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Items: 1 to 50 of 222

1.

Structural, functional, and molecular impact on the cardiovascular system in ApoE-/- mice exposed to aerosol from candidate modified risk tobacco products, Carbon Heated Tobacco Product 1.2 and Tobacco Heating System 2.2, compared with cigarette smoke.

Szostak J, Titz B, Schlage WK, Guedj E, Sewer A, Phillips B, Leroy P, Buettner A, Neau L, Trivedi K, Martin F, Ivanov NV, Vanscheeuwijck P, Peitsch MC, Hoeng J.

Chem Biol Interact. 2019 Nov 6:108887. doi: 10.1016/j.cbi.2019.108887. [Epub ahead of print]

PMID:
31705857
2.

Respirable aerosol exposures of nicotine dry powder formulations to in vitro, ex vivo, and in vivo pre-clinical models demonstrate consistency of pharmacokinetic profiles.

Sciuscio D, Hoeng J, Peitsch MC, Vanscheeuwijck P.

Inhal Toxicol. 2019 May;31(6):248-257. doi: 10.1080/08958378.2019.1662526. Epub 2019 Sep 9.

PMID:
31496314
3.

Application of a multi-layer systems toxicology framework for in vitro assessment of the biological effects of Classic Tobacco e-liquid and its corresponding aerosol using an e-cigarette device with MESH™ technology.

Iskandar AR, Zanetti F, Marescotti D, Titz B, Sewer A, Kondylis A, Leroy P, Belcastro V, Torres LO, Acali S, Majeed S, Steiner S, Trivedi K, Guedj E, Merg C, Schneider T, Frentzel S, Martin F, Ivanov NV, Peitsch MC, Hoeng J.

Arch Toxicol. 2019 Nov;93(11):3229-3247. doi: 10.1007/s00204-019-02565-9. Epub 2019 Sep 7.

PMID:
31494692
4.

NPA: an R package for computing network perturbation amplitudes using gene expression data and two-layer networks.

Martin F, Gubian S, Talikka M, Hoeng J, Peitsch MC.

BMC Bioinformatics. 2019 Sep 3;20(1):451. doi: 10.1186/s12859-019-3016-x.

5.

3D human microvessel-on-a-chip model for studying monocyte-to-endothelium adhesion under flow - application in systems toxicology.

Poussin C, Kramer B, Lanz HL, Van den Heuvel A, Laurent A, Olivier T, Vermeer M, Peric D, Baumer K, Dulize R, Guedj E, Ivanov NV, Peitsch MC, Hoeng J, Joore J.

ALTEX. 2019 Aug 22. doi: 10.14573/altex.1811301. [Epub ahead of print]

6.

Effects of different discoloration challenges and whitening treatments on dental hard tissues and composite resin restorations.

Zhao X, Zanetti F, Wang L, Pan J, Majeed S, Malmstrom H, Peitsch MC, Hoeng J, Ren Y.

J Dent. 2019 Oct;89:103182. doi: 10.1016/j.jdent.2019.103182. Epub 2019 Aug 17.

PMID:
31430508
7.

Antiparasitic properties of leaf extracts derived from selected Nicotiana species and Nicotiana tabacum varieties.

Schorderet Weber S, Kaminski KP, Perret JL, Leroy P, Mazurov A, Peitsch MC, Ivanov NV, Hoeng J.

Food Chem Toxicol. 2019 Oct;132:110660. doi: 10.1016/j.fct.2019.110660. Epub 2019 Jul 3.

8.

Effects of Switching to a Heat-Not-Burn Tobacco Product on Biologically Relevant Biomarkers to Assess a Candidate Modified Risk Tobacco Product: A Randomized Trial.

Lüdicke F, Ansari SM, Lama N, Blanc N, Bosilkovska M, Donelli A, Picavet P, Baker G, Haziza C, Peitsch M, Weitkunat R.

Cancer Epidemiol Biomarkers Prev. 2019 Nov;28(11):1934-1943. doi: 10.1158/1055-9965.EPI-18-0915. Epub 2019 Jul 3.

PMID:
31270101
9.

Mitochondria as a possible target for nicotine action.

Malińska D, Więckowski MR, Michalska B, Drabik K, Prill M, Patalas-Krawczyk P, Walczak J, Szymański J, Mathis C, Van der Toorn M, Luettich K, Hoeng J, Peitsch MC, Duszyński J, Szczepanowska J.

J Bioenerg Biomembr. 2019 Aug;51(4):259-276. doi: 10.1007/s10863-019-09800-z. Epub 2019 Jun 13. Review.

10.

A Meta-Analysis of the Performance of a Blood-Based Exposure Response Gene Signature Across Clinical Studies on the Tobacco Heating System 2.2 (THS 2.2).

Martin F, Talikka M, Ivanov NV, Haziza C, Hoeng J, Peitsch MC.

Front Pharmacol. 2019 Mar 26;10:198. doi: 10.3389/fphar.2019.00198. eCollection 2019.

11.

Toxicological assessment of Tobacco Heating System 2.2: Findings from an independent peer review.

Boué S, Schlage WK, Page D, Hoeng J, Peitsch MC.

Regul Toxicol Pharmacol. 2019 Jun;104:115-127. doi: 10.1016/j.yrtph.2019.03.007. Epub 2019 Mar 14. Review.

12.

GladiaTOX: GLobal Assessment of Dose-IndicAtor in TOXicology.

Belcastro V, Cano S, Marescotti D, Acali S, Poussin C, Gonzalez-Suarez I, Martin F, Bonjour F, Ivanov NV, Peitsch MC, Hoeng J.

Bioinformatics. 2019 Oct 15;35(20):4190-4192. doi: 10.1093/bioinformatics/btz187.

13.

Biological changes in C57BL/6 mice following 3 weeks of inhalation exposure to cigarette smoke or e-vapor aerosols.

Lee KM, Hoeng J, Harbo S, Kogel U, Gardner W, Oldham M, Benson E, Talikka M, Kondylis A, Martin F, Titz B, Ansari S, Trivedi K, Guedj E, Elamin A, Ivanov NV, Vanscheeuwijck P, Peitsch MC, McKinney WJ Jr.

Inhal Toxicol. 2018 Nov - Dec;30(13-14):553-567. doi: 10.1080/08958378.2019.1576807. Epub 2019 Mar 8.

PMID:
30849254
14.

A lower impact of an acute exposure to electronic cigarette aerosols than to cigarette smoke in human organotypic buccal and small airway cultures was demonstrated using systems toxicology assessment.

Iskandar AR, Zanetti F, Kondylis A, Martin F, Leroy P, Majeed S, Steiner S, Xiang Y, Ortega Torres L, Trivedi K, Guedj E, Merg C, Frentzel S, Ivanov NV, Doshi U, Lee KM, McKinney WJ Jr, Peitsch MC, Hoeng J.

Intern Emerg Med. 2019 Sep;14(6):863-883. doi: 10.1007/s11739-019-02055-x. Epub 2019 Mar 5.

15.

Construction of a Suite of Computable Biological Network Models Focused on Mucociliary Clearance in the Respiratory Tract.

Yepiskoposyan H, Talikka M, Vavassori S, Martin F, Sewer A, Gubian S, Luettich K, Peitsch MC, Hoeng J.

Front Genet. 2019 Feb 15;10:87. doi: 10.3389/fgene.2019.00087. eCollection 2019.

16.

Assessing the lung cancer risk reduction potential of candidate modified risk tobacco products.

Hoeng J, Maeder S, Vanscheeuwijck P, Peitsch MC.

Intern Emerg Med. 2019 Sep;14(6):821-834. doi: 10.1007/s11739-019-02045-z. Epub 2019 Feb 14.

17.

A six-month systems toxicology inhalation/cessation study in ApoE-/- mice to investigate cardiovascular and respiratory exposure effects of modified risk tobacco products, CHTP 1.2 and THS 2.2, compared with conventional cigarettes.

Phillips B, Szostak J, Titz B, Schlage WK, Guedj E, Leroy P, Vuillaume G, Martin F, Buettner A, Elamin A, Sewer A, Sierro N, Choukrallah MA, Schneider T, Ivanov NV, Teng C, Tung CK, Lim WT, Yeo YS, Vanscheeuwijck P, Peitsch MC, Hoeng J.

Food Chem Toxicol. 2019 Apr;126:113-141. doi: 10.1016/j.fct.2019.02.008. Epub 2019 Feb 12.

18.

How complex should an in vitro model be? Evaluation of complex 3D alveolar model with transcriptomic data and computational biological network models.

Marescotti D, Serchi T, Luettich K, Xiang Y, Moschini E, Talikka M, Martin F, Baumer K, Dulize R, Peric D, Bornand D, Guedj E, Sewer A, Cambier S, Contal S, Chary A, Gutleb AC, Frentzel S, Ivanov NV, Peitsch MC, Hoeng J.

ALTEX. 2019;36(3):388-402. doi: 10.14573/altex.1811221. Epub 2019 Feb 12.

19.

Corrigendum to "The biological effects of long-term exposure of human bronchial epithelial cells to total particulate matter from a candidate modified-risk tobacco product" published in Toxicology in Vitro, Volume 50, August 2018, Pages 95-108.

van der Toorn M, Sewer A, Marescotti D, Johne S, Baumer K, Bornand D, Dulize R, Merg C, Corciulo M, Scotti E, Pak C, Leroy P, Guedj E, Ivanov N, Martin F, Peitsch M, Hoeng J, Luettich K.

Toxicol In Vitro. 2019 Apr;56:194-195. doi: 10.1016/j.tiv.2019.01.011. Epub 2019 Jan 25. No abstract available.

20.

Assessment of a 72-hour repeated exposure to Swedish snus extract and total particulate matter from 3R4F cigarette smoke on gingival organotypic cultures.

Zanetti F, Sewer A, Titz B, Schlage WK, Iskandar AR, Kondylis A, Leroy P, Guedj E, Trivedi K, Elamin A, Martin F, Frentzel S, Ivanov NV, Peitsch MC, Hoeng J.

Food Chem Toxicol. 2019 Mar;125:252-270. doi: 10.1016/j.fct.2018.12.056. Epub 2019 Jan 2.

21.

Effects of cigarette smoke and tobacco heating aerosol on color stability of dental enamel, dentin, and composite resin restorations.

Zanetti F, Zhao X, Pan J, Peitsch MC, Hoeng J, Ren Y.

Quintessence Int. 2019 Jan 25;50(2):156-166. doi: 10.3290/j.qi.a41601. Epub 2018 Dec 18.

PMID:
30564805
22.

The impact of genome evolution on the allotetraploid Nicotiana rustica - an intriguing story of enhanced alkaloid production.

Sierro N, Battey JND, Bovet L, Liedschulte V, Ouadi S, Thomas J, Broye H, Laparra H, Vuarnoz A, Lang G, Goepfert S, Peitsch MC, Ivanov NV.

BMC Genomics. 2018 Nov 29;19(1):855. doi: 10.1186/s12864-018-5241-5.

23.

A lung/liver-on-a-chip platform for acute and chronic toxicity studies.

Bovard D, Sandoz A, Luettich K, Frentzel S, Iskandar A, Marescotti D, Trivedi K, Guedj E, Dutertre Q, Peitsch MC, Hoeng J.

Lab Chip. 2018 Dec 4;18(24):3814-3829. doi: 10.1039/c8lc01029c.

PMID:
30460365
24.

Tobacco Heating System 2.2 has a limited impact on DNA methylation of candidate enhancers in mouse lung compared with cigarette smoke.

Choukrallah MA, Sierro N, Martin F, Baumer K, Thomas J, Ouadi S, Hoeng J, Peitsch MC, Ivanov NV.

Food Chem Toxicol. 2019 Jan;123:501-510. doi: 10.1016/j.fct.2018.11.020. Epub 2018 Nov 9.

25.

Embracing Transparency Through Data Sharing.

Boué S, Byrne M, Hayes AW, Hoeng J, Peitsch MC.

Int J Toxicol. 2018 Oct 3:1091581818803880. doi: 10.1177/1091581818803880. [Epub ahead of print]

26.

Proteomics and Lipidomics in Inflammatory Bowel Disease Research: From Mechanistic Insights to Biomarker Identification.

Titz B, Gadaleta RM, Lo Sasso G, Elamin A, Ekroos K, Ivanov NV, Peitsch MC, Hoeng J.

Int J Mol Sci. 2018 Sep 15;19(9). pii: E2775. doi: 10.3390/ijms19092775. Review.

27.

The sbv IMPROVER Systems Toxicology Computational Challenge: Identification of Human and Species-Independent Blood Response Markers as Predictors of Smoking Exposure and Cessation Status.

Belcastro V, Poussin C, Xiang Y, Giordano M, Tripathi KP, Boda A, Boué S, Guarracino M, Martin F, Peitsch MC, Hoeng J, Romero R, Tarca AL, Duan Z, Yang H, Gong X, Wang P, Zhang C, Yang W, Sarac OS, Bilgen I, Balci AT, Kumar R, Dhanda SK.

Comput Toxicol. 2018 Feb;5:38-51. doi: 10.1016/j.comtox.2017.07.004. Epub 2017 Jul 14.

28.

Comparative effects of a candidate modified-risk tobacco product Aerosol and cigarette smoke on human organotypic small airway cultures: a systems toxicology approach.

Iskandar AR, Martinez Y, Martin F, Schlage WK, Leroy P, Sewer A, Torres LO, Majeed S, Merg C, Trivedi K, Guedj E, Frentzel S, Mathis C, Ivanov NV, Peitsch MC, Hoeng J.

Toxicol Res (Camb). 2017 Sep 28;6(6):930-946. doi: 10.1039/c7tx00152e. eCollection 2017 Nov 1.

29.

In vitro systems toxicology-based assessment of the potential modified risk tobacco product CHTP 1.2 for vascular inflammation- and cytotoxicity-associated mechanisms promoting adhesion of monocytic cells to human coronary arterial endothelial cells.

Poussin C, Laurent A, Kondylis A, Marescotti D, van der Toorn M, Guedj E, Goedertier D, Acali S, Pak C, Dulize R, Baumer K, Peric D, Maluenda E, Bornand D, Suarez IG, Schlage WK, Ivanov NV, Peitsch MC, Hoeng J.

Food Chem Toxicol. 2018 Oct;120:390-406. doi: 10.1016/j.fct.2018.07.025. Epub 2018 Jul 17.

30.

Interrogating the microbiome: experimental and computational considerations in support of study reproducibility.

Poussin C, Sierro N, Boué S, Battey J, Scotti E, Belcastro V, Peitsch MC, Ivanov NV, Hoeng J.

Drug Discov Today. 2018 Sep;23(9):1644-1657. doi: 10.1016/j.drudis.2018.06.005. Epub 2018 Jun 8. Review.

31.

Physiological and biological characterization of smokers with and without COPD.

Chaudhary N, Luettich K, Peck MJ, Pierri E, Felber-Medlin L, Vuillaume G, Leroy P, Hoeng J, Peitsch MC.

Version 2. F1000Res. 2017 Jun 13 [revised 2018 Jan 1];6:877. doi: 10.12688/f1000research.11698.2. eCollection 2017.

32.

A 90-day OECD TG 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects of the aerosol from the carbon heated tobacco product version 1.2 (CHTP1.2) compared with cigarette smoke. I. Inhalation exposure, clinical pathology and histopathology.

Phillips BW, Schlage WK, Titz B, Kogel U, Sciuscio D, Martin F, Leroy P, Vuillaume G, Krishnan S, Lee T, Veljkovic E, Elamin A, Merg C, Ivanov NV, Peitsch MC, Hoeng J, Vanscheeuwijck P.

Food Chem Toxicol. 2018 Jun;116(Pt B):388-413. doi: 10.1016/j.fct.2018.04.015. Epub 2018 Apr 11.

33.

A 90-day OECD TG 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects of the aerosol from the carbon heated tobacco product version 1.2 (CHTP1.2) compared with cigarette smoke. II. Systems toxicology assessment.

Titz B, Kogel U, Martin F, Schlage WK, Xiang Y, Nury C, Dijon S, Baumer K, Peric D, Bornand D, Dulize R, Phillips B, Leroy P, Vuillaume G, Lebrun S, Elamin A, Guedj E, Trivedi K, Ivanov NV, Vanscheeuwijck P, Peitsch MC, Hoeng J.

Food Chem Toxicol. 2018 May;115:284-301. doi: 10.1016/j.fct.2018.02.058. Epub 2018 Mar 13.

34.

The biological effects of long-term exposure of human bronchial epithelial cells to total particulate matter from a candidate modified-risk tobacco product.

van der Toorn M, Sewer A, Marescotti D, Johne S, Baumer K, Bornand D, Dulize R, Merg C, Corciulo M, Scotti E, Pak C, Leroy P, Guedj E, Ivanov N, Martin F, Peitsch M, Hoeng J, Luettich K.

Toxicol In Vitro. 2018 Aug;50:95-108. doi: 10.1016/j.tiv.2018.02.019. Epub 2018 Mar 7. Erratum in: Toxicol In Vitro. 2019 Apr;56:194-195.

35.

Assessment of the impact of aerosol from a potential modified risk tobacco product compared with cigarette smoke on human organotypic oral epithelial cultures under different exposure regimens.

Zanetti F, Sewer A, Scotti E, Titz B, Schlage WK, Leroy P, Kondylis A, Vuillaume G, Iskandar AR, Guedj E, Trivedi K, Schneider T, Elamin A, Martin F, Frentzel S, Ivanov NV, Peitsch MC, Hoeng J.

Food Chem Toxicol. 2018 May;115:148-169. doi: 10.1016/j.fct.2018.02.062. Epub 2018 Mar 2.

36.

Comparative biological impacts of an aerosol from carbon-heated tobacco and smoke from cigarettes on human respiratory epithelial cultures: A systems toxicology assessment.

Iskandar AR, Martin F, Leroy P, Schlage WK, Mathis C, Titz B, Kondylis A, Schneider T, Vuillaume G, Sewer A, Guedj E, Trivedi K, Elamin A, Frentzel S, Ivanov NV, Peitsch MC, Hoeng J.

Food Chem Toxicol. 2018 May;115:109-126. doi: 10.1016/j.fct.2018.02.063. Epub 2018 Mar 1.

37.

Assessment of mitochondrial function following short- and long-term exposure of human bronchial epithelial cells to total particulate matter from a candidate modified-risk tobacco product and reference cigarettes.

Malinska D, Szymański J, Patalas-Krawczyk P, Michalska B, Wojtala A, Prill M, Partyka M, Drabik K, Walczak J, Sewer A, Johne S, Luettich K, Peitsch MC, Hoeng J, Duszyński J, Szczepanowska J, van der Toorn M, Wieckowski MR.

Food Chem Toxicol. 2018 May;115:1-12. doi: 10.1016/j.fct.2018.02.013. Epub 2018 Feb 13.

38.

Effects of cigarette smoking on color stability of dental resin composites.

Zhao X, Zanetti F, Majeed S, Pan J, Malmstrom H, Peitsch MC, Hoeng J, Ren Y.

Am J Dent. 2017 Dec;30(6):316-322.

PMID:
29251454
39.

Supporting evidence-based analysis for modified risk tobacco products through a toxicology data-sharing infrastructure.

Boué S, Exner T, Ghosh S, Belcastro V, Dokler J, Page D, Boda A, Bonjour F, Hardy B, Vanscheeuwijck P, Hoeng J, Peitsch M.

Version 2. F1000Res. 2017 Jan 5 [revised 2017 Jan 1];6:12. doi: 10.12688/f1000research.10493.2. eCollection 2017.

40.

Perplexing Conclusions Concerning Heat-Not-Burn Tobacco Cigarettes.

Maeder S, Peitsch MC.

JAMA Intern Med. 2017 Nov 1;177(11):1698-1699. doi: 10.1001/jamainternmed.2017.5840. No abstract available.

PMID:
29114792
41.

Toxicity of the main electronic cigarette components, propylene glycol, glycerin, and nicotine, in Sprague-Dawley rats in a 90-day OECD inhalation study complemented by molecular endpoints.

Phillips B, Titz B, Kogel U, Sharma D, Leroy P, Xiang Y, Vuillaume G, Lebrun S, Sciuscio D, Ho J, Nury C, Guedj E, Elamin A, Esposito M, Krishnan S, Schlage WK, Veljkovic E, Ivanov NV, Martin F, Peitsch MC, Hoeng J, Vanscheeuwijck P.

Food Chem Toxicol. 2017 Nov;109(Pt 1):315-332. doi: 10.1016/j.fct.2017.09.001. Epub 2017 Sep 5.

42.

Mechanistic Evaluation of the Impact of Smoking and Chronic Obstructive Pulmonary Disease on the Nasal Epithelium.

Talikka M, Martin F, Sewer A, Vuillaume G, Leroy P, Luettich K, Chaudhary N, Peck MJ, Peitsch MC, Hoeng J.

Clin Med Insights Circ Respir Pulm Med. 2017 Jun 5;11:1179548417710928. doi: 10.1177/1179548417710928. eCollection 2017.

43.

Novel approaches to develop community-built biological network models for potential drug discovery.

Talikka M, Bukharov N, Hayes WS, Hofmann-Apitius M, Alexopoulos L, Peitsch MC, Hoeng J.

Expert Opin Drug Discov. 2017 Aug;12(8):849-857. doi: 10.1080/17460441.2017.1335302. Epub 2017 Jun 6. Review.

PMID:
28585481
44.

Systems toxicology meta-analysis of in vitro assessment studies: biological impact of a candidate modified-risk tobacco product aerosol compared with cigarette smoke on human organotypic cultures of the aerodigestive tract.

Iskandar AR, Titz B, Sewer A, Leroy P, Schneider T, Zanetti F, Mathis C, Elamin A, Frentzel S, Schlage WK, Martin F, Ivanov NV, Peitsch MC, Hoeng J.

Toxicol Res (Camb). 2017 May 29;6(5):631-653. doi: 10.1039/c7tx00047b. eCollection 2017 Sep 1.

45.

Multicomponent aerosol particle deposition in a realistic cast of the human upper respiratory tract.

Nordlund M, Belka M, Kuczaj AK, Lizal F, Jedelsky J, Elcner J, Jicha M, Sauser Y, Le Bouhellec S, Cosandey S, Majeed S, Vuillaume G, Peitsch MC, Hoeng J.

Inhal Toxicol. 2017 Feb;29(3):113-125. doi: 10.1080/08958378.2017.1315196.

PMID:
28470142
46.

Systems Toxicology: Real World Applications and Opportunities.

Hartung T, FitzGerald RE, Jennings P, Mirams GR, Peitsch MC, Rostami-Hodjegan A, Shah I, Wilks MF, Sturla SJ.

Chem Res Toxicol. 2017 Apr 17;30(4):870-882. doi: 10.1021/acs.chemrestox.7b00003. Epub 2017 Mar 31.

47.

Aerosol from Tobacco Heating System 2.2 has reduced impact on mouse heart gene expression compared with cigarette smoke.

Szostak J, Boué S, Talikka M, Guedj E, Martin F, Phillips B, Ivanov NV, Peitsch MC, Hoeng J.

Food Chem Toxicol. 2017 Mar;101:157-167. doi: 10.1016/j.fct.2017.01.013. Epub 2017 Jan 19.

48.

Crowd-Sourced Verification of Computational Methods and Data in Systems Toxicology: A Case Study with a Heat-Not-Burn Candidate Modified Risk Tobacco Product.

Poussin C, Belcastro V, Martin F, Boué S, Peitsch MC, Hoeng J.

Chem Res Toxicol. 2017 Apr 17;30(4):934-945. doi: 10.1021/acs.chemrestox.6b00345. Epub 2017 Feb 9.

PMID:
28085253
49.

Comparative systems toxicology analysis of cigarette smoke and aerosol from a candidate modified risk tobacco product in organotypic human gingival epithelial cultures: A 3-day repeated exposure study.

Zanetti F, Titz B, Sewer A, Lo Sasso G, Scotti E, Schlage WK, Mathis C, Leroy P, Majeed S, Torres LO, Keppler BR, Elamin A, Trivedi K, Guedj E, Martin F, Frentzel S, Ivanov NV, Peitsch MC, Hoeng J.

Food Chem Toxicol. 2017 Mar;101:15-35. doi: 10.1016/j.fct.2016.12.027. Epub 2016 Dec 23.

50.

Evaluation of the Tobacco Heating System 2.2 (THS2.2). Part 5: microRNA expression from a 90-day rat inhalation study indicates that exposure to THS2.2 aerosol causes reduced effects on lung tissue compared with cigarette smoke.

Sewer A, Kogel U, Talikka M, Wong ET, Martin F, Xiang Y, Guedj E, Ivanov NV, Hoeng J, Peitsch MC.

Regul Toxicol Pharmacol. 2016 Nov 30;81 Suppl 2:S82-S92. doi: 10.1016/j.yrtph.2016.11.018. Epub 2016 Nov 17.

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