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Items: 1 to 50 of 52

1.

Sym021, a promising anti-PD1 clinical candidate antibody derived from a new chicken antibody discovery platform.

Gjetting T, Gad M, Fröhlich C, Lindsted T, Melander MC, Bhatia VK, Grandal MM, Dietrich N, Uhlenbrock F, Galler GR, Strandh M, Lantto J, Bouquin T, Horak ID, Kragh M, Pedersen MW, Koefoed K.

MAbs. 2019 May/Jun;11(4):666-680. doi: 10.1080/19420862.2019.1596514. Epub 2019 May 3.

2.

Clinical and pathophysiological aspects of bicuspid aortic valve disease.

Pedersen MW, Groth KA, Mortensen KH, Brodersen J, Gravholt CH, Andersen NH.

Cardiol Young. 2019 Jan;29(1):1-10. doi: 10.1017/S1047951118001658. Epub 2018 Oct 30. Review.

PMID:
30375310
3.

Author Correction: 137 ancient human genomes from across the Eurasian steppes.

de Barros Damgaard P, Marchi N, Rasmussen S, Peyrot M, Renaud G, Korneliussen T, Moreno-Mayar JV, Pedersen MW, Goldberg A, Usmanova E, Baimukhanov N, Loman V, Hedeager L, Pedersen AG, Nielsen K, Afanasiev G, Akmatov K, Aldashev A, Alpaslan A, Baimbetov G, Bazaliiskii VI, Beisenov A, Boldbaatar B, Boldgiv B, Dorzhu C, Ellingvag S, Erdenebaatar D, Dajani R, Dmitriev E, Evdokimov V, Frei KM, Gromov A, Goryachev A, Hakonarson H, Hegay T, Khachatryan Z, Khaskhanov R, Kitov E, Kolbina A, Kubatbek T, Kukushkin A, Kukushkin I, Lau N, Margaryan A, Merkyte I, Mertz IV, Mertz VK, Mijiddorj E, Moiyesev V, Mukhtarova G, Nurmukhanbetov B, Orozbekova Z, Panyushkina I, Pieta K, Smrčka V, Shevnina I, Logvin A, Sjogren KG, Štolcova T, Taravella AM, Tashbaeva K, Tkachev A, Tulegenov T, Voyakin D, Yepiskoposyan L, Undrakhbold S, Varfolomeev V, Weber A, Wilson Sayres MA, Kradin N, Allentoft ME, Orlando L, Nielsen R, Sikora M, Heyer E, Kristiansen K, Willerslev E.

Nature. 2018 Nov;563(7729):E16. doi: 10.1038/s41586-018-0488-1.

PMID:
30166629
4.

137 ancient human genomes from across the Eurasian steppes.

Damgaard PB, Marchi N, Rasmussen S, Peyrot M, Renaud G, Korneliussen T, Moreno-Mayar JV, Pedersen MW, Goldberg A, Usmanova E, Baimukhanov N, Loman V, Hedeager L, Pedersen AG, Nielsen K, Afanasiev G, Akmatov K, Aldashev A, Alpaslan A, Baimbetov G, Bazaliiskii VI, Beisenov A, Boldbaatar B, Boldgiv B, Dorzhu C, Ellingvag S, Erdenebaatar D, Dajani R, Dmitriev E, Evdokimov V, Frei KM, Gromov A, Goryachev A, Hakonarson H, Hegay T, Khachatryan Z, Khaskhanov R, Kitov E, Kolbina A, Kubatbek T, Kukushkin A, Kukushkin I, Lau N, Margaryan A, Merkyte I, Mertz IV, Mertz VK, Mijiddorj E, Moiyesev V, Mukhtarova G, Nurmukhanbetov B, Orozbekova Z, Panyushkina I, Pieta K, Smrčka V, Shevnina I, Logvin A, Sjögren KG, Štolcová T, Taravella AM, Tashbaeva K, Tkachev A, Tulegenov T, Voyakin D, Yepiskoposyan L, Undrakhbold S, Varfolomeev V, Weber A, Wilson Sayres MA, Kradin N, Allentoft ME, Orlando L, Nielsen R, Sikora M, Heyer E, Kristiansen K, Willerslev E.

Nature. 2018 May;557(7705):369-374. doi: 10.1038/s41586-018-0094-2. Epub 2018 May 9. Erratum in: Nature. 2018 Aug 30;:.

PMID:
29743675
5.

Ancient Biomolecules and Evolutionary Inference.

Cappellini E, Prohaska A, Racimo F, Welker F, Pedersen MW, Allentoft ME, de Barros Damgaard P, Gutenbrunner P, Dunne J, Hammann S, Roffet-Salque M, Ilardo M, Moreno-Mayar JV, Wang Y, Sikora M, Vinner L, Cox J, Evershed RP, Willerslev E.

Annu Rev Biochem. 2018 Jun 20;87:1029-1060. doi: 10.1146/annurev-biochem-062917-012002. Epub 2018 Apr 25. Review.

PMID:
29709200
6.

Sym004-induced EGFR elimination is associated with profound anti-tumor activity in EGFRvIII patient-derived glioblastoma models.

Keir ST, Chandramohan V, Hemphill CD, Grandal MM, Melander MC, Pedersen MW, Horak ID, Kragh M, Desjardins A, Friedman HS, Bigner DD.

J Neurooncol. 2018 Jul;138(3):489-498. doi: 10.1007/s11060-018-2832-6. Epub 2018 Mar 21.

7.

Efficacy of Sym004 in Patients With Metastatic Colorectal Cancer With Acquired Resistance to Anti-EGFR Therapy and Molecularly Selected by Circulating Tumor DNA Analyses: A Phase 2 Randomized Clinical Trial.

Montagut C, Argilés G, Ciardiello F, Poulsen TT, Dienstmann R, Kragh M, Kopetz S, Lindsted T, Ding C, Vidal J, Clausell-Tormos J, Siravegna G, Sánchez-Martín FJ, Koefoed K, Pedersen MW, Grandal MM, Dvorkin M, Wyrwicz L, Rovira A, Cubillo A, Salazar R, Desseigne F, Nadal C, Albanell J, Zagonel V, Siena S, Fumi G, Rospo G, Nadler P, Horak ID, Bardelli A, Tabernero J.

JAMA Oncol. 2018 Apr 12;4(4):e175245. doi: 10.1001/jamaoncol.2017.5245. Epub 2018 Apr 12. Erratum in: JAMA Oncol. 2019 May 1;5(5):745.

8.

Rupture of an Abdominal Aortic Aneurysm in a Young Man with Marfan Syndrome.

Pedersen MW, Huynh KD, Baandrup UT, Nielsen DG, Andersen NH.

Ann Vasc Surg. 2018 Apr;48:252.e5-252.e8. doi: 10.1016/j.avsg.2017.10.024. Epub 2018 Feb 5.

PMID:
29421423
9.

An ERBB1-3 Neutralizing Antibody Mixture With High Activity Against Drug-Resistant HER2+ Breast Cancers With ERBB Ligand Overexpression.

Schwarz LJ, Hutchinson KE, Rexer BN, Estrada MV, Gonzalez Ericsson PI, Sanders ME, Dugger TC, Formisano L, Guerrero-Zotano A, Red-Brewer M, Young CD, Lantto J, Pedersen MW, Kragh M, Horak ID, Arteaga CL.

J Natl Cancer Inst. 2017 Nov 1;109(11). doi: 10.1093/jnci/djx065.

10.

Population characteristics of a large whale shark aggregation inferred from seawater environmental DNA.

Sigsgaard EE, Nielsen IB, Bach SS, Lorenzen ED, Robinson DP, Knudsen SW, Pedersen MW, Jaidah MA, Orlando L, Willerslev E, Møller PR, Thomsen PF.

Nat Ecol Evol. 2016 Nov 21;1(1):4. doi: 10.1038/s41559-016-0004.

PMID:
28812572
11.

Simultaneous Targeting of Two Distinct Epitopes on MET Effectively Inhibits MET- and HGF-Driven Tumor Growth by Multiple Mechanisms.

Grandal MM, Havrylov S, Poulsen TT, Koefoed K, Dahlman A, Galler GR, Conrotto P, Collins S, Eriksen KW, Kaufman D, Woude GFV, Jacobsen HJ, Horak ID, Kragh M, Lantto J, Bouquin T, Park M, Pedersen MW.

Mol Cancer Ther. 2017 Dec;16(12):2780-2791. doi: 10.1158/1535-7163.MCT-17-0374. Epub 2017 Aug 11.

12.

Sym015: A Highly Efficacious Antibody Mixture against MET-Amplified Tumors.

Poulsen TT, Grandal MM, Skartved NJØ, Hald R, Alifrangis L, Koefoed K, Lindsted T, Fröhlich C, Pollmann SE, Eriksen KW, Dahlman A, Jacobsen HJ, Bouquin T, Pedersen MW, Horak ID, Lantto J, Kragh M.

Clin Cancer Res. 2017 Oct 1;23(19):5923-5935. doi: 10.1158/1078-0432.CCR-17-0782. Epub 2017 Jul 5.

13.

Ancient plant DNA in lake sediments.

Parducci L, Bennett KD, Ficetola GF, Alsos IG, Suyama Y, Wood JR, Pedersen MW.

New Phytol. 2017 May;214(3):924-942. doi: 10.1111/nph.14470. Epub 2017 Apr 3. Review.

14.

DNA evidence of bowhead whale exploitation by Greenlandic Paleo-Inuit 4,000 years ago.

Seersholm FV, Pedersen MW, Søe MJ, Shokry H, Mak SS, Ruter A, Raghavan M, Fitzhugh W, Kjær KH, Willerslev E, Meldgaard M, Kapel CM, Hansen AJ.

Nat Commun. 2016 Nov 8;7:13389. doi: 10.1038/ncomms13389.

15.

Postglacial viability and colonization in North America's ice-free corridor.

Pedersen MW, Ruter A, Schweger C, Friebe H, Staff RA, Kjeldsen KK, Mendoza ML, Beaudoin AB, Zutter C, Larsen NK, Potter BA, Nielsen R, Rainville RA, Orlando L, Meltzer DJ, Kjær KH, Willerslev E.

Nature. 2016 Sep 1;537(7618):45-49. doi: 10.1038/nature19085. Epub 2016 Aug 10.

PMID:
27509852
16.

A combination of two antibodies recognizing non-overlapping epitopes of HER2 induces kinase activity-dependent internalization of HER2.

Szymanska M, Fosdahl AM, Nikolaysen F, Pedersen MW, Grandal MM, Stang E, Bertelsen V.

J Cell Mol Med. 2016 Oct;20(10):1999-2011. doi: 10.1111/jcmm.12899. Epub 2016 Jul 28.

17.

Cetuximab Resistance in Squamous Carcinomas of the Upper Aerodigestive Tract Is Driven by Receptor Tyrosine Kinase Plasticity: Potential for mAb Mixtures.

Kjær I, Lindsted T, Fröhlich C, Olsen JV, Horak ID, Kragh M, Pedersen MW.

Mol Cancer Ther. 2016 Jul;15(7):1614-26. doi: 10.1158/1535-7163.MCT-15-0565. Epub 2016 May 11.

18.

Historical DNA documents long-distance natal homing in marine fish.

Bonanomi S, Overgaard Therkildsen N, Retzel A, Berg Hedeholm R, Pedersen MW, Meldrup D, Pampoulie C, Hemmer-Hansen J, Grønkjaer P, Nielsen EE.

Mol Ecol. 2016 Jun;25(12):2727-34. doi: 10.1111/mec.13580. Epub 2016 Mar 14.

PMID:
26859133
19.

Performance assessment of two whole-lake acoustic positional telemetry systems--is reality mining of free-ranging aquatic animals technologically possible?

Baktoft H, Zajicek P, Klefoth T, Svendsen JC, Jacobsen L, Pedersen MW, March Morla D, Skov C, Nakayama S, Arlinghaus R.

PLoS One. 2015 May 22;10(5):e0126534. doi: 10.1371/journal.pone.0126534. eCollection 2015.

20.

Safety and Activity of the First-in-Class Sym004 Anti-EGFR Antibody Mixture in Patients with Refractory Colorectal Cancer.

Dienstmann R, Patnaik A, Garcia-Carbonero R, Cervantes A, Benavent M, Roselló S, Tops BB, van der Post RS, Argilés G, Skartved NJ, Hansen UH, Hald R, Pedersen MW, Kragh M, Horak ID, Braun S, Van Cutsem E, Tolcher AW, Tabernero J.

Cancer Discov. 2015 Jun;5(6):598-609. doi: 10.1158/2159-8290.CD-14-1432. Epub 2015 May 11.

21.

Pan-HER, an Antibody Mixture Simultaneously Targeting EGFR, HER2, and HER3, Effectively Overcomes Tumor Heterogeneity and Plasticity.

Jacobsen HJ, Poulsen TT, Dahlman A, Kjær I, Koefoed K, Sen JW, Weilguny D, Bjerregaard B, Andersen CR, Horak ID, Pedersen MW, Kragh M, Lantto J.

Clin Cancer Res. 2015 Sep 15;21(18):4110-22. doi: 10.1158/1078-0432.CCR-14-3312. Epub 2015 Apr 23.

22.

Targeting Three Distinct HER2 Domains with a Recombinant Antibody Mixture Overcomes Trastuzumab Resistance.

Pedersen MW, Jacobsen HJ, Koefoed K, Dahlman A, Kjær I, Poulsen TT, Meijer PJ, Nielsen LS, Horak ID, Lantto J, Kragh M.

Mol Cancer Ther. 2015 Mar;14(3):669-80. doi: 10.1158/1535-7163.MCT-14-0697. Epub 2015 Jan 22.

23.

Ancient and modern environmental DNA.

Pedersen MW, Overballe-Petersen S, Ermini L, Sarkissian CD, Haile J, Hellstrom M, Spens J, Thomsen PF, Bohmann K, Cappellini E, Schnell IB, Wales NA, Carøe C, Campos PF, Schmidt AM, Gilbert MT, Hansen AJ, Orlando L, Willerslev E.

Philos Trans R Soc Lond B Biol Sci. 2015 Jan 19;370(1660):20130383. doi: 10.1098/rstb.2013.0383. Review.

24.

Sym004, a novel EGFR antibody mixture, can overcome acquired resistance to cetuximab.

Iida M, Brand TM, Starr MM, Li C, Huppert EJ, Luthar N, Pedersen MW, Horak ID, Kragh M, Wheeler DL.

Neoplasia. 2013 Oct;15(10):1196-206.

25.

Sym004, a novel anti-EGFR antibody mixture, augments radiation response in human lung and head and neck cancers.

Huang S, Peet CR, Saker J, Li C, Armstrong EA, Kragh M, Pedersen MW, Harari PM.

Mol Cancer Ther. 2013 Dec;12(12):2772-81. doi: 10.1158/1535-7163.MCT-13-0587. Epub 2013 Oct 15.

26.

Targeting the ERBB family in cancer: couples therapy.

Tebbutt N, Pedersen MW, Johns TG.

Nat Rev Cancer. 2013 Sep;13(9):663-73. doi: 10.1038/nrc3559. Epub 2013 Aug 16. Review.

PMID:
23949426
27.

Combination of two anti-CD5 monoclonal antibodies synergistically induces complement-dependent cytotoxicity of chronic lymphocytic leukaemia cells.

Klitgaard JL, Koefoed K, Geisler C, Gadeberg OV, Frank DA, Petersen J, Jurlander J, Pedersen MW.

Br J Haematol. 2013 Oct;163(2):182-93. doi: 10.1111/bjh.12503. Epub 2013 Aug 8.

PMID:
23927424
28.

Analysing migrations of Atlantic cod Gadus morhua in the north-east Atlantic Ocean: then, now and the future.

Neuenfeldt S, Righton D, Neat F, Wright PJ, Svedäng H, Michalsen K, Subbey S, Steingrund P, Thorsteinsson V, Pampoulie C, Andersen KH, Pedersen MW, Metcalfe J.

J Fish Biol. 2013 Mar;82(3):741-63. doi: 10.1111/jfb.12043. Review.

PMID:
23464542
29.

Rational identification of an optimal antibody mixture for targeting the epidermal growth factor receptor.

Koefoed K, Steinaa L, Søderberg JN, Kjær I, Jacobsen HJ, Meijer PJ, Haurum JS, Jensen A, Kragh M, Andersen PS, Pedersen MW.

MAbs. 2011 Nov-Dec;3(6):584-95. doi: 10.4161/mabs.3.6.17955. Epub 2011 Nov 1.

30.

Preclinical pharmacokinetics and safety of Sym004: a synergistic antibody mixture directed against epidermal growth factor receptor.

Skartved NJ, Jacobsen HJ, Pedersen MW, Jensen PF, Sen JW, Jørgensen TK, Hey A, Kragh M.

Clin Cancer Res. 2011 Sep 15;17(18):5962-72. doi: 10.1158/1078-0432.CCR-11-1209. Epub 2011 Aug 8.

31.

Sym004: a novel synergistic anti-epidermal growth factor receptor antibody mixture with superior anticancer efficacy.

Pedersen MW, Jacobsen HJ, Koefoed K, Hey A, Pyke C, Haurum JS, Kragh M.

Cancer Res. 2010 Jan 15;70(2):588-97. doi: 10.1158/0008-5472.CAN-09-1417. Epub 2010 Jan 12.

32.

The effect of marine n-3 fatty acids in different doses on plasma concentrations of Lp-PLA2 in healthy adults.

Pedersen MW, Koenig W, Christensen JH, Schmidt EB.

Eur J Nutr. 2009 Feb;48(1):1-5. doi: 10.1007/s00394-008-0758-z. Epub 2008 Nov 21.

PMID:
19030909
33.

GLI1 is involved in cell cycle regulation and proliferation of NT2 embryonal carcinoma stem cells.

Vestergaard J, Lind-Thomsen A, Pedersen MW, Jarmer HO, Bak M, Hasholt L, Tommerup N, Tümer Z, Larsen LA.

DNA Cell Biol. 2008 May;27(5):251-6. doi: 10.1089/dna.2007.0625.

PMID:
18241033
34.

EGFR induces expression of IRF-1 via STAT1 and STAT3 activation leading to growth arrest of human cancer cells.

Andersen P, Pedersen MW, Woetmann A, Villingshøj M, Stockhausen MT, Odum N, Poulsen HS.

Int J Cancer. 2008 Jan 15;122(2):342-9.

35.

Activation of the EGFR gene target EphA2 inhibits epidermal growth factor-induced cancer cell motility.

Larsen AB, Pedersen MW, Stockhausen MT, Grandal MV, van Deurs B, Poulsen HS.

Mol Cancer Res. 2007 Mar;5(3):283-93.

36.

EGFRvIII escapes down-regulation due to impaired internalization and sorting to lysosomes.

Grandal MV, Zandi R, Pedersen MW, Willumsen BM, van Deurs B, Poulsen HS.

Carcinogenesis. 2007 Jul;28(7):1408-17. Epub 2007 Mar 19.

PMID:
17372273
37.

[Mutations in the epidermal growth factor receptor: structure and biological function in human tumors].

Pedersen MW, Poulsen HS.

Ugeskr Laeger. 2006 Jun 12;168(24):2354-61. Review. Danish.

PMID:
16822420
38.

Hedgehog signaling in small-cell lung cancer: frequent in vivo but a rare event in vitro.

Vestergaard J, Pedersen MW, Pedersen N, Ensinger C, Tümer Z, Tommerup N, Poulsen HS, Larsen LA.

Lung Cancer. 2006 Jun;52(3):281-90. Epub 2006 Apr 17.

PMID:
16616798
39.

Differential response to gefitinib of cells expressing normal EGFR and the mutant EGFRvIII.

Pedersen MW, Pedersen N, Ottesen LH, Poulsen HS.

Br J Cancer. 2005 Oct 17;93(8):915-23.

40.

Analysis of the epidermal growth factor receptor specific transcriptome: effect of receptor expression level and an activating mutation.

Pedersen MW, Pedersen N, Damstrup L, Villingshøj M, Sønder SU, Rieneck K, Bovin LF, Spang-Thomsen M, Poulsen HS.

J Cell Biochem. 2005 Oct 1;96(2):412-27.

PMID:
16075456
41.

The insulinoma-associated 1: a novel promoter for targeted cancer gene therapy for small-cell lung cancer.

Pedersen N, Pedersen MW, Lan MS, Breslin MB, Poulsen HS.

Cancer Gene Ther. 2006 Apr;13(4):375-84.

PMID:
16052225
42.

New targets for detection and treatment of small cell lung cancer.

Pedersen N, Pedersen MW, Poulsen TT, Mortensen S, Sørensen SB, Rieneck K, Bovin LF, Poulsen HS.

Chest. 2004 May;125(5 Suppl):154S. No abstract available.

PMID:
15136481
43.
44.

Transcriptional gene expression profiling of small cell lung cancer cells.

Pedersen N, Mortensen S, Sørensen SB, Pedersen MW, Rieneck K, Bovin LF, Poulsen HS.

Cancer Res. 2003 Apr 15;63(8):1943-53.

45.

Profile of differentially expressed genes mediated by the type III epidermal growth factor receptor mutation expressed in a small-cell lung cancer cell line.

Pedersen MW, Thykjaer T, Ørntoft TF, Damstrup L, Poulsen HS.

Br J Cancer. 2001 Oct 19;85(8):1211-8. Erratum in: Br J Cancer 2001 Dec 14;85(12):2023-5.

46.

The type III epidermal growth factor receptor mutation. Biological significance and potential target for anti-cancer therapy.

Pedersen MW, Meltorn M, Damstrup L, Poulsen HS.

Ann Oncol. 2001 Jun;12(6):745-60. Review.

PMID:
11484948
47.
48.
50.

The effect of whisky and wine consumption on total phenol content and antioxidant capacity of plasma from healthy volunteers.

Duthie GG, Pedersen MW, Gardner PT, Morrice PC, Jenkinson AM, McPhail DB, Steele GM.

Eur J Clin Nutr. 1998 Oct;52(10):733-6.

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