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Vimentin Phosphorylation Is Required for Normal Cell Division of Immature Astrocytes.

de Pablo Y, Marasek P, Pozo-Rodrigálvarez A, Wilhelmsson U, Inagaki M, Pekna M, Pekny M.

Cells. 2019 Sep 1;8(9). pii: E1016. doi: 10.3390/cells8091016.


The role of GFAP and vimentin in learning and memory.

Wilhelmsson U, Pozo-Rodrigalvarez A, Kalm M, de Pablo Y, Widestrand Å, Pekna M, Pekny M.

Biol Chem. 2019 Aug 27;400(9):1147-1156. doi: 10.1515/hsz-2019-0199.


Nestin Regulates Neurogenesis in Mice Through Notch Signaling From Astrocytes to Neural Stem Cells.

Wilhelmsson U, Lebkuechner I, Leke R, Marasek P, Yang X, Antfolk D, Chen M, Mohseni P, Lasič E, Bobnar ST, Stenovec M, Zorec R, Nagy A, Sahlgren C, Pekna M, Pekny M.

Cereb Cortex. 2019 Sep 13;29(10):4050-4066. doi: 10.1093/cercor/bhy284.


Inflammation in the hippocampus affects IGF1 receptor signaling and contributes to neurological sequelae in rheumatoid arthritis.

Andersson KME, Wasén C, Juzokaite L, Leifsdottir L, Erlandsson MC, Silfverswärd ST, Stokowska A, Pekna M, Pekny M, Olmarker K, Heckemann RA, Kalm M, Bokarewa MI.

Proc Natl Acad Sci U S A. 2018 Dec 18;115(51):E12063-E12072. doi: 10.1073/pnas.1810553115. Epub 2018 Dec 3.


Grafting Neural Stem and Progenitor Cells Into the Hippocampus of Juvenile, Irradiated Mice Normalizes Behavior Deficits.

Sato Y, Shinjyo N, Sato M, Nilsson MKL, Osato K, Zhu C, Pekna M, Kuhn HG, Blomgren K.

Front Neurol. 2018 Sep 11;9:715. doi: 10.3389/fneur.2018.00715. eCollection 2018.


Astrocyte activation and reactive gliosis-A new target in stroke?

Pekny M, Wilhelmsson U, Tatlisumak T, Pekna M.

Neurosci Lett. 2019 Jan 10;689:45-55. doi: 10.1016/j.neulet.2018.07.021. Epub 2018 Jul 17. Review.


Increased Neuronal Differentiation of Neural Progenitor Cells Derived from Phosphovimentin-Deficient Mice.

Chen M, Puschmann TB, Marasek P, Inagaki M, Pekna M, Wilhelmsson U, Pekny M.

Mol Neurobiol. 2018 Jul;55(7):5478-5489. doi: 10.1007/s12035-017-0759-0. Epub 2017 Sep 27.


Activation of complement factor B contributes to murine and human myocardial ischemia/reperfusion injury.

Chun N, Haddadin AS, Liu J, Hou Y, Wong KA, Lee D, Rushbrook JI, Gulaya K, Hines R, Hollis T, Nistal Nuno B, Mangi AA, Hashim S, Pekna M, Catalfamo A, Chin HY, Patel F, Rayala S, Shevde K, Heeger PS, Zhang M.

PLoS One. 2017 Jun 29;12(6):e0179450. doi: 10.1371/journal.pone.0179450. eCollection 2017.


Long-Term Improvements After Multimodal Rehabilitation in Late Phase After Stroke: A Randomized Controlled Trial.

Bunketorp-Käll L, Lundgren-Nilsson Å, Samuelsson H, Pekny T, Blomvé K, Pekna M, Pekny M, Blomstrand C, Nilsson M.

Stroke. 2017 Jul;48(7):1916-1924. doi: 10.1161/STROKEAHA.116.016433. Epub 2017 Jun 15. Erratum in: Stroke. 2017 Sep;48(9):e272.


Injury Leads to the Appearance of Cells with Characteristics of Both Microglia and Astrocytes in Mouse and Human Brain.

Wilhelmsson U, Andersson D, de Pablo Y, Pekny R, Ståhlberg A, Mulder J, Mitsios N, Hortobágyi T, Pekny M, Pekna M.

Cereb Cortex. 2017 Jun 1;27(6):3360-3377. doi: 10.1093/cercor/bhx069.


Drugs targeting intermediate filaments can improve neurosupportive properties of astrocytes.

de Pablo Y, Chen M, Möllerström E, Pekna M, Pekny M.

Brain Res Bull. 2018 Jan;136:130-138. doi: 10.1016/j.brainresbull.2017.01.021. Epub 2017 Jan 31.


Intranasal C3a treatment ameliorates cognitive impairment in a mouse model of neonatal hypoxic-ischemic brain injury.

Morán J, Stokowska A, Walker FR, Mallard C, Hagberg H, Pekna M.

Exp Neurol. 2017 Apr;290:74-84. doi: 10.1016/j.expneurol.2017.01.001. Epub 2017 Jan 4.


Neural Progenitor Cells in Cerebral Cortex of Epilepsy Patients do not Originate from Astrocytes Expressing GLAST.

Chen M, Puschmann TB, Wilhelmsson U, Örndal C, Pekna M, Malmgren K, Rydenhag B, Pekny M.

Cereb Cortex. 2017 Dec 1;27(12):5672-5682. doi: 10.1093/cercor/bhw338.


Complement peptide C3a stimulates neural plasticity after experimental brain ischaemia.

Stokowska A, Atkins AL, Morán J, Pekny T, Bulmer L, Pascoe MC, Barnum SR, Wetsel RA, Nilsson JA, Dragunow M, Pekna M.

Brain. 2017 Feb;140(2):353-369. doi: 10.1093/brain/aww314. Epub 2016 Dec 12.


C3 deficiency ameliorates the negative effects of irradiation of the young brain on hippocampal development and learning.

Kalm M, Andreasson U, Björk-Eriksson T, Zetterberg H, Pekny M, Blennow K, Pekna M, Blomgren K.

Oncotarget. 2016 Apr 12;7(15):19382-94. doi: 10.18632/oncotarget.8400.


Activation of Complement C3 Does Not Hamper the Outcome of Experimental Intramuscular Islet Transplantation.

Espes D, Pekna M, Nilsson B, Carlsson PO.

Transplantation. 2016 Mar;100(3):e6-7. doi: 10.1097/TP.0000000000001083. No abstract available.


Deficiency of the Complement Component 3 but Not Factor B Aggravates Staphylococcus aureus Septic Arthritis in Mice.

Na M, Jarneborn A, Ali A, Welin A, Magnusson M, Stokowska A, Pekna M, Jin T.

Infect Immun. 2016 Mar 24;84(4):930-939. doi: 10.1128/IAI.01520-15. Print 2016 Apr.


Astrocytes: a central element in neurological diseases.

Pekny M, Pekna M, Messing A, Steinhäuser C, Lee JM, Parpura V, Hol EM, Sofroniew MV, Verkhratsky A.

Acta Neuropathol. 2016 Mar;131(3):323-45. doi: 10.1007/s00401-015-1513-1. Epub 2015 Dec 15. Review.


Reactive gliosis in the pathogenesis of CNS diseases.

Pekny M, Pekna M.

Biochim Biophys Acta. 2016 Mar;1862(3):483-91. doi: 10.1016/j.bbadis.2015.11.014. Epub 2015 Dec 2. Review.


Heterogeneity of Notch signaling in astrocytes and the effects of GFAP and vimentin deficiency.

Lebkuechner I, Wilhelmsson U, Möllerström E, Pekna M, Pekny M.

J Neurochem. 2015 Oct;135(2):234-48. doi: 10.1111/jnc.13213. Epub 2015 Aug 10.


Complement Peptide C3a Promotes Astrocyte Survival in Response to Ischemic Stress.

Shinjyo N, de Pablo Y, Pekny M, Pekna M.

Mol Neurobiol. 2016 Jul;53(5):3076-3087. doi: 10.1007/s12035-015-9204-4. Epub 2015 May 14.


Astrocyte reactivity and reactive astrogliosis: costs and benefits.

Pekny M, Pekna M.

Physiol Rev. 2014 Oct;94(4):1077-98. doi: 10.1152/physrev.00041.2013. Review.


Glia in the pathogenesis of neurodegenerative diseases.

Verkhratsky A, Parpura V, Pekna M, Pekny M, Sofroniew M.

Biochem Soc Trans. 2014 Oct;42(5):1291-301. doi: 10.1042/BST20140107. Review.


Short general anaesthesia induces prolonged changes in gene expression in the mouse hippocampus.

Pekny T, Andersson D, Wilhelmsson U, Pekna M, Pekny M.

Acta Anaesthesiol Scand. 2014 Oct;58(9):1127-33. doi: 10.1111/aas.12369. Epub 2014 Jul 17.


The dual role of astrocyte activation and reactive gliosis.

Pekny M, Wilhelmsson U, Pekna M.

Neurosci Lett. 2014 Apr 17;565:30-8. doi: 10.1016/j.neulet.2013.12.071. Epub 2014 Jan 7. Review.


Altered cognitive performance and synaptic function in the hippocampus of mice lacking C3.

Perez-Alcazar M, Daborg J, Stokowska A, Wasling P, Björefeldt A, Kalm M, Zetterberg H, Carlström KE, Blomgren K, Ekdahl CT, Hanse E, Pekna M.

Exp Neurol. 2014 Mar;253:154-64. doi: 10.1016/j.expneurol.2013.12.013. Epub 2013 Dec 28.


Axonal regeneration after sciatic nerve lesion is delayed but complete in GFAP- and vimentin-deficient mice.

Berg A, Zelano J, Pekna M, Wilhelmsson U, Pekny M, Cullheim S.

PLoS One. 2013 Nov 1;8(11):e79395. doi: 10.1371/journal.pone.0079395. eCollection 2013.


Cardioembolic and small vessel disease stroke show differences in associations between systemic C3 levels and outcome.

Stokowska A, Olsson S, Holmegaard L, Jood K, Blomstrand C, Jern C, Pekna M.

PLoS One. 2013 Aug 20;8(8):e72133. doi: 10.1371/journal.pone.0072133. eCollection 2013.


Plasticity response in the contralesional hemisphere after subtle neurotrauma: gene expression profiling after partial deafferentation of the hippocampus.

Andersson D, Wilhelmsson U, Nilsson M, Kubista M, Ståhlberg A, Pekna M, Pekny M.

PLoS One. 2013 Jul 25;8(7):e70699. doi: 10.1371/journal.pone.0070699. Print 2013.


Intermediate filaments are important for astrocyte response to oxidative stress induced by oxygen-glucose deprivation and reperfusion.

de Pablo Y, Nilsson M, Pekna M, Pekny M.

Histochem Cell Biol. 2013 Jul;140(1):81-91. doi: 10.1007/s00418-013-1110-0. Epub 2013 Jun 12.


Receptor for complement peptide C3a: a therapeutic target for neonatal hypoxic-ischemic brain injury.

Järlestedt K, Rousset CI, Ståhlberg A, Sourkova H, Atkins AL, Thornton C, Barnum SR, Wetsel RA, Dragunow M, Pekny M, Mallard C, Hagberg H, Pekna M.

FASEB J. 2013 Sep;27(9):3797-804. doi: 10.1096/fj.13-230011. Epub 2013 Jun 4.


Grafting of neural stem and progenitor cells to the hippocampus of young, irradiated mice causes gliosis and disrupts the granule cell layer.

Sato Y, Shinjyo N, Sato M, Osato K, Zhu C, Pekna M, Kuhn HG, Blomgren K.

Cell Death Dis. 2013 Apr 18;4:e591. doi: 10.1038/cddis.2013.92.


The neurobiology of brain injury.

Pekna M, Pekny M.

Cerebrum. 2012 Jul;2012:9. Epub 2012 Jul 30.


Complement gene single nucleotide polymorphisms and biomarker endophenotypes of Alzheimer's disease.

Daborg J, Holmgren S, Abramsson A, Andreasson U, Zetterberg M, Nilsson S, Minthon L, Skoog I, Blennow K, Pekna M, Hanse E, Zetterberg H.

J Alzheimers Dis. 2013;35(1):51-7. doi: 10.3233/JAD-121930.


Bioactive 3D cell culture system minimizes cellular stress and maintains the in vivo-like morphological complexity of astroglial cells.

Puschmann TB, Zandén C, De Pablo Y, Kirchhoff F, Pekna M, Liu J, Pekny M.

Glia. 2013 Mar;61(3):432-40. doi: 10.1002/glia.22446. Epub 2013 Jan 7.


The effects of a rhythm and music-based therapy program and therapeutic riding in late recovery phase following stroke: a study protocol for a three-armed randomized controlled trial.

Bunketorp Käll L, Lundgren-Nilsson Å, Blomstrand C, Pekna M, Pekny M, Nilsson M.

BMC Neurol. 2012 Nov 21;12:141. doi: 10.1186/1471-2377-12-141.


Modulation of neural plasticity as a basis for stroke rehabilitation.

Pekna M, Pekny M, Nilsson M.

Stroke. 2012 Oct;43(10):2819-28. Epub 2012 Aug 23. Review. No abstract available.


Photothrombosis-induced infarction of the mouse cerebral cortex is not affected by the Nrf2-activator sulforaphane.

Porritt MJ, Andersson HC, Hou L, Nilsson Å, Pekna M, Pekny M, Nilsson M.

PLoS One. 2012;7(7):e41090. doi: 10.1371/journal.pone.0041090. Epub 2012 Jul 23.


Astrocytes negatively regulate neurogenesis through the Jagged1-mediated Notch pathway.

Wilhelmsson U, Faiz M, de Pablo Y, Sjöqvist M, Andersson D, Widestrand A, Potokar M, Stenovec M, Smith PL, Shinjyo N, Pekny T, Zorec R, Ståhlberg A, Pekna M, Sahlgren C, Pekny M.

Stem Cells. 2012 Oct;30(10):2320-9. doi: 10.1002/stem.1196.


Reduced removal of synaptic terminals from axotomized spinal motoneurons in the absence of complement C3.

Berg A, Zelano J, Stephan A, Thams S, Barres BA, Pekny M, Pekna M, Cullheim S.

Exp Neurol. 2012 Sep;237(1):8-17. doi: 10.1016/j.expneurol.2012.06.008. Epub 2012 Jun 19.


Cerebrospinal fluid levels of complement proteins C3, C4 and CR1 in Alzheimer's disease.

Daborg J, Andreasson U, Pekna M, Lautner R, Hanse E, Minthon L, Blennow K, Hansson O, Zetterberg H.

J Neural Transm (Vienna). 2012 Jul;119(7):789-97. doi: 10.1007/s00702-012-0797-8. Epub 2012 Apr 10.


Glial cells in (patho)physiology.

Parpura V, Heneka MT, Montana V, Oliet SH, Schousboe A, Haydon PG, Stout RF Jr, Spray DC, Reichenbach A, Pannicke T, Pekny M, Pekna M, Zorec R, Verkhratsky A.

J Neurochem. 2012 Apr;121(1):4-27. doi: 10.1111/j.1471-4159.2012.07664.x. Epub 2012 Feb 2. Review.


Nephrotic syndrome and subepithelial deposits in a mouse model of immune-mediated anti-podocyte glomerulonephritis.

Meyer-Schwesinger C, Dehde S, Klug P, Becker JU, Mathey S, Arefi K, Balabanov S, Venz S, Endlich KH, Pekna M, Gessner JE, Thaiss F, Meyer TN.

J Immunol. 2011 Sep 15;187(6):3218-29. doi: 10.4049/jimmunol.1003451. Epub 2011 Aug 15.


Trace fear conditioning detects hypoxic-ischemic brain injury in neonatal mice.

Järlestedt K, Atkins AL, Hagberg H, Pekna M, Mallard C.

Dev Neurosci. 2011;33(3-4):222-30. doi: 10.1159/000329710. Epub 2011 Jul 21.


Plasma C3 and C3a levels in cryptogenic and large-vessel disease stroke: associations with outcome.

Stokowska A, Olsson S, Holmegaard L, Jood K, Blomstrand C, Jern C, Pekna M.

Cerebrovasc Dis. 2011;32(2):114-22. doi: 10.1159/000328238. Epub 2011 Jun 28.


Genetic variation in complement component C3 shows association with ischaemic stroke.

Olsson S, Stokowska A, Holmegaard L, Jood K, Blomstrand C, Pekna M, Jern C.

Eur J Neurol. 2011 Oct;18(10):1272-4. doi: 10.1111/j.1468-1331.2011.03377.x. Epub 2011 Mar 17.


Defining cell populations with single-cell gene expression profiling: correlations and identification of astrocyte subpopulations.

Ståhlberg A, Andersson D, Aurelius J, Faiz M, Pekna M, Kubista M, Pekny M.

Nucleic Acids Res. 2011 Mar;39(4):e24. doi: 10.1093/nar/gkq1182. Epub 2010 Nov 25.


Complement opsonization enhances friend virus infection of B cells and thereby amplifies the virus-specific CD8+ T cell response.

Bila C, Oberhauser V, Ammann CG, Ejaz A, Huber G, Schimmer S, Messer R, Pekna M, von Laer D, Dittmer U, Hasenkrug KJ, Stoiber H, Bánki Z.

J Virol. 2011 Jan;85(2):1151-5. doi: 10.1128/JVI.01821-10. Epub 2010 Nov 3.


Attenuation of reactive gliosis does not affect infarct volume in neonatal hypoxic-ischemic brain injury in mice.

Järlestedt K, Rousset CI, Faiz M, Wilhelmsson U, Ståhlberg A, Sourkova H, Pekna M, Mallard C, Hagberg H, Pekny M.

PLoS One. 2010 Apr 28;5(4):e10397. doi: 10.1371/journal.pone.0010397.


Complement-derived anaphylatoxin C3a regulates in vitro differentiation and migration of neural progenitor cells.

Shinjyo N, Ståhlberg A, Dragunow M, Pekny M, Pekna M.

Stem Cells. 2009 Nov;27(11):2824-32. doi: 10.1002/stem.225.

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