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Evaluation of the NAD+ biosynthetic pathway in ALS patients and effect of modulating NAD+ levels in hSOD1-linked ALS mouse models.

Harlan BA, Killoy KM, Pehar M, Liu L, Auwerx J, Vargas MR.

Exp Neurol. 2020 Jan 31;327:113219. doi: 10.1016/j.expneurol.2020.113219. [Epub ahead of print]


Anesthetics: from modes of action to unconsciousness and neurotoxicity.

Iqbal F, Thompson AJ, Riaz S, Pehar M, Rice T, Syed NI.

J Neurophysiol. 2019 Aug 1;122(2):760-787. doi: 10.1152/jn.00210.2019. Epub 2019 Jun 26.


Enhanced SIRT6 activity abrogates the neurotoxic phenotype of astrocytes expressing ALS-linked mutant SOD1.

Harlan BA, Pehar M, Killoy KM, Vargas MR.

FASEB J. 2019 Jun;33(6):7084-7091. doi: 10.1096/fj.201802752R. Epub 2019 Mar 6.


Decreased glutathione levels cause overt motor neuron degeneration in hSOD1WT over-expressing mice.

Killoy KM, Harlan BA, Pehar M, Helke KL, Johnson JA, Vargas MR.

Exp Neurol. 2018 Apr;302:129-135. doi: 10.1016/j.expneurol.2018.01.004. Epub 2018 Jan 4.


Evaluation of different jumping tests in defining position-specific and performance-level differences in high level basketball players.

Pehar M, Sekulic D, Sisic N, Spasic M, Uljevic O, Krolo A, Milanovic Z, Sattler T.

Biol Sport. 2017 Sep;34(3):263-272. doi: 10.5114/biolsport.2017.67122. Epub 2017 Apr 5.


Role and Therapeutic Potential of Astrocytes in Amyotrophic Lateral Sclerosis.

Pehar M, Harlan BA, Killoy KM, Vargas MR.

Curr Pharm Des. 2017;23(33):5010-5021. doi: 10.2174/1381612823666170622095802. Review.


Nicotinamide Adenine Dinucleotide Metabolism and Neurodegeneration.

Pehar M, Harlan BA, Killoy KM, Vargas MR.

Antioxid Redox Signal. 2018 Jun 20;28(18):1652-1668. doi: 10.1089/ars.2017.7145. Epub 2017 Jun 27. Review.


Nitration and Glycation Turn Mature NGF into a Toxic Factor for Motor Neurons: A Role for p75NTR and RAGE Signaling in ALS.

Kim MJ, Vargas MR, Harlan BA, Killoy KM, Ball LE, Comte-Walters S, Gooz M, Yamamoto Y, Beckman JS, Barbeito L, Pehar M.

Antioxid Redox Signal. 2018 Jun 20;28(18):1587-1602. doi: 10.1089/ars.2016.6966. Epub 2017 Jun 26.


Analyzing the relationship between anthropometric and motor indices with basketball specific pre-planned and non-planned agility performances.

Pehar M, Sisic N, Sekulic D, Coh M, Uljevic O, Spasic M, Krolo A, Idrizovic K.

J Sports Med Phys Fitness. 2018 Jul-Aug;58(7-8):1037-1044. doi: 10.23736/S0022-4707.17.07346-7. Epub 2017 May 9.


Evaluation of Basketball-Specific Agility: Applicability of Preplanned and Nonplanned Agility Performances for Differentiating Playing Positions and Playing Levels.

Sekulic D, Pehar M, Krolo A, Spasic M, Uljevic O, Calleja-González J, Sattler T.

J Strength Cond Res. 2017 Aug;31(8):2278-2288. doi: 10.1519/JSC.0000000000001646.


The mitochondrial division inhibitor Mdivi-1 rescues mammalian neurons from anesthetic-induced cytotoxicity.

Xu F, Armstrong R, Urrego D, Qazzaz M, Pehar M, Armstrong JN, Shutt T, Syed N.

Mol Brain. 2016 Mar 24;9:35. doi: 10.1186/s13041-016-0210-x.


Enhancing NAD+ Salvage Pathway Reverts the Toxicity of Primary Astrocytes Expressing Amyotrophic Lateral Sclerosis-linked Mutant Superoxide Dismutase 1 (SOD1).

Harlan BA, Pehar M, Sharma DR, Beeson G, Beeson CC, Vargas MR.

J Biol Chem. 2016 May 13;291(20):10836-46. doi: 10.1074/jbc.M115.698779. Epub 2016 Mar 21.


Improved proteostasis in the secretory pathway rescues Alzheimer's disease in the mouse.

Peng Y, Kim MJ, Hullinger R, O'Riordan KJ, Burger C, Pehar M, Puglielli L.

Brain. 2016 Mar;139(Pt 3):937-52. doi: 10.1093/brain/awv385. Epub 2016 Jan 19.


Changes in Protein Expression and Lysine Acetylation Induced by Decreased Glutathione Levels in Astrocytes.

Pehar M, Ball LE, Sharma DR, Harlan BA, Comte-Walters S, Neely BA, Vargas MR.

Mol Cell Proteomics. 2016 Feb;15(2):493-505. doi: 10.1074/mcp.M115.049288. Epub 2015 Oct 20.


Pseudo-outbreak of Sphingomonas and Methylobacterium sp. Associated with Contamination of Heparin-Saline Solution Syringes Used During Bone Marrow Aspiration.

Rock C, Wong BC, Dionne K, Pehar M, Kickler TS, Perl TM, Romagnoli M, Ross T, Wakefield T, Trexler P, Carroll K, Maragakis LL.

Infect Control Hosp Epidemiol. 2016 Jan;37(1):116-7. doi: 10.1017/ice.2015.248. Epub 2015 Oct 12. No abstract available.


The amyloid precursor protein (APP) intracellular domain regulates translation of p44, a short isoform of p53, through an IRES-dependent mechanism.

Li M, Pehar M, Liu Y, Bhattacharyya A, Zhang SC, O'Riordan KJ, Burger C, D'Adamio L, Puglielli L.

Neurobiol Aging. 2015 Oct;36(10):2725-36. doi: 10.1016/j.neurobiolaging.2015.06.021. Epub 2015 Jun 21.


Agility performance in high-level junior basketball players: the predictive value of anthropometrics and power qualities.

Sisic N, Jelicic M, Pehar M, Spasic M, Sekulic D.

J Sports Med Phys Fitness. 2016 Jul-Aug;56(7-8):884-93. Epub 2015 May 5.


Mitochondria-targeted catalase reverts the neurotoxicity of hSOD1G⁹³A astrocytes without extending the survival of ALS-linked mutant hSOD1 mice.

Pehar M, Beeson G, Beeson CC, Johnson JA, Vargas MR.

PLoS One. 2014 Jul 23;9(7):e103438. doi: 10.1371/journal.pone.0103438. eCollection 2014.


Substance use and misuse and potential doping behaviour in rugby union players.

Sekulic D, Bjelanovic L, Pehar M, Pelivan K, Zenic N.

Res Sports Med. 2014;22(3):226-39. doi: 10.1080/15438627.2014.915839.


Deficient import of acetyl-CoA into the ER lumen causes neurodegeneration and propensity to infections, inflammation, and cancer.

Peng Y, Li M, Clarkson BD, Pehar M, Lao PJ, Hillmer AT, Barnhart TE, Christian BT, Mitchell HA, Bendlin BB, Sandor M, Puglielli L.

J Neurosci. 2014 May 14;34(20):6772-89. doi: 10.1523/JNEUROSCI.0077-14.2014.


Detection and prevalence of adenoviral conjunctivitis among hospital employees using real-time polymerase chain reaction as an infection prevention tool.

Kuo IC, Espinosa C, Forman M, Pehar M, Maragakis LL, Valsamakis A.

Infect Control Hosp Epidemiol. 2014 Jun;35(6):728-31. doi: 10.1086/676428. Epub 2014 Apr 23.


Post-translational regulation of CD133 by ATase1/ATase2-mediated lysine acetylation.

Mak AB, Pehar M, Nixon AM, Williams RA, Uetrecht AC, Puglielli L, Moffat J.

J Mol Biol. 2014 May 29;426(11):2175-82. doi: 10.1016/j.jmb.2014.02.012. Epub 2014 Feb 17.


P44, the 'longevity-assurance' isoform of P53, regulates tau phosphorylation and is activated in an age-dependent fashion.

Pehar M, Ko MH, Li M, Scrable H, Puglielli L.

Aging Cell. 2014 Jun;13(3):449-56. doi: 10.1111/acel.12192. Epub 2014 Feb 25.


Central line maintenance bundles and CLABSIs in ambulatory oncology patients.

Rinke ML, Bundy DG, Chen AR, Milstone AM, Colantuoni E, Pehar M, Herpst C, Fratino L, Miller MR.

Pediatrics. 2013 Nov;132(5):e1403-12. doi: 10.1542/peds.2013-0302. Epub 2013 Oct 7.


Ambulatory pediatric oncology CLABSIs: epidemiology and risk factors.

Rinke ML, Milstone AM, Chen AR, Mirski K, Bundy DG, Colantuoni E, Pehar M, Herpst C, Miller MR.

Pediatr Blood Cancer. 2013 Nov;60(11):1882-9. doi: 10.1002/pbc.24677. Epub 2013 Jul 23.


Calorie restriction attenuates astrogliosis but not amyloid plaque load in aged rhesus macaques: a preliminary quantitative imaging study.

Sridharan A, Pehar M, Salamat MS, Pugh TD, Bendlin BB, Willette AA, Anderson RM, Kemnitz JW, Colman RJ, Weindruch RH, Puglielli L, Johnson SC.

Brain Res. 2013 May 1;1508:1-8. doi: 10.1016/j.brainres.2013.02.046. Epub 2013 Mar 7.


Red blood cell distribution width as a prognostic marker of mortality in patients on chronic dialysis: a single center, prospective longitudinal study.

Sičaja M, Pehar M, Đerek L, Starčević B, Vuletić V, Romić Ž, Božikov V.

Croat Med J. 2013 Feb;54(1):25-32.


Lysine acetylation in the lumen of the ER: a novel and essential function under the control of the UPR.

Pehar M, Puglielli L.

Biochim Biophys Acta. 2013 Mar;1833(3):686-97. doi: 10.1016/j.bbamcr.2012.12.004. Epub 2012 Dec 13. Review.


SLC33A1/AT-1 protein regulates the induction of autophagy downstream of IRE1/XBP1 pathway.

Pehar M, Jonas MC, Hare TM, Puglielli L.

J Biol Chem. 2012 Aug 24;287(35):29921-30. doi: 10.1074/jbc.M112.363911. Epub 2012 Jul 11.


Spontaneous diaphragmatic rupture related to local invasion by retroperitoneal liposarcoma.

Pehar M, Vukoja I, Rozić D, Mišković J.

Ann R Coll Surg Engl. 2012 Jan;94(1):e18-9. doi: 10.1308/003588412X13171221499423.


An outbreak of human parainfluenza virus 3 infection in an outpatient hematopoietic stem cell transplantation clinic.

Sydnor ER, Greer A, Budd AP, Pehar M, Munshaw S, Neofytos D, Perl TM, Valsamakis A.

Am J Infect Control. 2012 Sep;40(7):601-5. doi: 10.1016/j.ajic.2011.11.011. Epub 2012 Mar 8.


Biochemical inhibition of the acetyltransferases ATase1 and ATase2 reduces β-secretase (BACE1) levels and Aβ generation.

Ding Y, Ko MH, Pehar M, Kotch F, Peters NR, Luo Y, Salamat SM, Puglielli L.

J Biol Chem. 2012 Mar 9;287(11):8424-33. doi: 10.1074/jbc.M111.310136. Epub 2012 Jan 20.


AT-1 is the ER membrane acetyl-CoA transporter and is essential for cell viability.

Jonas MC, Pehar M, Puglielli L.

J Cell Sci. 2010 Oct 1;123(Pt 19):3378-88. doi: 10.1242/jcs.068841. Epub 2010 Sep 7.


Altered longevity-assurance activity of p53:p44 in the mouse causes memory loss, neurodegeneration and premature death.

Pehar M, O'Riordan KJ, Burns-Cusato M, Andrzejewski ME, del Alcazar CG, Burger C, Scrable H, Puglielli L.

Aging Cell. 2010 Apr;9(2):174-90. doi: 10.1111/j.1474-9726.2010.00547.x.


Carotid endarterectomy unexpectedly resulted in optimal blood pressure control.

Kirin I, Kirin M, Sicaja M, Missoni S, Pehar M, Prka Z, Spoljarić M, Bozikov V.

Coll Antropol. 2009 Dec;33(4):1229-31.


Lead exposure stimulates VEGF expression in the spinal cord and extends survival in a mouse model of ALS.

Barbeito AG, Martinez-Palma L, Vargas MR, Pehar M, Mañay N, Beckman JS, Barbeito L, Cassina P.

Neurobiol Dis. 2010 Mar;37(3):574-80. doi: 10.1016/j.nbd.2009.11.007. Epub 2009 Nov 13.


[Biochemical markers in the diagnosis of acute coronary syndrome].

Romić E, Unić A, Derek L, Pehar M.

Acta Med Croatica. 2009 Feb;63(1):15-9. Croatian.


Anti-citrullinated protein antibody and rheumatoid factor in patients with end-stage renal disease.

Romic Z, Unic A, Derek L, Zivkovic M, Marijancevic D, Kes P, Pehar M.

Clin Chem Lab Med. 2009;47(8):959-62. doi: 10.1515/CCLM.2009.217.


Transcriptional profile of primary astrocytes expressing ALS-linked mutant SOD1.

Vargas MR, Pehar M, Díaz-Amarilla PJ, Beckman JS, Barbeito L.

J Neurosci Res. 2008 Dec;86(16):3515-25. doi: 10.1002/jnr.21797.


Mitochondrial dysfunction in SOD1G93A-bearing astrocytes promotes motor neuron degeneration: prevention by mitochondrial-targeted antioxidants.

Cassina P, Cassina A, Pehar M, Castellanos R, Gandelman M, de León A, Robinson KM, Mason RP, Beckman JS, Barbeito L, Radi R.

J Neurosci. 2008 Apr 16;28(16):4115-22. doi: 10.1523/JNEUROSCI.5308-07.2008.


The right atrial thrombus: the sword of Damocles with real risk of massive pulmonary embolism.

Kirin M, Cerić R, Spoljarić M, Pehar M, Cavrić G, Spoljarić IR, Kirin I.

Angiology. 2008 Aug-Sep;59(4):415-20. doi: 10.1177/0003319707306218. Epub 2008 Apr 2.


Nogo receptor antagonizes p75NTR-dependent motor neuron death.

Dupuis L, Pehar M, Cassina P, Rene F, Castellanos R, Rouaux C, Gandelman M, Dimou L, Schwab ME, Loeffler JP, Barbeito L, Gonzalez de Aguilar JL.

Proc Natl Acad Sci U S A. 2008 Jan 15;105(2):740-5. doi: 10.1073/pnas.0703842105. Epub 2008 Jan 8.


Mitochondrial superoxide production and nuclear factor erythroid 2-related factor 2 activation in p75 neurotrophin receptor-induced motor neuron apoptosis.

Pehar M, Vargas MR, Robinson KM, Cassina P, Díaz-Amarilla PJ, Hagen TM, Radi R, Barbeito L, Beckman JS.

J Neurosci. 2007 Jul 18;27(29):7777-85.


Peroxynitrite transforms nerve growth factor into an apoptotic factor for motor neurons.

Pehar M, Vargas MR, Robinson KM, Cassina P, England P, Beckman JS, Alzari PM, Barbeito L.

Free Radic Biol Med. 2006 Dec 1;41(11):1632-44. Epub 2006 Aug 15.


Selective fluorescent imaging of superoxide in vivo using ethidium-based probes.

Robinson KM, Janes MS, Pehar M, Monette JS, Ross MF, Hagen TM, Murphy MP, Beckman JS.

Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15038-43. Epub 2006 Oct 2.


Modulation of p75-dependent motor neuron death by a small non-peptidyl mimetic of the neurotrophin loop 1 domain.

Pehar M, Cassina P, Vargas MR, Xie Y, Beckman JS, Massa SM, Longo FM, Barbeito L.

Eur J Neurosci. 2006 Sep;24(6):1575-80.


Complexity of astrocyte-motor neuron interactions in amyotrophic lateral sclerosis.

Pehar M, Vargas MR, Cassina P, Barbeito AG, Beckman JS, Barbeito L.

Neurodegener Dis. 2005;2(3-4):139-46. Review.


Increased glutathione biosynthesis by Nrf2 activation in astrocytes prevents p75NTR-dependent motor neuron apoptosis.

Vargas MR, Pehar M, Cassina P, Beckman JS, Barbeito L.

J Neurochem. 2006 May;97(3):687-96. Epub 2006 Mar 8.

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