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Items: 31


TRPM4 is highly expressed in human colorectal tumor buds and contributes to proliferation, cell cycle, and invasion of colorectal cancer cells.

Kappel S, Stokłosa P, Hauert B, Ross-Kaschitza D, Borgström A, Baur R, Galván JA, Zlobec I, Peinelt C.

Mol Oncol. 2019 Nov;13(11):2393-2405. doi: 10.1002/1878-0261.12566. Epub 2019 Sep 12.


Store-operated calcium entry in disease: Beyond STIM/Orai expression levels.

Kappel S, Borgström A, Stokłosa P, Dörr K, Peinelt C.

Semin Cell Dev Biol. 2019 Oct;94:66-73. doi: 10.1016/j.semcdb.2019.01.003. Epub 2019 Jan 12. Review.


Identification of potent and selective small molecule inhibitors of the cation channel TRPM4.

Ozhathil LC, Delalande C, Bianchi B, Nemeth G, Kappel S, Thomet U, Ross-Kaschitza D, Simonin C, Rubin M, Gertsch J, Lochner M, Peinelt C, Reymond JL, Abriel H.

Br J Pharmacol. 2018 Jun;175(12):2504-2519. doi: 10.1111/bph.14220. Epub 2018 Apr 29.


Correction to: Store-Operated Ca2+ Entry as a Prostate Cancer Biomarker - a Riddle with Perspectives.

Kappel S, Marques IJ, Zoni E, Stokłosa P, Peinelt C, Mercader N, Kruithof-de Julio M, Borgström A.

Curr Mol Biol Rep. 2018;4(3):142. doi: 10.1007/s40610-018-0097-7. Epub 2018 Jun 20.


Store-Operated Ca2+ Entry as a Prostate Cancer Biomarker - a Riddle with Perspectives.

Kappel S, Marques IJ, Zoni E, Stokłosa P, Peinelt C, Mercader N, Kruithof-de Julio M, Borgström A.

Curr Mol Biol Rep. 2017;3(4):208-217. doi: 10.1007/s40610-017-0072-8. Epub 2017 Oct 28. Review. Erratum in: Curr Mol Biol Rep. 2018;4(3):142.


Cell type-specific glycosylation of Orai1 modulates store-operated Ca2+ entry.

Dörr K, Kilch T, Kappel S, Alansary D, Schwär G, Niemeyer BA, Peinelt C.

Sci Signal. 2016 Mar 8;9(418):ra25. doi: 10.1126/scisignal.aaa9913.


Regulation of Ca(2+) signaling in prostate cancer cells.

Kilch T, Kappel S, Peinelt C.

Channels (Austin). 2016;10(3):170-1. doi: 10.1080/19336950.2015.1137176. Epub 2016 Jan 8. No abstract available.


Transient receptor potential melastatin 4 channel contributes to migration of androgen-insensitive prostate cancer cells.

Holzmann C, Kappel S, Kilch T, Jochum MM, Urban SK, Jung V, Stöckle M, Rother K, Greiner M, Peinelt C.

Oncotarget. 2015 Dec 8;6(39):41783-93. doi: 10.18632/oncotarget.6157.


Differential Redox Regulation of Ca²⁺ Signaling and Viability in Normal and Malignant Prostate Cells.

Holzmann C, Kilch T, Kappel S, Dörr K, Jung V, Stöckle M, Bogeski I, Peinelt C.

Biophys J. 2015 Oct 6;109(7):1410-9. doi: 10.1016/j.bpj.2015.08.006.


Regulation of endogenous and heterologous Ca²⁺ release-activated Ca²⁺ currents by pH.

Beck A, Fleig A, Penner R, Peinelt C.

Cell Calcium. 2014 Sep;56(3):235-43. doi: 10.1016/j.ceca.2014.07.011. Epub 2014 Aug 2.


Patch-clamp measurement of ICRAC and ORAI channel activity.

Alansary D, Kilch T, Holzmann C, Peinelt C, Hoth M, Lis A.

Cold Spring Harb Protoc. 2014 Jun 2;2014(6):602-7. doi: 10.1101/pdb.top066795.


The minimal requirements to use calcium imaging to analyze ICRAC.

Alansary D, Kilch T, Holzmann C, Peinelt C, Hoth M, Lis A.

Cold Spring Harb Protoc. 2014 Jun 2;2014(6):638-42. doi: 10.1101/pdb.prot073262.


Measuring endogenous ICRAC and ORAI currents with the patch-clamp technique.

Alansary D, Kilch T, Holzmann C, Peinelt C, Hoth M, Lis A.

Cold Spring Harb Protoc. 2014 Jun 2;2014(6):630-7. doi: 10.1101/pdb.prot073254.


ICRAC controls the rapid androgen response in human primary prostate epithelial cells and is altered in prostate cancer.

Holzmann C, Kilch T, Kappel S, Armbrüster A, Jung V, Stöckle M, Bogeski I, Schwarz EC, Peinelt C.

Oncotarget. 2013 Nov;4(11):2096-107.


Mutations of the Ca2+-sensing stromal interaction molecule STIM1 regulate Ca2+ influx by altered oligomerization of STIM1 and by destabilization of the Ca2+ channel Orai1.

Kilch T, Alansary D, Peglow M, Dörr K, Rychkov G, Rieger H, Peinelt C, Niemeyer BA.

J Biol Chem. 2013 Jan 18;288(3):1653-64. doi: 10.1074/jbc.M112.417246. Epub 2012 Dec 4.


ORMDL3 modulates store-operated calcium entry and lymphocyte activation.

Carreras-Sureda A, Cantero-Recasens G, Rubio-Moscardo F, Kiefer K, Peinelt C, Niemeyer BA, Valverde MA, Vicente R.

Hum Mol Genet. 2013 Feb 1;22(3):519-30. doi: 10.1093/hmg/dds450. Epub 2012 Oct 25.


ORAI1 Ca(2+) channels control endothelin-1-induced mitogenesis and melanogenesis in primary human melanocytes.

Stanisz H, Stark A, Kilch T, Schwarz EC, Müller CS, Peinelt C, Hoth M, Niemeyer BA, Vogt T, Bogeski I.

J Invest Dermatol. 2012 May;132(5):1443-51. doi: 10.1038/jid.2011.478. Epub 2012 Feb 9.


A single lysine in the N-terminal region of store-operated channels is critical for STIM1-mediated gating.

Lis A, Zierler S, Peinelt C, Fleig A, Penner R.

J Gen Physiol. 2010 Dec;136(6):673-86. doi: 10.1085/jgp.201010484.


Pharmacology of ORAI channels as a tool to understand their physiological functions.

Bogeski I, Al-Ansary D, Qu B, Niemeyer BA, Hoth M, Peinelt C.

Expert Rev Clin Pharmacol. 2010 May;3(3):291-303. doi: 10.1586/ecp.10.23.


Differential redox regulation of ORAI ion channels: a mechanism to tune cellular calcium signaling.

Bogeski I, Kummerow C, Al-Ansary D, Schwarz EC, Koehler R, Kozai D, Takahashi N, Peinelt C, Griesemer D, Bozem M, Mori Y, Hoth M, Niemeyer BA.

Sci Signal. 2010 Mar 30;3(115):ra24. doi: 10.1126/scisignal.2000672.


IP(3) receptor subtype-dependent activation of store-operated calcium entry through I(CRAC).

Peinelt C, Beck A, Monteilh-Zoller MK, Penner R, Fleig A.

Cell Calcium. 2009 Apr;45(4):326-30. doi: 10.1016/j.ceca.2008.12.001. Epub 2009 Jan 20.


2-Aminoethoxydiphenyl borate directly facilitates and indirectly inhibits STIM1-dependent gating of CRAC channels.

Peinelt C, Lis A, Beck A, Fleig A, Penner R.

J Physiol. 2008 Jul 1;586(13):3061-73. doi: 10.1113/jphysiol.2008.151365. Epub 2008 Apr 10.


STIM2 protein mediates distinct store-dependent and store-independent modes of CRAC channel activation.

Parvez S, Beck A, Peinelt C, Soboloff J, Lis A, Monteilh-Zoller M, Gill DL, Fleig A, Penner R.

FASEB J. 2008 Mar;22(3):752-61. Epub 2007 Sep 28.


CRACM1, CRACM2, and CRACM3 are store-operated Ca2+ channels with distinct functional properties.

Lis A, Peinelt C, Beck A, Parvez S, Monteilh-Zoller M, Fleig A, Penner R.

Curr Biol. 2007 May 1;17(9):794-800. Epub 2007 Apr 19.


CRACM1 multimers form the ion-selective pore of the CRAC channel.

Vig M, Beck A, Billingsley JM, Lis A, Parvez S, Peinelt C, Koomoa DL, Soboloff J, Gill DL, Fleig A, Kinet JP, Penner R.

Curr Biol. 2006 Oct 24;16(20):2073-9. Epub 2006 Sep 14.


Amplification of CRAC current by STIM1 and CRACM1 (Orai1).

Peinelt C, Vig M, Koomoa DL, Beck A, Nadler MJ, Koblan-Huberson M, Lis A, Fleig A, Penner R, Kinet JP.

Nat Cell Biol. 2006 Jul;8(7):771-3. Epub 2006 May 30.


CRACM1 is a plasma membrane protein essential for store-operated Ca2+ entry.

Vig M, Peinelt C, Beck A, Koomoa DL, Rabah D, Koblan-Huberson M, Kraft S, Turner H, Fleig A, Penner R, Kinet JP.

Science. 2006 May 26;312(5777):1220-3. Epub 2006 Apr 27.


Kinetics of Ca2+ binding to the SR Ca-ATPase in the E1 state.

Peinelt C, Apell HJ.

Biophys J. 2005 Oct;89(4):2427-33. Epub 2005 Jul 22.


Time-resolved partial reactions of the SR Ca-ATPase investigated with a fluorescent styryl dye.

Peinelt C, Apell HJ.

Ann N Y Acad Sci. 2003 Apr;986:325-6. No abstract available.


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