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Items: 35


Aurora A kinase phosphorylates Hec1 to regulate metaphase kinetochore-microtubule dynamics.

DeLuca KF, Meppelink A, Broad AJ, Mick JE, Peersen OB, Pektas S, Lens SMA, DeLuca JG.

J Cell Biol. 2018 Jan 2;217(1):163-177. doi: 10.1083/jcb.201707160. Epub 2017 Nov 29.


Novel function of a dynein light chain in actin assembly during clathrin-mediated endocytosis.

Farrell KB, McDonald S, Lamb AK, Worcester C, Peersen OB, Di Pietro SM.

J Cell Biol. 2017 Aug 7;216(8):2565-2580. doi: 10.1083/jcb.201604123. Epub 2017 Jul 13.


Picornaviral polymerase structure, function, and fidelity modulation.

Peersen OB.

Virus Res. 2017 Apr 15;234:4-20. doi: 10.1016/j.virusres.2017.01.026. Epub 2017 Feb 2. Review.


Poliovirus Polymerase Leu420 Facilitates RNA Recombination and Ribavirin Resistance.

Kempf BJ, Peersen OB, Barton DJ.

J Virol. 2016 Sep 12;90(19):8410-21. doi: 10.1128/JVI.00078-16. Print 2016 Oct 1.


Peptide Synthesis on a Next-Generation DNA Sequencing Platform.

Svensen N, Peersen OB, Jaffrey SR.

Chembiochem. 2016 Sep 2;17(17):1628-35. doi: 10.1002/cbic.201600298. Epub 2016 Jul 6.


ATP Is an Allosteric Inhibitor of Coxsackievirus B3 Polymerase.

Karr JP, Peersen OB.

Biochemistry. 2016 Jul 19;55(28):3995-4002. doi: 10.1021/acs.biochem.6b00467. Epub 2016 Jul 6.


Homology-Based Identification of a Mutation in the Coronavirus RNA-Dependent RNA Polymerase That Confers Resistance to Multiple Mutagens.

Sexton NR, Smith EC, Blanc H, Vignuzzi M, Peersen OB, Denison MR.

J Virol. 2016 Jul 27;90(16):7415-7428. doi: 10.1128/JVI.00080-16. Print 2016 Aug 15.


Design of a Genetically Stable High Fidelity Coxsackievirus B3 Polymerase That Attenuates Virus Growth in Vivo.

McDonald S, Block A, Beaucourt S, Moratorio G, Vignuzzi M, Peersen OB.

J Biol Chem. 2016 Jul 1;291(27):13999-4011. doi: 10.1074/jbc.M116.726596. Epub 2016 May 2.


Strange kinetics of bulk-mediated diffusion on lipid bilayers.

Krapf D, Campagnola G, Nepal K, Peersen OB.

Phys Chem Chem Phys. 2016 May 14;18(18):12633-41. doi: 10.1039/c6cp00937a. Epub 2016 Apr 20.


Superdiffusive motion of membrane-targeting C2 domains.

Campagnola G, Nepal K, Schroder BW, Peersen OB, Krapf D.

Sci Rep. 2015 Dec 7;5:17721. doi: 10.1038/srep17721.


Editorial overview: Virus replication in animals and plants.

Kao CC, Peersen OB.

Curr Opin Virol. 2014 Dec;9:iv-v. doi: 10.1016/j.coviro.2014.10.002. Epub 2014 Oct 30. No abstract available.


Structure-function relationships underlying the replication fidelity of viral RNA-dependent RNA polymerases.

Campagnola G, McDonald S, Beaucourt S, Vignuzzi M, Peersen OB.

J Virol. 2015 Jan;89(1):275-86. doi: 10.1128/JVI.01574-14. Epub 2014 Oct 15.


Distinct conformations of a putative translocation element in poliovirus polymerase.

Sholders AJ, Peersen OB.

J Mol Biol. 2014 Apr 3;426(7):1407-19. doi: 10.1016/j.jmb.2013.12.031. Epub 2014 Jan 12.


Structures of coxsackievirus, rhinovirus, and poliovirus polymerase elongation complexes solved by engineering RNA mediated crystal contacts.

Gong P, Kortus MG, Nix JC, Davis RE, Peersen OB.

PLoS One. 2013 May 8;8(5):e60272. doi: 10.1371/journal.pone.0060272. Print 2013.


Polyprotein context regulates the activity of poliovirus 2CATPase bound to bilayer nanodiscs.

Springer CL, Huntoon HP, Peersen OB.

J Virol. 2013 May;87(10):5994-6004. doi: 10.1128/JVI.03491-12. Epub 2013 Mar 20.


Structural features of a picornavirus polymerase involved in the polyadenylation of viral RNA.

Kempf BJ, Kelly MM, Springer CL, Peersen OB, Barton DJ.

J Virol. 2013 May;87(10):5629-44. doi: 10.1128/JVI.02590-12. Epub 2013 Mar 6.


Coxsackievirus B3 mutator strains are attenuated in vivo.

Gnädig NF, Beaucourt S, Campagnola G, Bordería AV, Sanz-Ramos M, Gong P, Blanc H, Peersen OB, Vignuzzi M.

Proc Natl Acad Sci U S A. 2012 Aug 21;109(34):E2294-303. doi: 10.1073/pnas.1204022109. Epub 2012 Aug 1.


A template RNA entry channel in the fingers domain of the poliovirus polymerase.

Kortus MG, Kempf BJ, Haworth KG, Barton DJ, Peersen OB.

J Mol Biol. 2012 Apr 6;417(4):263-78. doi: 10.1016/j.jmb.2012.01.049. Epub 2012 Feb 1.


Millisecond time-scale folding and unfolding of DNA hairpins using rapid-mixing stopped-flow kinetics.

Nayak RK, Peersen OB, Hall KB, Van Orden A.

J Am Chem Soc. 2012 Feb 8;134(5):2453-6. doi: 10.1021/ja208490w. Epub 2012 Jan 30.


High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors.

Campagnola G, Gong P, Peersen OB.

Antiviral Res. 2011 Sep;91(3):241-51. doi: 10.1016/j.antiviral.2011.06.006. Epub 2011 Jun 21.


Structural basis for active site closure by the poliovirus RNA-dependent RNA polymerase.

Gong P, Peersen OB.

Proc Natl Acad Sci U S A. 2010 Dec 28;107(52):22505-10. doi: 10.1073/pnas.1007626107. Epub 2010 Dec 10.


Poliovirus polymerase residue 5 plays a critical role in elongation complex stability.

Hobdey SE, Kempf BJ, Steil BP, Barton DJ, Peersen OB.

J Virol. 2010 Aug;84(16):8072-84. doi: 10.1128/JVI.02147-09. Epub 2010 Jun 9.


A quantitative stopped-flow fluorescence assay for measuring polymerase elongation rates.

Gong P, Campagnola G, Peersen OB.

Anal Biochem. 2009 Aug 1;391(1):45-55. doi: 10.1016/j.ab.2009.04.035. Epub 2009 May 3.


Analysis of flavivirus NS5 methyltransferase cap binding.

Geiss BJ, Thompson AA, Andrews AJ, Sons RL, Gari HH, Keenan SM, Peersen OB.

J Mol Biol. 2009 Feb 6;385(5):1643-54. doi: 10.1016/j.jmb.2008.11.058. Epub 2008 Dec 11.


A fluorescence polarization-based screening assay for nucleic acid polymerase elongation activity.

Mestas SP, Sholders AJ, Peersen OB.

Anal Biochem. 2007 Jun 15;365(2):194-200. Epub 2007 Apr 2.


Stabilization of poliovirus polymerase by NTP binding and fingers-thumb interactions.

Thompson AA, Albertini RA, Peersen OB.

J Mol Biol. 2007 Mar 9;366(5):1459-74. Epub 2006 Dec 1.


Nucleotide channel of RNA-dependent RNA polymerase used for intermolecular uridylylation of protein primer.

Tellez AB, Crowder S, Spagnolo JF, Thompson AA, Peersen OB, Brutlag DL, Kirkegaard K.

J Mol Biol. 2006 Mar 24;357(2):665-75. Epub 2006 Jan 5.


Structural basis for proteolysis-dependent activation of the poliovirus RNA-dependent RNA polymerase.

Thompson AA, Peersen OB.

EMBO J. 2004 Sep 1;23(17):3462-71. Epub 2004 Aug 12.


Self-association of the yeast nucleosome assembly protein 1.

McBryant SJ, Peersen OB.

Biochemistry. 2004 Aug 17;43(32):10592-9.


Dimeric structure of the Oxytricha nova telomere end-binding protein alpha-subunit bound to ssDNA.

Peersen OB, Ruggles JA, Schultz SC.

Nat Struct Biol. 2002 Mar;9(3):182-7.


Molecular tuning of ion binding to calcium signaling proteins.

Falke JJ, Drake SK, Hazard AL, Peersen OB.

Q Rev Biophys. 1994 Aug;27(3):219-90. Review. No abstract available.


Solid-state NMR approaches for studying membrane protein structure.

Smith SO, Peersen OB.

Annu Rev Biophys Biomol Struct. 1992;21:25-47. Review. No abstract available.


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