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Items: 47

1.

A general method to quantify ligand-driven oligomerization from fluorescence-based images.

Stoneman MR, Biener G, Ward RJ, Pediani JD, Badu D, Eis A, Popa I, Milligan G, Raicu V.

Nat Methods. 2019 Jun;16(6):493-496. doi: 10.1038/s41592-019-0408-9. Epub 2019 May 20.

PMID:
31110281
2.

Visualization of the activation of the histamine H3 receptor (H3R) using novel fluorescence resonance energy transfer biosensors and their potential application to the study of H3R pharmacology.

Liu Y, Zeng H, Pediani JD, Ward RJ, Chen LY, Wu N, Ma L, Tang M, Yang Y, An S, Guo XX, Hao Q, Xu TR.

FEBS J. 2018 Jun;285(12):2319-2336. doi: 10.1111/febs.14484. Epub 2018 May 13.

3.

Spatial Intensity Distribution Analysis: Studies of G Protein-Coupled Receptor Oligomerisation.

Pediani JD, Ward RJ, Marsango S, Milligan G.

Trends Pharmacol Sci. 2018 Feb;39(2):175-186. doi: 10.1016/j.tips.2017.09.001. Epub 2017 Oct 9. Review.

4.

A Molecular Basis for Selective Antagonist Destabilization of Dopamine D3 Receptor Quaternary Organization.

Marsango S, Caltabiano G, Jiménez-Rosés M, Millan MJ, Pediani JD, Ward RJ, Milligan G.

Sci Rep. 2017 May 18;7(1):2134. doi: 10.1038/s41598-017-02249-3.

5.

Spatial intensity distribution analysis quantifies the extent and regulation of homodimerization of the secretin receptor.

Ward RJ, Pediani JD, Harikumar KG, Miller LJ, Milligan G.

Biochem J. 2017 May 24;474(11):1879-1895. doi: 10.1042/BCJ20170184.

6.

Multiple AMPK activators inhibit l-carnitine uptake in C2C12 skeletal muscle myotubes.

Shaw A, Jeromson S, Watterson KR, Pediani JD, Gallagher IJ, Whalley T, Dreczkowski G, Brooks N, Galloway SD, Hamilton DL.

Am J Physiol Cell Physiol. 2017 Jun 1;312(6):C689-C696. doi: 10.1152/ajpcell.00026.2016. Epub 2017 Mar 15.

7.

Dynamic Regulation of Quaternary Organization of the M1 Muscarinic Receptor by Subtype-selective Antagonist Drugs.

Pediani JD, Ward RJ, Godin AG, Marsango S, Milligan G.

J Biol Chem. 2016 Jun 17;291(25):13132-46. doi: 10.1074/jbc.M115.712562. Epub 2016 Apr 14.

8.

Regulation of oligomeric organization of the serotonin 5-hydroxytryptamine 2C (5-HT2C) receptor observed by spatial intensity distribution analysis.

Ward RJ, Pediani JD, Godin AG, Milligan G.

J Biol Chem. 2015 May 15;290(20):12844-57. doi: 10.1074/jbc.M115.644724. Epub 2015 Mar 30.

9.

Roundabout 1 exists predominantly as a basal dimeric complex and this is unaffected by binding of the ligand Slit2.

Zakrys L, Ward RJ, Pediani JD, Godin AG, Graham GJ, Milligan G.

Biochem J. 2014 Jul 1;461(1):61-73. doi: 10.1042/BJ20140190.

PMID:
24673457
10.

The pharmacology of TUG-891, a potent and selective agonist of the free fatty acid receptor 4 (FFA4/GPR120), demonstrates both potential opportunity and possible challenges to therapeutic agonism.

Hudson BD, Shimpukade B, Mackenzie AE, Butcher AJ, Pediani JD, Christiansen E, Heathcote H, Tobin AB, Ulven T, Milligan G.

Mol Pharmacol. 2013 Nov;84(5):710-25. doi: 10.1124/mol.113.087783. Epub 2013 Aug 26.

11.

Predicting small molecule fluorescent probe localization in living cells using QSAR modeling. 1. Overview and models for probes of structure, properties and function in single cells.

Horobin RW, Rashid-Doubell F, Pediani JD, Milligan G.

Biotech Histochem. 2013 Nov;88(8):440-60. doi: 10.3109/10520295.2013.780634. Epub 2013 Jun 13. Review.

PMID:
23758207
12.

The protein kinase C inhibitor, Ro-31-7459, is a potent activator of ERK and JNK MAP kinases in HUVECs and yet inhibits cyclic AMP-stimulated SOCS-3 gene induction through inactivation of the transcription factor c-Jun.

Wiejak J, Dunlop J, Stoyle C, Lappin G, McIlroy A, Pediani JD, Gao S, Yarwood SJ.

Cell Signal. 2012 Aug;24(8):1690-9. doi: 10.1016/j.cellsig.2012.04.016. Epub 2012 Apr 25.

13.

Novel role for proteinase-activated receptor 2 (PAR2) in membrane trafficking of proteinase-activated receptor 4 (PAR4).

Cunningham MR, McIntosh KA, Pediani JD, Robben J, Cooke AE, Nilsson M, Gould GW, Mundell S, Milligan G, Plevin R.

J Biol Chem. 2012 May 11;287(20):16656-69. doi: 10.1074/jbc.M111.315911. Epub 2012 Mar 12.

14.

Intramolecular fluorescence resonance energy transfer (FRET) sensors of the orexin OX1 and OX2 receptors identify slow kinetics of agonist activation.

Xu TR, Ward RJ, Pediani JD, Milligan G.

J Biol Chem. 2012 Apr 27;287(18):14937-49. doi: 10.1074/jbc.M111.334300. Epub 2012 Mar 2.

15.

Heteromultimerization of cannabinoid CB(1) receptor and orexin OX(1) receptor generates a unique complex in which both protomers are regulated by orexin A.

Ward RJ, Pediani JD, Milligan G.

J Biol Chem. 2011 Oct 28;286(43):37414-28. doi: 10.1074/jbc.M111.287649. Epub 2011 Sep 9.

16.

Developing chemical genetic approaches to explore G protein-coupled receptor function: validation of the use of a receptor activated solely by synthetic ligand (RASSL).

Alvarez-Curto E, Prihandoko R, Tautermann CS, Zwier JM, Pediani JD, Lohse MJ, Hoffmann C, Tobin AB, Milligan G.

Mol Pharmacol. 2011 Dec;80(6):1033-46. doi: 10.1124/mol.111.074674. Epub 2011 Aug 31.

17.
18.

Ligand-induced internalization of the orexin OX(1) and cannabinoid CB(1) receptors assessed via N-terminal SNAP and CLIP-tagging.

Ward RJ, Pediani JD, Milligan G.

Br J Pharmacol. 2011 Mar;162(6):1439-52. doi: 10.1111/j.1476-5381.2010.01156.x.

19.

Applications of fluorescence and bioluminescence resonance energy transfer to drug discovery at G protein coupled receptors.

Alvarez-Curto E, Pediani JD, Milligan G.

Anal Bioanal Chem. 2010 Sep;398(1):167-80. doi: 10.1007/s00216-010-3823-4. Epub 2010 Jun 2. Review.

PMID:
20517598
20.
21.

The role of GPCR dimerisation/oligomerisation in receptor signalling.

Milligan G, Canals M, Pediani JD, Ellis J, Lopez-Gimenez JF.

Ernst Schering Found Symp Proc. 2006;(2):145-61. Review.

PMID:
17703581
22.

Agonist occupancy of a single monomeric element is sufficient to cause internalization of the dimeric beta2-adrenoceptor.

Sartania N, Appelbe S, Pediani JD, Milligan G.

Cell Signal. 2007 Sep;19(9):1928-38. Epub 2007 May 18.

PMID:
17561373
23.

The alpha1b-adrenoceptor exists as a higher-order oligomer: effective oligomerization is required for receptor maturation, surface delivery, and function.

Lopez-Gimenez JF, Canals M, Pediani JD, Milligan G.

Mol Pharmacol. 2007 Apr;71(4):1015-29. Epub 2007 Jan 12.

PMID:
17220353
24.
25.

Oligomeric structure of the alpha1b-adrenoceptor: comparisons with rhodopsin.

Milligan G, Pediani JD, Canals M, Lopez-Gimenez JF.

Vision Res. 2006 Dec;46(27):4434-41. Epub 2006 Sep 26. Review.

26.

Phosphorylation-independent internalisation and desensitisation of the human sphingosine-1-phosphate receptor S1P3.

Rutherford C, Ord-Shrimpton FU, Sands WA, Pediani JD, Benovic JL, McGrath JC, Palmer TM.

Cell Signal. 2005 Aug;17(8):997-1009. Epub 2004 Dec 20.

PMID:
15894172
27.

Beta-arrestin-dependent spontaneous alpha1a-adrenoceptor endocytosis causes intracellular transportation of alpha-blockers via recycling compartments.

Pediani JD, Colston JF, Caldwell D, Milligan G, Daly CJ, McGrath JC.

Mol Pharmacol. 2005 Apr;67(4):992-1004. Epub 2004 Dec 30.

PMID:
15626751
29.

Quantitative imaging in live human cells reveals intracellular alpha(1)-adrenoceptor ligand-binding sites.

Mackenzie JF, Daly CJ, Pediani JD, McGrath JC.

J Pharmacol Exp Ther. 2000 Aug;294(2):434-43.

PMID:
10900216
31.

Importance of agonists in alpha-adrenoceptor classification and localisation of alpha1-adrenoceptors in human prostate.

McGrath JC, Naghadeh MA, Pediani JD, Mackenzie JF, Daly CJ.

Eur Urol. 1999;36 Suppl 1:80-8.

PMID:
10393479
32.

P2Y receptor-mediated Ca2+ signalling in cultured rat aortic smooth muscle cells.

Pediani JD, McGrath JC, Wilson SM.

Br J Pharmacol. 1999 Apr;126(7):1660-6.

33.
34.

Activation of apical P2U purine receptors permits inhibition of adrenaline-evoked cyclic AMP accumulation in cultured equine sweat gland epithelial cells.

Wilson SM, Rakhit S, Murdoch R, Pediani JD, Elder HY, Baines DL, Ko WH, Wong PY.

J Exp Biol. 1996 Oct;199(Pt 10):2153-60.

35.
36.

Calcium-dependent regulation of membrane ion permeability in a cell line derived from the equine sweat gland epithelium.

Wilson SM, Ko WH, Pediani JD, Rakhit S, Nichol JA, Bovell DL.

Comp Biochem Physiol A Physiol. 1995 Jun;111(2):215-21.

PMID:
7788349
37.
38.

The regulation of membrane 125I- and 86Rb+ permeability in a virally transformed cell line (NCL-SG3) derived from the human sweat gland epithelium.

Wilson SM, Whiteford ML, Bovell DL, Pediani JD, Ko WH, Smith GL, Lee CM, Elder HY.

Exp Physiol. 1994 May;79(3):445-59.

39.

Extracellular ATP can activate autonomic signal transduction pathways in cultured equine sweat gland epithelial cells.

Ko WH, O'Dowd JJ, Pediani JD, Bovell DL, Elder HY, Jenkinson DM, Wilson SM.

J Exp Biol. 1994 May;190:239-52.

40.

The effect of removing external sodium upon the cholinergic regulation of potassium permeability in the rat submandibular gland in vitro.

Pediani JD, McEwan PE, Elder HY, Wilson SM.

Comp Biochem Physiol Pharmacol Toxicol Endocrinol. 1994 Feb;107(2):283-8.

PMID:
7749595
41.

Investigation of stimulus-secretion coupling in equine sweat gland epithelia using cell culture techniques.

Wilson SM, Pediani JD, Ko WH, Bovell DL, Kitson S, Montgomery I, Brown UM, Smith GL, Elder HY, Jenkinson DM.

J Exp Biol. 1993 Oct;183:279-99.

42.

Amiloride impairs the cholinergic regulation of potassium permeability in the human sweat gland but not in the rat submandibular gland.

Wilson SM, Pediani JD, Jenkinson DM, Elder HY.

Experientia. 1992 Dec 1;48(11-12):1115-7.

PMID:
1473575
43.

The cholinergic regulation of potassium (86Rb+) permeability in sweat glands isolated from patients with cystic fibrosis.

Wilson SM, Pediani JD, Cockburn F, Bovell DL, Jenkinson DM, Paton JY, Coutts J, Davidson R, Lambert J, Morris G, et al.

Exp Physiol. 1991 Jul;76(4):573-8.

44.

Localisation of calcium ions and calcium-ATPase activity within myelinated nerve fibres of the adult guinea-pig optic nerve.

Maxwell WL, Watt C, Pediani JD, Graham DI, Adams JH, Gennarelli TA.

J Anat. 1991 Jun;176:71-9.

45.

The role of potassium and other ions in the control of aldosterone synthesis.

Kenyon CJ, Shepherd RM, Fraser R, Pediani JD, Elder HY.

Endocr Res. 1991;17(1-2):225-36.

PMID:
1652431
46.

The effects of removing external sodium upon the control of potassium (86Rb+) permeability in the isolated human sweat gland.

Wilson SM, Bovell DL, Elder HY, Jenkinson DM, Pediani JD.

Exp Physiol. 1990 Sep;75(5):649-56.

47.

Potassium (86Rb+) efflux from the rat submandibular gland under sodium-free conditions in vitro.

Bovell DL, Elder HY, Pediani JD, Wilson SM.

J Physiol. 1989 Sep;416:503-15.

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