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One-Pot Radiosynthesis and Biological Evaluation of a Caspase-3 Selective 5-[123,125I]iodo-1,2,3-triazole derived Isatin SPECT Tracer.

Glaser M, Rajkumar V, Diocou S, Gendron T, Yan R, Sin PKB, Sander K, Carroll L, Pedley RB, Aboagye EO, Witney TH, Årstad E.

Sci Rep. 2019 Dec 17;9(1):19299. doi: 10.1038/s41598-019-55992-0.


Vinculins interaction with talin is essential for mammary epithelial differentiation.

Wang P, Wu J, Wood A, Jones M, Pedley R, Li W, Ross RS, Ballestrem C, Gilmore AP, Streuli CH.

Sci Rep. 2019 Dec 5;9(1):18400. doi: 10.1038/s41598-019-54784-w.


Longitudinal Photoacoustic Imaging of the Pharmacodynamic Effect of Vascular Targeted Therapy on Tumors.

Johnson SP, Ogunlade O, Lythgoe MF, Beard P, Pedley RB.

Clin Cancer Res. 2019 Dec 15;25(24):7436-7447. doi: 10.1158/1078-0432.CCR-19-0360. Epub 2019 Sep 24.


Nuclear decoupling is part of a rapid protein-level cellular response to high-intensity mechanical loading.

Gilbert HTJ, Mallikarjun V, Dobre O, Jackson MR, Pedley R, Gilmore AP, Richardson SM, Swift J.

Nat Commun. 2019 Sep 12;10(1):4149. doi: 10.1038/s41467-019-11923-1.


Improving mental health literacy among young people aged 11-15 years in Java, Indonesia: co-development and feasibility testing of a culturally-appropriate, user-centred resource (IMPeTUs) - a study protocol.

Brooks H, Irmansyah I, Lovell K, Savitri I, Utomo B, Prawira B, Iskandar L, Renwick L, Pedley R, Kusumayati A, Bee P.

BMC Health Serv Res. 2019 Jul 12;19(1):484. doi: 10.1186/s12913-019-4328-2.


Testing the psychometric properties of the illness perceptions questionnaire for OCD (IPQ-O).

Pedley R, Berry K, Bee P, Gellatly J, Wearden A.

BMC Psychiatry. 2019 Jul 10;19(1):217. doi: 10.1186/s12888-019-2195-3.


Computational fluid dynamics with imaging of cleared tissue and of in vivo perfusion predicts drug uptake and treatment responses in tumours.

d'Esposito A, Sweeney PW, Ali M, Saleh M, Ramasawmy R, Roberts TA, Agliardi G, Desjardins A, Lythgoe MF, Pedley RB, Shipley R, Walker-Samuel S.

Nat Biomed Eng. 2018 Oct;2(10):773-787. doi: 10.1038/s41551-018-0306-y. Epub 2018 Oct 10.


Illness perceptions in people with obsessive-compulsive disorder; A qualitative study.

Pedley R, Bee P, Wearden A, Berry K.

PLoS One. 2019 Mar 20;14(3):e0213495. doi: 10.1371/journal.pone.0213495. eCollection 2019.


Non-invasive imaging of disrupted protein homeostasis induced by proteasome inhibitor treatment using chemical exchange saturation transfer MRI.

Zhu Y, Ramasawmy R, Johnson SP, Taylor V, Gibb A, Pedley RB, Chattopadhyay N, Lythgoe MF, Golay X, Bradley D, Walker-Samuel S.

Sci Rep. 2018 Oct 10;8(1):15068. doi: 10.1038/s41598-018-33549-x.


Collaborative, individualised lifestyle interventions are acceptable to people with first episode psychosis; a qualitative study.

Pedley R, Lovell K, Bee P, Bradshaw T, Gellatly J, Ward K, Woodham A, Wearden A.

BMC Psychiatry. 2018 Apr 25;18(1):111. doi: 10.1186/s12888-018-1692-0.


Qualitative systematic review of barriers and facilitators to patient-involved antipsychotic prescribing.

Pedley R, McWilliams C, Lovell K, Brooks H, Rushton K, Drake RJ, Rumbold B, Bell V, Bee P.

BJPsych Open. 2018 Jan;4(1):5-14. doi: 10.1192/bjo.2017.5.


A Dual Reporter Iodinated Labeling Reagent for Cancer Positron Emission Tomography Imaging and Fluorescence-Guided Surgery.

Lu Z, Pham TT, Rajkumar V, Yu Z, Pedley RB, Årstad E, Maher J, Yan R.

J Med Chem. 2018 Feb 22;61(4):1636-1645. doi: 10.1021/acs.jmedchem.7b01746. Epub 2018 Feb 6.


Self-care support for children and adolescents with long-term conditions: the REfOCUS evidence synthesis.

Bee P, Pedley R, Rithalia A, Richardson G, Pryjmachuk S, Kirk S, Bower P.

Southampton (UK): NIHR Journals Library; 2018 Jan.


Targeting Multiple Effector Pathways in Pancreatic Ductal Adenocarcinoma with a G-Quadruplex-Binding Small Molecule.

Marchetti C, Zyner KG, Ohnmacht SA, Robson M, Haider SM, Morton JP, Marsico G, Vo T, Laughlin-Toth S, Ahmed AA, Di Vita G, Pazitna I, Gunaratnam M, Besser RJ, Andrade ACG, Diocou S, Pike JA, Tannahill D, Pedley RB, Evans TRJ, Wilson WD, Balasubramanian S, Neidle S.

J Med Chem. 2018 Mar 22;61(6):2500-2517. doi: 10.1021/acs.jmedchem.7b01781. Epub 2018 Feb 7.


Fucoidan Prolongs the Circulation Time of Dextran-Coated Iron Oxide Nanoparticles.

Abdollah MRA, Carter TJ, Jones C, Kalber TL, Rajkumar V, Tolner B, Gruettner C, Zaw-Thin M, Baguña Torres J, Ellis M, Robson M, Pedley RB, Mulholland P, T M de Rosales R, Chester KA.

ACS Nano. 2018 Feb 27;12(2):1156-1169. doi: 10.1021/acsnano.7b06734. Epub 2018 Jan 17.


Investigating Low-Velocity Fluid Flow in Tumors with Convection-MRI.

Walker-Samuel S, Roberts TA, Ramasawmy R, Burrell JS, Johnson SP, Siow BM, Richardson S, Gonçalves MR, Pendse D, Robinson SP, Pedley RB, Lythgoe MF.

Cancer Res. 2018 Apr 1;78(7):1859-1872. doi: 10.1158/0008-5472.CAN-17-1546. Epub 2018 Jan 9.


Separating obsessive-compulsive disorder from the self. A qualitative study of family member perceptions.

Pedley R, Bee P, Berry K, Wearden A.

BMC Psychiatry. 2017 Sep 7;17(1):326. doi: 10.1186/s12888-017-1470-4.


Drug Delivery Strategies for Platinum-Based Chemotherapy.

Browning RJ, Reardon PJT, Parhizkar M, Pedley RB, Edirisinghe M, Knowles JC, Stride E.

ACS Nano. 2017 Sep 26;11(9):8560-8578. doi: 10.1021/acsnano.7b04092. Epub 2017 Aug 31. Review.


Clinical effectiveness, cost-effectiveness and acceptability of low-intensity interventions in the management of obsessive-compulsive disorder: the Obsessive-Compulsive Treatment Efficacy randomised controlled Trial (OCTET).

Lovell K, Bower P, Gellatly J, Byford S, Bee P, McMillan D, Arundel C, Gilbody S, Gega L, Hardy G, Reynolds S, Barkham M, Mottram P, Lidbetter N, Pedley R, Molle J, Peckham E, Knopp-Hoffer J, Price O, Connell J, Heslin M, Foley C, Plummer F, Roberts C.

Health Technol Assess. 2017 Jun;21(37):1-132. doi: 10.3310/hta21370.


Low-intensity cognitive-behaviour therapy interventions for obsessive-compulsive disorder compared to waiting list for therapist-led cognitive-behaviour therapy: 3-arm randomised controlled trial of clinical effectiveness.

Lovell K, Bower P, Gellatly J, Byford S, Bee P, McMillan D, Arundel C, Gilbody S, Gega L, Hardy G, Reynolds S, Barkham M, Mottram P, Lidbetter N, Pedley R, Molle J, Peckham E, Knopp-Hoffer J, Price O, Connell J, Heslin M, Foley C, Plummer F, Roberts C.

PLoS Med. 2017 Jun 27;14(6):e1002337. doi: 10.1371/journal.pmed.1002337. eCollection 2017 Jun.


Electrohydrodynamic fabrication of core-shell PLGA nanoparticles with controlled release of cisplatin for enhanced cancer treatment.

Reardon PJ, Parhizkar M, Harker AH, Browning RJ, Vassileva V, Stride E, Pedley RB, Edirisinghe M, Knowles JC.

Int J Nanomedicine. 2017 May 23;12:3913-3926. doi: 10.2147/IJN.S134833. eCollection 2017.


Tunable Semiconducting Polymer Nanoparticles with INDT-Based Conjugated Polymers for Photoacoustic Molecular Imaging.

Stahl T, Bofinger R, Lam I, Fallon KJ, Johnson P, Ogunlade O, Vassileva V, Pedley RB, Beard PC, Hailes HC, Bronstein H, Tabor AB.

Bioconjug Chem. 2017 Jun 21;28(6):1734-1740. doi: 10.1021/acs.bioconjchem.7b00185. Epub 2017 May 31.


Understanding experiences of and preferences for service user and carer involvement in physical health care discussions within mental health care planning.

Small N, Brooks H, Grundy A, Pedley R, Gibbons C, Lovell K, Bee P.

BMC Psychiatry. 2017 Apr 13;17(1):138. doi: 10.1186/s12888-017-1287-1.


Low intensity interventions for Obsessive-Compulsive Disorder (OCD): a qualitative study of mental health practitioner experiences.

Gellatly J, Pedley R, Molloy C, Butler J, Lovell K, Bee P.

BMC Psychiatry. 2017 Feb 22;17(1):77. doi: 10.1186/s12888-017-1238-x.


Monitoring the Growth of an Orthotopic Tumour Xenograft Model: Multi-Modal Imaging Assessment with Benchtop MRI (1T), High-Field MRI (9.4T), Ultrasound and Bioluminescence.

Ramasawmy R, Johnson SP, Roberts TA, Stuckey DJ, David AL, Pedley RB, Lythgoe MF, Siow B, Walker-Samuel S.

PLoS One. 2016 May 25;11(5):e0156162. doi: 10.1371/journal.pone.0156162. eCollection 2016.


Acute changes in liver tumour perfusion measured non-invasively with arterial spin labelling.

Johnson SP, Ramasawmy R, Campbell-Washburn AE, Wells JA, Robson M, Rajkumar V, Lythgoe MF, Pedley RB, Walker-Samuel S.

Br J Cancer. 2016 Apr 12;114(8):897-904. doi: 10.1038/bjc.2016.51. Epub 2016 Mar 31.


Mitosis and mitochondrial priming for apoptosis.

Pedley R, Gilmore AP.

Biol Chem. 2016 Jul 1;397(7):595-605. doi: 10.1515/hsz-2016-0134. Review.


Hypoxia-induced nitric oxide production and tumour perfusion is inhibited by pegylated arginine deiminase (ADI-PEG20).

Burrows N, Cane G, Robson M, Gaude E, Howat WJ, Szlosarek PW, Pedley RB, Frezza C, Ashcroft M, Maxwell PH.

Sci Rep. 2016 Mar 14;6:22950. doi: 10.1038/srep22950.


Decomposition of spontaneous fluctuations in tumour oxygenation using BOLD MRI and independent component analysis.

Gonçalves MR, Johnson SP, Ramasawmy R, Pedley RB, Lythgoe MF, Walker-Samuel S.

Br J Cancer. 2015 Oct 20;113(8):1168-77. doi: 10.1038/bjc.2015.270. Erratum in: Br J Cancer. 2016 Jun 14;114(12):e13.


Activity of the DNA minor groove cross-linking agent SG2000 (SJG-136) against canine tumours.

Mellinas-Gomez M, Spanswick VJ, Paredes-Moscosso SR, Robson M, Pedley RB, Thurston DE, Baines SJ, Stell A, Hartley JA.

BMC Vet Res. 2015 Aug 19;11:215. doi: 10.1186/s12917-015-0534-2.


A G-quadruplex-binding compound showing anti-tumour activity in an in vivo model for pancreatic cancer.

Ohnmacht SA, Marchetti C, Gunaratnam M, Besser RJ, Haider SM, Di Vita G, Lowe HL, Mellinas-Gomez M, Diocou S, Robson M, Šponer J, Islam B, Pedley RB, Hartley JA, Neidle S.

Sci Rep. 2015 Jun 16;5:11385. doi: 10.1038/srep11385.


Functional native disulfide bridging enables delivery of a potent, stable and targeted antibody-drug conjugate (ADC).

Nunes JP, Morais M, Vassileva V, Robinson E, Rajkumar VS, Smith ME, Pedley RB, Caddick S, Baker JR, Chudasama V.

Chem Commun (Camb). 2015 Jul 7;51(53):10624-7. doi: 10.1039/c5cc03557k. Epub 2015 Jun 5.


Significant Therapeutic Efficacy with Combined Radioimmunotherapy and Cetuximab in Preclinical Models of Colorectal Cancer.

Vassileva V, Rajkumar V, Mazzantini M, Robson M, Badar A, Sharma S, Årstad E, Hochhauser D, Lythgoe MF, Kinghorn J, Boxer GM, Pedley RB.

J Nucl Med. 2015 Aug;56(8):1239-45. doi: 10.2967/jnumed.115.157362. Epub 2015 Jun 4. Erratum in: J Nucl Med. 2015 Nov;56(11):1807. Kinghorn, Jane [added].


Texture analysis of (125)I-A5B7 anti-CEA antibody SPECT differentiates metastatic colorectal cancer model phenotypes and anti-vascular therapy response.

Rajkumar V, Goh V, Siddique M, Robson M, Boxer G, Pedley RB, Cook GJ.

Br J Cancer. 2015 Jun 9;112(12):1882-7. doi: 10.1038/bjc.2015.166. Epub 2015 May 19.


The HELPER programme: HEalthy Living and Prevention of Early Relapse – three exploratory randomised controlled trials of phase-specific interventions in first-episode psychosis.

Marshall M, Barrowclough C, Drake R, Husain N, Lobban F, Lovell K, Wearden A, Bradshaw T, Day C, Fitzsimmons M, Pedley R, Piccuci R, Picken A, Larkin W, Tomenson B, Warburton J, Gregg L.

Southampton (UK): NIHR Journals Library; 2015 Apr.


Hepatic arterial spin labelling MRI: an initial evaluation in mice.

Ramasawmy R, Campbell-Washburn AE, Wells JA, Johnson SP, Pedley RB, Walker-Samuel S, Lythgoe MF.

NMR Biomed. 2015 Feb;28(2):272-80. doi: 10.1002/nbm.3251. Epub 2014 Dec 17.


Prolonging the circulatory retention of SPIONs using dextran sulfate: in vivo tracking achieved by functionalisation with near-infrared dyes.

Abdollah MR, Kalber T, Tolner B, Southern P, Bear JC, Robson M, Pedley RB, Parkin IP, Pankhurst QA, Mulholland P, Chester K.

Faraday Discuss. 2014;175:41-58. doi: 10.1039/c4fd00114a.


Obsessive Compulsive Treatment Efficacy Trial (OCTET) comparing the clinical and cost effectiveness of self-managed therapies: study protocol for a randomised controlled trial.

Gellatly J, Bower P, McMillan D, Roberts C, Byford S, Bee P, Gilbody S, Arundel C, Hardy G, Barkham M, Reynolds S, Gega L, Mottram P, Lidbetter N, Pedley R, Peckham E, Connell J, Molle J, O'Leary N, Lovell K.

Trials. 2014 Jul 10;15:278. doi: 10.1186/1745-6215-15-278.


An exploratory randomized controlled study of a healthy living intervention in early intervention services for psychosis: the INTERvention to encourage ACTivity, improve diet, and reduce weight gain (INTERACT) study.

Lovell K, Wearden A, Bradshaw T, Tomenson B, Pedley R, Davies LM, Husain N, Woodham A, Escott D, Swarbrick CM, Femi-Ajao O, Warburton J, Marshall M.

J Clin Psychiatry. 2014 May;75(5):498-505. doi: 10.4088/JCP.13m08503.


Noninvasive quantification of solid tumor microstructure using VERDICT MRI.

Panagiotaki E, Walker-Samuel S, Siow B, Johnson SP, Rajkumar V, Pedley RB, Lythgoe MF, Alexander DC.

Cancer Res. 2014 Apr 1;74(7):1902-12. doi: 10.1158/0008-5472.CAN-13-2511. Epub 2014 Feb 3.


Improving room layouts for venepuncture, cannulation and ABG equipment on surgical wards.

Pedley R, Whitehouse A, Hammond S.

BMJ Qual Improv Rep. 2014 Feb 7;2(2). pii: u554.w477. doi: 10.1136/bmjquality.u554.w477. eCollection 2014.


Prospects for enhancement of targeted radionuclide therapy of cancer using ultrasound.

Browning RJ, Rajkumar V, Pedley RB, Eckersley RJ, Blower PJ.

J Labelled Comp Radiopharm. 2014 Apr;57(4):279-84. doi: 10.1002/jlcr.3157. Epub 2013 Dec 18. Review.


In vivo imaging of glucose uptake and metabolism in tumors.

Walker-Samuel S, Ramasawmy R, Torrealdea F, Rega M, Rajkumar V, Johnson SP, Richardson S, Gonçalves M, Parkes HG, Arstad E, Thomas DL, Pedley RB, Lythgoe MF, Golay X.

Nat Med. 2013 Aug;19(8):1067-72. doi: 10.1038/nm.3252. Epub 2013 Jul 7.


GC-targeted C8-linked pyrrolobenzodiazepine-biaryl conjugates with femtomolar in vitro cytotoxicity and in vivo antitumor activity in mouse models.

Rahman KM, Jackson PJ, James CH, Basu BP, Hartley JA, de la Fuente M, Schatzlein A, Robson M, Pedley RB, Pepper C, Fox KR, Howard PW, Thurston DE.

J Med Chem. 2013 Apr 11;56(7):2911-35. doi: 10.1021/jm301882a. Epub 2013 Mar 21.


Adrenomedullin haploinsufficiency predisposes to secondary lymphedema.

Nikitenko LL, Shimosawa T, Henderson S, Mäkinen T, Shimosawa H, Qureshi U, Pedley RB, Rees MC, Fujita T, Boshoff C.

J Invest Dermatol. 2013 Jul;133(7):1768-76. doi: 10.1038/jid.2013.47. Epub 2013 Jan 30.


A one-pot three-component radiochemical reaction for rapid assembly of 125I-labeled molecular probes.

Yan R, Sander K, Galante E, Rajkumar V, Badar A, Robson M, El-Emir E, Lythgoe MF, Pedley RB, Årstad E.

J Am Chem Soc. 2013 Jan 16;135(2):703-9. doi: 10.1021/ja307926g. Epub 2013 Jan 7.


A comparative study of PDGFR inhibition with imatinib on radiolabeled antibody targeting and clearance in two pathologically distinct models of colon adenocarcinoma.

Rajkumar VS, Boxer G, Robson M, Muddle J, Papastavrou Y, Pedley RB.

Tumour Biol. 2012 Dec;33(6):2019-29. doi: 10.1007/s13277-012-0461-9. Epub 2012 Jul 26.


Evolving role of mental health nurses in the physical health care of people with serious mental health illness.

Bradshaw T, Pedley R.

Int J Ment Health Nurs. 2012 Jun;21(3):266-73. doi: 10.1111/j.1447-0349.2012.00818.x.


Regulator of G-protein signaling 5 (RGS5) protein: a novel marker of cancer vasculature elicited and sustained by the tumor's proangiogenic microenvironment.

Silini A, Ghilardi C, Figini S, Sangalli F, Fruscio R, Dahse R, Pedley RB, Giavazzi R, Bani M.

Cell Mol Life Sci. 2012 Apr;69(7):1167-78. doi: 10.1007/s00018-011-0862-8. Epub 2011 Dec 1.


Developing a healthy living intervention for people with early psychosis using the Medical Research Council's guidelines on complex interventions: phase 1 of the HELPER - InterACT programme.

Bradshaw T, Wearden A, Marshall M, Warburton J, Husain N, Pedley R, Escott D, Swarbrick C, Lovell K.

Int J Nurs Stud. 2012 Apr;49(4):398-406. doi: 10.1016/j.ijnurstu.2011.10.008. Epub 2011 Nov 1.


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