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The emerging role of mast cell proteases in asthma.

Pejler G.

Eur Respir J. 2019 Aug 1. pii: 1900685. doi: 10.1183/13993003.00685-2019. [Epub ahead of print] Review.


Experimental autoimmune encephalomyelitis potentiates mouse mast cell protease 4-dependent pressor responses to centrally or systemically administered big endothelin-1.

Desbiens L, Lapointe C, Gendron L, Gharagozloo M, Vincent L, Pejler G, Gris D, D'Orleans-Juste P.

J Pharmacol Exp Ther. 2019 Jun 27. pii: jpet.118.256016. doi: 10.1124/jpet.118.256016. [Epub ahead of print]


Streptococcal sagA activates a proinflammatory response in mast cells by a sublytic mechanism.

von Beek C, Waern I, Eriksson J, Melo FR, Robinson C, Waller AS, Sellin ME, Guss B, Pejler G.

Cell Microbiol. 2019 Jun 3:e13064. doi: 10.1111/cmi.13064. [Epub ahead of print]


Lysosomotropic challenge of mast cells causes intra-granular reactive oxygen species production.

Paivandy A, Eriksson J, Melo FR, Sellin ME, Pejler G.

Cell Death Discov. 2019 May 15;5:95. doi: 10.1038/s41420-019-0177-3. eCollection 2019.


Mouse mast cell protease 4 suppresses scar formation after traumatic spinal cord injury.

Vangansewinkel T, Lemmens S, Geurts N, Quanten K, Dooley D, Pejler G, Hendrix S.

Sci Rep. 2019 Mar 6;9(1):3715. doi: 10.1038/s41598-019-39551-1.


Local delivery of temozolomide via a biologically inert carrier (Temodex) prolongs survival in glioma patients, irrespectively of the methylation status of MGMT.

Karlsson I, Veevnik D, Fedulov A, Yurkshtovich N, Yurkshtovich T, Pejler G, Lokot I.

Neoplasma. 2019 Mar 5;66(2):288-293. doi: 10.4149/neo_2018_180613N393. Epub 2018 Dec 12.


Mast Cell Degranulation Exacerbates Skin Rejection by Enhancing Neutrophil Recruitment.

Ngo Nyekel F, Pacreau E, Benadda S, Msallam R, Åbrink M, Pejler G, Davoust J, Benhamou M, Charles N, Launay P, Blank U, Gautier G.

Front Immunol. 2018 Nov 20;9:2690. doi: 10.3389/fimmu.2018.02690. eCollection 2018.


Mouse mast cells and mast cell proteases do not play a significant role in acute tissue injury pain induced by formalin.

Magnúsdóttir EI, Grujic M, Roers A, Hartmann K, Pejler G, Lagerström MC.

Mol Pain. 2018 Jan-Dec;14:1744806918808161. doi: 10.1177/1744806918808161. Epub 2018 Oct 3.


Mouse Mast Cell Protease 4 Deletion Protects Heart Function and Survival After Permanent Myocardial Infarction.

Houde M, Schwertani A, Touil H, Desbiens L, Sarrhini O, Lecomte R, Lepage M, Gagnon H, Takai S, Pejler G, Jacques D, Gobeil F Jr, Day R, D'Orléans-Juste P.

Front Pharmacol. 2018 Aug 31;9:868. doi: 10.3389/fphar.2018.00868. eCollection 2018.


Mitogen-Activated Protein Kinase Signaling Regulates Proteoglycan Composition of Mast Cell Secretory Granules.

Hu Frisk JM, Kjellén L, Melo FR, Öhrvik H, Pejler G.

Front Immunol. 2018 Jul 19;9:1670. doi: 10.3389/fimmu.2018.01670. eCollection 2018.


The Effect of Lipopolysaccharide-Induced Experimental Bovine Mastitis on Clinical Parameters, Inflammatory Markers, and the Metabolome: A Kinetic Approach.

Johnzon CF, Dahlberg J, Gustafson AM, Waern I, Moazzami AA, Östensson K, Pejler G.

Front Immunol. 2018 Jun 25;9:1487. doi: 10.3389/fimmu.2018.01487. eCollection 2018.


The controversial role of mast cells in fibrosis.

Bradding P, Pejler G.

Immunol Rev. 2018 Mar;282(1):198-231. doi: 10.1111/imr.12626. Review.


Induction of Human Lung Mast Cell Apoptosis by Granule Permeabilization: A Novel Approach for Targeting Mast Cells.

Paivandy A, Sandelin M, Igelström H, Landelius P, Janson C, Melo FR, Pejler G.

Front Immunol. 2017 Nov 27;8:1645. doi: 10.3389/fimmu.2017.01645. eCollection 2017.


Copper Regulates Maturation and Expression of an MITF:Tryptase Axis in Mast Cells.

Hu Frisk JM, Kjellén L, Kaler SG, Pejler G, Öhrvik H.

J Immunol. 2017 Dec 15;199(12):4132-4141. doi: 10.4049/jimmunol.1700786. Epub 2017 Nov 10.


Increased mast cell degranulation and co-localization of mast cells with the NMDA receptor-1 during healing after Achilles tendon rupture.

Alim MA, Ackermann PW, Eliasson P, Blomgran P, Kristiansson P, Pejler G, Peterson M.

Cell Tissue Res. 2017 Dec;370(3):451-460. doi: 10.1007/s00441-017-2684-y. Epub 2017 Oct 3.


Mast cell chymase decreases the severity of group B Streptococcus infections.

Gendrin C, Shubin NJ, Boldenow E, Merillat S, Clauson M, Power D, Doran KS, Abrink M, Pejler G, Rajagopal L, Piliponsky AM.

J Allergy Clin Immunol. 2018 Jul;142(1):120-129.e6. doi: 10.1016/j.jaci.2017.07.042. Epub 2017 Sep 12.


Mast Cells and MCPT4 Chymase Promote Renal Impairment after Partial Ureteral Obstruction.

Pons M, Ali L, Beghdadi W, Danelli L, Alison M, Madjène LC, Calvo J, Claver J, Vibhushan S, Åbrink M, Pejler G, Poli-Mérol ML, Peuchmaur M, El Ghoneimi A, Blank U.

Front Immunol. 2017 May 4;8:450. doi: 10.3389/fimmu.2017.00450. eCollection 2017.


Acidic pH is essential for maintaining mast cell secretory granule homeostasis.

Pejler G, Hu Frisk JM, Sjöström D, Paivandy A, Öhrvik H.

Cell Death Dis. 2017 May 11;8(5):e2785. doi: 10.1038/cddis.2017.206.


Inhibition of the BET family of epigenetic reader proteins: A novel principle for modulating gene expression in IgE-activated mast cells.

Garcia-Faroldi G, Rönnberg E, Grujic M, Pejler G.

Immun Inflamm Dis. 2017 Jun;5(2):141-150. doi: 10.1002/iid3.150. Epub 2017 Mar 13.


Excessive dietary intake of vitamin A reduces skull bone thickness in mice.

Lind T, Öhman C, Calounova G, Rasmusson A, Andersson G, Pejler G, Melhus H.

PLoS One. 2017 Apr 20;12(4):e0176217. doi: 10.1371/journal.pone.0176217. eCollection 2017.


The combined action of mast cell chymase, tryptase and carboxypeptidase A3 protects against melanoma colonization of the lung.

Grujic M, Paivandy A, Gustafson AM, Thomsen AR, Öhrvik H, Pejler G.

Oncotarget. 2017 Apr 11;8(15):25066-25079. doi: 10.18632/oncotarget.15339.


Siramesine causes preferential apoptosis of mast cells in skin biopsies from psoriatic lesions.

Hagforsen E, Lampinen M, Paivandy A, Weström S, Velin H, Öberg S, Pejler G, Rollman O.

Br J Dermatol. 2017 Jul;177(1):179-187. doi: 10.1111/bjd.15336. Epub 2017 May 15.


Tryptase-catalyzed core histone truncation: A novel epigenetic regulatory mechanism in mast cells.

Melo FR, Wallerman O, Paivandy A, Calounova G, Gustafson AM, Sabari BR, Zabucchi G, Allis CD, Pejler G.

J Allergy Clin Immunol. 2017 Aug;140(2):474-485. doi: 10.1016/j.jaci.2016.11.044. Epub 2017 Jan 17.


Increased Bone Mass in Female Mice Lacking Mast Cell Chymase.

Lind T, Gustafson AM, Calounova G, Hu L, Rasmusson A, Jonsson KB, Wernersson S, Åbrink M, Andersson G, Larsson S, Melhus H, Pejler G.

PLoS One. 2016 Dec 9;11(12):e0167964. doi: 10.1371/journal.pone.0167964. eCollection 2016.


Equine Airway Mast Cells are Sensitive to Cell Death Induced by Lysosomotropic Agents.

Wernersson S, Riihimäki M, Pejler G, Waern I.

Scand J Immunol. 2017 Jan;85(1):30-34. doi: 10.1111/sji.12502.


Mastitis Pathogens with High Virulence in a Mouse Model Produce a Distinct Cytokine Profile In Vivo.

Johnzon CF, Artursson K, Söderlund R, Guss B, Rönnberg E, Pejler G.

Front Immunol. 2016 Sep 22;7:368. eCollection 2016.


Significant Contribution of Mouse Mast Cell Protease 4 in Early Phases of Experimental Autoimmune Encephalomyelitis.

Desbiens L, Lapointe C, Gharagozloo M, Mahmoud S, Pejler G, Gris D, D'Orléans-Juste P.

Mediators Inflamm. 2016;2016:9797021. doi: 10.1155/2016/9797021. Epub 2016 Aug 17.


Mast cells promote melanoma colonization of lungs.

Öhrvik H, Grujic M, Waern I, Gustafson AM, Ernst N, Roers A, Hartmann K, Pejler G.

Oncotarget. 2016 Oct 18;7(42):68990-69001. doi: 10.18632/oncotarget.11837.


Live Staphylococcus aureus Induces Expression and Release of Vascular Endothelial Growth Factor in Terminally Differentiated Mouse Mast Cells.

Johnzon CF, Rönnberg E, Guss B, Pejler G.

Front Immunol. 2016 Jun 23;7:247. doi: 10.3389/fimmu.2016.00247. eCollection 2016.


Proteome analysis of mast cell releasates reveals a role for chymase in the regulation of coagulation factor XIIIA levels via proteolytic degradation.

Shubin NJ, Glukhova VA, Clauson M, Truong P, Abrink M, Pejler G, White NJ, Deutsch GH, Reeves SR, Vaisar T, James RG, Piliponsky AM.

J Allergy Clin Immunol. 2017 Jan;139(1):323-334. doi: 10.1016/j.jaci.2016.03.051. Epub 2016 May 13.


IGF-1 degradation by mouse mast cell protease 4 promotes cell death and adverse cardiac remodeling days after a myocardial infarction.

Tejada T, Tan L, Torres RA, Calvert JW, Lambert JP, Zaidi M, Husain M, Berce MD, Naib H, Pejler G, Abrink M, Graham RM, Lefer DJ, Naqvi N, Husain A.

Proc Natl Acad Sci U S A. 2016 Jun 21;113(25):6949-54. doi: 10.1073/pnas.1603127113. Epub 2016 Jun 6.


IL-6 and IL-17A degradation by mast cells is mediated by a serglycin:serine protease axis.

Waern I, Karlsson I, Pejler G, Wernersson S.

Immun Inflamm Dis. 2015 Dec 2;4(1):70-9. doi: 10.1002/iid3.95. eCollection 2016 Mar.


Endothelin receptor antagonist macitentan or deletion of mouse mast cell protease 4 delays lesion development in atherosclerotic mice.

Houde M, Desbiens L, Schwertani A, Pejler G, Iglarz M, D'Orléans-Juste P.

Life Sci. 2016 Aug 15;159:71-75. doi: 10.1016/j.lfs.2016.03.018. Epub 2016 Mar 12.


Mast cells promote scar remodeling and functional recovery after spinal cord injury via mouse mast cell protease 6.

Vangansewinkel T, Geurts N, Quanten K, Nelissen S, Lemmens S, Geboes L, Dooley D, Vidal PM, Pejler G, Hendrix S.

FASEB J. 2016 May;30(5):2040-57. doi: 10.1096/fj.201500114R. Epub 2016 Feb 25.


Activated mast cells promote differentiation of B cells into effector cells.

Palm AK, Garcia-Faroldi G, Lundberg M, Pejler G, Kleinau S.

Sci Rep. 2016 Feb 5;6:20531. doi: 10.1038/srep20531.


Serglycin determines secretory granule repertoire and regulates natural killer cell and cytotoxic T lymphocyte cytotoxicity.

Sutton VR, Brennan AJ, Ellis S, Danne J, Thia K, Jenkins MR, Voskoboinik I, Pejler G, Johnstone RW, Andrews DM, Trapani JA.

FEBS J. 2016 Mar;283(5):947-61. doi: 10.1111/febs.13649. Epub 2016 Jan 22.


The Role of Mast Cells in Bacterial Infection.

Johnzon CF, Rönnberg E, Pejler G.

Am J Pathol. 2016 Jan;186(1):4-14. doi: 10.1016/j.ajpath.2015.06.024. Epub 2015 Oct 23. Review.


Serglycin protects against high fat diet-induced increase in serum LDL in mice.

Meen AJ, Drevon CA, Pejler G, Jenssen TG, Olstad OK, Åbrink M, Kolset SO.

Glycoconj J. 2015 Dec;32(9):703-14. doi: 10.1007/s10719-015-9621-7. Epub 2015 Sep 21.


Ctr2 Regulates Mast Cell Maturation by Affecting the Storage and Expression of Tryptase and Proteoglycans.

Öhrvik H, Logeman B, Noguchi G, Eriksson I, Kjellén L, Thiele DJ, Pejler G.

J Immunol. 2015 Oct 15;195(8):3654-64. doi: 10.4049/jimmunol.1500283. Epub 2015 Sep 4.


Ablation of human skin mast cells in situ by lysosomotropic agents.

Hagforsen E, Paivandy A, Lampinen M, Weström S, Calounova G, Melo FR, Rollman O, Pejler G.

Exp Dermatol. 2015 Jul;24(7):516-21. doi: 10.1111/exd.12699. Epub 2015 Apr 16.


Approaches for analyzing the roles of mast cells and their proteases in vivo.

Galli SJ, Tsai M, Marichal T, Tchougounova E, Reber LL, Pejler G.

Adv Immunol. 2015;126:45-127. doi: 10.1016/ Epub 2015 Feb 7. Review.


Chymase inhibitor-sensitive synthesis of endothelin-1 (1-31) by recombinant mouse mast cell protease 4 and human chymase.

Semaan W, Desbiens L, Houde M, Labonté J, Gagnon H, Yamamoto D, Takai S, Laidlaw T, Bkaily G, Schwertani A, Pejler G, Levesque C, Desjardins R, Day R, D'Orléans-Juste P.

Biochem Pharmacol. 2015 Mar 15;94(2):91-100. doi: 10.1016/j.bcp.2015.02.001. Epub 2015 Feb 7.


Damnacanthal inhibits IgE receptor-mediated activation of mast cells.

Garcia-Vilas JA, Medina MA, Melo FR, Pejler G, Garcia-Faroldi G.

Mol Immunol. 2015 May;65(1):86-93. doi: 10.1016/j.molimm.2015.01.008. Epub 2015 Feb 2.


Mefloquine, an anti-malaria agent, causes reactive oxygen species-dependent cell death in mast cells via a secretory granule-mediated pathway.

Paivandy A, Calounova G, Zarnegar B, Ohrvik H, Melo FR, Pejler G.

Pharmacol Res Perspect. 2014 Dec;2(6):e00066. doi: 10.1002/prp2.66. Epub 2014 Aug 24.


Induction of mast cell apoptosis by a novel secretory granule-mediated pathway.

Melo FR, Wernersson S, Pejler G.

Methods Mol Biol. 2015;1220:325-37. doi: 10.1007/978-1-4939-1568-2_20.


Granzyme H is a novel protease expressed by human mast cells.

Rönnberg E, Calounova G, Sutton VR, Trapani JA, Rollman O, Hagforsen E, Pejler G.

Int Arch Allergy Immunol. 2014;165(1):68-74. doi: 10.1159/000368403. Epub 2014 Oct 21.


Mast cell secretory granules: armed for battle.

Wernersson S, Pejler G.

Nat Rev Immunol. 2014 Jul;14(7):478-94. doi: 10.1038/nri3690. Epub 2014 Jun 6. Review.


The role of mouse mast cell proteases in the proliferative phase of wound healing in microdeformational wound therapy.

Succar J, Douaiher J, Lancerotto L, Li Q, Yamaguchi R, Younan G, Pejler G, Orgill DP.

Plast Reconstr Surg. 2014 Sep;134(3):459-67. doi: 10.1097/PRS.0000000000000432.


Mast cells are activated by Staphylococcus aureus in vitro but do not influence the outcome of intraperitoneal S. aureus infection in vivo.

Rönnberg E, Johnzon CF, Calounova G, Garcia Faroldi G, Grujic M, Hartmann K, Roers A, Guss B, Lundequist A, Pejler G.

Immunology. 2014 Oct;143(2):155-63. doi: 10.1111/imm.12297.


Nuclear receptor 4a3 (nr4a3) regulates murine mast cell responses and granule content.

Garcia-Faroldi G, Melo FR, Bruemmer D, Conneely OM, Pejler G, Lundequist A.

PLoS One. 2014 Feb 20;9(2):e89311. doi: 10.1371/journal.pone.0089311. eCollection 2014.

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