaerter PG, Thomas D, Sullivan DJ, Paneth N, Gehrie E, Spitalnik S, Hod E, Pollack L, Nicholson WT, Pirofski LA, Bailey JA, Tobian AA.

J Clin Invest. 2020 Apr 7. pii: 138745. doi: 10.1172/JCI138745. [Epub ahead of print] Review.


The Influenza A Virus M2 Protein trans-Complementation System Offers a Set of Tools for the Undergraduate Virology Laboratory.

Grantham ML, McCown MF, Pekosz A.

J Microbiol Biol Educ. 2019 Apr 26;20(1). pii: 20.1.16. doi: 10.1128/jmbe.v20i1.1667. eCollection 2019.


IL-1 receptor antagonist therapy mitigates placental dysfunction and perinatal injury following Zika virus infection.

Lei J, Vermillion MS, Jia B, Xie H, Xie L, McLane MW, Sheffield JS, Pekosz A, Brown A, Klein SL, Burd I.

JCI Insight. 2019 Feb 28;4(7). pii: 122678. doi: 10.1172/jci.insight.122678. eCollection 2019 Apr 4.


Influenza A Virus M2 Protein Apical Targeting Is Required for Efficient Virus Replication.

Wohlgemuth N, Lane AP, Pekosz A.

J Virol. 2018 Oct 29;92(22). pii: e01425-18. doi: 10.1128/JVI.01425-18. Print 2018 Nov 15.


Moving Forward: Recent Developments for the Ferret Biomedical Research Model.

Albrecht RA, Liu WC, Sant AJ, Tompkins SM, Pekosz A, Meliopoulos V, Cherry S, Thomas PG, Schultz-Cherry S.

mBio. 2018 Jul 17;9(4). pii: e01113-18. doi: 10.1128/mBio.01113-18. Review.


Production of amphiregulin and recovery from influenza is greater in males than females.

Vermillion MS, Ursin RL, Kuok DIT, Vom Steeg LG, Wohlgemuth N, Hall OJ, Fink AL, Sasse E, Nelson A, Ndeh R, McGrath-Morrow S, Mitzner W, Chan MCW, Pekosz A, Klein SL.

Biol Sex Differ. 2018 Jul 17;9(1):24. doi: 10.1186/s13293-018-0184-8.


Stability of the Influenza Virus Hemagglutinin Protein Correlates with Evolutionary Dynamics.

Klein EY, Blumenkrantz D, Serohijos A, Shakhnovich E, Choi JM, Rodrigues JV, Smith BD, Lane AP, Feldman A, Pekosz A.

mSphere. 2018 Jan 3;3(1). pii: e00554-17. doi: 10.1128/mSphereDirect.00554-17. eCollection 2018 Jan-Feb.


The M2 protein of live, attenuated influenza vaccine encodes a mutation that reduces replication in human nasal epithelial cells.

Wohlgemuth N, Ye Y, Fenstermacher KJ, Liu H, Lane AP, Pekosz A.

Vaccine. 2017 Dec 4;35(48 Pt B):6691-6699. doi: 10.1016/j.vaccine.2017.10.018. Epub 2017 Oct 25.


Mutations in the Influenza A Virus M1 Protein Enhance Virus Budding To Complement Lethal Mutations in the M2 Cytoplasmic Tail.

Liu H, Grantham ML, Pekosz A.

J Virol. 2017 Dec 14;92(1). pii: e00858-17. doi: 10.1128/JVI.00858-17. Print 2018 Jan 1.


Evaluation of the innate immune responses to influenza and live-attenuated influenza vaccine infection in primary differentiated human nasal epithelial cells.

Forero A, Fenstermacher K, Wohlgemuth N, Nishida A, Carter V, Smith EA, Peng X, Hayes M, Francis D, Treanor J, Morrison J, Klein SL, Lane A, Katze MG, Pekosz A.

Vaccine. 2017 Oct 27;35(45):6112-6121. doi: 10.1016/j.vaccine.2017.09.058. Epub 2017 Sep 28.


A novel real-time RT-PCR assay for influenza C tested in Peruvian children.

Howard LM, Johnson M, Gil AI, Pekosz A, Griffin MR, Edwards KM, Lanata CF, Grijalva CG, Williams JV; RESPIRA-PERU Group.

J Clin Virol. 2017 Nov;96:12-16. doi: 10.1016/j.jcv.2017.08.014. Epub 2017 Sep 1.


Intrauterine Zika virus infection of pregnant immunocompetent mice models transplacental transmission and adverse perinatal outcomes.

Vermillion MS, Lei J, Shabi Y, Baxter VK, Crilly NP, McLane M, Griffin DE, Pekosz A, Klein SL, Burd I.

Nat Commun. 2017 Feb 21;8:14575. doi: 10.1038/ncomms14575.


Progesterone-Based Therapy Protects Against Influenza by Promoting Lung Repair and Recovery in Females.

Hall OJ, Limjunyawong N, Vermillion MS, Robinson DP, Wohlgemuth N, Pekosz A, Mitzner W, Klein SL.

PLoS Pathog. 2016 Sep 15;12(9):e1005840. doi: 10.1371/journal.ppat.1005840. eCollection 2016 Sep.


Pathogenesis and Molecular Mechanisms of Zika Virus.

Nayak S, Lei J, Pekosz A, Klein S, Burd I.

Semin Reprod Med. 2016 Sep;34(5):266-272. Epub 2016 Sep 9. Review.


Epizootics in Industrial Livestock Production: Preventable Gaps in Biosecurity and Biocontainment.

Leibler JH, Dalton K, Pekosz A, Gray GC, Silbergeld EK.

Zoonoses Public Health. 2017 Mar;64(2):137-145. doi: 10.1111/zph.12292. Epub 2016 Sep 4.


Estrogenic compounds reduce influenza A virus replication in primary human nasal epithelial cells derived from female, but not male, donors.

Peretz J, Pekosz A, Lane AP, Klein SL.

Am J Physiol Lung Cell Mol Physiol. 2016 Mar 1;310(5):L415-25. doi: 10.1152/ajplung.00398.2015. Epub 2015 Dec 18.


Restricted replication of the live attenuated influenza A virus vaccine during infection of primary differentiated human nasal epithelial cells.

Fischer WA 2nd, King LS, Lane AP, Pekosz A.

Vaccine. 2015 Aug 26;33(36):4495-504. doi: 10.1016/j.vaccine.2015.07.023. Epub 2015 Jul 18.


Exposure to electronic cigarettes impairs pulmonary anti-bacterial and anti-viral defenses in a mouse model.

Sussan TE, Gajghate S, Thimmulappa RK, Ma J, Kim JH, Sudini K, Consolini N, Cormier SA, Lomnicki S, Hasan F, Pekosz A, Biswal S.

PLoS One. 2015 Feb 4;10(2):e0116861. doi: 10.1371/journal.pone.0116861. eCollection 2015.


Selective inactivation of USP18 isopeptidase activity in vivo enhances ISG15 conjugation and viral resistance.

Ketscher L, Hannß R, Morales DJ, Basters A, Guerra S, Goldmann T, Hausmann A, Prinz M, Naumann R, Pekosz A, Utermöhlen O, Lenschow DJ, Knobeloch KP.

Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):1577-82. doi: 10.1073/pnas.1412881112. Epub 2015 Jan 20.


Transcriptional profiling of the spleen in progressive visceral leishmaniasis reveals mixed expression of type 1 and type 2 cytokine-responsive genes.

Espitia CM, Saldarriaga OA, Travi BL, Osorio EY, Hernandez A, Band M, Patel MJ, Medina AA, Cappello M, Pekosz A, Melby PC.

BMC Immunol. 2014 Nov 26;15:38. doi: 10.1186/s12865-014-0038-z.


Sex-based biology and the rational design of influenza vaccination strategies.

Klein SL, Pekosz A.

J Infect Dis. 2014 Jul 15;209 Suppl 3:S114-9. doi: 10.1093/infdis/jiu066. Review.


Influenza A H1N1 pandemic strain evolution--divergence and the potential for antigenic drift variants.

Klein EY, Serohijos AW, Choi JM, Shakhnovich EI, Pekosz A.

PLoS One. 2014 Apr 3;9(4):e93632. doi: 10.1371/journal.pone.0093632. eCollection 2014.


Mind the gap: social media engagement by public health researchers.

Keller B, Labrique A, Jain KM, Pekosz A, Levine O.

J Med Internet Res. 2014 Jan 14;16(1):e8. doi: 10.2196/jmir.2982.


Prospects for oral replicating adenovirus-vectored vaccines.

Deal C, Pekosz A, Ketner G.

Vaccine. 2013 Jul 11;31(32):3236-43. doi: 10.1016/j.vaccine.2013.05.016. Epub 2013 May 22. Review.


Tropism and infectivity of influenza virus, including highly pathogenic avian H5N1 virus, in ferret tracheal differentiated primary epithelial cell cultures.

Zeng H, Goldsmith CS, Maines TR, Belser JA, Gustin KM, Pekosz A, Zaki SR, Katz JM, Tumpey TM.

J Virol. 2013 Mar;87(5):2597-607. doi: 10.1128/JVI.02885-12. Epub 2012 Dec 19.


Antibody responses and cross protection against lethal influenza A viruses differ between the sexes in C57BL/6 mice.

Lorenzo ME, Hodgson A, Robinson DP, Kaplan JB, Pekosz A, Klein SL.

Vaccine. 2011 Nov 15;29(49):9246-55. doi: 10.1016/j.vaccine.2011.09.110. Epub 2011 Oct 6.


Mutations in the membrane-proximal region of the influenza A virus M2 protein cytoplasmic tail have modest effects on virus replication.

Stewart SM, Pekosz A.

J Virol. 2011 Dec;85(23):12179-87. doi: 10.1128/JVI.05970-11. Epub 2011 Sep 14.


Influenza virus-like particles containing M2 induce broadly cross protective immunity.

Song JM, Wang BZ, Park KM, Van Rooijen N, Quan FS, Kim MC, Jin HT, Pekosz A, Compans RW, Kang SM.

PLoS One. 2011 Jan 18;6(1):e14538. doi: 10.1371/journal.pone.0014538.


No evidence of infection with avian influenza viruses among US poultry workers in the Delmarva Peninsula, Maryland and Virginia, USA.

Leibler JH, Silbergeld EK, Pekosz A, Gray GC.

J Agromedicine. 2011 Jan;16(1):52-7. doi: 10.1080/1059924X.2011.533612.


The impact of sex, gender and pregnancy on 2009 H1N1 disease.

Klein SL, Passaretti C, Anker M, Olukoya P, Pekosz A.

Biol Sex Differ. 2010 Nov 4;1(1):5. doi: 10.1186/2042-6410-1-5.


Delivery of woodchuck hepatitis virus-like particle presented influenza M2e by recombinant attenuated Salmonella displaying a delayed lysis phenotype.

Ameiss K, Ashraf S, Kong W, Pekosz A, Wu WH, Milich D, Billaud JN, Curtiss R 3rd.

Vaccine. 2010 Sep 24;28(41):6704-13. doi: 10.1016/j.vaccine.2010.07.083. Epub 2010 Aug 5.


The cholesterol recognition/interaction amino acid consensus motif of the influenza A virus M2 protein is not required for virus replication but contributes to virulence.

Stewart SM, Wu WH, Lalime EN, Pekosz A.

Virology. 2010 Sep 30;405(2):530-8. doi: 10.1016/j.virol.2010.06.035. Epub 2010 Jul 24.


Human antibodies reveal a protective epitope that is highly conserved among human and nonhuman influenza A viruses.

Grandea AG 3rd, Olsen OA, Cox TC, Renshaw M, Hammond PW, Chan-Hui PY, Mitcham JL, Cieplak W, Stewart SM, Grantham ML, Pekosz A, Kiso M, Shinya K, Hatta M, Kawaoka Y, Moyle M.

Proc Natl Acad Sci U S A. 2010 Jul 13;107(28):12658-63. doi: 10.1073/pnas.0911806107. Epub 2010 Jul 1.


Tyrosines in the influenza A virus M2 protein cytoplasmic tail are critical for production of infectious virus particles.

Grantham ML, Stewart SM, Lalime EN, Pekosz A.

J Virol. 2010 Sep;84(17):8765-76. doi: 10.1128/JVI.00853-10. Epub 2010 Jun 23.


The Xs and Y of immune responses to viral vaccines.

Klein SL, Jedlicka A, Pekosz A.

Lancet Infect Dis. 2010 May;10(5):338-49. doi: 10.1016/S1473-3099(10)70049-9. Review. Erratum in: Lancet Infect Dis. 2010 Nov;10(11):740.


Seoul virus suppresses NF-kappaB-mediated inflammatory responses of antigen presenting cells from Norway rats.

Au RY, Jedlicka AE, Li W, Pekosz A, Klein SL.

Virology. 2010 Apr 25;400(1):115-27. doi: 10.1016/j.virol.2010.01.027. Epub 2010 Feb 18.


Influenza virus assays based on virus-inducible reporter cell lines.

Li Y, Larrimer A, Curtiss T, Kim J, Jones A, Baird-Tomlinson H, Pekosz A, Olivo PD.

Influenza Other Respir Viruses. 2009 Sep;3(5):241-51.


Palmitoylation of the influenza A virus M2 protein is not required for virus replication in vitro but contributes to virus virulence.

Grantham ML, Wu WH, Lalime EN, Lorenzo ME, Klein SL, Pekosz A.

J Virol. 2009 Sep;83(17):8655-61. doi: 10.1128/JVI.01129-09. Epub 2009 Jun 24.


Sialic acid recognition is a key determinant of influenza A virus tropism in murine trachea epithelial cell cultures.

Pekosz A, Newby C, Bose PS, Lutz A.

Virology. 2009 Mar 30;386(1):61-7. doi: 10.1016/j.virol.2009.01.005. Epub 2009 Feb 4.


Roles for the recycling endosome, Rab8, and Rab11 in hantavirus release from epithelial cells.

Rowe RK, Suszko JW, Pekosz A.

Virology. 2008 Dec 20;382(2):239-49. doi: 10.1016/j.virol.2008.09.021. Epub 2008 Oct 31.


An immunosuppressed Syrian golden hamster model for SARS-CoV infection.

Schaecher SR, Stabenow J, Oberle C, Schriewer J, Buller RM, Sagartz JE, Pekosz A.

Virology. 2008 Oct 25;380(2):312-21. doi: 10.1016/j.virol.2008.07.026. Epub 2008 Aug 28.


The transmembrane domain of the severe acute respiratory syndrome coronavirus ORF7b protein is necessary and sufficient for its retention in the Golgi complex.

Schaecher SR, Diamond MS, Pekosz A.

J Virol. 2008 Oct;82(19):9477-91. doi: 10.1128/JVI.00784-08. Epub 2008 Jul 16.


Emerging viral diseases.

Pekosz A, Glass GE.

Md Med. 2008 Winter;9(1):11, 13-6. Review. No abstract available.


Severe acute respiratory syndrome coronavirus gene 7 products contribute to virus-induced apoptosis.

Schaecher SR, Touchette E, Schriewer J, Buller RM, Pekosz A.

J Virol. 2007 Oct;81(20):11054-68. Epub 2007 Aug 8.


IFN-stimulated gene 15 functions as a critical antiviral molecule against influenza, herpes, and Sindbis viruses.

Lenschow DJ, Lai C, Frias-Staheli N, Giannakopoulos NV, Lutz A, Wolff T, Osiak A, Levine B, Schmidt RE, García-Sastre A, Leib DA, Pekosz A, Knobeloch KP, Horak I, Virgin HW 4th.

Proc Natl Acad Sci U S A. 2007 Jan 23;104(4):1371-6. Epub 2007 Jan 16.

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