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HITTING the Diagnosis: Testing for Heparin-Induced Thrombocytopenia in Cancer Patients.

Fenelus M, Peerschke EIB.

Am J Clin Pathol. 2018 Jul 3;150(2):116-120. doi: 10.1093/ajcp/aqy040.


Is the A-Chain the Engine That Drives the Diversity of C1q Functions? Revisiting Its Unique Structure.

Ghebrehiwet B, Kandov E, Kishore U, Peerschke EIB.

Front Immunol. 2018 Feb 5;9:162. doi: 10.3389/fimmu.2018.00162. eCollection 2018.


The Coags Uncomplicated App: Fulfilling Educational Gaps Around Diagnosis and Laboratory Testing of Coagulation Disorders.

Kessler C, Peerschke EI, Chitlur MB, Kulkarni R, Holot N, Cooper DL.

JMIR Med Educ. 2017 Apr 18;3(1):e6. doi: 10.2196/mededu.6858.


Plasma DNA-based molecular diagnosis, prognostication, and monitoring of patients with EWSR1 fusion-positive sarcomas.

Shukla NN, Patel JA, Magnan H, Zehir A, You D, Tang J, Meng F, Samoila A, Slotkin EK, Ambati SR, Chou AJ, Wexler LH, Meyers PA, Peerschke EI, Viale A, Berger MF, Ladanyi M.

JCO Precis Oncol. 2017;2017. doi: 10.1200/PO.16.00028. Epub 2017 May 23.


Analysis of the Interaction between Globular Head Modules of Human C1q and Its Candidate Receptor gC1qR.

Pednekar L, Pathan AA, Paudyal B, Tsolaki AG, Kaur A, Abozaid SM, Kouser L, Khan HA, Peerschke EI, Shamji MH, Stenbeck G, Ghebrehiwet B, Kishore U.

Front Immunol. 2016 Dec 13;7:567. doi: 10.3389/fimmu.2016.00567. eCollection 2016.


C1q as an autocrine and paracrine regulator of cellular functions.

Ghebrehiwet B, Hosszu KH, Peerschke EI.

Mol Immunol. 2017 Apr;84:26-33. doi: 10.1016/j.molimm.2016.11.003. Epub 2016 Nov 30. Review.


Guideline for Reversal of Antithrombotics in Intracranial Hemorrhage: Executive Summary. A Statement for Healthcare Professionals From the Neurocritical Care Society and the Society of Critical Care Medicine.

Frontera JA, Lewin JJ 3rd, Rabinstein AA, Aisiku IP, Alexandrov AW, Cook AM, Del Zoppo GJ, Kumar M, Peerschke EI, Stiefel MF, Teitelbaum JS, Wartenberg KE, Zerfoss CL.

Crit Care Med. 2016 Dec;44(12):2251-2257. No abstract available.


The complement and contact activation systems: partnership in pathogenesis beyond angioedema.

Ghebrehiwet B, Kaplan AP, Joseph K, Peerschke EI.

Immunol Rev. 2016 Nov;274(1):281-289. doi: 10.1111/imr.12469. Review.


Identification of the gC1qR sites for the HIV-1 viral envelope protein gp41 and the HCV core protein: Implications in viral-specific pathogenesis and therapy.

Pednekar L, Valentino A, Ji Y, Tumma N, Valentino C, Kadoor A, Hosszu KK, Ramadass M, Kew RR, Kishore U, Peerschke EI, Ghebrehiwet B.

Mol Immunol. 2016 Jun;74:18-26. doi: 10.1016/j.molimm.2016.03.016. Epub 2016 Apr 23.


Soluble gC1qR in Blood and Body Fluids: Examination in a Pancreatic Cancer Patient Cohort.

Peerschke EI, Brandwijk RJ, Dembitzer FR, Kinoshita Y, Ghebrehiwet B.

Int J Cancer Res Mol Mech. 2015 Oct;1(3). doi: 10.16966/ijcrmm.110. Epub 2015 Sep 3.


Guideline for Reversal of Antithrombotics in Intracranial Hemorrhage: A Statement for Healthcare Professionals from the Neurocritical Care Society and Society of Critical Care Medicine.

Frontera JA, Lewin JJ 3rd, Rabinstein AA, Aisiku IP, Alexandrov AW, Cook AM, del Zoppo GJ, Kumar MA, Peerschke EI, Stiefel MF, Teitelbaum JS, Wartenberg KE, Zerfoss CL.

Neurocrit Care. 2016 Feb;24(1):6-46. doi: 10.1007/s12028-015-0222-x. Review.


Consensus Guidelines for Practical Competencies in Anatomic Pathology and Laboratory Medicine for the Undifferentiated Graduating Medical Student.

Magid MS, Shah DT, Cambor CL, Conran RM, Lin AY, Peerschke EIB, Pessin MS, Harris IB.

Acad Pathol. 2015 Oct 5;2(4):2374289515605336. doi: 10.1177/2374289515605336. eCollection 2015 Oct-Dec.


Classical complement pathway activation in immune thrombocytopenia purpura: inhibition by a novel C1s inhibitor.

Peerschke EI, Panicker S, Bussel J.

Br J Haematol. 2016 Jun;173(6):942-5. doi: 10.1111/bjh.13648. Epub 2015 Aug 25. No abstract available.


Evaluation of new automated hematopoietic progenitor cell analysis in the clinical management of peripheral blood stem cell collections.

Peerschke EI, Moung C, Pessin MS, Maslak P.

Transfusion. 2015 Aug;55(8):2001-9. doi: 10.1111/trf.13078. Epub 2015 Mar 21.


Reference range determination for whole-blood platelet aggregation using the Multiplate analyzer.

Peerschke EI, Castellone DD, Stroobants AK, Francis J.

Am J Clin Pathol. 2014 Nov;142(5):647-56. doi: 10.1309/AJCPP43SEYCBJLHJ.


Using the hemoglobin content of reticulocytes (RET-He) to evaluate anemia in patients with cancer.

Peerschke EI, Pessin MS, Maslak P.

Am J Clin Pathol. 2014 Oct;142(4):506-12. doi: 10.1309/AJCPCVZ5B0BOYJGN.


cC1qR/CR and gC1qR/p33: observations in cancer.

Peerschke EI, Ghebrehiwet B.

Mol Immunol. 2014 Oct;61(2):100-9. doi: 10.1016/j.molimm.2014.06.011. Epub 2014 Jul 16. Review.


Monocyte Expressed Macromolecular C1 and C1q Receptors as Molecular Sensors of Danger: Implications in SLE.

Ghebrehiwet B, Hosszu KK, Valentino A, Ji Y, Peerschke EI.

Front Immunol. 2014 Jun 26;5:278. doi: 10.3389/fimmu.2014.00278. eCollection 2014. Review.


Soluble gC1qR is an autocrine signal that induces B1R expression on endothelial cells.

Ghebrehiwet B, Ji Y, Valentino A, Pednekar L, Ramadass M, Habiel D, Kew RR, Hosszu KH, Galanakis DK, Kishore U, Peerschke EI.

J Immunol. 2014 Jan 1;192(1):377-84. doi: 10.4049/jimmunol.1302031. Epub 2013 Dec 6.


Purification of C1q receptors and functional analysis.

Ghebrehiwet B, Peerschke EI.

Methods Mol Biol. 2014;1100:319-27. doi: 10.1007/978-1-62703-724-2_26.


Targeting gC1qR domains for therapy against infection and inflammation.

Ghebrehiwet B, Jesty J, Vinayagasundaram R, Vinayagasundaram U, Ji Y, Valentino A, Tumma N, Hosszu KH, Peerschke EI.

Adv Exp Med Biol. 2013;735:97-110. Review.


DC-SIGN, C1q, and gC1qR form a trimolecular receptor complex on the surface of monocyte-derived immature dendritic cells.

Hosszu KK, Valentino A, Vinayagasundaram U, Vinayagasundaram R, Joyce MG, Ji Y, Peerschke EI, Ghebrehiwet B.

Blood. 2012 Aug 9;120(6):1228-36. doi: 10.1182/blood-2011-07-369728. Epub 2012 Jun 13.


gC1qR expression in normal and pathologic human tissues: differential expression in tissues of epithelial and mesenchymal origin.

Dembitzer FR, Kinoshita Y, Burstein D, Phelps RG, Beasley MB, Garcia R, Harpaz N, Jaffer S, Thung SN, Unger PD, Ghebrehiwet B, Peerschke EI.

J Histochem Cytochem. 2012 Jun;60(6):467-74. doi: 10.1369/0022155412440882.


Recommendations for appropriate activated partial thromboplastin time reagent selection and utilization.

Fritsma GA, Dembitzer FR, Randhawa A, Marques MB, Van Cott EM, Adcock-Funk D, Peerschke EI.

Am J Clin Pathol. 2012 Jun;137(6):904-8. doi: 10.1309/AJCP3J1ZKYBFQXJM.


Cell surface expression and function of the macromolecular c1 complex on the surface of human monocytes.

Hosszu KK, Valentino A, Ji Y, Matkovic M, Pednekar L, Rehage N, Tumma N, Peerschke EI, Ghebrehiwet B.

Front Immunol. 2012 Mar 5;3:38. doi: 10.3389/fimmu.2012.00038. eCollection 2012.


The C1q family of proteins: insights into the emerging non-traditional functions.

Ghebrehiwet B, Hosszu KK, Valentino A, Peerschke EI.

Front Immunol. 2012 Apr 5;3. pii: 52.


Structure-function studies using deletion mutants identify domains of gC1qR/p33 as potential therapeutic targets for vascular permeability and inflammation.

Ghebrehiwet B, Jesty J, Xu S, Vinayagasundaram R, Vinayagasundaram U, Ji Y, Valentino A, Hosszu KK, Mathew S, Joseph K, Kaplan AP, Peerschke EI.

Front Immunol. 2011 Nov 1;2. pii: 58.


Reduction of neutrophil activity decreases early microvascular injury after subarachnoid haemorrhage.

Friedrich V, Flores R, Muller A, Bi W, Peerschke EI, Sehba FA.

J Neuroinflammation. 2011 Aug 19;8:103. doi: 10.1186/1742-2094-8-103.


Cross-talk between the complement and the kinin system in vascular permeability.

Bossi F, Peerschke EI, Ghebrehiwet B, Tedesco F.

Immunol Lett. 2011 Oct 30;140(1-2):7-13. doi: 10.1016/j.imlet.2011.06.006. Epub 2011 Jul 6. Review.


Von Willebrand factor assay proficiency testing. The North American Specialized Coagulation Laboratory Association experience.

Chandler WL, Peerschke EI, Castellone DD, Meijer P; NASCOLA Proficiency Testing Committee.

Am J Clin Pathol. 2011 Jun;135(6):862-9. doi: 10.1309/AJCPH5JK4ONENPAE.


Blockade of gC1qR/p33, a receptor for C1q, inhibits adherence of Staphylococcus aureus to the microvascular endothelium.

Sethi S, Herrmann M, Roller J, von Müller L, Peerschke EI, Ghebrehiwet B, Bajric I, Menger MD, Laschke MW.

Microvasc Res. 2011 Jul;82(1):66-72. doi: 10.1016/j.mvr.2011.04.007. Epub 2011 Apr 22.


Lupus anticoagulant testing: performance and practices by north american clinical laboratories.

Dembitzer FR, Ledford Kraemer MR, Meijer P, Peerschke EI.

Am J Clin Pathol. 2010 Nov;134(5):764-73. doi: 10.1309/AJCP4SPPLG5XVIXF.


Screening coagulation testing using the APTT: which reagent to choose?

Dembitzer FR, Suarez Y, Aledort LM, Peerschke EI.

Am J Hematol. 2010 Sep;85(9):726. doi: 10.1002/ajh.21780.


Complement activation on platelets: implications for vascular inflammation and thrombosis.

Peerschke EI, Yin W, Ghebrehiwet B.

Mol Immunol. 2010 Aug;47(13):2170-5. doi: 10.1016/j.molimm.2010.05.009. Epub 2010 Jun 1. Review.


Complement activation on platelets correlates with a decrease in circulating immature platelets in patients with immune thrombocytopenic purpura.

Peerschke EI, Andemariam B, Yin W, Bussel JB.

Br J Haematol. 2010 Feb;148(4):638-45. doi: 10.1111/j.1365-2141.2009.07995.x. Epub 2009 Nov 19.


Role of the receptor for the globular domain of C1q protein in the pathogenesis of hepatitis C virus-related cryoglobulin vascular damage.

Sansonno D, Tucci FA, Ghebrehiwet B, Lauletta G, Peerschke EI, Conteduca V, Russi S, Gatti P, Sansonno L, Dammacco F.

J Immunol. 2009 Nov 1;183(9):6013-20. doi: 10.4049/jimmunol.0902038. Epub 2009 Oct 14.


Novel pathogenic mechanism and therapeutic approaches to angioedema associated with C1 inhibitor deficiency.

Bossi F, Fischetti F, Regoli D, Durigutto P, Frossi B, Gobeil F Jr, Ghebrehiwet B, Peerschke EI, Cicardi M, Tedesco F.

J Allergy Clin Immunol. 2009 Dec;124(6):1303-10.e4. doi: 10.1016/j.jaci.2009.08.007.


Evidence that a C1q/C1qR system regulates monocyte-derived dendritic cell differentiation at the interface of innate and acquired immunity.

Hosszu KK, Santiago-Schwarz F, Peerschke EI, Ghebrehiwet B.

Innate Immun. 2010 Apr;16(2):115-27. doi: 10.1177/1753425909339815. Epub 2009 Aug 26.


Serum complement activation on heterologous platelets is associated with arterial thrombosis in patients with systemic lupus erythematosus and antiphospholipid antibodies.

Peerschke EI, Yin W, Alpert DR, Roubey RA, Salmon JE, Ghebrehiwet B.

Lupus. 2009 May;18(6):530-8. doi: 10.1177/0961203308099974.


2008 ACLPS panel discussion on resident education in clinical pathology.

Luning Prak ET, Young DS, Kamoun M, Nachamkin I, Alexander CB, Spitalnik SL, Peerschke EI, Smith BR.

Am J Clin Pathol. 2009 May;131(5):618-22. doi: 10.1309/AJCPPI03HMYAAEOJ.


Laboratory assessment of factor VIII inhibitor titer: the North American Specialized Coagulation Laboratory Association experience.

Peerschke EI, Castellone DD, Ledford-Kraemer M, Van Cott EM, Meijer P; NASCOLA Proficiency Testing Committee.

Am J Clin Pathol. 2009 Apr;131(4):552-8. doi: 10.1309/AJCPMKP94CODILWS.


Platelet mediated complement activation.

Peerschke EI, Yin W, Ghebrehiwet B.

Adv Exp Med Biol. 2008;632:81-91. Review.


Development of proteomic signatures of platelet activation using surface-enhanced laser desorption/ionization technology in a clinical setting.

Yin W, Czuchlewski D, Peerschke EI.

Am J Clin Pathol. 2008 Jun;129(6):862-9. doi: 10.1309/BC0RXR50KKKWCVHM.


Expression of complement components and inhibitors on platelet microparticles.

Yin W, Ghebrehiwet B, Peerschke EI.

Platelets. 2008 May;19(3):225-33. doi: 10.1080/09537100701777311.


Regulated complement deposition on the surface of human endothelial cells: effect of tobacco smoke and shear stress.

Yin W, Ghebrehiwet B, Weksler B, Peerschke EI.

Thromb Res. 2008;122(2):221-8. doi: 10.1016/j.thromres.2007.11.005. Epub 2007 Dec 31.


Anti-heparin platelet factor 4 antibodies in systemic lupus erythematosus are associated with IgM antiphospholipid antibodies and the antiphospholipid syndrome.

Alpert D, Mandl LA, Erkan D, Yin W, Peerschke EI, Salmon JE.

Ann Rheum Dis. 2008 Mar;67(3):395-401. Epub 2007 Jul 20.


Proposed research training guidelines for residents in laboratory medicine.

Peerschke EI, Agrawal Y, Alexander CB, Bovill E, Laposata M.

Clin Lab Med. 2007 Jun;27(2):241-53; abstract v-vi. Review.


The contribution of gC1qR/p33 in infection and inflammation.

Peerschke EI, Ghebrehiwet B.

Immunobiology. 2007;212(4-5):333-42. Epub 2007 Jan 3.


Examination of platelet function in whole blood under dynamic flow conditions with the cone and plate(let) analyzer: effect of erythrocytosis and thrombocytosis.

Peerschke EI, Silver RT, Weksler BB, Yin W, Bernhardt B, Varon D.

Am J Clin Pathol. 2007 Mar;127(3):422-8.


Classical pathway complement activation on human endothelial cells.

Yin W, Ghebrehiwet B, Weksler B, Peerschke EI.

Mol Immunol. 2007 Mar;44(9):2228-34. Epub 2006 Dec 14.

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