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Items: 1 to 50 of 179

1.

Aging-like Spontaneous Epigenetic Silencing Facilitates Wnt Activation, Stemness, and BrafV600E-Induced Tumorigenesis.

Tao Y, Kang B, Petkovich DA, Bhandari YR, In J, Stein-O'Brien G, Kong X, Xie W, Zachos N, Maegawa S, Vaidya H, Brown S, Chiu Yen RW, Shao X, Thakor J, Lu Z, Cai Y, Zhang Y, Mallona I, Peinado MA, Zahnow CA, Ahuja N, Fertig E, Issa JP, Baylin SB, Easwaran H.

Cancer Cell. 2019 Feb 11;35(2):315-328.e6. doi: 10.1016/j.ccell.2019.01.005.

PMID:
30753828
2.

Interplay between post-translational cyclooxygenase-2 modifications and the metabolic and proteomic profile in a colorectal cancer cohort.

Prieto P, Jaén RI, Calle D, Gómez-Serrano M, Núñez E, Fernández-Velasco M, Martín-Sanz P, Alonso S, Vázquez J, Cerdán S, Peinado MÁ, Boscá L.

World J Gastroenterol. 2019 Jan 28;25(4):433-446. doi: 10.3748/wjg.v25.i4.433.

3.

Adipose tissue mitochondrial dysfunction in human obesity is linked to a specific DNA methylation signature in adipose-derived stem cells.

Ejarque M, Ceperuelo-Mallafré V, Serena C, Maymo-Masip E, Duran X, Díaz-Ramos A, Millan-Scheiding M, Núñez-Álvarez Y, Núñez-Roa C, Gama P, Garcia-Roves PM, Peinado MA, Gimble JM, Zorzano A, Vendrell J, Fernández-Veledo S.

Int J Obes (Lond). 2019 Jun;43(6):1256-1268. doi: 10.1038/s41366-018-0219-6. Epub 2018 Sep 27.

PMID:
30262812
4.

Kallikreins Stepwise Scoring Reveals Three Subtypes of Papillary Thyroid Cancer with Prognostic Implications.

Buj R, Mallona I, Díez-Villanueva A, Zafon C, Mate JL, Roca M, Puig-Domingo M, Reverter JL, Mauricio D, Peinado MA, Jordà M.

Thyroid. 2018 May;28(5):601-612. doi: 10.1089/thy.2017.0501.

PMID:
29635968
5.

The Pancancer DNA Methylation Trackhub: A Window to The Cancer Genome Atlas Epigenomics Data.

Mallona I, Sierco A, Peinado MA.

Methods Mol Biol. 2018;1766:123-135. doi: 10.1007/978-1-4939-7768-0_7.

PMID:
29605850
6.

Increased Global DNA Hypomethylation in Distant Metastatic and Dedifferentiated Thyroid Cancer.

Klein Hesselink EN, Zafon C, Villalmanzo N, Iglesias C, van Hemel BM, Klein Hesselink MS, Montero-Conde C, Buj R, Mauricio D, Peinado MA, Puig-Domingo M, Riesco-Eizaguirre G, Reverter JL, Robledo M, Links TP, Jordà M.

J Clin Endocrinol Metab. 2018 Feb 1;103(2):397-406. doi: 10.1210/jc.2017-01613.

PMID:
29165662
7.

Comparative proteomic study of early hypoxic response in the cerebral cortex of rats submitted to two different hypoxic models.

Ovelleiro D, Blanco S, Hernández R, Peinado MÁ.

Proteomics Clin Appl. 2017 Dec;11(11-12). doi: 10.1002/prca.201700058. Epub 2017 Aug 22.

PMID:
28697276
8.

Survivin, a key player in cancer progression, increases in obesity and protects adipose tissue stem cells from apoptosis.

Ejarque M, Ceperuelo-Mallafré V, Serena C, Pachón G, Núñez-Álvarez Y, Terrón-Puig M, Calvo E, Núñez-Roa C, Oliva-Olivera W, Tinahones FJ, Peinado MA, Vendrell J, Fernández-Veledo S.

Cell Death Dis. 2017 May 18;8(5):e2802. doi: 10.1038/cddis.2017.209.

9.

Angiogenesis is VEGF-independent in the aged striatum of male rats exposed to acute hypoxia.

Molina F, Del Moral ML, Peinado MÁ, Rus A.

Biogerontology. 2017 Oct;18(5):759-768. doi: 10.1007/s10522-017-9709-5. Epub 2017 May 13.

PMID:
28501895
10.

Chainy: an universal tool for standardized relative quantification in real-time PCR.

Mallona I, Díez-Villanueva A, Martín B, Peinado MA.

Bioinformatics. 2017 May 1;33(9):1411-1413. doi: 10.1093/bioinformatics/btw839. Erratum in: Bioinformatics. 2017 May 1;33(9):1429.

PMID:
28453678
11.

Chainy: an universal tool for standardized relative quantification in real-time PCR.

Mallona I, Díez-Villanueva A, Martín B, Peinado MA.

Bioinformatics. 2017 May 1;33(9):1429. doi: 10.1093/bioinformatics/btx113. No abstract available.

PMID:
28419190
12.

Truke, a web tool to check for and handle excel misidentified gene symbols.

Mallona I, Peinado MA.

BMC Genomics. 2017 Mar 21;18(1):242. doi: 10.1186/s12864-017-3631-8.

13.

The epigenetic landscape of Alu repeats delineates the structural and functional genomic architecture of colon cancer cells.

Jordà M, Díez-Villanueva A, Mallona I, Martín B, Lois S, Barrera V, Esteller M, Vavouri T, Peinado MA.

Genome Res. 2017 Jan;27(1):118-132. doi: 10.1101/gr.207522.116. Epub 2016 Dec 20.

14.

Melatonin influences NO/NOS pathway and reduces oxidative and nitrosative stress in a model of hypoxic-ischemic brain damage.

Blanco S, Hernández R, Franchelli G, Ramos-Álvarez MM, Peinado MÁ.

Nitric Oxide. 2017 Jan 30;62:32-43. doi: 10.1016/j.niox.2016.12.001. Epub 2016 Dec 8.

PMID:
27940344
15.

DNA methylation profiling identifies PTRF/Cavin-1 as a novel tumor suppressor in Ewing sarcoma when co-expressed with caveolin-1.

Huertas-Martínez J, Court F, Rello-Varona S, Herrero-Martín D, Almacellas-Rabaiget O, Sáinz-Jaspeado M, Garcia-Monclús S, Lagares-Tena L, Buj R, Hontecillas-Prieto L, Sastre A, Azorin D, Sanjuan X, López-Alemany R, Moran S, Roma J, Gallego S, Mora J, García Del Muro X, Giangrande PH, Peinado MA, Alonso J, de Alava E, Monk D, Esteller M, Tirado OM.

Cancer Lett. 2017 Feb 1;386:196-207. doi: 10.1016/j.canlet.2016.11.020. Epub 2016 Nov 25.

PMID:
27894957
16.

Response of the Nitric Oxide System to Hypobaric Hypoxia in the Aged Striatum.

Molina F, Del Moral ML, Peinado MÁ, Rus A.

Gerontology. 2017;63(1):36-44. Epub 2016 Oct 20.

PMID:
27760428
17.

Predictive variables of open reduction in intertrochanteric fracture nailing: a report of 210 cases.

Díaz VJ, Cañizares AC, Martín IA, Peinado MA, Doussoux PC.

Injury. 2016 Sep;47 Suppl 3:S51-S55. doi: 10.1016/S0020-1383(16)30606-4.

PMID:
27692107
18.

APC promoter is frequently methylated in pancreatic juice of patients with pancreatic carcinomas or periampullary tumors.

Ginesta MM, Diaz-Riascos ZV, Busquets J, Pelaez N, Serrano T, Peinado MÀ, Jorba R, García-Borobia FJ, Capella G, Fabregat J.

Oncol Lett. 2016 Sep;12(3):2210-2216. Epub 2016 Jul 15.

19.

DNA methylation dynamics in cellular commitment and differentiation.

Suelves M, Carrió E, Núñez-Álvarez Y, Peinado MA.

Brief Funct Genomics. 2016 Nov;15(6):443-453. Epub 2016 Jun 8. Review.

PMID:
27416614
20.

Downregulation of the Deiminase PADI2 Is an Early Event in Colorectal Carcinogenesis and Indicates Poor Prognosis.

Cantariño N, Musulén E, Valero V, Peinado MA, Perucho M, Moreno V, Forcales SV, Douet J, Buschbeck M.

Mol Cancer Res. 2016 Sep;14(9):841-8. doi: 10.1158/1541-7786.MCR-16-0034. Epub 2016 Jun 8.

21.

Muscle cell identity requires Pax7-mediated lineage-specific DNA demethylation.

Carrió E, Magli A, Muñoz M, Peinado MA, Perlingeiro R, Suelves M.

BMC Biol. 2016 Apr 13;14:30. doi: 10.1186/s12915-016-0250-9.

22.

Quantification of unmethylated Alu (QUAlu): a tool to assess global hypomethylation in routine clinical samples.

Buj R, Mallona I, Díez-Villanueva A, Barrera V, Mauricio D, Puig-Domingo M, Reverter JL, Matias-Guiu X, Azuara D, Ramírez JL, Alonso S, Rosell R, Capellà G, Perucho M, Robledo M, Peinado MA, Jordà M.

Oncotarget. 2016 Mar 1;7(9):10536-46. doi: 10.18632/oncotarget.7233.

23.

A knowledgebase of the human Alu repetitive elements.

Mallona I, Jordà M, Peinado MA.

J Biomed Inform. 2016 Apr;60:77-83. doi: 10.1016/j.jbi.2016.01.010. Epub 2016 Jan 28.

24.

regioneR: an R/Bioconductor package for the association analysis of genomic regions based on permutation tests.

Gel B, Díez-Villanueva A, Serra E, Buschbeck M, Peinado MA, Malinverni R.

Bioinformatics. 2016 Jan 15;32(2):289-91. doi: 10.1093/bioinformatics/btv562. Epub 2015 Sep 30.

25.

Epigenetics override pro-inflammatory PTGS transcriptomic signature towards selective hyperactivation of PGE2 in colorectal cancer.

Cebola I, Custodio J, Muñoz M, Díez-Villanueva A, Paré L, Prieto P, Aussó S, Coll-Mulet L, Boscá L, Moreno V, Peinado MA.

Clin Epigenetics. 2015 Jul 24;7:74. doi: 10.1186/s13148-015-0110-4. eCollection 2015.

26.

Nitric Oxide, Inflammation, Lipid Profile, and Cortisol in Normal- and Overweight Women With Fibromyalgia.

Rus A, Molina F, Gassó M, Camacho MV, Peinado MÁ, del Moral ML.

Biol Res Nurs. 2016 Mar;18(2):138-46. doi: 10.1177/1099800415591035. Epub 2015 Jul 1.

PMID:
26134428
27.

Wanderer, an interactive viewer to explore DNA methylation and gene expression data in human cancer.

Díez-Villanueva A, Mallona I, Peinado MA.

Epigenetics Chromatin. 2015 Jun 23;8:22. doi: 10.1186/s13072-015-0014-8. eCollection 2015.

28.

Overlapping DNA methylation dynamics in mouse intestinal cell differentiation and early stages of malignant progression.

Forn M, Díez-Villanueva A, Merlos-Suárez A, Muñoz M, Lois S, Carriò E, Jordà M, Bigas A, Batlle E, Peinado MA.

PLoS One. 2015 May 1;10(5):e0123263. doi: 10.1371/journal.pone.0123263. eCollection 2015.

29.

Deconstruction of DNA methylation patterns during myogenesis reveals specific epigenetic events in the establishment of the skeletal muscle lineage.

Carrió E, Díez-Villanueva A, Lois S, Mallona I, Cases I, Forn M, Peinado MA, Suelves M.

Stem Cells. 2015 Jun;33(6):2025-36. doi: 10.1002/stem.1998. Epub 2015 Apr 21.

30.

Pea (Pisum sativum L.) seed albumin extracts show anti-inflammatory effect in the DSS model of mouse colitis.

Utrilla MP, Peinado MJ, Ruiz R, Rodriguez-Nogales A, Algieri F, Rodriguez-Cabezas ME, Clemente A, Galvez J, Rubio LA.

Mol Nutr Food Res. 2015 Apr;59(4):807-19. doi: 10.1002/mnfr.201400630. Epub 2015 Mar 2.

PMID:
25626675
31.

Caveolin-1 is down-regulated in alveolar rhabdomyosarcomas and negatively regulates tumor growth.

Huertas-Martínez J, Rello-Varona S, Herrero-Martín D, Barrau I, García-Monclús S, Sáinz-Jaspeado M, Lagares-Tena L, Núñez-Álvarez Y, Mateo-Lozano S, Mora J, Roma J, Toran N, Moran S, López-Alemany R, Gallego S, Esteller M, Peinado MA, Del Muro XG, Tirado OM.

Oncotarget. 2014 Oct 30;5(20):9744-55.

32.

Methylation plotter: a web tool for dynamic visualization of DNA methylation data.

Mallona I, Díez-Villanueva A, Peinado MA.

Source Code Biol Med. 2014 Jun 7;9:11. doi: 10.1186/1751-0473-9-11. eCollection 2014.

33.

Proteomic characterization of nitrated cell targets after hypobaric hypoxia and reoxygenation in rat brain.

Peinado MÁ, Hernández R, Peragón J, Ovelleiro D, Pedrosa JÁ, Blanco S.

J Proteomics. 2014 Sep 23;109:309-21. doi: 10.1016/j.jprot.2014.07.015. Epub 2014 Jul 23.

PMID:
25064252
34.

DNA methylation profiling of well-differentiated thyroid cancer uncovers markers of recurrence free survival.

Mancikova V, Buj R, Castelblanco E, Inglada-Pérez L, Diez A, de Cubas AA, Curras-Freixes M, Maravall FX, Mauricio D, Matias-Guiu X, Puig-Domingo M, Capel I, Bella MR, Lerma E, Castella E, Reverter JL, Peinado MÁ, Jorda M, Robledo M.

Int J Cancer. 2014 Aug 1;135(3):598-610. doi: 10.1002/ijc.28703. Epub 2014 Jan 13.

35.

Long range epigenetic silencing is a trans-species mechanism that results in cancer specific deregulation by overriding the chromatin domains of normal cells.

Forn M, Muñoz M, Tauriello DV, Merlos-Suárez A, Rodilla V, Bigas A, Batlle E, Jordà M, Peinado MA.

Mol Oncol. 2013 Dec;7(6):1129-41. doi: 10.1016/j.molonc.2013.08.008. Epub 2013 Aug 30.

36.

Short-term hypoxia/reoxygenation activates the angiogenic pathway in rat caudate putamen.

Molina F, Rus A, Peinado MA, Del Moral ML.

J Biosci. 2013 Jun;38(2):363-71.

PMID:
23660671
37.

Epigenetics of host-pathogen interactions: the road ahead and the road behind.

Gómez-Díaz E, Jordà M, Peinado MA, Rivero A.

PLoS Pathog. 2012;8(11):e1003007. doi: 10.1371/journal.ppat.1003007. Epub 2012 Nov 29. Review.

38.

Genetic and epigenetic markers in the evaluation of pancreatic masses.

Ginestà MM, Mora J, Mayor R, Farré A, Peinado MA, Busquets J, Serrano T, Capellá G, Fabregat J.

J Clin Pathol. 2013 Mar;66(3):192-7. doi: 10.1136/jclinpath-2012-201123. Epub 2012 Nov 7.

PMID:
23135349
39.

Evaluation of single CpG sites as proxies of CpG island methylation states at the genome scale.

Barrera V, Peinado MA.

Nucleic Acids Res. 2012 Dec;40(22):11490-8. doi: 10.1093/nar/gks928. Epub 2012 Oct 12.

40.

Hypobaric hypoxia and reoxygenation induce proteomic profile changes in the rat brain cortex.

Hernández R, Blanco S, Peragón J, Pedrosa JÁ, Peinado MÁ.

Neuromolecular Med. 2013 Mar;15(1):82-94. doi: 10.1007/s12017-012-8197-7. Epub 2012 Sep 8.

PMID:
22961459
41.

Epigenetic deregulation of the COX pathway in cancer.

Cebola I, Peinado MA.

Prog Lipid Res. 2012 Oct;51(4):301-13. doi: 10.1016/j.plipres.2012.02.005. Epub 2012 May 3. Review.

PMID:
22580191
42.

Upregulation of cardiac NO/NOS system during short-term hypoxia and the subsequent reoxygenation period.

Rus A, Del Moral ML, Molina F, Peinado MA.

Eur J Histochem. 2011 May 17;55(2):e17. doi: 10.4081/ejh.2011.e17.

43.

Dynamics of bivalent chromatin domains upon drug induced reactivation and resilencing in cancer cells.

Mayor R, Muñoz M, Coolen MW, Custodio J, Esteller M, Clark SJ, Peinado MA.

Epigenetics. 2011 Sep 1;6(9):1138-48. doi: 10.4161/epi.6.9.16066. Epub 2011 Sep 1.

PMID:
21852760
44.

Nitric oxide averts hypoxia-induced damage during reoxygenation in rat heart.

Rus A, Molina F, Peinado MÁ, Del Moral ML.

Microsc Res Tech. 2011 Dec;74(12):1093-103. doi: 10.1002/jemt.21000. Epub 2011 Apr 29.

PMID:
21538695
45.

Is endothelial-nitric-oxide-synthase-derived nitric oxide involved in cardiac hypoxia/reoxygenation-related damage?

Rus A, Peinado MA, Blanco S, Del Moral ML.

J Biosci. 2011 Mar;36(1):69-78.

PMID:
21451249
46.

Epigenetic deregulation across chromosome 2q14.2 differentiates normal from prostate cancer and provides a regional panel of novel DNA methylation cancer biomarkers.

Devaney J, Stirzaker C, Qu W, Song JZ, Statham AL, Patterson KI, Horvath LG, Tabor B, Coolen MW, Hulf T, Kench JG, Henshall SM, Pe Benito R, Haynes AM, Mayor R, Peinado MA, Sutherland RL, Clark SJ.

Cancer Epidemiol Biomarkers Prev. 2011 Jan;20(1):148-59. doi: 10.1158/1055-9965.EPI-10-0719. Epub 2010 Nov 23.

47.

Endothelial NOS-derived nitric oxide prevents injury resulting from reoxygenation in the hypoxic lung.

Rus A, Molina F, Peinado MA, del Moral ML.

Free Radic Res. 2010 Sep;44(9):1027-35. doi: 10.3109/10715762.2010.498479.

PMID:
20815765
48.

Endogenous nitric oxide can act as beneficial or deleterious in the hypoxic lung depending on the reoxygenation time.

Rus A, Molina F, Peinado MÁ, Del Moral ML.

Anat Rec (Hoboken). 2010 Dec;293(12):2193-201. doi: 10.1002/ar.21229. Epub 2010 Aug 23.

49.

Novel methylation panel for the early detection of colorectal tumors in stool DNA.

Azuara D, Rodriguez-Moranta F, de Oca J, Soriano-Izquierdo A, Mora J, Guardiola J, Biondo S, Blanco I, Peinado MA, Moreno V, Esteller M, Capellá G.

Clin Colorectal Cancer. 2010 Jul;9(3):168-76. doi: 10.3816/CCC.2010.n.023.

PMID:
20643622
50.

Methods for DNA methylation analysis and applications in colon cancer.

Jordà M, Peinado MA.

Mutat Res. 2010 Nov 10;693(1-2):84-93. doi: 10.1016/j.mrfmmm.2010.06.010. Epub 2010 Jun 25. Review.

PMID:
20599551

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