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Vimentin Phosphorylation Is Required for Normal Cell Division of Immature Astrocytes.

Pablo Y, Marasek P, Pozo-Rodrigálvarez A, Wilhelmsson U, Inagaki M, Pekna M, Pekny M.

Cells. 2019 Sep 1;8(9). pii: E1016. doi: 10.3390/cells8091016.


The role of GFAP and vimentin in learning and memory.

Wilhelmsson U, Pozo-Rodrigalvarez A, Kalm M, de Pablo Y, Widestrand Å, Pekna M, Pekny M.

Biol Chem. 2019 Aug 27;400(9):1147-1156. doi: 10.1515/hsz-2019-0199.


Vimentin is required for normal accumulation of body fat.

Wilhelmsson U, Stillemark-Billton P, Borén J, Pekny M.

Biol Chem. 2019 Aug 27;400(9):1157-1162. doi: 10.1515/hsz-2019-0170.


Nestin Regulates Neurogenesis in Mice Through Notch Signaling From Astrocytes to Neural Stem Cells.

Wilhelmsson U, Lebkuechner I, Leke R, Marasek P, Yang X, Antfolk D, Chen M, Mohseni P, Lasič E, Bobnar ST, Stenovec M, Zorec R, Nagy A, Sahlgren C, Pekna M, Pekny M.

Cereb Cortex. 2019 Sep 13;29(10):4050-4066. doi: 10.1093/cercor/bhy284.


Inflammation in the hippocampus affects IGF1 receptor signaling and contributes to neurological sequelae in rheumatoid arthritis.

Andersson KME, Wasén C, Juzokaite L, Leifsdottir L, Erlandsson MC, Silfverswärd ST, Stokowska A, Pekna M, Pekny M, Olmarker K, Heckemann RA, Kalm M, Bokarewa MI.

Proc Natl Acad Sci U S A. 2018 Dec 18;115(51):E12063-E12072. doi: 10.1073/pnas.1810553115. Epub 2018 Dec 3.


Vimentin deficiency in macrophages induces increased oxidative stress and vascular inflammation but attenuates atherosclerosis in mice.

Håversen L, Sundelin JP, Mardinoglu A, Rutberg M, Ståhlman M, Wilhelmsson U, Hultén LM, Pekny M, Fogelstrand P, Bentzon JF, Levin M, Borén J.

Sci Rep. 2018 Nov 19;8(1):16973. doi: 10.1038/s41598-018-34659-2.


Astrocyte activation and reactive gliosis-A new target in stroke?

Pekny M, Wilhelmsson U, Tatlisumak T, Pekna M.

Neurosci Lett. 2019 Jan 10;689:45-55. doi: 10.1016/j.neulet.2018.07.021. Epub 2018 Jul 17. Review.


The cysteine residue of glial fibrillary acidic protein is a critical target for lipoxidation and required for efficient network organization.

Viedma-Poyatos Á, de Pablo Y, Pekny M, Pérez-Sala D.

Free Radic Biol Med. 2018 May 20;120:380-394. doi: 10.1016/j.freeradbiomed.2018.04.007. Epub 2018 Apr 7.


Attenuation of reactive gliosis in stroke-injured mouse brain does not affect neurogenesis from grafted human iPSC-derived neural progenitors.

Laterza C, Uoshima N, Tornero D, Wilhelmsson U, Stokowska A, Ge R, Pekny M, Lindvall O, Kokaia Z.

PLoS One. 2018 Feb 5;13(2):e0192118. doi: 10.1371/journal.pone.0192118. eCollection 2018.


Increased Neuronal Differentiation of Neural Progenitor Cells Derived from Phosphovimentin-Deficient Mice.

Chen M, Puschmann TB, Marasek P, Inagaki M, Pekna M, Wilhelmsson U, Pekny M.

Mol Neurobiol. 2018 Jul;55(7):5478-5489. doi: 10.1007/s12035-017-0759-0. Epub 2017 Sep 27.


Long-Term Improvements After Multimodal Rehabilitation in Late Phase After Stroke: A Randomized Controlled Trial.

Bunketorp-Käll L, Lundgren-Nilsson Å, Samuelsson H, Pekny T, Blomvé K, Pekna M, Pekny M, Blomstrand C, Nilsson M.

Stroke. 2017 Jul;48(7):1916-1924. doi: 10.1161/STROKEAHA.116.016433. Epub 2017 Jun 15. Erratum in: Stroke. 2017 Sep;48(9):e272.


Injury Leads to the Appearance of Cells with Characteristics of Both Microglia and Astrocytes in Mouse and Human Brain.

Wilhelmsson U, Andersson D, de Pablo Y, Pekny R, Ståhlberg A, Mulder J, Mitsios N, Hortobágyi T, Pekny M, Pekna M.

Cereb Cortex. 2017 Jun 1;27(6):3360-3377. doi: 10.1093/cercor/bhx069.


Drugs targeting intermediate filaments can improve neurosupportive properties of astrocytes.

de Pablo Y, Chen M, Möllerström E, Pekna M, Pekny M.

Brain Res Bull. 2018 Jan;136:130-138. doi: 10.1016/j.brainresbull.2017.01.021. Epub 2017 Jan 31.


The challenge of regenerative therapies for the optic nerve in glaucoma.

Calkins DJ, Pekny M, Cooper ML, Benowitz L; Lasker/IRRF Initiative on Astrocytes and Glaucomatous Neurodegeneration Participants.

Exp Eye Res. 2017 Apr;157:28-33. doi: 10.1016/j.exer.2017.01.007. Epub 2017 Jan 30. Review.


Neural Progenitor Cells in Cerebral Cortex of Epilepsy Patients do not Originate from Astrocytes Expressing GLAST.

Chen M, Puschmann TB, Wilhelmsson U, Örndal C, Pekna M, Malmgren K, Rydenhag B, Pekny M.

Cereb Cortex. 2017 Dec 1;27(12):5672-5682. doi: 10.1093/cercor/bhw338.


Targeting innate immunity for neurodegenerative disorders of the central nervous system.

Andreasson KI, Bachstetter AD, Colonna M, Ginhoux F, Holmes C, Lamb B, Landreth G, Lee DC, Low D, Lynch MA, Monsonego A, O'Banion MK, Pekny M, Puschmann T, Russek-Blum N, Sandusky LA, Selenica ML, Takata K, Teeling J, Town T, Van Eldik LJ.

J Neurochem. 2016 Sep;138(5):653-93. doi: 10.1111/jnc.13667. Review. Erratum in: J Neurochem. 2017 Apr;141(1):151.


C3 deficiency ameliorates the negative effects of irradiation of the young brain on hippocampal development and learning.

Kalm M, Andreasson U, Björk-Eriksson T, Zetterberg H, Pekny M, Blennow K, Pekna M, Blomgren K.

Oncotarget. 2016 Apr 12;7(15):19382-94. doi: 10.18632/oncotarget.8400.


Astrocytes: a central element in neurological diseases.

Pekny M, Pekna M, Messing A, Steinhäuser C, Lee JM, Parpura V, Hol EM, Sofroniew MV, Verkhratsky A.

Acta Neuropathol. 2016 Mar;131(3):323-45. doi: 10.1007/s00401-015-1513-1. Epub 2015 Dec 15. Review.


Reactive gliosis in the pathogenesis of CNS diseases.

Pekny M, Pekna M.

Biochim Biophys Acta. 2016 Mar;1862(3):483-91. doi: 10.1016/j.bbadis.2015.11.014. Epub 2015 Dec 2. Review.


Retinal functional alterations in mice lacking intermediate filament proteins glial fibrillary acidic protein and vimentin.

Wunderlich KA, Tanimoto N, Grosche A, Zrenner E, Pekny M, Reichenbach A, Seeliger MW, Pannicke T, Perez MT.

FASEB J. 2015 Dec;29(12):4815-28. doi: 10.1096/fj.15-272963. Epub 2015 Aug 6.


Heterogeneity of Notch signaling in astrocytes and the effects of GFAP and vimentin deficiency.

Lebkuechner I, Wilhelmsson U, Möllerström E, Pekna M, Pekny M.

J Neurochem. 2015 Oct;135(2):234-48. doi: 10.1111/jnc.13213. Epub 2015 Aug 10.


Complement Peptide C3a Promotes Astrocyte Survival in Response to Ischemic Stress.

Shinjyo N, de Pablo Y, Pekny M, Pekna M.

Mol Neurobiol. 2016 Jul;53(5):3076-3087. doi: 10.1007/s12035-015-9204-4. Epub 2015 May 14.


GFAP and vimentin deficiency alters gene expression in astrocytes and microglia in wild-type mice and changes the transcriptional response of reactive glia in mouse model for Alzheimer's disease.

Kamphuis W, Kooijman L, Orre M, Stassen O, Pekny M, Hol EM.

Glia. 2015 Jun;63(6):1036-56. doi: 10.1002/glia.22800. Epub 2015 Mar 2.


Glial fibrillary acidic protein (GFAP) and the astrocyte intermediate filament system in diseases of the central nervous system.

Hol EM, Pekny M.

Curr Opin Cell Biol. 2015 Feb;32:121-30. doi: 10.1016/ Epub 2015 Mar 2. Review.


Astrocyte reactivity and reactive astrogliosis: costs and benefits.

Pekny M, Pekna M.

Physiol Rev. 2014 Oct;94(4):1077-98. doi: 10.1152/physrev.00041.2013. Review.


Classification of subpopulations of cells within human primary brain tumors by single cell gene expression profiling.

Möllerström E, Rydenhag B, Andersson D, Lebkuechner I, Puschmann TB, Chen M, Wilhelmsson U, Ståhlberg A, Malmgren K, Pekny M.

Neurochem Res. 2015 Feb;40(2):336-52. doi: 10.1007/s11064-014-1431-y. Epub 2014 Sep 24. Review.


Glia in the pathogenesis of neurodegenerative diseases.

Verkhratsky A, Parpura V, Pekna M, Pekny M, Sofroniew M.

Biochem Soc Trans. 2014 Oct;42(5):1291-301. doi: 10.1042/BST20140107. Review.


Beneficial effects of gfap/vimentin reactive astrocytes for axonal remodeling and motor behavioral recovery in mice after stroke.

Liu Z, Li Y, Cui Y, Roberts C, Lu M, Wilhelmsson U, Pekny M, Chopp M.

Glia. 2014 Dec;62(12):2022-33. doi: 10.1002/glia.22723. Epub 2014 Jul 15.


Short general anaesthesia induces prolonged changes in gene expression in the mouse hippocampus.

Pekny T, Andersson D, Wilhelmsson U, Pekna M, Pekny M.

Acta Anaesthesiol Scand. 2014 Oct;58(9):1127-33. doi: 10.1111/aas.12369. Epub 2014 Jul 17.


The dual role of astrocyte activation and reactive gliosis.

Pekny M, Wilhelmsson U, Pekna M.

Neurosci Lett. 2014 Apr 17;565:30-8. doi: 10.1016/j.neulet.2013.12.071. Epub 2014 Jan 7. Review.


Direct cell lysis for single-cell gene expression profiling.

Svec D, Andersson D, Pekny M, Sjöback R, Kubista M, Ståhlberg A.

Front Oncol. 2013 Nov 7;3:274. doi: 10.3389/fonc.2013.00274. eCollection 2013.


Axonal regeneration after sciatic nerve lesion is delayed but complete in GFAP- and vimentin-deficient mice.

Berg A, Zelano J, Pekna M, Wilhelmsson U, Pekny M, Cullheim S.

PLoS One. 2013 Nov 1;8(11):e79395. doi: 10.1371/journal.pone.0079395. eCollection 2013.


HB-EGF affects astrocyte morphology, proliferation, differentiation, and the expression of intermediate filament proteins.

Puschmann TB, Zandén C, Lebkuechner I, Philippot C, de Pablo Y, Liu J, Pekny M.

J Neurochem. 2014 Mar;128(6):878-89. doi: 10.1111/jnc.12519. Epub 2013 Nov 26.


A novel method for three-dimensional culture of central nervous system neurons.

Puschmann TB, de Pablo Y, Zandén C, Liu J, Pekny M.

Tissue Eng Part C Methods. 2014 Jun;20(6):485-92. doi: 10.1089/ten.TEC.2013.0445. Epub 2014 Jan 8.


Plasticity response in the contralesional hemisphere after subtle neurotrauma: gene expression profiling after partial deafferentation of the hippocampus.

Andersson D, Wilhelmsson U, Nilsson M, Kubista M, Ståhlberg A, Pekna M, Pekny M.

PLoS One. 2013 Jul 25;8(7):e70699. doi: 10.1371/journal.pone.0070699. Print 2013.


Versatile and simple approach to determine astrocyte territories in mouse neocortex and hippocampus.

Grosche A, Grosche J, Tackenberg M, Scheller D, Gerstner G, Gumprecht A, Pannicke T, Hirrlinger PG, Wilhelmsson U, Hüttmann K, Härtig W, Steinhäuser C, Pekny M, Reichenbach A.

PLoS One. 2013 Jul 23;8(7):e69143. doi: 10.1371/journal.pone.0069143. Print 2013.


Astrocytoma grade IV (glioblastoma multiforme) displays 3 subtypes with unique expression profiles of intermediate filament proteins.

Skalli O, Wilhelmsson U, Orndahl C, Fekete B, Malmgren K, Rydenhag B, Pekny M.

Hum Pathol. 2013 Oct;44(10):2081-8. doi: 10.1016/j.humpath.2013.03.013. Epub 2013 Jun 18.


Intermediate filaments are important for astrocyte response to oxidative stress induced by oxygen-glucose deprivation and reperfusion.

de Pablo Y, Nilsson M, Pekna M, Pekny M.

Histochem Cell Biol. 2013 Jul;140(1):81-91. doi: 10.1007/s00418-013-1110-0. Epub 2013 Jun 12.


Receptor for complement peptide C3a: a therapeutic target for neonatal hypoxic-ischemic brain injury.

Järlestedt K, Rousset CI, Ståhlberg A, Sourkova H, Atkins AL, Thornton C, Barnum SR, Wetsel RA, Dragunow M, Pekny M, Mallard C, Hagberg H, Pekna M.

FASEB J. 2013 Sep;27(9):3797-804. doi: 10.1096/fj.13-230011. Epub 2013 Jun 4.


Synemin is expressed in reactive astrocytes and Rosenthal fibers in Alexander disease.

Pekny T, Faiz M, Wilhelmsson U, Curtis MA, Matej R, Skalli O, Pekny M.

APMIS. 2014 Jan;122(1):76-80. doi: 10.1111/apm.12088. Epub 2013 Apr 18.


The neurobiology of brain injury.

Pekna M, Pekny M.

Cerebrum. 2012 Jul;2012:9. Epub 2012 Jul 30.


Bioactive 3D cell culture system minimizes cellular stress and maintains the in vivo-like morphological complexity of astroglial cells.

Puschmann TB, Zandén C, De Pablo Y, Kirchhoff F, Pekna M, Liu J, Pekny M.

Glia. 2013 Mar;61(3):432-40. doi: 10.1002/glia.22446. Epub 2013 Jan 7.


The effects of a rhythm and music-based therapy program and therapeutic riding in late recovery phase following stroke: a study protocol for a three-armed randomized controlled trial.

Bunketorp Käll L, Lundgren-Nilsson Å, Blomstrand C, Pekna M, Pekny M, Nilsson M.

BMC Neurol. 2012 Nov 21;12:141. doi: 10.1186/1471-2377-12-141.


Attenuating astrocyte activation accelerates plaque pathogenesis in APP/PS1 mice.

Kraft AW, Hu X, Yoon H, Yan P, Xiao Q, Wang Y, Gil SC, Brown J, Wilhelmsson U, Restivo JL, Cirrito JR, Holtzman DM, Kim J, Pekny M, Lee JM.

FASEB J. 2013 Jan;27(1):187-98. doi: 10.1096/fj.12-208660. Epub 2012 Oct 4.


Modulation of neural plasticity as a basis for stroke rehabilitation.

Pekna M, Pekny M, Nilsson M.

Stroke. 2012 Oct;43(10):2819-28. Epub 2012 Aug 23. Review. No abstract available.


Photothrombosis-induced infarction of the mouse cerebral cortex is not affected by the Nrf2-activator sulforaphane.

Porritt MJ, Andersson HC, Hou L, Nilsson Å, Pekna M, Pekny M, Nilsson M.

PLoS One. 2012;7(7):e41090. doi: 10.1371/journal.pone.0041090. Epub 2012 Jul 23.


Astrocytes negatively regulate neurogenesis through the Jagged1-mediated Notch pathway.

Wilhelmsson U, Faiz M, de Pablo Y, Sjöqvist M, Andersson D, Widestrand A, Potokar M, Stenovec M, Smith PL, Shinjyo N, Pekny T, Zorec R, Ståhlberg A, Pekna M, Sahlgren C, Pekny M.

Stem Cells. 2012 Oct;30(10):2320-9. doi: 10.1002/stem.1196.


IFN-γ-induced increase in the mobility of MHC class II compartments in astrocytes depends on intermediate filaments.

Vardjan N, Gabrijel M, Potokar M, Svajger U, Kreft M, Jeras M, de Pablo Y, Faiz M, Pekny M, Zorec R.

J Neuroinflammation. 2012 Jun 26;9:144. doi: 10.1186/1742-2094-9-144.


Reduced removal of synaptic terminals from axotomized spinal motoneurons in the absence of complement C3.

Berg A, Zelano J, Stephan A, Thams S, Barres BA, Pekny M, Pekna M, Cullheim S.

Exp Neurol. 2012 Sep;237(1):8-17. doi: 10.1016/j.expneurol.2012.06.008. Epub 2012 Jun 19.


Glial cells in (patho)physiology.

Parpura V, Heneka MT, Montana V, Oliet SH, Schousboe A, Haydon PG, Stout RF Jr, Spray DC, Reichenbach A, Pannicke T, Pekny M, Pekna M, Zorec R, Verkhratsky A.

J Neurochem. 2012 Apr;121(1):4-27. doi: 10.1111/j.1471-4159.2012.07664.x. Epub 2012 Feb 2. Review.

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