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Items: 1 to 50 of 59


Metformin reduces liver glucose production by inhibition of fructose-1-6-bisphosphatase.

Hunter RW, Hughey CC, Lantier L, Sundelin EI, Peggie M, Zeqiraj E, Sicheri F, Jessen N, Wasserman DH, Sakamoto K.

Nat Med. 2018 Sep;24(9):1395-1406. doi: 10.1038/s41591-018-0159-7. Epub 2018 Aug 27.


DHX15 regulates CMTR1-dependent gene expression and cell proliferation.

Inesta-Vaquera F, Chaugule VK, Galloway A, Chandler L, Rojas-Fernandez A, Weidlich S, Peggie M, Cowling VH.

Life Sci Alliance. 2018 Jun 18;1(3):e201800092. doi: 10.26508/lsa.201800092.


Structure of PINK1 and mechanisms of Parkinson's disease-associated mutations.

Kumar A, Tamjar J, Waddell AD, Woodroof HI, Raimi OG, Shaw AM, Peggie M, Muqit MM, van Aalten DM.

Elife. 2017 Oct 5;6. pii: e29985. doi: 10.7554/eLife.29985.


Interleukin-1 and TRAF6-dependent activation of TAK1 in the absence of TAB2 and TAB3.

Zhang J, Macartney T, Peggie M, Cohen P.

Biochem J. 2017 Jun 26;474(13):2235-2248. doi: 10.1042/BCJ20170288.


Roles of the TRAF6 and Pellino E3 ligases in MyD88 and RANKL signaling.

Strickson S, Emmerich CH, Goh ETH, Zhang J, Kelsall IR, Macartney T, Hastie CJ, Knebel A, Peggie M, Marchesi F, Arthur JSC, Cohen P.

Proc Natl Acad Sci U S A. 2017 Apr 25;114(17):E3481-E3489. doi: 10.1073/pnas.1702367114. Epub 2017 Apr 12.


GFAT1 phosphorylation by AMPK promotes VEGF-induced angiogenesis.

Zibrova D, Vandermoere F, Göransson O, Peggie M, Mariño KV, Knierim A, Spengler K, Weigert C, Viollet B, Morrice NA, Sakamoto K, Heller R.

Biochem J. 2017 Mar 7;474(6):983-1001. doi: 10.1042/BCJ20160980.


mRNA Cap Methylation in Pluripotency and Differentiation.

Grasso L, Suska O, Davidson L, Gonatopoulos-Pournatzis T, Williamson R, Wasmus L, Wiedlich S, Peggie M, Stavridis MP, Cowling VH.

Cell Rep. 2016 Aug 2;16(5):1352-1365. doi: 10.1016/j.celrep.2016.06.089. Epub 2016 Jul 21.


Molecular basis of RNA guanine-7 methyltransferase (RNMT) activation by RAM.

Varshney D, Petit AP, Bueren-Calabuig JA, Jansen C, Fletcher DA, Peggie M, Weidlich S, Scullion P, Pisliakov AV, Cowling VH.

Nucleic Acids Res. 2016 Dec 1;44(21):10423-10436. Epub 2016 Jul 15.


Phosphoproteomic screening identifies Rab GTPases as novel downstream targets of PINK1.

Lai YC, Kondapalli C, Lehneck R, Procter JB, Dill BD, Woodroof HI, Gourlay R, Peggie M, Macartney TJ, Corti O, Corvol JC, Campbell DG, Itzen A, Trost M, Muqit MM.

EMBO J. 2015 Nov 12;34(22):2840-61. doi: 10.15252/embj.201591593. Epub 2015 Oct 15.


Binding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation.

Kazlauskaite A, Martínez-Torres RJ, Wilkie S, Kumar A, Peltier J, Gonzalez A, Johnson C, Zhang J, Hope AG, Peggie M, Trost M, van Aalten DM, Alessi DR, Prescott AR, Knebel A, Walden H, Muqit MM.

EMBO Rep. 2015 Aug;16(8):939-54. doi: 10.15252/embr.201540352. Epub 2015 Jun 25.


Phosphorylation of synaptic vesicle protein 2A at Thr84 by casein kinase 1 family kinases controls the specific retrieval of synaptotagmin-1.

Zhang N, Gordon SL, Fritsch MJ, Esoof N, Campbell DG, Gourlay R, Velupillai S, Macartney T, Peggie M, van Aalten DM, Cousin MA, Alessi DR.

J Neurosci. 2015 Feb 11;35(6):2492-507. doi: 10.1523/JNEUROSCI.4248-14.2015.


Protein kinase IKKβ-catalyzed phosphorylation of IRF5 at Ser462 induces its dimerization and nuclear translocation in myeloid cells.

Lopez-Pelaez M, Lamont DJ, Peggie M, Shpiro N, Gray NS, Cohen P.

Proc Natl Acad Sci U S A. 2014 Dec 9;111(49):17432-7. doi: 10.1073/pnas.1418399111. Epub 2014 Oct 17.


The LKB1-salt-inducible kinase pathway functions as a key gluconeogenic suppressor in the liver.

Patel K, Foretz M, Marion A, Campbell DG, Gourlay R, Boudaba N, Tournier E, Titchenell P, Peggie M, Deak M, Wan M, Kaestner KH, Göransson O, Viollet B, Gray NS, Birnbaum MJ, Sutherland C, Sakamoto K.

Nat Commun. 2014 Aug 4;5:4535. doi: 10.1038/ncomms5535.


An unexpected twist to the activation of IKKβ: TAK1 primes IKKβ for activation by autophosphorylation.

Zhang J, Clark K, Lawrence T, Peggie MW, Cohen P.

Biochem J. 2014 Aug 1;461(3):531-7. doi: 10.1042/BJ20140444.


Phosphorylation of Parkin at Serine65 is essential for activation: elaboration of a Miro1 substrate-based assay of Parkin E3 ligase activity.

Kazlauskaite A, Kelly V, Johnson C, Baillie C, Hastie CJ, Peggie M, Macartney T, Woodroof HI, Alessi DR, Pedrioli PG, Muqit MM.

Open Biol. 2014 Mar 19;4:130213. doi: 10.1098/rsob.130213.


Glucose-6-phosphate-mediated activation of liver glycogen synthase plays a key role in hepatic glycogen synthesis.

von Wilamowitz-Moellendorff A, Hunter RW, García-Rocha M, Kang L, López-Soldado I, Lantier L, Patel K, Peggie MW, Martínez-Pons C, Voss M, Calbó J, Cohen PT, Wasserman DH, Guinovart JJ, Sakamoto K.

Diabetes. 2013 Dec;62(12):4070-82. doi: 10.2337/db13-0880. Epub 2013 Aug 29.


Protein phosphatase 4 is phosphorylated and inactivated by Cdk in response to spindle toxins and interacts with γ-tubulin.

Voss M, Campbell K, Saranzewa N, Campbell DG, Hastie CJ, Peggie MW, Martin-Granados C, Prescott AR, Cohen PT.

Cell Cycle. 2013 Sep 1;12(17):2876-87. doi: 10.4161/cc.25919. Epub 2013 Aug 2.


DEAF1 is a Pellino1-interacting protein required for interferon production by Sendai virus and double-stranded RNA.

Ordureau A, Enesa K, Nanda S, Le Francois B, Peggie M, Prescott A, Albert PR, Cohen P.

J Biol Chem. 2013 Aug 23;288(34):24569-80. doi: 10.1074/jbc.M113.479550. Epub 2013 Jul 11.


Phosphorylation of CRTC3 by the salt-inducible kinases controls the interconversion of classically activated and regulatory macrophages.

Clark K, MacKenzie KF, Petkevicius K, Kristariyanto Y, Zhang J, Choi HG, Peggie M, Plater L, Pedrioli PG, McIver E, Gray NS, Arthur JS, Cohen P.

Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):16986-91. doi: 10.1073/pnas.1215450109. Epub 2012 Oct 2.


Analysis of substrate specificity and cyclin Y binding of PCTAIRE-1 kinase.

Shehata SN, Hunter RW, Ohta E, Peggie MW, Lou HJ, Sicheri F, Zeqiraj E, Turk BE, Sakamoto K.

Cell Signal. 2012 Nov;24(11):2085-94. doi: 10.1016/j.cellsig.2012.06.018. Epub 2012 Jul 11.


The Dac-tag, an affinity tag based on penicillin-binding protein 5.

Lee DW, Peggie M, Deak M, Toth R, Gage ZO, Wood N, Schilde C, Kurz T, Knebel A.

Anal Biochem. 2012 Sep 1;428(1):64-72. doi: 10.1016/j.ab.2012.06.007. Epub 2012 Jun 15.


The ancient drug salicylate directly activates AMP-activated protein kinase.

Hawley SA, Fullerton MD, Ross FA, Schertzer JD, Chevtzoff C, Walker KJ, Peggie MW, Zibrova D, Green KA, Mustard KJ, Kemp BE, Sakamoto K, Steinberg GR, Hardie DG.

Science. 2012 May 18;336(6083):918-22. doi: 10.1126/science.1215327. Epub 2012 Apr 19.


Essential role for IKKβ in production of type 1 interferons by plasmacytoid dendritic cells.

Pauls E, Shpiro N, Peggie M, Young ER, Sorcek RJ, Tan L, Choi HG, Cohen P.

J Biol Chem. 2012 Jun 1;287(23):19216-28. doi: 10.1074/jbc.M112.345405. Epub 2012 Apr 16.


The AMPK-related kinase SIK2 is regulated by cAMP via phosphorylation at Ser358 in adipocytes.

Henriksson E, Jones HA, Patel K, Peggie M, Morrice N, Sakamoto K, Göransson O.

Biochem J. 2012 Jun 15;444(3):503-14. doi: 10.1042/BJ20111932.


Novel cross-talk within the IKK family controls innate immunity.

Clark K, Peggie M, Plater L, Sorcek RJ, Young ER, Madwed JB, Hough J, McIver EG, Cohen P.

Biochem J. 2011 Feb 15;434(1):93-104. doi: 10.1042/BJ20101701.


Allosteric regulation of glycogen synthase controls glycogen synthesis in muscle.

Bouskila M, Hunter RW, Ibrahim AF, Delattre L, Peggie M, van Diepen JA, Voshol PJ, Jensen J, Sakamoto K.

Cell Metab. 2010 Nov 3;12(5):456-66. doi: 10.1016/j.cmet.2010.10.006.


Evidence that glycogen synthase kinase-3 isoforms have distinct substrate preference in the brain.

Soutar MP, Kim WY, Williamson R, Peggie M, Hastie CJ, McLauchlan H, Snider WD, Gordon-Weeks PR, Sutherland C.

J Neurochem. 2010 Nov;115(4):974-83. doi: 10.1111/j.1471-4159.2010.06988.x. Epub 2010 Oct 5.


Ppm1E is an in cellulo AMP-activated protein kinase phosphatase.

Voss M, Paterson J, Kelsall IR, Martín-Granados C, Hastie CJ, Peggie MW, Cohen PT.

Cell Signal. 2011 Jan;23(1):114-24. doi: 10.1016/j.cellsig.2010.08.010. Epub 2010 Aug 27. Erratum in: Cell Signal. 2011 May;23(5):947.


IRAK1-independent pathways required for the interleukin-1-stimulated activation of the Tpl2 catalytic subunit and its dissociation from ABIN2.

Handoyo H, Stafford MJ, McManus E, Baltzis D, Peggie M, Cohen P.

Biochem J. 2009 Oct 23;424(1):109-18. doi: 10.1042/BJ20091271. Retraction in: Biochem J. 2014 Jan 1;457(1):227.


DAZAP1 interacts via its RNA-recognition motifs with the C-termini of other RNA-binding proteins.

Yang HT, Peggie M, Cohen P, Rousseau S.

Biochem Biophys Res Commun. 2009 Mar 13;380(3):705-9. doi: 10.1016/j.bbrc.2009.01.166. Epub 2009 Jan 31.


Identification of the phosphorylation sites on the E3 ubiquitin ligase Pellino that are critical for activation by IRAK1 and IRAK4.

Smith H, Peggie M, Campbell DG, Vandermoere F, Carrick E, Cohen P.

Proc Natl Acad Sci U S A. 2009 Mar 24;106(12):4584-90. doi: 10.1073/pnas.0900774106. Epub 2009 Mar 5.


Proteolysis of the tumour suppressor hDlg in response to osmotic stress is mediated by caspases and independent of phosphorylation.

Iñesta-Vaquera FA, Centeno F, del Reino P, Sabio G, Peggie M, Cuenda A.

FEBS J. 2009 Jan;276(2):387-400. doi: 10.1111/j.1742-4658.2008.06783.x. Epub 2008 Nov 28.


Relative resistance of Cdk5-phosphorylated CRMP2 to dephosphorylation.

Cole AR, Soutar MP, Rembutsu M, van Aalten L, Hastie CJ, McLauchlan H, Peggie M, Balastik M, Lu KP, Sutherland C.

J Biol Chem. 2008 Jun 27;283(26):18227-37. doi: 10.1074/jbc.M801645200. Epub 2008 May 6.


Enhanced binding of TBK1 by an optineurin mutant that causes a familial form of primary open angle glaucoma.

Morton S, Hesson L, Peggie M, Cohen P.

FEBS Lett. 2008 Mar 19;582(6):997-1002. doi: 10.1016/j.febslet.2008.02.047. Epub 2008 Feb 26.


Control of AMPK-related kinases by USP9X and atypical Lys(29)/Lys(33)-linked polyubiquitin chains.

Al-Hakim AK, Zagorska A, Chapman L, Deak M, Peggie M, Alessi DR.

Biochem J. 2008 Apr 15;411(2):249-60. doi: 10.1042/BJ20080067.


Interleukin-1 (IL-1) induces the Lys63-linked polyubiquitination of IL-1 receptor-associated kinase 1 to facilitate NEMO binding and the activation of IkappaBalpha kinase.

Windheim M, Stafford M, Peggie M, Cohen P.

Mol Cell Biol. 2008 Mar;28(5):1783-91. doi: 10.1128/MCB.02380-06. Epub 2008 Jan 7.


The IRAK-catalysed activation of the E3 ligase function of Pellino isoforms induces the Lys63-linked polyubiquitination of IRAK1.

Ordureau A, Smith H, Windheim M, Peggie M, Carrick E, Morrice N, Cohen P.

Biochem J. 2008 Jan 1;409(1):43-52.


Molecular mechanisms involved in the regulation of cytokine production by muramyl dipeptide.

Windheim M, Lang C, Peggie M, Plater LA, Cohen P.

Biochem J. 2007 Jun 1;404(2):179-90. Erratum in: Biochem J. 2008 Feb 1;409(3):789.


TAK1-binding protein 1 is a pseudophosphatase.

Conner SH, Kular G, Peggie M, Shepherd S, Schüttelkopf AW, Cohen P, Van Aalten DM.

Biochem J. 2006 Nov 1;399(3):427-34.


Interleukin-1 stimulated activation of the COT catalytic subunit through the phosphorylation of Thr290 and Ser62.

Stafford MJ, Morrice NA, Peggie MW, Cohen P.

FEBS Lett. 2006 Jul 10;580(16):4010-4. Epub 2006 Jun 15.


Phosphorylation and 14-3-3 binding of Arabidopsis trehalose-phosphate synthase 5 in response to 2-deoxyglucose.

Harthill JE, Meek SE, Morrice N, Peggie MW, Borch J, Wong BH, Mackintosh C.

Plant J. 2006 Jul;47(2):211-23. Epub 2006 Jun 8.


Characterization of the reversible phosphorylation and activation of ERK8.

Klevernic IV, Stafford MJ, Morrice N, Peggie M, Morton S, Cohen P.

Biochem J. 2006 Feb 15;394(Pt 1):365-73.


Chaperoned ubiquitylation--crystal structures of the CHIP U box E3 ubiquitin ligase and a CHIP-Ubc13-Uev1a complex.

Zhang M, Windheim M, Roe SM, Peggie M, Cohen P, Prodromou C, Pearl LH.

Mol Cell. 2005 Nov 23;20(4):525-38.


Nur77 is phosphorylated in cells by RSK in response to mitogenic stimulation.

Wingate AD, Campbell DG, Peggie M, Arthur JS.

Biochem J. 2006 Feb 1;393(Pt 3):715-24.


Nogo-B is a new physiological substrate for MAPKAP-K2.

Rousseau S, Peggie M, Campbell DG, Nebreda AR, Cohen P.

Biochem J. 2005 Oct 15;391(Pt 2):433-40.


MSKs are required for the transcription of the nuclear orphan receptors Nur77, Nurr1 and Nor1 downstream of MAPK signalling.

Darragh J, Soloaga A, Beardmore VA, Wingate AD, Wiggin GR, Peggie M, Arthur JS.

Biochem J. 2005 Sep 15;390(Pt 3):749-59.


The tRNA methylase METTL1 is phosphorylated and inactivated by PKB and RSK in vitro and in cells.

Cartlidge RA, Knebel A, Peggie M, Alexandrov A, Phizicky EM, Cohen P.

EMBO J. 2005 May 4;24(9):1696-705. Epub 2005 Apr 14.


p38gamma regulates the localisation of SAP97 in the cytoskeleton by modulating its interaction with GKAP.

Sabio G, Arthur JS, Kuma Y, Peggie M, Carr J, Murray-Tait V, Centeno F, Goedert M, Morrice NA, Cuenda A.

EMBO J. 2005 Mar 23;24(6):1134-45. Epub 2005 Feb 24.

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