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Safety and immunogenicity of 15-valent pneumococcal conjugate vaccine (PCV-15) compared to PCV-13 in healthy older adults.

Stacey HL, Rosen J, Peterson JT, Williams-Diaz A, Gakhar V, Sterling TM, Acosta CJ, Nolan KM, Li J, Pedley A, Benner P, Abeygunawardana C, Kosinski M, Smith WJ, Pujar H, Musey LK.

Hum Vaccin Immunother. 2019 Jan 16:1-10. doi: 10.1080/21645515.2018.1532249. [Epub ahead of print]


Microtubule-directed transport of purine metabolons drives their cytosolic transit to mitochondria.

Chan CY, Pedley AM, Kim D, Xia C, Zhuang X, Benkovic SJ.

Proc Natl Acad Sci U S A. 2018 Dec 18;115(51):13009-13014. doi: 10.1073/pnas.1814042115. Epub 2018 Dec 3.


Liver Fat is Associated With Markers of Inflammation and Oxidative Stress in Analysis of Data From the Framingham Heart Study.

Fricker ZP, Pedley A, Massaro JM, Vasan RS, Hoffmann U, Benjamin EJ, Long MT.

Clin Gastroenterol Hepatol. 2018 Nov 23. pii: S1542-3565(18)31280-1. doi: 10.1016/j.cgh.2018.11.037. [Epub ahead of print]


Bezlotoxumab Is Associated With a Reduction in Cumulative Inpatient-Days: Analysis of the Hospitalization Data From the MODIFY I and II Clinical Trials.

Basu A, Prabhu VS, Dorr MB, Golan Y, Dubberke ER, Cornely OA, Heimann SM, Pedley A, Xu R, Hanson ME, Marcella S.

Open Forum Infect Dis. 2018 Nov 15;5(11):ofy218. doi: 10.1093/ofid/ofy218. eCollection 2018 Nov.


Thirty-Day Readmissions in Hospitalized Patients Who Received Bezlotoxumab With Antibacterial Drug Treatment for Clostridium difficile Infection.

Prabhu VS, Cornely OA, Golan Y, Dubberke ER, Heimann SM, Hanson ME, Liao J, Pedley A, Dorr MB, Marcella S.

Clin Infect Dis. 2017 Oct 1;65(7):1218-1221. doi: 10.1093/cid/cix523.


Detecting Purinosome Metabolon Formation with Fluorescence Microscopy.

Pedley AM, Benkovic SJ.

Methods Mol Biol. 2018;1764:279-289. doi: 10.1007/978-1-4939-7759-8_17.


Role of HSP90 in the Regulation of de Novo Purine Biosynthesis.

Pedley AM, Karras GI, Zhang X, Lindquist S, Benkovic SJ.

Biochemistry. 2018 Jun 12;57(23):3217-3221. doi: 10.1021/acs.biochem.8b00140. Epub 2018 Mar 23.


Visceral and Intrahepatic Fat Are Associated with Cardiometabolic Risk Factors Above Other Ectopic Fat Depots: The Framingham Heart Study.

Lee JJ, Pedley A, Hoffmann U, Massaro JM, Levy D, Long MT.

Am J Med. 2018 Jun;131(6):684-692.e12. doi: 10.1016/j.amjmed.2018.02.002. Epub 2018 Mar 5.


A simple clinical model predicts incident hepatic steatosis in a community-based cohort: The Framingham Heart Study.

Long MT, Pedley A, Massaro JM, Hoffmann U, Ma J, Loomba R, Chung RT, Benjamin EJ.

Liver Int. 2018 Aug;38(8):1495-1503. doi: 10.1111/liv.13709. Epub 2018 Mar 12.


Longitudinal Associations of Pericardial and Intrathoracic Fat With Progression of Coronary Artery Calcium (from the Framingham Heart Study).

Lee JJ, Pedley A, Hoffmann U, Massaro JM, O'Donnell CJ, Benjamin EJ, Long MT.

Am J Cardiol. 2018 Jan 15;121(2):162-167. doi: 10.1016/j.amjcard.2017.10.006. Epub 2017 Oct 19.


Selective Inhibition of STAT3 Phosphorylation Using a Nuclear-Targeted Kinase Inhibitor.

Bartolowits MD, Brown W, Ali R, Pedley AM, Chen Q, Harvey KE, Wendt MK, Davisson VJ.

ACS Chem Biol. 2017 Sep 15;12(9):2371-2378. doi: 10.1021/acschembio.7b00341. Epub 2017 Aug 18.


Contralateral routing of signals disrupts monaural level and spectral cues to sound localisation on the horizontal plane.

Pedley AJ, Kitterick PT.

Hear Res. 2017 Sep;353:104-111. doi: 10.1016/j.heares.2017.06.007. Epub 2017 Jun 21.


Prospective, randomized, double-blind, Phase 2 dose-ranging study comparing efficacy and safety of imipenem/cilastatin plus relebactam with imipenem/cilastatin alone in patients with complicated urinary tract infections.

Sims M, Mariyanovski V, McLeroth P, Akers W, Lee YC, Brown ML, Du J, Pedley A, Kartsonis NA, Paschke A.

J Antimicrob Chemother. 2017 Sep 1;72(9):2616-2626. doi: 10.1093/jac/dkx139.


Bezlotoxumab and Recurrent Clostridium difficile Infection.

Wilcox M, Dorr M-B, Pedley A.

N Engl J Med. 2017 Apr 20;376(16):1594-6. doi: 10.1056/NEJMc1702531. No abstract available.


Upper Body Subcutaneous Fat Is Associated with Cardiometabolic Risk Factors.

Lee JJ, Pedley A, Therkelsen KE, Hoffmann U, Massaro JM, Levy D, Long MT.

Am J Med. 2017 Aug;130(8):958-966.e1. doi: 10.1016/j.amjmed.2017.01.044. Epub 2017 Feb 24.


Relation of Iliac Artery Calcium With Adiposity Measures and Peripheral Artery Disease.

Lee JJ, Pedley A, Weinberg I, Britton KA, Massaro JM, Hoffmann U, Manders E, Fox CS, Murabito JM.

Am J Cardiol. 2017 Apr 15;119(8):1217-1223. doi: 10.1016/j.amjcard.2016.12.037. Epub 2017 Jan 25.


Bezlotoxumab for Prevention of Recurrent Clostridium difficile Infection.

Wilcox MH, Gerding DN, Poxton IR, Kelly C, Nathan R, Birch T, Cornely OA, Rahav G, Bouza E, Lee C, Jenkin G, Jensen W, Kim YS, Yoshida J, Gabryelski L, Pedley A, Eves K, Tipping R, Guris D, Kartsonis N, Dorr MB; MODIFY I and MODIFY II Investigators.

N Engl J Med. 2017 Jan 26;376(4):305-317. doi: 10.1056/NEJMoa1602615.


A New View into the Regulation of Purine Metabolism: The Purinosome.

Pedley AM, Benkovic SJ.

Trends Biochem Sci. 2017 Feb;42(2):141-154. doi: 10.1016/j.tibs.2016.09.009. Epub 2016 Oct 28. Review.


Bi-directional analysis between fatty liver and cardiovascular disease risk factors.

Ma J, Hwang SJ, Pedley A, Massaro JM, Hoffmann U, Chung RT, Benjamin EJ, Levy D, Fox CS, Long MT.

J Hepatol. 2017 Feb;66(2):390-397. doi: 10.1016/j.jhep.2016.09.022. Epub 2016 Oct 10.


Association of Changes in Abdominal Fat Quantity and Quality With Incident Cardiovascular Disease Risk Factors.

Lee JJ, Pedley A, Hoffmann U, Massaro JM, Fox CS.

J Am Coll Cardiol. 2016 Oct 4;68(14):1509-21. doi: 10.1016/j.jacc.2016.06.067.


Phase 2, Dose-Ranging Study of Relebactam with Imipenem-Cilastatin in Subjects with Complicated Intra-abdominal Infection.

Lucasti C, Vasile L, Sandesc D, Venskutonis D, McLeroth P, Lala M, Rizk ML, Brown ML, Losada MC, Pedley A, Kartsonis NA, Paschke A.

Antimicrob Agents Chemother. 2016 Sep 23;60(10):6234-43. doi: 10.1128/AAC.00633-16. Print 2016 Oct.


The Association between Non-Invasive Hepatic Fibrosis Markers and Cardiometabolic Risk Factors in the Framingham Heart Study.

Long MT, Pedley A, Massaro JM, Hoffmann U, Fox CS.

PLoS One. 2016 Jun 24;11(6):e0157517. doi: 10.1371/journal.pone.0157517. eCollection 2016.


Thyroid function and cardiovascular disease risk factors in euthyroid adults: a cross-sectional and longitudinal study.

Lee JJ, Pedley A, Marqusee E, Sutherland P, Hoffmann U, Massaro JM, Fox CS.

Clin Endocrinol (Oxf). 2016 Dec;85(6):932-941. doi: 10.1111/cen.13124. Epub 2016 Jul 14.


Adipose Tissue Depots and Their Cross-Sectional Associations With Circulating Biomarkers of Metabolic Regulation.

Lee JJ, Britton KA, Pedley A, Massaro JM, Speliotes EK, Murabito JM, Hoffmann U, Ingram C, Keaney JF Jr, Vasan RS, Fox CS.

J Am Heart Assoc. 2016 May 4;5(5). pii: e002936. doi: 10.1161/JAHA.115.002936.


Development and Validation of the Framingham Steatosis Index to Identify Persons With Hepatic Steatosis.

Long MT, Pedley A, Colantonio LD, Massaro JM, Hoffmann U, Muntner P, Fox CS.

Clin Gastroenterol Hepatol. 2016 Aug;14(8):1172-1180.e2. doi: 10.1016/j.cgh.2016.03.034. Epub 2016 Apr 1.


Cross-Sectional Associations of Computed Tomography (CT)-Derived Adipose Tissue Density and Adipokines: The Framingham Heart Study.

Lee JJ, Pedley A, Hoffmann U, Massaro JM, Keaney JF Jr, Vasan RS, Fox CS.

J Am Heart Assoc. 2016 Feb 29;5(3):e002545. doi: 10.1161/JAHA.115.002545.


Spatial colocalization and functional link of purinosomes with mitochondria.

French JB, Jones SA, Deng H, Pedley AM, Kim D, Chan CY, Hu H, Pugh RJ, Zhao H, Zhang Y, Huang TJ, Fang Y, Zhuang X, Benkovic SJ.

Science. 2016 Feb 12;351(6274):733-7. doi: 10.1126/science.aac6054.


Association Between Prolactin and Incidence of Cardiovascular Risk Factors in the Framingham Heart Study.

Therkelsen KE, Abraham TM, Pedley A, Massaro JM, Sutherland P, Hoffmann U, Fox CS.

J Am Heart Assoc. 2016 Feb 23;5(2). pii: e002640. doi: 10.1161/JAHA.115.002640.


Intramuscular fat and physical performance at the Framingham Heart Study.

Therkelsen KE, Pedley A, Hoffmann U, Fox CS, Murabito JM.

Age (Dordr). 2016 Apr;38(2):31. doi: 10.1007/s11357-016-9893-2. Epub 2016 Feb 22.


Adipose tissue attenuation as a marker of adipose tissue quality: Associations with six-year changes in body weight.

Therkelsen KE, Pedley A, Rosenquist KJ, Hoffmann U, Massaro JM, Murabito JM, Fox CS.

Obesity (Silver Spring). 2016 Feb;24(2):499-505. doi: 10.1002/oby.21337. Epub 2015 Dec 23.


Association between visceral and subcutaneous adipose depots and incident cardiovascular disease risk factors.

Abraham TM, Pedley A, Massaro JM, Hoffmann U, Fox CS.

Circulation. 2015 Oct 27;132(17):1639-47. doi: 10.1161/CIRCULATIONAHA.114.015000. Epub 2015 Aug 20.


The Association Between Subcutaneous Fat Density and the Propensity to Store Fat Viscerally.

Yeoh AJ, Pedley A, Rosenquist KJ, Hoffmann U, Fox CS.

J Clin Endocrinol Metab. 2015 Aug;100(8):E1056-64. doi: 10.1210/jc.2014-4032. Epub 2015 Jun 10.


Hepatic steatosis is associated with lower levels of physical activity measured via accelerometry.

Long MT, Pedley A, Massaro JM, Hoffmann U, Esliger DW, Vasan RS, Fox CS, Murabito JM.

Obesity (Silver Spring). 2015 Jun;23(6):1259-66. doi: 10.1002/oby.21058. Epub 2015 May 9.


Moderate-to-vigorous physical activity with accelerometry is associated with visceral adipose tissue in adults.

Murabito JM, Pedley A, Massaro JM, Vasan RS, Esliger D, Blease SJ, Hoffman U, Fox CS.

J Am Heart Assoc. 2015 Mar 3;4(3):e001379. doi: 10.1161/JAHA.114.001379.


Identification of FAK substrate peptides via colorimetric screening of a one-bead one-peptide combinatorial library.

Witucki LA, Borowicz LS, Pedley AM, Curtis-Fisk J, Kuszpit EG.

J Pept Sci. 2015 Apr;21(4):302-11. doi: 10.1002/psc.2751. Epub 2015 Feb 27.


Purinosome formation as a function of the cell cycle.

Chan CY, Zhao H, Pugh RJ, Pedley AM, French J, Jones SA, Zhuang X, Jinnah H, Huang TJ, Benkovic SJ.

Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):1368-73. doi: 10.1073/pnas.1423009112. Epub 2015 Jan 20.


Quantitative analysis of purine nucleotides indicates that purinosomes increase de novo purine biosynthesis.

Zhao H, Chiaro CR, Zhang L, Smith PB, Chan CY, Pedley AM, Pugh RJ, French JB, Patterson AD, Benkovic SJ.

J Biol Chem. 2015 Mar 13;290(11):6705-13. doi: 10.1074/jbc.M114.628701. Epub 2015 Jan 20.


Fat quality and incident cardiovascular disease, all-cause mortality, and cancer mortality.

Rosenquist KJ, Massaro JM, Pedley A, Long MT, Kreger BE, Vasan RS, Murabito JM, Hoffmann U, Fox CS.

J Clin Endocrinol Metab. 2015 Jan;100(1):227-34. doi: 10.1210/jc.2013-4296.


Association of fat density with subclinical atherosclerosis.

Alvey NJ, Pedley A, Rosenquist KJ, Massaro JM, O'Donnell CJ, Hoffmann U, Fox CS.

J Am Heart Assoc. 2014 Aug 28;3(4). pii: e000788. doi: 10.1161/JAHA.114.000788.


Flexibility of PCNA-protein interface accommodates differential binding partners.

Pedley AM, Lill MA, Davisson VJ.

PLoS One. 2014 Jul 18;9(7):e102481. doi: 10.1371/journal.pone.0102481. eCollection 2014.


Conformational changes involving ammonia tunnel formation and allosteric control in GMP synthetase.

Oliver JC, Gudihal R, Burgner JW, Pedley AM, Zwierko AT, Davisson VJ, Linger RS.

Arch Biochem Biophys. 2014 Mar 1;545:22-32. doi: 10.1016/ Epub 2014 Jan 13.


Visceral and subcutaneous fat quality and cardiometabolic risk.

Rosenquist KJ, Pedley A, Massaro JM, Therkelsen KE, Murabito JM, Hoffmann U, Fox CS.

JACC Cardiovasc Imaging. 2013 Jul;6(7):762-71. doi: 10.1016/j.jcmg.2012.11.021. Epub 2013 May 8.


Intramuscular fat and associations with metabolic risk factors in the Framingham Heart Study.

Therkelsen KE, Pedley A, Speliotes EK, Massaro JM, Murabito J, Hoffmann U, Fox CS.

Arterioscler Thromb Vasc Biol. 2013 Apr;33(4):863-70. doi: 10.1161/ATVBAHA.112.301009. Epub 2013 Jan 24.


Prevalence, distribution, and risk factor correlates of high thoracic periaortic fat in the Framingham Heart Study.

Britton KA, Pedley A, Massaro JM, Corsini EM, Murabito JM, Hoffmann U, Fox CS.

J Am Heart Assoc. 2012 Dec;1(6):e004200. doi: 10.1161/JAHA.112.004200. Epub 2012 Dec 19.


No psychological effect of color context in a low level vision task.

Pedley A, Wade AR.

F1000Res. 2013 Nov 15;2:247. doi: 10.12688/f1000research.2-247.v1. eCollection 2013.


Aminotransferase levels are associated with cardiometabolic risk above and beyond visceral fat and insulin resistance: the Framingham Heart Study.

Porter SA, Pedley A, Massaro JM, Vasan RS, Hoffmann U, Fox CS.

Arterioscler Thromb Vasc Biol. 2013 Jan;33(1):139-46. doi: 10.1161/ATVBAHA.112.300075. Epub 2012 Nov 15.


Association of female reproductive factors with body composition: the Framingham Heart Study.

Trikudanathan S, Pedley A, Massaro JM, Hoffmann U, Seely EW, Murabito JM, Fox CS.

J Clin Endocrinol Metab. 2013 Jan;98(1):236-44. doi: 10.1210/jc.2012-1785. Epub 2012 Oct 23.


The ratio of visceral to subcutaneous fat, a metric of body fat distribution, is a unique correlate of cardiometabolic risk.

Kaess BM, Pedley A, Massaro JM, Murabito J, Hoffmann U, Fox CS.

Diabetologia. 2012 Oct;55(10):2622-2630. doi: 10.1007/s00125-012-2639-5. Epub 2012 Aug 17.


An evidence-based score to detect prevalent peripheral artery disease (PAD).

Duval S, Massaro JM, Jaff MR, Boden WE, Alberts MJ, Califf RM, Eagle KA, D'Agostino RB Sr, Pedley A, Fonarow GC, Murabito JM, Steg PG, Bhatt DL, Hirsch AT; REACH Registry Investigators.

Vasc Med. 2012 Oct;17(5):342-51. doi: 10.1177/1358863X12445102. Epub 2012 Jun 17.


Relation of vascular growth factors with CT-derived measures of body fat distribution: the Framingham Heart Study.

Kaess BM, Pedley A, Massaro JM, Larson MG, Corsini E, Hoffmann U, Smith HM, Sawyer DB, Vasan RS, Fox CS.

J Clin Endocrinol Metab. 2012 Mar;97(3):987-94. doi: 10.1210/jc.2011-2310. Epub 2011 Dec 14.

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