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The γ-hydroxybutyric acid (GHB) analogue NCS-382 is a substrate for both monocarboxylate transporters subtypes 1 and 4.

Thiesen L, Belew ZM, Griem-Krey N, Pedersen SF, Crocoll C, Nour-Eldin HH, Wellendorph P.

Eur J Pharm Sci. 2020 Feb 15;143:105203. doi: 10.1016/j.ejps.2019.105203. Epub 2019 Dec 20.


Annual Meeting of the International Society of Cancer Metabolism (ISCaM): Metabolic Adaptations and Targets in Cancer.

Avnet S, Baldini N, Brisson L, Pedersen SF, Porporato PE, Sonveaux P, Szabadkai G, Pastorekova S.

Front Oncol. 2019 Nov 28;9:1332. doi: 10.3389/fonc.2019.01332. eCollection 2019. Review.


3D multicellular models to study the regulation and roles of acid-base transporters in breast cancer.

Czaplinska D, Elingaard-Larsen LO, Rolver MG, Severin M, Pedersen SF.

Biochem Soc Trans. 2019 Dec 20;47(6):1689-1700. doi: 10.1042/BST20190131.


The Acidic Tumor Microenvironment as a Driver of Cancer.

Boedtkjer E, Pedersen SF.

Annu Rev Physiol. 2019 Nov 15. doi: 10.1146/annurev-physiol-021119-034627. [Epub ahead of print]


The SLC9A-C Mammalian Na+/H+ Exchanger Family: Molecules, Mechanisms, and Physiology.

Pedersen SF, Counillon L.

Physiol Rev. 2019 Oct 1;99(4):2015-2113. doi: 10.1152/physrev.00028.2018. Review.


Effects of oxygen-glucose deprivation (OGD) on barrier properties and mRNA transcript levels of selected marker proteins in brain endothelial cells/astrocyte co-cultures.

Tornabene E, Helms HCC, Pedersen SF, Brodin B.

PLoS One. 2019 Aug 19;14(8):e0221103. doi: 10.1371/journal.pone.0221103. eCollection 2019.


Molecular basis for the binding and selective dephosphorylation of Na+/H+ exchanger 1 by calcineurin.

Hendus-Altenburger R, Wang X, Sjøgaard-Frich LM, Pedraz-Cuesta E, Sheftic SR, Bendsøe AH, Page R, Kragelund BB, Pedersen SF, Peti W.

Nat Commun. 2019 Aug 2;10(1):3489. doi: 10.1038/s41467-019-11391-7.


Perigraft seroma penetrating the aortic sac and rupturing into the intraperitoneal cavity.

Broda M, Budtz-Lilly J, Vammen S, Pedersen SF.

J Vasc Surg Cases Innov Tech. 2019 Jun 29;5(3):298-301. doi: 10.1016/j.jvscit.2019.03.020. eCollection 2019 Sep.


Assessing Cell Viability and Death in 3D Spheroid Cultures of Cancer Cells.

Rolver MG, Elingaard-Larsen LO, Pedersen SF.

J Vis Exp. 2019 Jun 16;(148). doi: 10.3791/59714.


18F-FDG PET/MR-imaging in a Göttingen Minipig model of atherosclerosis: Correlations with histology and quantitative gene expression.

Ludvigsen TP, Pedersen SF, Vegge A, Ripa RS, Johannesen HH, Hansen AE, Löfgren J, Schumacher-Petersen C, Kirk RK, Pedersen HD, Christoffersen BØ, Ørbæk M, Forman JL, Klausen TL, Olsen LH, Kjaer A.

Atherosclerosis. 2019 Jun;285:55-63. doi: 10.1016/j.atherosclerosis.2019.04.209. Epub 2019 Apr 9.


Profibrotic epithelial phenotype: a central role for MRTF and TAZ.

Bialik JF, Ding M, Speight P, Dan Q, Miranda MZ, Di Ciano-Oliveira C, Kofler MM, Rotstein OD, Pedersen SF, Szászi K, Kapus A.

Sci Rep. 2019 Mar 13;9(1):4323. doi: 10.1038/s41598-019-40764-7.


Validation of contrast enhanced cine steady-state free precession and T2-weighted CMR for assessment of ischemic myocardial area-at-risk in the presence of reperfusion injury.

Hansen ESS, Pedersen SF, Pedersen SB, Bøtker HE, Kim WY.

Int J Cardiovasc Imaging. 2019 Jun;35(6):1039-1045. doi: 10.1007/s10554-019-01569-x. Epub 2019 Mar 9.


HER2 and p95HER2 differentially regulate miRNA expression in MCF-7 breast cancer cells and downregulate MYB proteins through miR-221/222 and miR-503.

Gorbatenko A, Søkilde R, Sorensen EE, Newie I, Persson H, Morancho B, Arribas J, Litman T, Rovira C, Pedersen SF.

Sci Rep. 2019 Mar 4;9(1):3352. doi: 10.1038/s41598-019-39733-x.


The Na+ /H+ exchanger NHE1 localizes as clusters to cryptic lamellipodia and accelerates collective epithelial cell migration.

Jensen HH, Pedersen GA, Morgen JJ, Parsons M, Pedersen SF, Nejsum LN.

J Physiol. 2019 Feb;597(3):849-867. doi: 10.1113/JP277383. Epub 2018 Dec 17.


Na+,HCO3--cotransporter NBCn1 (Slc4a7) accelerates ErbB2-induced breast cancer development and tumor growth in mice.

Lee S, Axelsen TV, Jessen N, Pedersen SF, Vahl P, Boedtkjer E.

Oncogene. 2018 Oct;37(41):5569-5584. doi: 10.1038/s41388-018-0353-6. Epub 2018 Jun 15.


The acid-base transport proteins NHE1 and NBCn1 regulate cell cycle progression in human breast cancer cells.

Flinck M, Kramer SH, Schnipper J, Andersen AP, Pedersen SF.

Cell Cycle. 2018;17(9):1056-1067. doi: 10.1080/15384101.2018.1464850. Epub 2018 Jul 13.


Trafficking, localization and degradation of the Na+,HCO3- co-transporter NBCn1 in kidney and breast epithelial cells.

Olesen CW, Vogensen J, Axholm I, Severin M, Schnipper J, Pedersen IS, von Stemann JH, Schrøder JM, Christensen DP, Pedersen SF.

Sci Rep. 2018 May 9;8(1):7435. doi: 10.1038/s41598-018-25059-7.


Roles of pH in control of cell proliferation.

Flinck M, Kramer SH, Pedersen SF.

Acta Physiol (Oxf). 2018 Jul;223(3):e13068. doi: 10.1111/apha.13068. Epub 2018 Apr 16. Review.


The net acid extruders NHE1, NBCn1 and MCT4 promote mammary tumor growth through distinct but overlapping mechanisms.

Andersen AP, Samsøe-Petersen J, Oernbo EK, Boedtkjer E, Moreira JMA, Kveiborg M, Pedersen SF.

Int J Cancer. 2018 Jun 15;142(12):2529-2542. doi: 10.1002/ijc.31276. Epub 2018 Feb 7.


MCT1 and MCT4 Expression and Lactate Flux Activity Increase During White and Brown Adipogenesis and Impact Adipocyte Metabolism.

Petersen C, Nielsen MD, Andersen ES, Basse AL, Isidor MS, Markussen LK, Viuff BM, Lambert IH, Hansen JB, Pedersen SF.

Sci Rep. 2017 Oct 12;7(1):13101. doi: 10.1038/s41598-017-13298-z.


Tumor microenvironment conditions alter Akt and Na+/H+ exchanger NHE1 expression in endothelial cells more than hypoxia alone: implications for endothelial cell function in cancer.

Pedersen AK, Mendes Lopes de Melo J, Mørup N, Tritsaris K, Pedersen SF.

BMC Cancer. 2017 Aug 14;17(1):542. doi: 10.1186/s12885-017-3532-x.


TGF-β1 regulates the expression and transcriptional activity of TAZ protein via a Smad3-independent, myocardin-related transcription factor-mediated mechanism.

Miranda MZ, Bialik JF, Speight P, Dan Q, Yeung T, Szászi K, Pedersen SF, Kapus A.

J Biol Chem. 2017 Sep 8;292(36):14902-14920. doi: 10.1074/jbc.M117.780502. Epub 2017 Jul 24.


Annual Meeting of the International Society of Cancer Metabolism (ISCaM): Metabolic Networks in Cancer.

Baldini N, De Milito A, Feron O, Gillies RJ, Michiels C, Otto AM, Pastoreková S, Pedersen SF, Porporato PE, Sonveaux P, Supuran CT, Avnet S.

Front Pharmacol. 2017 Jul 4;8:411. doi: 10.3389/fphar.2017.00411. eCollection 2017.


A phosphorylation-motif for tuneable helix stabilisation in intrinsically disordered proteins - Lessons from the sodium proton exchanger 1 (NHE1).

Hendus-Altenburger R, Lambrughi M, Terkelsen T, Pedersen SF, Papaleo E, Lindorff-Larsen K, Kragelund BB.

Cell Signal. 2017 Sep;37:40-51. doi: 10.1016/j.cellsig.2017.05.015. Epub 2017 May 26.


Alternating pH landscapes shape epithelial cancer initiation and progression: Focus on pancreatic cancer.

Pedersen SF, Novak I, Alves F, Schwab A, Pardo LA.

Bioessays. 2017 Jun;39(6). doi: 10.1002/bies.201600253. Epub 2017 Apr 25. Review.


Roles of pH and the Na+/H+ exchanger NHE1 in cancer: From cell biology and animal models to an emerging translational perspective?

Stock C, Pedersen SF.

Semin Cancer Biol. 2017 Apr;43:5-16. doi: 10.1016/j.semcancer.2016.12.001. Epub 2016 Dec 19. Review.


Oncogenic p95HER2 regulates Na+-HCO3- cotransporter NBCn1 mRNA stability in breast cancer cells via 3'UTR-dependent processes.

Gorbatenko A, Olesen CW, Loebl N, Sigurdsson HH, Bianchi C, Pedraz-Cuesta E, Christiansen J, Pedersen SF.

Biochem J. 2016 Nov 1;473(21):4027-4044. Epub 2016 Sep 8.


HER2-encoded mir-4728 forms a receptor-independent circuit with miR-21-5p through the non-canonical poly(A) polymerase PAPD5.

Newie I, Søkilde R, Persson H, Jacomasso T, Gorbatenko A, Borg Å, de Hoon M, Pedersen SF, Rovira C.

Sci Rep. 2016 Oct 18;6:35664. doi: 10.1038/srep35664.


PET/MR Imaging in Vascular Disease: Atherosclerosis and Inflammation.

Ripa RS, Pedersen SF, Kjær A.

PET Clin. 2016 Oct;11(4):479-88. doi: 10.1016/j.cpet.2016.05.009. Epub 2016 Jul 27. Review.


Roles of acid-extruding ion transporters in regulation of breast cancer cell growth in a 3-dimensional microenvironment.

Andersen AP, Flinck M, Oernbo EK, Pedersen NB, Viuff BM, Pedersen SF.

Mol Cancer. 2016 Jun 6;15(1):45. doi: 10.1186/s12943-016-0528-0.


[Better reception of the acutely ill patient].

Pedersen SF, Malme KN, Wammer AC, Jacobsen LM, Hatleskog ML, Lauritzen M, Bårdsen R, Faiz KW.

Tidsskr Nor Laegeforen. 2016 May 24;136(9):787-8. doi: 10.4045/tidsskr.16.0274. eCollection 2016 May. Norwegian. No abstract available.


Assessment of different 3D culture systems to study tumor phenotype and chemosensitivity in pancreatic ductal adenocarcinoma.

Zeeberg K, Cardone RA, Greco MR, Saccomano M, Nøhr-Nielsen A, Alves F, Pedersen SF, Reshkin SJ.

Int J Oncol. 2016 Jul;49(1):243-52. doi: 10.3892/ijo.2016.3513. Epub 2016 May 10.


Prolactin Signaling Stimulates Invasion via Na(+)/H(+) Exchanger NHE1 in T47D Human Breast Cancer Cells.

Pedraz-Cuesta E, Fredsted J, Jensen HH, Bornebusch A, Nejsum LN, Kragelund BB, Pedersen SF.

Mol Endocrinol. 2016 Jul;30(7):693-708. doi: 10.1210/me.2015-1299. Epub 2016 May 13.


Cardiovascular MR T2-STIR imaging does not discriminate between intramyocardial haemorrhage and microvascular obstruction during the subacute phase of a reperfused myocardial infarction.

Hansen ES, Pedersen SF, Pedersen SB, Kjærgaard U, Schmidt NH, Bøtker HE, Kim WY.

Open Heart. 2016 Apr 20;3(1):e000346. doi: 10.1136/openhrt-2015-000346. eCollection 2016.


The human Na(+)/H(+) exchanger 1 is a membrane scaffold protein for extracellular signal-regulated kinase 2.

Hendus-Altenburger R, Pedraz-Cuesta E, Olesen CW, Papaleo E, Schnell JA, Hopper JT, Robinson CV, Pedersen SF, Kragelund BB.

BMC Biol. 2016 Apr 15;14:31. doi: 10.1186/s12915-016-0252-7.


Monocarboxylate Transporters MCT1 and MCT4 Regulate Migration and Invasion of Pancreatic Ductal Adenocarcinoma Cells.

Kong SC, Nøhr-Nielsen A, Zeeberg K, Reshkin SJ, Hoffmann EK, Novak I, Pedersen SF.

Pancreas. 2016 Aug;45(7):1036-47. doi: 10.1097/MPA.0000000000000571.


Biophysics and Physiology of the Volume-Regulated Anion Channel (VRAC)/Volume-Sensitive Outwardly Rectifying Anion Channel (VSOR).

Pedersen SF, Okada Y, Nilius B.

Pflugers Arch. 2016 Mar;468(3):371-83. doi: 10.1007/s00424-015-1781-6. Epub 2016 Jan 6. Review.


The P2X7 receptor regulates cell survival, migration and invasion of pancreatic ductal adenocarcinoma cells.

Giannuzzo A, Pedersen SF, Novak I.

Mol Cancer. 2015 Nov 25;14:203. doi: 10.1186/s12943-015-0472-4.


Protein receptor-independent plasma membrane remodeling by HAMLET: a tumoricidal protein-lipid complex.

Nadeem A, Sanborn J, Gettel DL, James HC, Rydström A, Ngassam VN, Klausen TK, Pedersen SF, Lam M, Parikh AN, Svanborg C.

Sci Rep. 2015 Nov 12;5:16432. doi: 10.1038/srep16432.


Myocardin-related Transcription Factor Regulates Nox4 Protein Expression: LINKING CYTOSKELETAL ORGANIZATION TO REDOX STATE.

Rozycki M, Bialik JF, Speight P, Dan Q, Knudsen TE, Szeto SG, Yuen DA, Szászi K, Pedersen SF, Kapus A.

J Biol Chem. 2016 Jan 1;291(1):227-43. doi: 10.1074/jbc.M115.674606. Epub 2015 Nov 10.


Glycosylation of solute carriers: mechanisms and functional consequences.

Pedersen NB, Carlsson MC, Pedersen SF.

Pflugers Arch. 2016 Feb;468(2):159-76. doi: 10.1007/s00424-015-1730-4. Epub 2015 Sep 18. Review.


PDGFRβ and oncogenic mutant PDGFRα D842V promote disassembly of primary cilia through a PLCγ- and AURKA-dependent mechanism.

Nielsen BS, Malinda RR, Schmid FM, Pedersen SF, Christensen ST, Pedersen LB.

J Cell Sci. 2015 Oct 1;128(19):3543-9. doi: 10.1242/jcs.173559. Epub 2015 Aug 19.


Disrupting Na⁺, HCO₃⁻-cotransporter NBCn1 (Slc4a7) delays murine breast cancer development.

Lee S, Axelsen TV, Andersen AP, Vahl P, Pedersen SF, Boedtkjer E.

Oncogene. 2016 Apr 21;35(16):2112-22. doi: 10.1038/onc.2015.273. Epub 2015 Jul 27.


The glutamate transport inhibitor DL-Threo-β-Benzyloxyaspartic acid (DL-TBOA) differentially affects SN38- and oxaliplatin-induced death of drug-resistant colorectal cancer cells.

Pedraz-Cuesta E, Christensen S, Jensen AA, Jensen NF, Bunch L, Romer MU, Brünner N, Stenvang J, Pedersen SF.

BMC Cancer. 2015 May 16;15:411. doi: 10.1186/s12885-015-1405-8.


64Cu-DOTATATE PET/MRI for Detection of Activated Macrophages in Carotid Atherosclerotic Plaques: Studies in Patients Undergoing Endarterectomy.

Pedersen SF, Sandholt BV, Keller SH, Hansen AE, Clemmensen AE, Sillesen H, Højgaard L, Ripa RS, Kjær A.

Arterioscler Thromb Vasc Biol. 2015 Jul;35(7):1696-703. doi: 10.1161/ATVBAHA.114.305067. Epub 2015 May 14.


Intrinsically disordered cytoplasmic domains of two cytokine receptors mediate conserved interactions with membranes.

Haxholm GW, Nikolajsen LF, Olsen JG, Fredsted J, Larsen FH, Goffin V, Pedersen SF, Brooks AJ, Waters MJ, Kragelund BB.

Biochem J. 2015 Jun 15;468(3):495-506. doi: 10.1042/BJ20141243. Epub 2015 Apr 7.


Corrigendum: Acid-base transport in pancreatic cancer: Molecular mechanisms and clinical potential.

Kong SC, Giannuzzo A, Novak I, Pedersen SF.

Biochem Cell Biol. 2015 Jun;93(3):272. doi: 10.1139/bcb-2015-0026. Epub 2015 Mar 5. No abstract available.


The identification of a volume-regulated anion channel: an amazing Odyssey.

Pedersen SF, Klausen TK, Nilius B.

Acta Physiol (Oxf). 2015 Apr;213(4):868-81. doi: 10.1111/apha.12450. Epub 2015 Jan 28. Review.


Osmotic shrinkage elicits FAK- and Src phosphorylation and Src-dependent NKCC1 activation in NIH3T3 cells.

Rasmussen LJ, Müller HS, Jørgensen B, Pedersen SF, Hoffmann EK.

Am J Physiol Cell Physiol. 2015 Jan 15;308(2):C101-10. doi: 10.1152/ajpcell.00070.2014. Epub 2014 Nov 5.


Acid-base transport in pancreatic cancer: molecular mechanisms and clinical potential.

Kong SC, Giannuzzo A, Novak I, Pedersen SF.

Biochem Cell Biol. 2014 Dec;92(6):449-59. doi: 10.1139/bcb-2014-0078. Epub 2014 Aug 26. Review. Erratum in: Biochem Cell Biol. 2015 Jun;93(3):272. Gianuzzo, Andrea [corrected to Giannuzzo, Andrea].


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