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Can external interventions crowd in intrinsic motivation? A cluster randomised field experiment on mandatory accreditation of general practice in Denmark.

Pedersen LB, Andersen MKK, Jensen UT, Waldorff FB, Jacobsen CB.

Soc Sci Med. 2018 Jun 22;211:224-233. doi: 10.1016/j.socscimed.2018.06.023. [Epub ahead of print]


The E3 ubiquitin ligase SMURF1 regulates cell-fate specification and outflow tract septation during mammalian heart development.

Koefoed K, Skat-Rørdam J, Andersen P, Warzecha CB, Pye M, Andersen TA, Ajbro KD, Bendsen E, Narimatsu M, Vilhardt F, Pedersen LB, Wrana JL, Anderson RH, Møllgård K, Christensen ST, Larsen LA.

Sci Rep. 2018 Jun 22;8(1):9542. doi: 10.1038/s41598-018-27854-8.


Regulation of ciliary membrane protein trafficking and signalling by kinesin motor proteins.

Morthorst SK, Christensen ST, Pedersen LB.

FEBS J. 2018 Jun 12. doi: 10.1111/febs.14583. [Epub ahead of print] Review.


Lenalidomide plus bendamustine-rituximab does not overcome the adverse impact of TP53 mutations in mantle cell lymphoma.

Eskelund CW, Albertsson-Lindblad A, Kolstad A, Laurell A, Räty R, Pedersen LB, Geisler CH, Jerkeman M, Grønbæk K.

Haematologica. 2018 May 24. pii: haematol.2018.194399. doi: 10.3324/haematol.2018.194399. [Epub ahead of print] No abstract available.


CEP128 Localizes to the Subdistal Appendages of the Mother Centriole and Regulates TGF-β/BMP Signaling at the Primary Cilium.

Mönnich M, Borgeskov L, Breslin L, Jakobsen L, Rogowski M, Doganli C, Schrøder JM, Mogensen JB, Blinkenkjær L, Harder LM, Lundberg E, Geimer S, Christensen ST, Andersen JS, Larsen LA, Pedersen LB.

Cell Rep. 2018 Mar 6;22(10):2584-2592. doi: 10.1016/j.celrep.2018.02.043.


Depth and durability of response to ibrutinib in CLL: 5-year follow-up of a phase 2 study.

Ahn IE, Farooqui MZH, Tian X, Valdez J, Sun C, Soto S, Lotter J, Housel S, Stetler-Stevenson M, Yuan CM, Maric I, Calvo KR, Nierman P, Hughes TE, Saba NS, Marti GE, Pittaluga S, Herman SEM, Niemann CU, Pedersen LB, Geisler CH, Childs R, Aue G, Wiestner A.

Blood. 2018 May 24;131(21):2357-2366. doi: 10.1182/blood-2017-12-820910. Epub 2018 Feb 26.


TSC1 and TSC2 regulate cilia length and canonical Hedgehog signaling via different mechanisms.

Rosengren T, Larsen LJ, Pedersen LB, Christensen ST, Møller LB.

Cell Mol Life Sci. 2018 Jul;75(14):2663-2680. doi: 10.1007/s00018-018-2761-8. Epub 2018 Feb 2.


Ibrutinib, lenalidomide, and rituximab in relapsed or refractory mantle cell lymphoma (PHILEMON): a multicentre, open-label, single-arm, phase 2 trial.

Jerkeman M, Eskelund CW, Hutchings M, Räty R, Wader KF, Laurell A, Toldbod H, Pedersen LB, Niemann CU, Dahl C, Kuitunen H, Geisler CH, Grønbæk K, Kolstad A.

Lancet Haematol. 2018 Mar;5(3):e109-e116. doi: 10.1016/S2352-3026(18)30018-8. Epub 2018 Jan 29.


How is defensive medicine understood and experienced in a primary care setting? A qualitative focus group study among Danish general practitioners.

Assing Hvidt E, Lykkegaard J, Pedersen LB, Pedersen KM, Munck A, Andersen MK.

BMJ Open. 2017 Dec 21;7(12):e019851. doi: 10.1136/bmjopen-2017-019851.


IFT20 modulates ciliary PDGFRα signaling by regulating the stability of Cbl E3 ubiquitin ligases.

Schmid FM, Schou KB, Vilhelm MJ, Holm MS, Breslin L, Farinelli P, Larsen LA, Andersen JS, Pedersen LB, Christensen ST.

J Cell Biol. 2018 Jan 2;217(1):151-161. doi: 10.1083/jcb.201611050. Epub 2017 Dec 13.


TP53 mutations identify younger mantle cell lymphoma patients who do not benefit from intensive chemoimmunotherapy.

Eskelund CW, Dahl C, Hansen JW, Westman M, Kolstad A, Pedersen LB, Montano-Almendras CP, Husby S, Freiburghaus C, Ek S, Pedersen A, Niemann C, Räty R, Brown P, Geisler CH, Andersen MK, Guldberg P, Jerkeman M, Grønbæk K.

Blood. 2017 Oct 26;130(17):1903-1910. doi: 10.1182/blood-2017-04-779736. Epub 2017 Aug 17.


Chronic Lymphocytic Leukemia with Mutated IGHV4-34 Receptors: Shared and Distinct Immunogenetic Features and Clinical Outcomes.

Xochelli A, Baliakas P, Kavakiotis I, Agathangelidis A, Sutton LA, Minga E, Ntoufa S, Tausch E, Yan XJ, Shanafelt T, Plevova K, Boudjogra M, Rossi D, Davis Z, Navarro A, Sandberg Y, Vojdeman FJ, Scarfo L, Stavroyianni N, Sudarikov A, Veronese S, Tzenou T, Karan-Djurasevic T, Catherwood M, Kienle D, Chatzouli M, Facco M, Bahlo J, Pott C, Pedersen LB, Mansouri L, Smedby KE, Chu CC, Giudicelli V, Lefranc MP, Panagiotidis P, Juliusson G, Anagnostopoulos A, Vlahavas I, Antic D, Trentin L, Montillo M, Niemann C, Döhner H, Langerak AW, Pospisilova S, Hallek M, Campo E, Chiorazzi N, Maglaveras N, Oscier D, Gaidano G, Jelinek DF, Stilgenbauer S, Chouvarda I, Darzentas N, Belessi C, Davi F, Hadzidimitriou A, Rosenquist R, Ghia P, Stamatopoulos K.

Clin Cancer Res. 2017 Sep 1;23(17):5292-5301. doi: 10.1158/1078-0432.CCR-16-3100. Epub 2017 May 23.


General practitioners' attitudes towards and experiences with referrals due to supplemental health insurance.

Andersen MK, Pedersen LB, Dupont M, Pedersen KM, Munck A, Nexøe J.

Fam Pract. 2017 Sep 1;34(5):581-586. doi: 10.1093/fampra/cmx035.


User Fees in General Practice: Willingness to Pay and Potential Substitution Patterns-Results from a Danish GP Patient Survey.

Kronborg C, Pedersen LB, Fournaise A, Kronborg CN.

Appl Health Econ Health Policy. 2017 Oct;15(5):615-624. doi: 10.1007/s40258-017-0325-y.


Accreditation in general practice in Denmark: study protocol for a cluster-randomized controlled trial.

Andersen MK, Pedersen LB, Siersma V, Bro F, Reventlow S, Søndergaard J, Kousgaard MB, Waldorff FB.

Trials. 2017 Feb 13;18(1):69. doi: 10.1186/s13063-017-1818-6.


KIF13B establishes a CAV1-enriched microdomain at the ciliary transition zone to promote Sonic hedgehog signalling.

Schou KB, Mogensen JB, Morthorst SK, Nielsen BS, Aleliunaite A, Serra-Marques A, Fürstenberg N, Saunier S, Bizet AA, Veland IR, Akhmanova A, Christensen ST, Pedersen LB.

Nat Commun. 2017 Jan 30;8:14177. doi: 10.1038/ncomms14177.


Work motivation, task delegation and job satisfaction of general practice staff: a cross-sectional study.

Riisgaard H, Søndergaard J, Munch M, Le JV, Ledderer L, Pedersen LB, Nexøe J.

Fam Pract. 2017 Apr 1;34(2):188-193. doi: 10.1093/fampra/cmw142.


Associations between degrees of task delegation and job satisfaction of general practitioners and their staff: a cross-sectional study.

Riisgaard H, Søndergaard J, Munch M, Le JV, Ledderer L, Pedersen LB, Nexøe J.

BMC Health Serv Res. 2017 Jan 17;17(1):44. doi: 10.1186/s12913-017-1984-y.


Molecular Monitoring after Autologous Stem Cell Transplantation and Preemptive Rituximab Treatment of Molecular Relapse; Results from the Nordic Mantle Cell Lymphoma Studies (MCL2 and MCL3) with Median Follow-Up of 8.5 Years.

Kolstad A, Pedersen LB, Eskelund CW, Husby S, Grønbæk K, Jerkeman M, Laurell A, Räty R, Elonen E, Andersen NS, Brown PD, Kimby E, Bentzen H, Sundström C, Ehinger M, Karjalainen-Lindsberg ML, Delabie J, Ralfkiær E, Fagerli UM, Nilsson-Ehle H, Lauritzsen GF, Kuittinen O, Niemann C, Geisler CH; Nordic Lymphoma Group.

Biol Blood Marrow Transplant. 2017 Mar;23(3):428-435. doi: 10.1016/j.bbmt.2016.12.634. Epub 2016 Dec 27.


Personal health records in the Netherlands: potential user preferences quantified by a discrete choice experiment.

Determann D, Lambooij MS, Gyrd-Hansen D, de Bekker-Grob EW, Steyerberg EW, Heldoorn M, Pedersen LB, de Wit GA.

J Am Med Inform Assoc. 2017 May 1;24(3):529-536. doi: 10.1093/jamia/ocw158.


Variation in general practitioners' information-seeking behaviour - a cross-sectional study on the influence of gender, age and practice form.

Le JV, Pedersen LB, Riisgaard H, Lykkegaard J, Nexøe J, Lemmergaard J, Søndergaard J.

Scand J Prim Health Care. 2016 Dec;34(4):327-335. Epub 2016 Nov 2.


15-year follow-up of the Second Nordic Mantle Cell Lymphoma trial (MCL2): prolonged remissions without survival plateau.

Eskelund CW, Kolstad A, Jerkeman M, Räty R, Laurell A, Eloranta S, Smedby KE, Husby S, Pedersen LB, Andersen NS, Eriksson M, Kimby E, Bentzen H, Kuittinen O, Lauritzsen GF, Nilsson-Ehle H, Ralfkiaer E, Ehinger M, Sundström C, Delabie J, Karjalainen-Lindsberg ML, Workman CT, Garde C, Elonen E, Brown P, Grønbaek K, Geisler CH.

Br J Haematol. 2016 Nov;175(3):410-418. doi: 10.1111/bjh.14241. Epub 2016 Jul 5.


Tubulin transport in cilia: How many tubulin cargo-binding sites per IFT particle? (retrospective on DOI 10.1002/bies.201400007).

Pedersen LB.

Bioessays. 2017 Jan;39(1):1. doi: 10.1002/bies.201600201. Epub 2016 Oct 21. No abstract available.


Asymmetric information and user orientation in general practice: Exploring the agency relationship in a best-worst scaling study.

Pedersen LB, Hess S, Kjær T.

J Health Econ. 2016 Dec;50:115-130. doi: 10.1016/j.jhealeco.2016.09.008. Epub 2016 Sep 28.


Primary Cilia and Coordination of Receptor Tyrosine Kinase (RTK) and Transforming Growth Factor β (TGF-β) Signaling.

Christensen ST, Morthorst SK, Mogensen JB, Pedersen LB.

Cold Spring Harb Perspect Biol. 2017 Jun 1;9(6). pii: a028167. doi: 10.1101/cshperspect.a028167. Review.


Almost half of the Danish general practitioners have negative a priori attitudes towards a mandatory accreditation programme.

Waldorff FB, Nicolaisdóttir DR, Kousgaard MB, Reventlow S, Søndergaard J, Thorsen T, Andersen MK, Pedersen LB, Bisgaard L, Hutters CL, Bro F.

Dan Med J. 2016 Sep;63(9). pii: A5266.


Targeting of ASH Domain-Containing Proteins to the Centrosome.

Verdier P, Morthorst SK, Pedersen LB.

Methods Mol Biol. 2016;1454:15-33. doi: 10.1007/978-1-4939-3789-9_2.


Endocytic Control of Cellular Signaling at the Primary Cilium.

Pedersen LB, Mogensen JB, Christensen ST.

Trends Biochem Sci. 2016 Sep;41(9):784-797. doi: 10.1016/j.tibs.2016.06.002. Epub 2016 Jun 27. Review.


Lenalidomide-bendamustine-rituximab in patients older than 65 years with untreated mantle cell lymphoma.

Albertsson-Lindblad A, Kolstad A, Laurell A, Räty R, Grønbæk K, Sundberg J, Pedersen LB, Ralfkiær E, Karjalainen-Lindsberg ML, Sundström C, Ehinger M, Geisler C, Jerkeman M.

Blood. 2016 Oct 6;128(14):1814-1820. doi: 10.1182/blood-2016-03-704023. Epub 2016 Jun 27.


Different spectra of recurrent gene mutations in subsets of chronic lymphocytic leukemia harboring stereotyped B-cell receptors.

Sutton LA, Young E, Baliakas P, Hadzidimitriou A, Moysiadis T, Plevova K, Rossi D, Kminkova J, Stalika E, Pedersen LB, Malcikova J, Agathangelidis A, Davis Z, Mansouri L, Scarfò L, Boudjoghra M, Navarro A, Muggen AF, Yan XJ, Nguyen-Khac F, Larrayoz M, Panagiotidis P, Chiorazzi N, Niemann CU, Belessi C, Campo E, Strefford JC, Langerak AW, Oscier D, Gaidano G, Pospisilova S, Davi F, Ghia P, Stamatopoulos K, Rosenquist R; ERIC, the European Research Initiative on CLL.

Haematologica. 2016 Aug;101(8):959-67. doi: 10.3324/haematol.2016.141812. Epub 2016 May 19.


Ins and outs of GPCR signaling in primary cilia.

Schou KB, Pedersen LB, Christensen ST.

EMBO Rep. 2015 Sep;16(9):1099-113. doi: 10.15252/embr.201540530. Epub 2015 Aug 21. Review.


PDGFRβ and oncogenic mutant PDGFRα D842V promote disassembly of primary cilia through a PLCγ- and AURKA-dependent mechanism.

Nielsen BS, Malinda RR, Schmid FM, Pedersen SF, Christensen ST, Pedersen LB.

J Cell Sci. 2015 Oct 1;128(19):3543-9. doi: 10.1242/jcs.173559. Epub 2015 Aug 19.


The more we know, the more we have to discover: an exciting future for understanding cilia and ciliopathies.

Benmerah A, Durand B, Giles RH, Harris T, Kohl L, Laclef C, Meilhac SM, Mitchison HM, Pedersen LB, Roepman R, Swoboda P, Ueffing M, Bastin P.

Cilia. 2015 Mar 31;4:5. doi: 10.1186/s13630-015-0014-0. eCollection 2015.


miR-18b overexpression identifies mantle cell lymphoma patients with poor outcome and improves the MIPI-B prognosticator.

Husby S, Ralfkiaer U, Garde C, Zandi R, Ek S, Kolstad A, Jerkeman M, Laurell A, Räty R, Pedersen LB, Pedersen A, Ehinger M, Sundström C, Karjalainen-Lindsberg ML, Delabie J, Clasen-Linde E, Brown P, Cowland JB, Workman CT, Geisler CH, Grønbæk K.

Blood. 2015 Apr 23;125(17):2669-77. doi: 10.1182/blood-2014-06-584193. Epub 2015 Mar 3.


Not all IGHV3-21 chronic lymphocytic leukemias are equal: prognostic considerations.

Baliakas P, Agathangelidis A, Hadzidimitriou A, Sutton LA, Minga E, Tsanousa A, Scarfò L, Davis Z, Yan XJ, Shanafelt T, Plevova K, Sandberg Y, Vojdeman FJ, Boudjogra M, Tzenou T, Chatzouli M, Chu CC, Veronese S, Gardiner A, Mansouri L, Smedby KE, Pedersen LB, Moreno D, Van Lom K, Giudicelli V, Francova HS, Nguyen-Khac F, Panagiotidis P, Juliusson G, Angelis L, Anagnostopoulos A, Lefranc MP, Facco M, Trentin L, Catherwood M, Montillo M, Geisler CH, Langerak AW, Pospisilova S, Chiorazzi N, Oscier D, Jelinek DF, Darzentas N, Belessi C, Davi F, Ghia P, Rosenquist R, Stamatopoulos K.

Blood. 2015 Jan 29;125(5):856-9. doi: 10.1182/blood-2014-09-600874. Epub 2014 Dec 17.


Ibrutinib for previously untreated and relapsed or refractory chronic lymphocytic leukaemia with TP53 aberrations: a phase 2, single-arm trial.

Farooqui MZ, Valdez J, Martyr S, Aue G, Saba N, Niemann CU, Herman SE, Tian X, Marti G, Soto S, Hughes TE, Jones J, Lipsky A, Pittaluga S, Stetler-Stevenson M, Yuan C, Lee YS, Pedersen LB, Geisler CH, Calvo KR, Arthur DC, Maric I, Childs R, Young NS, Wiestner A.

Lancet Oncol. 2015 Feb;16(2):169-76. doi: 10.1016/S1470-2045(14)71182-9. Epub 2014 Dec 31.


Clinical effect of stereotyped B-cell receptor immunoglobulins in chronic lymphocytic leukaemia: a retrospective multicentre study.

Baliakas P, Hadzidimitriou A, Sutton LA, Minga E, Agathangelidis A, Nichelatti M, Tsanousa A, Scarfò L, Davis Z, Yan XJ, Shanafelt T, Plevova K, Sandberg Y, Vojdeman FJ, Boudjogra M, Tzenou T, Chatzouli M, Chu CC, Veronese S, Gardiner A, Mansouri L, Smedby KE, Pedersen LB, van Lom K, Giudicelli V, Francova HS, Nguyen-Khac F, Panagiotidis P, Juliusson G, Angelis L, Anagnostopoulos A, Lefranc MP, Facco M, Trentin L, Catherwood M, Montillo M, Geisler CH, Langerak AW, Pospisilova S, Chiorazzi N, Oscier D, Jelinek DF, Darzentas N, Belessi C, Davi F, Rosenquist R, Ghia P, Stamatopoulos K.

Lancet Haematol. 2014 Nov;1(2):e74-84. doi: 10.1016/S2352-3026(14)00005-2. Epub 2014 Nov 3.


ATMIN is a transcriptional regulator of both lung morphogenesis and ciliogenesis.

Goggolidou P, Stevens JL, Agueci F, Keynton J, Wheway G, Grimes DT, Patel SH, Hilton H, Morthorst SK, DiPaolo A, Williams DJ, Sanderson J, Khoronenkova SV, Powles-Glover N, Ermakov A, Esapa CT, Romero R, Dianov GL, Briscoe J, Johnson CA, Pedersen LB, Norris DP.

Development. 2014 Oct;141(20):3966-77. doi: 10.1242/dev.107755.



Pedersen LB.

Cilia. 2014 Aug 18;3:8. doi: 10.1186/2046-2530-3-8. eCollection 2014. No abstract available.


Silenced B-cell receptor response to autoantigen in a poor-prognostic subset of chronic lymphocytic leukemia.

Bergh AC, Evaldsson C, Pedersen LB, Geisler C, Stamatopoulos K, Rosenquist R, Rosén A.

Haematologica. 2014 Nov;99(11):1722-30. doi: 10.3324/haematol.2014.106054. Epub 2014 Aug 1.


Identification of conserved, centrosome-targeting ASH domains in TRAPPII complex subunits and TRAPPC8.

Schou KB, Morthorst SK, Christensen ST, Pedersen LB.

Cilia. 2014 Jun 18;3:6. doi: 10.1186/2046-2530-3-6. eCollection 2014.


Kif7 keeps cilia tips in shape.

Pedersen LB, Akhmanova A.

Nat Cell Biol. 2014 Jul;16(7):623-5. doi: 10.1038/ncb2997.


Patient preferences for treatment of low back pain-a discrete choice experiment.

Kløjgaard ME, Manniche C, Pedersen LB, Bech M, Søgaard R.

Value Health. 2014 Jun;17(4):390-6. doi: 10.1016/j.jval.2014.01.005. Epub 2014 Apr 21.


Continuous professional development for GPs: experience from Denmark.

Kjaer NK, Steenstrup AP, Pedersen LB, Halling A.

Postgrad Med J. 2014 Jul;90(1065):383-7. doi: 10.1136/postgradmedj-2012-131679. Epub 2014 May 26.


Ibrutinib-induced lymphocytosis in patients with chronic lymphocytic leukemia: correlative analyses from a phase II study.

Herman SE, Niemann CU, Farooqui M, Jones J, Mustafa RZ, Lipsky A, Saba N, Martyr S, Soto S, Valdez J, Gyamfi JA, Maric I, Calvo KR, Pedersen LB, Geisler CH, Liu D, Marti GE, Aue G, Wiestner A.

Leukemia. 2014 Nov;28(11):2188-96. doi: 10.1038/leu.2014.122. Epub 2014 Apr 4.


Nordic MCL3 study: 90Y-ibritumomab-tiuxetan added to BEAM/C in non-CR patients before transplant in mantle cell lymphoma.

Kolstad A, Laurell A, Jerkeman M, Grønbæk K, Elonen E, Räty R, Pedersen LB, Loft A, Bogsrud TV, Kimby E, Hansen PB, Fagerli UM, Nilsson-Ehle H, Lauritzsen GF, Lehmann AK, Sundstrom C, Karjalainen-Lindsberg ML, Ralfkiaer E, Ehinger M, Delabie J, Bentzen H, Schildt J, Kostova-Aherdan K, Frederiksen H, Brown Pde N, Geisler CH; Nordic Lymphoma Group.

Blood. 2014 May 8;123(19):2953-9. doi: 10.1182/blood-2013-12-541953. Epub 2014 Mar 20.


Cilia and coordination of signaling networks during heart development.

Koefoed K, Veland IR, Pedersen LB, Larsen LA, Christensen ST.

Organogenesis. 2014 Jan 1;10(1):108-25. doi: 10.4161/org.27483. Epub 2013 Dec 17. Review.


A divergent calponin homology (NN-CH) domain defines a novel family: implications for evolution of ciliary IFT complex B proteins.

Schou KB, Andersen JS, Pedersen LB.

Bioinformatics. 2014 Apr 1;30(7):899-902. doi: 10.1093/bioinformatics/btt661. Epub 2013 Nov 20.


The nucleotide-binding proteins Nubp1 and Nubp2 are negative regulators of ciliogenesis.

Kypri E, Christodoulou A, Maimaris G, Lethan M, Markaki M, Lysandrou C, Lederer CW, Tavernarakis N, Geimer S, Pedersen LB, Santama N.

Cell Mol Life Sci. 2014 Feb;71(3):517-38. doi: 10.1007/s00018-013-1401-6. Epub 2013 Jun 27.


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