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IL-33 Is a Cell-Intrinsic Regulator of Fitness during Early B Cell Development.

Stier MT, Mitra R, Nyhoff LE, Goleniewska K, Zhang J, Puccetti MV, Casanova HC, Seegmiller AC, Newcomb DC, Kendall PL, Eischen CM, Peebles RS Jr.

J Immunol. 2019 Sep 15;203(6):1457-1467. doi: 10.4049/jimmunol.1900408. Epub 2019 Aug 7.


The Innate Immune Protein S100A9 Protects from Th2-Mediated Allergic Airway Inflammation.

Palmer LD, Maloney KN, Boyd KL, Goleniewska AK, Toki S, Maxwell CN, Chazin WJ, Peebles RS Jr, Newcomb DC, Skaar EP.

Am J Respir Cell Mol Biol. 2019 Apr 3. doi: 10.1165/rcmb.2018-0217OC. [Epub ahead of print]


Using urine metabolomics to understand the pathogenesis of infant respiratory syncytial virus (RSV) infection and its role in childhood wheezing.

Turi KN, Romick-Rosendale L, Gebretsadik T, Watanabe M, Brunwasser S, Anderson LJ, Moore ML, Larkin EK, Peebles RS Jr, Hartert TV.

Metabolomics. 2018 Oct 1;14(10):135. doi: 10.1007/s11306-018-1431-z.


PPAR-γ in Macrophages Limits Pulmonary Inflammation and Promotes Host Recovery following Respiratory Viral Infection.

Huang S, Zhu B, Cheon IS, Goplen NP, Jiang L, Zhang R, Peebles RS, Mack M, Kaplan MH, Limper AH, Sun J.

J Virol. 2019 Apr 17;93(9). pii: e00030-19. doi: 10.1128/JVI.00030-19. Print 2019 May 1.


Proinflammatory Pathways in the Pathogenesis of Asthma.

Peebles RS Jr, Aronica MA.

Clin Chest Med. 2019 Mar;40(1):29-50. doi: 10.1016/j.ccm.2018.10.014. Review.


Aspirin-Exacerbated Respiratory Disease.

Rusznak M, Peebles RS Jr.

N Engl J Med. 2018 Dec 6;379(23):2280-2281. doi: 10.1056/NEJMc1813469. No abstract available.


Prostaglandin E2 in NSAID-exacerbated respiratory disease: protection against cysteinyl leukotrienes and group 2 innate lymphoid cells.

Rusznak M, Peebles RS Jr.

Curr Opin Allergy Clin Immunol. 2019 Feb;19(1):38-45. doi: 10.1097/ACI.0000000000000498. Review.


Controversies in Allergy: Is Asthma Chronic Obstructive Pulmonary Disease Overlap a Distinct Syndrome That Changes Treatment and Patient Outcomes?

Tashkin DP, Peebles RS Jr.

J Allergy Clin Immunol Pract. 2019 Apr;7(4):1142-1147. doi: 10.1016/j.jaip.2018.10.024. Epub 2018 Nov 14. Review. No abstract available.


Eosinophils Express LTA4 Hydrolase and Synthesize LTB4: Important for Asthma Pathogenesis?

Rusznak M, Peebles RS Jr.

Am J Respir Cell Mol Biol. 2019 Apr;60(4):375-376. doi: 10.1165/rcmb.2018-0367ED. No abstract available.


Host and Viral Determinants of Respiratory Syncytial Virus-induced Airway Mucus.

Stier MT, Peebles RS Jr.

Ann Am Thorac Soc. 2018 Nov;15(Suppl 3):S205-S209. doi: 10.1513/AnnalsATS.201806-380AW.


Human IgE mAbs define variability in commercial Aspergillus extract allergen composition.

Wurth MA, Hadadianpour A, Horvath DJ, Daniel J, Bogdan O, Goleniewska K, Pomés A, Hamilton RG, Peebles RS Jr, Smith SA.

JCI Insight. 2018 Oct 18;3(20). pii: 123387. doi: 10.1172/jci.insight.123387.


PD-1 up-regulation on CD4+ T cells promotes pulmonary fibrosis through STAT3-mediated IL-17A and TGF-β1 production.

Celada LJ, Kropski JA, Herazo-Maya JD, Luo W, Creecy A, Abad AT, Chioma OS, Lee G, Hassell NE, Shaginurova GI, Wang Y, Johnson JE, Kerrigan A, Mason WR, Baughman RP, Ayers GD, Bernard GR, Culver DA, Montgomery CG, Maher TM, Molyneaux PL, Noth I, Mutsaers SE, Prele CM, Peebles RS Jr, Newcomb DC, Kaminski N, Blackwell TS, Van Kaer L, Drake WP.

Sci Transl Med. 2018 Sep 26;10(460). pii: eaar8356. doi: 10.1126/scitranslmed.aar8356.


The Morphology and Assembly of Respiratory Syncytial Virus Revealed by Cryo-Electron Tomography.

Ke Z, Dillard RS, Chirkova T, Leon F, Stobart CC, Hampton CM, Strauss JD, Rajan D, Rostad CA, Taylor JV, Yi H, Shah R, Jin M, Hartert TV, Peebles RS Jr, Graham BS, Moore ML, Anderson LJ, Wright ER.

Viruses. 2018 Aug 20;10(8). pii: E446. doi: 10.3390/v10080446.


Testosterone Decreases House Dust Mite-Induced Type 2 and IL-17A-Mediated Airway Inflammation.

Fuseini H, Yung JA, Cephus JY, Zhang J, Goleniewska K, Polosukhin VV, Peebles RS Jr, Newcomb DC.

J Immunol. 2018 Oct 1;201(7):1843-1854. doi: 10.4049/jimmunol.1800293. Epub 2018 Aug 20.


The PGI2 Analog Cicaprost Inhibits IL-33-Induced Th2 Responses, IL-2 Production, and CD25 Expression in Mouse CD4+ T Cells.

Zhou W, Zhang J, Toki S, Goleniewska K, Johnson MO, Bloodworth MH, Newcomb DC, Peebles RS Jr.

J Immunol. 2018 Oct 1;201(7):1936-1945. doi: 10.4049/jimmunol.1700605. Epub 2018 Aug 20.


Prostaglandins in asthma and allergic diseases.

Peebles RS Jr.

Pharmacol Ther. 2019 Jan;193:1-19. doi: 10.1016/j.pharmthera.2018.08.001. Epub 2018 Aug 3. Review.


Mouse Models of Viral Infection.

Empey KM, Peebles RS Jr, Janssen WJ.

Methods Mol Biol. 2018;1809:395-414. doi: 10.1007/978-1-4939-8570-8_26.


Association of ST2 polymorphisms with atopy, asthma, and leukemia.

Bloodworth MH, Rusznak M, Bastarache L, Wang J, Denny JC, Peebles RS Jr.

J Allergy Clin Immunol. 2018 Sep;142(3):991-993.e3. doi: 10.1016/j.jaci.2018.03.020. Epub 2018 May 19. No abstract available.


Infant Viral Respiratory Infection Nasal Immune-Response Patterns and Their Association with Subsequent Childhood Recurrent Wheeze.

Turi KN, Shankar J, Anderson LJ, Rajan D, Gaston K, Gebretsadik T, Das SR, Stone C, Larkin EK, Rosas-Salazar C, Brunwasser SM, Moore ML, Peebles RS Jr, Hartert TV.

Am J Respir Crit Care Med. 2018 Oct 15;198(8):1064-1073. doi: 10.1164/rccm.201711-2348OC.


Glucagon-like peptide 1 receptor signaling attenuates respiratory syncytial virus-induced type 2 responses and immunopathology.

Bloodworth MH, Rusznak M, Pfister CC, Zhang J, Bastarache L, Calvillo SA, Chappell JD, Boyd KL, Toki S, Newcomb DC, Stier MT, Zhou W, Goleniewska K, Moore ML, Hartert TV, Niswender KD, Peebles RS Jr.

J Allergy Clin Immunol. 2018 Aug;142(2):683-687.e12. doi: 10.1016/j.jaci.2018.01.053. Epub 2018 Apr 17. No abstract available.


Endogenous PGI2 signaling through IP inhibits neutrophilic lung inflammation in LPS-induced acute lung injury mice model.

Toki S, Zhou W, Goleniewska K, Reiss S, Dulek DE, Newcomb DC, Lawson WE, Peebles RS Jr.

Prostaglandins Other Lipid Mediat. 2018 May;136:33-43. doi: 10.1016/j.prostaglandins.2018.04.001. Epub 2018 Apr 13.



Stone CA Jr, Hemler JA, Commins SP, Schuyler AJ, Phillips EJ, Peebles RS Jr, Fahrenholz JM.

J Allergy Clin Immunol. 2018 May;141(5):1957-1958. doi: 10.1016/j.jaci.2017.08.048. Epub 2018 Jan 19. No abstract available.


Glucagon-like peptide 1 signaling inhibits allergen-induced lung IL-33 release and reduces group 2 innate lymphoid cell cytokine production in vivo.

Toki S, Goleniewska K, Reiss S, Zhang J, Bloodworth MH, Stier MT, Zhou W, Newcomb DC, Ware LB, Stanwood GD, Galli A, Boyd KL, Niswender KD, Peebles RS Jr.

J Allergy Clin Immunol. 2018 Nov;142(5):1515-1528.e8. doi: 10.1016/j.jaci.2017.11.043. Epub 2018 Jan 10.


Nasopharyngeal Lactobacillus is associated with a reduced risk of childhood wheezing illnesses following acute respiratory syncytial virus infection in infancy.

Rosas-Salazar C, Shilts MH, Tovchigrechko A, Schobel S, Chappell JD, Larkin EK, Gebretsadik T, Halpin RA, Nelson KE, Moore ML, Anderson LJ, Peebles RS Jr, Das SR, Hartert TV.

J Allergy Clin Immunol. 2018 Nov;142(5):1447-1456.e9. doi: 10.1016/j.jaci.2017.10.049. Epub 2018 Jan 10.


Innate lymphoid cells and allergic disease.

Stier MT, Peebles RS Jr.

Ann Allergy Asthma Immunol. 2017 Dec;119(6):480-488. doi: 10.1016/j.anai.2017.08.290. Review. No abstract available.


IL-33 promotes the egress of group 2 innate lymphoid cells from the bone marrow.

Stier MT, Zhang J, Goleniewska K, Cephus JY, Rusznak M, Wu L, Van Kaer L, Zhou B, Newcomb DC, Peebles RS Jr.

J Exp Med. 2018 Jan 2;215(1):263-281. doi: 10.1084/jem.20170449. Epub 2017 Dec 8.


Testosterone Attenuates Group 2 Innate Lymphoid Cell-Mediated Airway Inflammation.

Cephus JY, Stier MT, Fuseini H, Yung JA, Toki S, Bloodworth MH, Zhou W, Goleniewska K, Zhang J, Garon SL, Hamilton RG, Poloshukin VV, Boyd KL, Peebles RS Jr, Newcomb DC.

Cell Rep. 2017 Nov 28;21(9):2487-2499. doi: 10.1016/j.celrep.2017.10.110.


Advances in mechanisms of allergic disease in 2016.

Rothenberg ME, Saito H, Peebles RS Jr.

J Allergy Clin Immunol. 2017 Dec;140(6):1622-1631. doi: 10.1016/j.jaci.2017.08.029. Epub 2017 Oct 13. Review.


Dietary Manganese Promotes Staphylococcal Infection of the Heart.

Juttukonda LJ, Berends ETM, Zackular JP, Moore JL, Stier MT, Zhang Y, Schmitz JE, Beavers WN, Wijers CD, Gilston BA, Kehl-Fie TE, Atkinson J, Washington MK, Peebles RS, Chazin WJ, Torres VJ, Caprioli RM, Skaar EP.

Cell Host Microbe. 2017 Oct 11;22(4):531-542.e8. doi: 10.1016/j.chom.2017.08.009. Epub 2017 Sep 21.


STAT1 Represses Cytokine-Producing Group 2 and Group 3 Innate Lymphoid Cells during Viral Infection.

Stier MT, Goleniewska K, Cephus JY, Newcomb DC, Sherrill TP, Boyd KL, Bloodworth MH, Moore ML, Chen K, Kolls JK, Peebles RS Jr.

J Immunol. 2017 Jul 15;199(2):510-519. doi: 10.4049/jimmunol.1601984. Epub 2017 Jun 2.


Is IL-1β inhibition the next therapeutic target in asthma?

Peebles RS Jr.

J Allergy Clin Immunol. 2017 Jun;139(6):1788-1789. doi: 10.1016/j.jaci.2017.03.018. Epub 2017 Apr 8. No abstract available.


Management of the Asthma-COPD Overlap Syndrome (ACOS): a Review of the Evidence.

Hines KL, Peebles RS Jr.

Curr Allergy Asthma Rep. 2017 Mar;17(3):15. doi: 10.1007/s11882-017-0683-4. Review.


A signalling cascade of IL-33 to IL-13 regulates metaplasia in the mouse stomach.

Petersen CP, Meyer AR, De Salvo C, Choi E, Schlegel C, Petersen A, Engevik AC, Prasad N, Levy SE, Peebles RS, Pizarro TT, Goldenring JR.

Gut. 2018 May;67(5):805-817. doi: 10.1136/gutjnl-2016-312779. Epub 2017 Feb 14.


Anaphylaxis after zoster vaccine: Implicating alpha-gal allergy as a possible mechanism.

Stone CA Jr, Hemler JA, Commins SP, Schuyler AJ, Phillips EJ, Peebles RS Jr, Fahrenholz JM.

J Allergy Clin Immunol. 2017 May;139(5):1710-1713.e2. doi: 10.1016/j.jaci.2016.10.037. Epub 2016 Dec 14. No abstract available.


Differences in the Nasopharyngeal Microbiome During Acute Respiratory Tract Infection With Human Rhinovirus and Respiratory Syncytial Virus in Infancy.

Rosas-Salazar C, Shilts MH, Tovchigrechko A, Schobel S, Chappell JD, Larkin EK, Shankar J, Yooseph S, Nelson KE, Halpin RA, Moore ML, Anderson LJ, Peebles RS Jr, Das SR, Hartert TV.

J Infect Dis. 2016 Dec 15;214(12):1924-1928.


Prostaglandin I2 Suppresses Proinflammatory Chemokine Expression, CD4 T Cell Activation, and STAT6-Independent Allergic Lung Inflammation.

Zhou W, Zhang J, Goleniewska K, Dulek DE, Toki S, Newcomb DC, Cephus JY, Collins RD, Wu P, Boothby MR, Peebles RS Jr.

J Immunol. 2016 Sep 1;197(5):1577-86. doi: 10.4049/jimmunol.1501063. Epub 2016 Jul 25.


Respiratory Syncytial Virus whole-genome sequencing identifies convergent evolution of sequence duplication in the C-terminus of the G gene.

Schobel SA, Stucker KM, Moore ML, Anderson LJ, Larkin EK, Shankar J, Bera J, Puri V, Shilts MH, Rosas-Salazar C, Halpin RA, Fedorova N, Shrivastava S, Stockwell TB, Peebles RS, Hartert TV, Das SR.

Sci Rep. 2016 May 23;6:26311. doi: 10.1038/srep26311.


Respiratory syncytial virus infection activates IL-13-producing group 2 innate lymphoid cells through thymic stromal lymphopoietin.

Stier MT, Bloodworth MH, Toki S, Newcomb DC, Goleniewska K, Boyd KL, Quitalig M, Hotard AL, Moore ML, Hartert TV, Zhou B, McKenzie AN, Peebles RS Jr.

J Allergy Clin Immunol. 2016 Sep;138(3):814-824.e11. doi: 10.1016/j.jaci.2016.01.050. Epub 2016 Apr 9.


EGFR Interacts with the Fusion Protein of Respiratory Syncytial Virus Strain 2-20 and Mediates Infection and Mucin Expression.

Currier MG, Lee S, Stobart CC, Hotard AL, Villenave R, Meng J, Pretto CD, Shields MD, Nguyen MT, Todd SO, Chi MH, Hammonds J, Krumm SA, Spearman P, Plemper RK, Sakamoto K, Peebles RS Jr, Power UF, Moore ML.

PLoS Pathog. 2016 May 6;12(5):e1005622. doi: 10.1371/journal.ppat.1005622. eCollection 2016 May.


The histone deacetylase inhibitor trichostatin A suppresses murine innate allergic inflammation by blocking group 2 innate lymphoid cell (ILC2) activation.

Toki S, Goleniewska K, Reiss S, Zhou W, Newcomb DC, Bloodworth MH, Stier MT, Boyd KL, Polosukhin VV, Subramaniam S, Peebles RS Jr.

Thorax. 2016 Jul;71(7):633-45. doi: 10.1136/thoraxjnl-2015-207728. Epub 2016 Apr 12.


Cerebral Amyloid Angiopathy Presenting with Synchronous Bilateral Intracerebral Macrohemorrhages.

Shelton JS, Davis LT, Peebles RS, Tillman BF, Mobley BC.

Case Rep Neurol. 2015 Nov 27;7(3):233-7. doi: 10.1159/000442085. eCollection 2015 Sep-Dec.


STAT6 Signaling Attenuates Interleukin-17-Producing γδ T Cells during Acute Klebsiella pneumoniae Infection.

Bloodworth MH, Newcomb DC, Dulek DE, Stier MT, Cephus JY, Zhang J, Goleniewska K, Kolls JK, Peebles RS Jr.

Infect Immun. 2016 Apr 22;84(5):1548-1555. doi: 10.1128/IAI.00646-15. Print 2016 May.


Heat Shock-Related Protein 20 Peptide Decreases Human Airway Constriction Downstream of β2-Adrenergic Receptor.

Banathy A, Cheung-Flynn J, Goleniewska K, Boyd KL, Newcomb DC, Peebles RS Jr, Komalavilas P.

Am J Respir Cell Mol Biol. 2016 Aug;55(2):225-33. doi: 10.1165/rcmb.2015-0139OC.


Prostaglandin I2 Signaling and Inhibition of Group 2 Innate Lymphoid Cell Responses.

Zhou W, Toki S, Zhang J, Goleniewksa K, Newcomb DC, Cephus JY, Dulek DE, Bloodworth MH, Stier MT, Polosuhkin V, Gangula RD, Mallal SA, Broide DH, Peebles RS Jr.

Am J Respir Crit Care Med. 2016 Jan 1;193(1):31-42. doi: 10.1164/rccm.201410-1793OC.


Minimally Invasive Sampling Method Identifies Differences in Taxonomic Richness of Nasal Microbiomes in Young Infants Associated with Mode of Delivery.

Shilts MH, Rosas-Salazar C, Tovchigrechko A, Larkin EK, Torralba M, Akopov A, Halpin R, Peebles RS, Moore ML, Anderson LJ, Nelson KE, Hartert TV, Das SR.

Microb Ecol. 2016 Jan;71(1):233-42. doi: 10.1007/s00248-015-0663-y. Epub 2015 Sep 14.


Estrogen and progesterone decrease let-7f microRNA expression and increase IL-23/IL-23 receptor signaling and IL-17A production in patients with severe asthma.

Newcomb DC, Cephus JY, Boswell MG, Fahrenholz JM, Langley EW, Feldman AS, Zhou W, Dulek DE, Goleniewska K, Woodward KB, Sevin CM, Hamilton RG, Kolls JK, Peebles RS Jr.

J Allergy Clin Immunol. 2015 Oct;136(4):1025-34.e11. doi: 10.1016/j.jaci.2015.05.046. Epub 2015 Aug 1.


Objectives, design and enrollment results from the Infant Susceptibility to Pulmonary Infections and Asthma Following RSV Exposure Study (INSPIRE).

Larkin EK, Gebretsadik T, Moore ML, Anderson LJ, Dupont WD, Chappell JD, Minton PA, Peebles RS Jr, Moore PE, Valet RS, Arnold DH, Rosas-Salazar C, Das SR, Polack FP, Hartert TV; INSPIRE Study.

BMC Pulm Med. 2015 Apr 30;15:45. doi: 10.1186/s12890-015-0040-0.


Interleukin-5 facilitates lung metastasis by modulating the immune microenvironment.

Zaynagetdinov R, Sherrill TP, Gleaves LA, McLoed AG, Saxon JA, Habermann AC, Connelly L, Dulek D, Peebles RS Jr, Fingleton B, Yull FE, Stathopoulos GT, Blackwell TS.

Cancer Res. 2015 Apr 15;75(8):1624-1634. doi: 10.1158/0008-5472.CAN-14-2379. Epub 2015 Feb 17.


TLR4 genotype and environmental LPS mediate RSV bronchiolitis through Th2 polarization.

Caballero MT, Serra ME, Acosta PL, Marzec J, Gibbons L, Salim M, Rodriguez A, Reynaldi A, Garcia A, Bado D, Buchholz UJ, Hijano DR, Coviello S, Newcomb D, Bellabarba M, Ferolla FM, Libster R, Berenstein A, Siniawaski S, Blumetti V, Echavarria M, Pinto L, Lawrence A, Ossorio MF, Grosman A, Mateu CG, Bayle C, Dericco A, Pellegrini M, Igarza I, Repetto HA, Grimaldi LA, Gudapati P, Polack NR, Althabe F, Shi M, Ferrero F, Bergel E, Stein RT, Peebles RS, Boothby M, Kleeberger SR, Polack FP.

J Clin Invest. 2015 Feb;125(2):571-82. doi: 10.1172/JCI75183. Epub 2015 Jan 2.


The role of prostaglandins in allergic lung inflammation and asthma.

Claar D, Hartert TV, Peebles RS Jr.

Expert Rev Respir Med. 2015 Feb;9(1):55-72. doi: 10.1586/17476348.2015.992783. Epub 2014 Dec 26. Review.

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