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Items: 29


WDFY2 restrains matrix metalloproteinase secretion and cell invasion by controlling VAMP3-dependent recycling.

Sneeggen M, Pedersen NM, Campsteijn C, Haugsten EM, Stenmark H, Schink KO.

Nat Commun. 2019 Jun 28;10(1):2850. doi: 10.1038/s41467-019-10794-w.


Concerted ESCRT and clathrin recruitment waves define the timing and morphology of intraluminal vesicle formation.

Wenzel EM, Schultz SW, Schink KO, Pedersen NM, Nähse V, Carlson A, Brech A, Stenmark H, Raiborg C.

Nat Commun. 2018 Jul 26;9(1):2932. doi: 10.1038/s41467-018-05345-8.


PtdIns3P controls mTORC1 signaling through lysosomal positioning.

Hong Z, Pedersen NM, Wang L, Torgersen ML, Stenmark H, Raiborg C.

J Cell Biol. 2017 Dec 4;216(12):4217-4233. doi: 10.1083/jcb.201611073. Epub 2017 Oct 13.


Differential Roles of AXIN1 and AXIN2 in Tankyrase Inhibitor-Induced Formation of Degradasomes and β-Catenin Degradation.

Thorvaldsen TE, Pedersen NM, Wenzel EM, Stenmark H.

PLoS One. 2017 Jan 20;12(1):e0170508. doi: 10.1371/journal.pone.0170508. eCollection 2017.


Formation of Tankyrase Inhibitor-Induced Degradasomes Requires Proteasome Activity.

Pedersen NM, Thorvaldsen TE, Schultz SW, Wenzel EM, Stenmark H.

PLoS One. 2016 Aug 2;11(8):e0160507. doi: 10.1371/journal.pone.0160507. eCollection 2016.


ER-endosome contact sites in endosome positioning and protrusion outgrowth.

Raiborg C, Wenzel EM, Pedersen NM, Stenmark H.

Biochem Soc Trans. 2016 Apr 15;44(2):441-6. doi: 10.1042/BST20150246. Review.


Phosphoinositides in membrane contact sites.

Raiborg C, Wenzel EM, Pedersen NM, Stenmark H.

Biochem Soc Trans. 2016 Apr 15;44(2):425-30. doi: 10.1042/BST20150190. Review.


Structure, Dynamics, and Functionality of Tankyrase Inhibitor-Induced Degradasomes.

Thorvaldsen TE, Pedersen NM, Wenzel EM, Schultz SW, Brech A, Liestøl K, Waaler J, Krauss S, Stenmark H.

Mol Cancer Res. 2015 Nov;13(11):1487-501. doi: 10.1158/1541-7786.MCR-15-0125. Epub 2015 Jun 29.


Repeated ER-endosome contacts promote endosome translocation and neurite outgrowth.

Raiborg C, Wenzel EM, Pedersen NM, Olsvik H, Schink KO, Schultz SW, Vietri M, Nisi V, Bucci C, Brech A, Johansen T, Stenmark H.

Nature. 2015 Apr 9;520(7546):234-8. doi: 10.1038/nature14359.


SARA and RNF11 at the crossroads of EGFR signaling and trafficking.

Kostaras E, Pedersen NM, Stenmark H, Fotsis T, Murphy C.

Methods Enzymol. 2014;535:225-47. doi: 10.1016/B978-0-12-397925-4.00014-6.


SARA and RNF11 interact with each other and ESCRT-0 core proteins and regulate degradative EGFR trafficking.

Kostaras E, Sflomos G, Pedersen NM, Stenmark H, Fotsis T, Murphy C.

Oncogene. 2013 Oct 31;32(44):5220-32. doi: 10.1038/onc.2012.554. Epub 2012 Dec 10.


Production of phosphatidylinositol 5-phosphate via PIKfyve and MTMR3 regulates cell migration.

Oppelt A, Lobert VH, Haglund K, Mackey AM, Rameh LE, Liestøl K, Schink KO, Pedersen NM, Wenzel EM, Haugsten EM, Brech A, Rusten TE, Stenmark H, Wesche J.

EMBO Rep. 2013 Jan;14(1):57-64. doi: 10.1038/embor.2012.183. Epub 2012 Nov 16.


Effect of cycloheximide on epidermal growth factor receptor trafficking and signaling.

Oksvold MP, Pedersen NM, Forfang L, Smeland EB.

FEBS Lett. 2012 Oct 19;586(20):3575-81. doi: 10.1016/j.febslet.2012.08.022. Epub 2012 Sep 6.


The PtdIns3P-binding protein Phafin 2 mediates epidermal growth factor receptor degradation by promoting endosome fusion.

Pedersen NM, Raiborg C, Brech A, Skarpen E, Roxrud I, Platta HW, Liestøl K, Stenmark H.

Traffic. 2012 Nov;13(11):1547-63. doi: 10.1111/j.1600-0854.2012.01400.x. Epub 2012 Aug 8.


A novel tankyrase inhibitor decreases canonical Wnt signaling in colon carcinoma cells and reduces tumor growth in conditional APC mutant mice.

Waaler J, Machon O, Tumova L, Dinh H, Korinek V, Wilson SR, Paulsen JE, Pedersen NM, Eide TJ, Machonova O, Gradl D, Voronkov A, von Kries JP, Krauss S.

Cancer Res. 2012 Jun 1;72(11):2822-32. doi: 10.1158/0008-5472.CAN-11-3336. Epub 2012 Mar 22.


The oncoprotein ErbB3 is endocytosed in the absence of added ligand in a clathrin-dependent manner.

Sak MM, Breen K, Rønning SB, Pedersen NM, Bertelsen V, Stang E, Madshus IH.

Carcinogenesis. 2012 May;33(5):1031-9. doi: 10.1093/carcin/bgs128. Epub 2012 Mar 20.


CIN85 regulates ubiquitination and degradative endosomal sorting of the EGF receptor.

Rønning SB, Pedersen NM, Madshus IH, Stang E.

Exp Cell Res. 2011 Aug 1;317(13):1804-16. doi: 10.1016/j.yexcr.2011.05.016. Epub 2011 May 20.


Cargo-dependent degradation of ESCRT-I as a feedback mechanism to modulate endosomal sorting.

Malerød L, Pedersen NM, Sem Wegner CE, Lobert VH, Leithe E, Brech A, Rivedal E, Liestøl K, Stenmark H.

Traffic. 2011 Sep;12(9):1211-26. doi: 10.1111/j.1600-0854.2011.01220.x. Epub 2011 Jun 13.


Ubiquitination of alpha 5 beta 1 integrin controls fibroblast migration through lysosomal degradation of fibronectin-integrin complexes.

Lobert VH, Brech A, Pedersen NM, Wesche J, Oppelt A, Malerød L, Stenmark H.

Dev Cell. 2010 Jul 20;19(1):148-59. doi: 10.1016/j.devcel.2010.06.010.


A phosphatidylinositol 3-kinase class III sub-complex containing VPS15, VPS34, Beclin 1, UVRAG and BIF-1 regulates cytokinesis and degradative endocytic traffic.

Thoresen SB, Pedersen NM, Liestøl K, Stenmark H.

Exp Cell Res. 2010 Dec 10;316(20):3368-78. doi: 10.1016/j.yexcr.2010.07.008. Epub 2010 Jul 17.


PtdIns(3)P controls cytokinesis through KIF13A-mediated recruitment of FYVE-CENT to the midbody.

Sagona AP, Nezis IP, Pedersen NM, Liestøl K, Poulton J, Rusten TE, Skotheim RI, Raiborg C, Stenmark H.

Nat Cell Biol. 2010 Apr;12(4):362-71. doi: 10.1038/ncb2036. Epub 2010 Mar 7.


Ultrastructural characterization of giant endosomes induced by GTPase-deficient Rab5.

Wegner CS, Malerød L, Pedersen NM, Progida C, Bakke O, Stenmark H, Brech A.

Histochem Cell Biol. 2010 Jan;133(1):41-55. doi: 10.1007/s00418-009-0643-8. Epub 2009 Oct 15. Erratum in: Histochem Cell Biol. 2010 Jan;133(1):57. Wegener, Catherine Sem [corrected to Wegner, Catherine Sem]; Prodiga, Cinzia [corrected to Progida, Cinzia].


Expression of epidermal growth factor receptor or ErbB3 facilitates geldanamycin-induced down-regulation of ErbB2.

Pedersen NM, Breen K, Rødland MS, Haslekås C, Stang E, Madshus IH.

Mol Cancer Res. 2009 Feb;7(2):275-84. doi: 10.1158/1541-7786.MCR-07-2183. Epub 2009 Feb 10.


An endosomally localized isoform of Eps15 interacts with Hrs to mediate degradation of epidermal growth factor receptor.

Roxrud I, Raiborg C, Pedersen NM, Stang E, Stenmark H.

J Cell Biol. 2008 Mar 24;180(6):1205-18. doi: 10.1083/jcb.200708115.


Geldanamycin-induced down-regulation of ErbB2 from the plasma membrane is clathrin dependent but proteasomal activity independent.

Pedersen NM, Madshus IH, Haslekås C, Stang E.

Mol Cancer Res. 2008 Mar;6(3):491-500. doi: 10.1158/1541-7786.MCR-07-0191.


Differential functions of Hrs and ESCRT proteins in endocytic membrane trafficking.

Raiborg C, Malerød L, Pedersen NM, Stenmark H.

Exp Cell Res. 2008 Feb 15;314(4):801-13. Epub 2007 Nov 26.


EGF-induced activation of the EGF receptor does not trigger mobilization of caveolae.

Kazazic M, Roepstorff K, Johannessen LE, Pedersen NM, van Deurs B, Stang E, Madshus IH.

Traffic. 2006 Nov;7(11):1518-27. Epub 2006 Sep 19.


Activation of the epidermal growth factor (EGF) receptor induces formation of EGF receptor- and Grb2-containing clathrin-coated pits.

Johannessen LE, Pedersen NM, Pedersen KW, Madshus IH, Stang E.

Mol Cell Biol. 2006 Jan;26(2):389-401.


Herceptin-induced inhibition of ErbB2 signaling involves reduced phosphorylation of Akt but not endocytic down-regulation of ErbB2.

Longva KE, Pedersen NM, Haslekås C, Stang E, Madshus IH.

Int J Cancer. 2005 Sep 1;116(3):359-67.

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