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Coupling of Smoothened to inhibitory G proteins reduces voltage-gated K+ currents in cardiomyocytes and prolongs cardiac action potential duration.

Cheng L, Al-Owais M, Covarrubias ML, Koch WJ, Manning DR, Peers C, Riobo-Del Galdo NA.

J Biol Chem. 2018 Jul 13;293(28):11022-11032. doi: 10.1074/jbc.RA118.001989. Epub 2018 May 25.


Multiple mechanisms mediating carbon monoxide inhibition of the voltage-gated K+ channel Kv1.5.

Al-Owais MM, Hettiarachchi NT, Boyle JP, Scragg JL, Elies J, Dallas ML, Lippiat JD, Steele DS, Peers C.

Cell Death Dis. 2017 Nov 2;8(11):e3163. doi: 10.1038/cddis.2017.568.


TRPA1-FGFR2 binding event is a regulatory oncogenic driver modulated by miRNA-142-3p.

Berrout J, Kyriakopoulou E, Moparthi L, Hogea AS, Berrout L, Ivan C, Lorger M, Boyle J, Peers C, Muench S, Gomez JE, Hu X, Hurst C, Hall T, Umamaheswaran S, Wesley L, Gagea M, Shires M, Manfield I, Knowles MA, Davies S, Suhling K, Gonzalez YT, Carragher N, Macleod K, Abbott NJ, Calin GA, Gamper N, Zygmunt PM, Timsah Z.

Nat Commun. 2017 Oct 16;8(1):947. doi: 10.1038/s41467-017-00983-w.


A key role for peroxynitrite-mediated inhibition of cardiac ERG (Kv11.1) K+ channels in carbon monoxide-induced proarrhythmic early afterdepolarizations.

Al-Owais MM, Hettiarachchi NT, Kirton HM, Hardy ME, Boyle JP, Scragg JL, Steele DS, Peers C.

FASEB J. 2017 Nov;31(11):4845-4854. doi: 10.1096/fj.201700259R. Epub 2017 Jul 25.


Intracellular zinc activates KCNQ channels by reducing their dependence on phosphatidylinositol 4,5-bisphosphate.

Gao H, Boillat A, Huang D, Liang C, Peers C, Gamper N.

Proc Natl Acad Sci U S A. 2017 Aug 1;114(31):E6410-E6419. doi: 10.1073/pnas.1620598114. Epub 2017 Jul 17.


Heme oxygenase-1 derived carbon monoxide suppresses Aβ1-42 toxicity in astrocytes.

Hettiarachchi NT, Boyle JP, Dallas ML, Al-Owais MM, Scragg JL, Peers C.

Cell Death Dis. 2017 Jun 15;8(6):e2884. doi: 10.1038/cddis.2017.276.


What to do after you've received your UKCAT results.

Peers C.

BMJ. 2017 May 5;357:i3868. doi: 10.1136/sbmj.i3868. No abstract available.


Astrocytic transporters in Alzheimer's disease.

Ugbode C, Hu Y, Whalley B, Peers C, Rattray M, Dallas ML.

Biochem J. 2017 Feb 1;474(3):333-355. doi: 10.1042/BCJ20160505. Review.


Resistance of dynamin-related protein 1 oligomers to disassembly impairs mitophagy, resulting in myocardial inflammation and heart failure.

Cahill TJ, Leo V, Kelly M, Stockenhuber A, Kennedy NW, Bao L, Cereghetti GM, Harper AR, Czibik G, Liao C, Bellahcene M, Steeples V, Ghaffari S, Yavari A, Mayer A, Poulton J, Ferguson DJ, Scorrano L, Hettiarachchi NT, Peers C, Boyle J, Hill RB, Simmons A, Watkins H, Dear TN, Ashrafian H.

J Biol Chem. 2016 Dec 2;291(49):25762. No abstract available.


Epac2-Rap1 Signaling Regulates Reactive Oxygen Species Production and Susceptibility to Cardiac Arrhythmias.

Yang Z, Kirton HM, Al-Owais M, Thireau J, Richard S, Peers C, Steele DS.

Antioxid Redox Signal. 2017 Jul 20;27(3):117-132. doi: 10.1089/ars.2015.6485. Epub 2016 Oct 27.


Person-Centered, Physical Activity for Patients with Low Back Pain: Piloting Service Delivery.

Bloxham S, Barter P, Scragg S, Peers C, Jane B, Layden J.

Healthcare (Basel). 2016 May 18;4(2). pii: E28. doi: 10.3390/healthcare4020028.


Redox-Dependent Modulation of T-Type Ca(2+) Channels in Sensory Neurons Contributes to Acute Anti-Nociceptive Effect of Substance P.

Huang D, Huang S, Gao H, Liu Y, Qi J, Chen P, Wang C, Scragg JL, Vakurov A, Peers C, Du X, Zhang H, Gamper N.

Antioxid Redox Signal. 2016 Aug 10;25(5):233-51. doi: 10.1089/ars.2015.6560.


Regulation of the T-type Ca(2+) channel Cav3.2 by hydrogen sulfide: emerging controversies concerning the role of H2 S in nociception.

Elies J, Scragg JL, Boyle JP, Gamper N, Peers C.

J Physiol. 2016 Aug 1;594(15):4119-29. doi: 10.1113/JP270963. Epub 2016 Feb 25. Review.


Modulation of Potassium Channels Inhibits Bunyavirus Infection.

Hover S, King B, Hall B, Loundras EA, Taqi H, Daly J, Dallas M, Peers C, Schnettler E, McKimmie C, Kohl A, Barr JN, Mankouri J.

J Biol Chem. 2016 Feb 12;291(7):3411-22. doi: 10.1074/jbc.M115.692673. Epub 2015 Dec 16.


This volume of Advances in Experimental Medicine and Biology holds the proceedings of the XVIIIth meeting. Introduction.

Peers C, Kumar P, Wyatt C, Gauda E, Nurse C, Prabhakar N.

Adv Exp Med Biol. 2015;860:v-vi. No abstract available.


A homozygous STIM1 mutation impairs store-operated calcium entry and natural killer cell effector function without clinical immunodeficiency.

Parry DA, Holmes TD, Gamper N, El-Sayed W, Hettiarachchi NT, Ahmed M, Cook GP, Logan CV, Johnson CA, Joss S, Peers C, Prescott K, Savic S, Inglehearn CF, Mighell AJ.

J Allergy Clin Immunol. 2016 Mar;137(3):955-7.e8. doi: 10.1016/j.jaci.2015.08.051. Epub 2015 Nov 10. No abstract available.


Acute Oxygen Sensing--Inching Ever Closer to an Elusive Mechanism.

Peers C.

Cell Metab. 2015 Nov 3;22(5):753-4. doi: 10.1016/j.cmet.2015.10.011.


The Golgi apparatus is a functionally distinct Ca2+ store regulated by the PKA and Epac branches of the β1-adrenergic signaling pathway.

Yang Z, Kirton HM, MacDougall DA, Boyle JP, Deuchars J, Frater B, Ponnambalam S, Hardy ME, White E, Calaghan SC, Peers C, Steele DS.

Sci Signal. 2015 Oct 13;8(398):ra101. doi: 10.1126/scisignal.aaa7677.


Resistance of Dynamin-related Protein 1 Oligomers to Disassembly Impairs Mitophagy, Resulting in Myocardial Inflammation and Heart Failure.

Cahill TJ, Leo V, Kelly M, Stockenhuber A, Kennedy NW, Bao L, Cereghetti GM, Harper AR, Czibik G, Liao C, Bellahcene M, Steeples V, Ghaffari S, Yavari A, Mayer A, Poulton J, Ferguson DJ, Scorrano L, Hettiarachchi NT, Peers C, Boyle J, Hill RB, Simmons A, Watkins H, Dear TN, Ashrafian H.

J Biol Chem. 2015 Oct 23;290(43):25907-19. doi: 10.1074/jbc.M115.665695. Epub 2015 Sep 14. Erratum in: J Biol Chem. 2016 Dec 2;291(49):25762.


GAL-021 and GAL-160 are Efficacious in Rat Models of Obstructive and Central Sleep Apnea and Inhibit BKCa in Isolated Rat Carotid Body Glomus Cells.

Dallas ML, Peers C, Golder FJ, Baby S, Gruber R, MacIntyre DE.

Adv Exp Med Biol. 2015;860:361-70. doi: 10.1007/978-3-319-18440-1_41.


Inhibition of T-type Ca2+ Channels by Hydrogen Sulfide.

Elies J, Scragg JL, Dallas ML, Huang D, Huang S, Boyle JP, Gamper N, Peers C.

Adv Exp Med Biol. 2015;860:353-60. doi: 10.1007/978-3-319-18440-1_40.


Heme Oxygenase-1 Influences Apoptosis via CO-mediated Inhibition of K+ Channels.

Al-Owais MM, Dallas ML, Boyle JP, Scragg JL, Peers C.

Adv Exp Med Biol. 2015;860:343-51. doi: 10.1007/978-3-319-18440-1_39.


T-Type Ca2+ Channel Regulation by CO: A Mechanism for Control of Cell Proliferation.

Duckles H, Al-Owais MM, Elies J, Johnson E, Boycott HE, Dallas ML, Porter KE, Boyle JP, Scragg JL, Peers C.

Adv Exp Med Biol. 2015;860:291-300. doi: 10.1007/978-3-319-18440-1_33.


Effect of parasitic infection on dopamine biosynthesis in dopaminergic cells.

Martin HL, Alsaady I, Howell G, Prandovszky E, Peers C, Robinson P, McConkey GA.

Neuroscience. 2015 Oct 15;306:50-62. doi: 10.1016/j.neuroscience.2015.08.005. Epub 2015 Aug 20.


GABAB receptors inhibit low-voltage activated and high-voltage activated Ca(2+) channels in sensory neurons via distinct mechanisms.

Huang D, Huang S, Peers C, Du X, Zhang H, Gamper N.

Biochem Biophys Res Commun. 2015 Sep 18;465(2):188-93. doi: 10.1016/j.bbrc.2015.07.137. Epub 2015 Jul 31.


Reproducing increased dopamine with infection to evaluate the role of parasite-encoded tyrosine hydroxylase activity.

McConkey GA, Peers C, Prandovszky E.

Infect Immun. 2015 Aug;83(8):3334-5. doi: 10.1128/IAI.00605-15. No abstract available.


H2S does not regulate proliferation via T-type Ca2+ channels.

Elies J, Johnson E, Boyle JP, Scragg JL, Peers C.

Biochem Biophys Res Commun. 2015 Jun 12;461(4):659-64. doi: 10.1016/j.bbrc.2015.04.087. Epub 2015 Apr 24.


Protection from neurodegeneration in the 6-hydroxydopamine (6-OHDA) model of Parkinson's with novel 1-hydroxypyridin-2-one metal chelators.

Workman DG, Tsatsanis A, Lewis FW, Boyle JP, Mousadoust M, Hettiarachchi NT, Hunter M, Peers CS, Tétard D, Duce JA.

Metallomics. 2015 May;7(5):867-76. doi: 10.1039/c4mt00326h. Epub 2015 Mar 17.


Novel ways to regulate T-type Ca(2+) channels.

Peers C, Elies J, Gamper N.

Channels (Austin). 2015;9(2):68-9. doi: 10.1080/19336950.2015.1017995. No abstract available.


Hepatitis C virus attenuates mitochondrial lipid β-oxidation by downregulating mitochondrial trifunctional-protein expression.

Amako Y, Munakata T, Kohara M, Siddiqui A, Peers C, Harris M.

J Virol. 2015 Apr;89(8):4092-101. doi: 10.1128/JVI.01653-14. Epub 2015 Feb 11.


Heme oxygenase-1 protects against Alzheimer's amyloid-β(1-42)-induced toxicity via carbon monoxide production.

Hettiarachchi N, Dallas M, Al-Owais M, Griffiths H, Hooper N, Scragg J, Boyle J, Peers C.

Cell Death Dis. 2014 Dec 11;5:e1569. doi: 10.1038/cddis.2014.529.


Oxygen-dependent hydroxylation by FIH regulates the TRPV3 ion channel.

Karttunen S, Duffield M, Scrimgeour NR, Squires L, Lim WL, Dallas ML, Scragg JL, Chicher J, Dave KA, Whitelaw ML, Peers C, Gorman JJ, Gleadle JM, Rychkov GY, Peet DJ.

J Cell Sci. 2015 Jan 15;128(2):225-31. doi: 10.1242/jcs.158451. Epub 2014 Nov 20.


Oxidative modulation of K+ channels in the central nervous system in neurodegenerative diseases and aging.

Peers C, Boyle JP.

Antioxid Redox Signal. 2015 Feb 20;22(6):505-21. doi: 10.1089/ars.2014.6007. Epub 2014 Dec 4. Review.


Hydrogen sulfide inhibits Cav3.2 T-type Ca2+ channels.

Elies J, Scragg JL, Huang S, Dallas ML, Huang D, MacDougall D, Boyle JP, Gamper N, Peers C.

FASEB J. 2014 Dec;28(12):5376-87. doi: 10.1096/fj.14-257113. Epub 2014 Sep 2.


Diverse mechanisms underlying the regulation of ion channels by carbon monoxide.

Peers C, Boyle JP, Scragg JL, Dallas ML, Al-Owais MM, Hettiarachichi NT, Elies J, Johnson E, Gamper N, Steele DS.

Br J Pharmacol. 2015 Mar;172(6):1546-56. doi: 10.1111/bph.12760. Epub 2014 Jul 2. Review.


Heme oxygenase-1 regulates cell proliferation via carbon monoxide-mediated inhibition of T-type Ca2+ channels.

Duckles H, Boycott HE, Al-Owais MM, Elies J, Johnson E, Dallas ML, Porter KE, Giuntini F, Boyle JP, Scragg JL, Peers C.

Pflugers Arch. 2015 Feb;467(2):415-27. doi: 10.1007/s00424-014-1503-5. Epub 2014 Apr 18.


Inhibition of the cardiac Na⁺ channel Nav1.5 by carbon monoxide.

Elies J, Dallas ML, Boyle JP, Scragg JL, Duke A, Steele DS, Peers C.

J Biol Chem. 2014 Jun 6;289(23):16421-9. doi: 10.1074/jbc.M114.569996. Epub 2014 Apr 9.


Gasotransmitter regulation of ion channels: a key step in O2 sensing by the carotid body.

Prabhakar NR, Peers C.

Physiology (Bethesda). 2014 Jan;29(1):49-57. doi: 10.1152/physiol.00034.2013. Review.


Carotid body chemotransduction gets the human touch.

Conde SV, Peers C.

J Physiol. 2013 Dec 15;591(24):6131-2. doi: 10.1113/jphysiol.2013.267625. No abstract available.


Hepatitis C virus NS5A inhibits mixed lineage kinase 3 to block apoptosis.

Amako Y, Igloi Z, Mankouri J, Kazlauskas A, Saksela K, Dallas M, Peers C, Harris M.

J Biol Chem. 2013 Aug 23;288(34):24753-63. doi: 10.1074/jbc.M113.491985. Epub 2013 Jul 15.


Carbon monoxide inhibition of Cav3.2 T-type Ca2+ channels reveals tonic modulation by thioredoxin.

Boycott HE, Dallas ML, Elies J, Pettinger L, Boyle JP, Scragg JL, Gamper N, Peers C.

FASEB J. 2013 Aug;27(8):3395-407. doi: 10.1096/fj.13-227249. Epub 2013 May 13.


Concluding remarks.

Peers C.

Adv Exp Med Biol. 2012;758:397-401. No abstract available.


VennPlex--a novel Venn diagram program for comparing and visualizing datasets with differentially regulated datapoints.

Cai H, Chen H, Yi T, Daimon CM, Boyle JP, Peers C, Maudsley S, Martin B.

PLoS One. 2013;8(1):e53388. doi: 10.1371/journal.pone.0053388. Epub 2013 Jan 7.


Modulation of ion channels and transporters by carbon monoxide: causes for concern?

Peers C.

Front Physiol. 2012 Dec 20;3:477. doi: 10.3389/fphys.2012.00477. eCollection 2012. No abstract available.


Ion channel regulation by the LKB1-AMPK signalling pathway: the key to carotid body activation by hypoxia and metabolic homeostasis at the whole body level.

Evans AM, Peers C, Wyatt CN, Kumar P, Hardie DG.

Adv Exp Med Biol. 2012;758:81-90. doi: 10.1007/978-94-007-4584-1_11. Review.


Foreword. The emergence of carbon monoxide (CO) and hydrogen sulphide (H(2)S) as biologically active gases.

Kumar P, Peers C.

Respir Physiol Neurobiol. 2012 Nov 15;184(2):115-6. doi: 10.1016/j.resp.2012.07.020. Epub 2012 Jul 27. No abstract available.


Carbon monoxide induces cardiac arrhythmia via induction of the late Na+ current.

Dallas ML, Yang Z, Boyle JP, Boycott HE, Scragg JL, Milligan CJ, Elies J, Duke A, Thireau J, Reboul C, Richard S, Bernus O, Steele DS, Peers C.

Am J Respir Crit Care Med. 2012 Oct 1;186(7):648-56. doi: 10.1164/rccm.201204-0688OC. Epub 2012 Jul 19.


Carbon monoxide mediates the anti-apoptotic effects of heme oxygenase-1 in medulloblastoma DAOY cells via K+ channel inhibition.

Al-Owais MM, Scragg JL, Dallas ML, Boycott HE, Warburton P, Chakrabarty A, Boyle JP, Peers C.

J Biol Chem. 2012 Jul 13;287(29):24754-64. doi: 10.1074/jbc.M112.357012. Epub 2012 May 16.


Reactive oxygen species are second messengers of neurokinin signaling in peripheral sensory neurons.

Linley JE, Ooi L, Pettinger L, Kirton H, Boyle JP, Peers C, Gamper N.

Proc Natl Acad Sci U S A. 2012 Jun 12;109(24):E1578-86. doi: 10.1073/pnas.1201544109. Epub 2012 May 14.


Peroxynitrite mediates disruption of Ca2+ homeostasis by carbon monoxide via Ca2+ ATPase degradation.

Hettiarachchi NT, Boyle JP, Bauer CC, Dallas ML, Pearson HA, Hara S, Gamper N, Peers C.

Antioxid Redox Signal. 2012 Sep 1;17(5):744-55. doi: 10.1089/ars.2011.4398. Epub 2012 Apr 5.


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