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Items: 45

1.

Discovery of β-Arrestin Biased, Orally Bioavailable, and CNS Penetrant Neurotensin Receptor 1 (NTR1) Allosteric Modulators.

Pinkerton AB, Peddibhotla S, Yamamoto F, Slosky LM, Bai Y, Maloney P, Hershberger P, Hedrick MP, Falter B, Ardecky RJ, Smith LH, Chung TDY, Jackson MR, Caron MG, Barak LS.

J Med Chem. 2019 Sep 12;62(17):8357-8363. doi: 10.1021/acs.jmedchem.9b00340. Epub 2019 Aug 20.

PMID:
31390201
2.

Improvement in Glycemic Control in Mice of Different Age Groups.

Gamage S, Peddibhotla S, Reddy PH, Dhurandhar NV, Hegde V.

Exp Clin Endocrinol Diabetes. 2019 Jul 24. doi: 10.1055/a-0961-7804. [Epub ahead of print]

PMID:
31340394
3.

E4orf1 protein reduces the need for endogenous insulin.

Peddibhotla S, Hegde V, Akheruzzaman M, Dhurandhar NV.

Nutr Diabetes. 2019 May 24;9(1):17. doi: 10.1038/s41387-019-0085-x.

4.

E4orf1: A protein for enhancing glucose uptake despite impaired proximal insulin signaling.

Shastri AA, Hegde V, Peddibhotla S, Feizy Z, Dhurandhar NV.

PLoS One. 2018 Dec 6;13(12):e0208427. doi: 10.1371/journal.pone.0208427. eCollection 2018.

5.

Repurposing antimalarial aminoquinolines and related compounds for treatment of retinal neovascularization.

McAnally D, Siddiquee K, Gomaa A, Szabo A, Vasile S, Maloney PR, Divlianska DB, Peddibhotla S, Morfa CJ, Hershberger P, Falter R, Williamson R, Terry DB, Farjo R, Pinkerton AB, Qi X, Quigley J, Boulton ME, Grant MB, Smith LH.

PLoS One. 2018 Sep 12;13(9):e0202436. doi: 10.1371/journal.pone.0202436. eCollection 2018.

6.

Discovery of Novel Small-Molecule Inducers of Heme Oxygenase-1 That Protect Human iPSC-Derived Cardiomyocytes from Oxidative Stress.

Kirby RJ, Divlianska DB, Whig K, Bryan N, Morfa CJ, Koo A, Nguyen KH, Maloney P, Peddibhotla S, Sessions EH, Hershberger PM, Smith LH, Malany S.

J Pharmacol Exp Ther. 2018 Jan;364(1):87-96. doi: 10.1124/jpet.117.243717. Epub 2017 Nov 3. Erratum in: J Pharmacol Exp Ther. 2018 Feb;364(2):179.

PMID:
29101218
7.

MondoA coordinately regulates skeletal myocyte lipid homeostasis and insulin signaling.

Ahn B, Soundarapandian MM, Sessions H, Peddibhotla S, Roth GP, Li JL, Sugarman E, Koo A, Malany S, Wang M, Yea K, Brooks J, Leone TC, Han X, Vega RB, Kelly DP.

J Clin Invest. 2016 Sep 1;126(9):3567-79. doi: 10.1172/JCI87382. Epub 2016 Aug 8.

8.

ML314: A Biased Neurotensin Receptor Ligand for Methamphetamine Abuse.

Barak LS, Bai Y, Peterson S, Evron T, Urs NM, Peddibhotla S, Hedrick MP, Hershberger P, Maloney PR, Chung TD, Rodriguiz RM, Wetsel WC, Thomas JB, Hanson GR, Pinkerton AB, Caron MG.

ACS Chem Biol. 2016 Jul 15;11(7):1880-90. doi: 10.1021/acschembio.6b00291. Epub 2016 May 5.

9.

The isolation and characterization of CTC subsets related to breast cancer dormancy.

Vishnoi M, Peddibhotla S, Yin W, T Scamardo A, George GC, Hong DS, Marchetti D.

Sci Rep. 2015 Dec 3;5:17533. doi: 10.1038/srep17533.

10.

Discovery of ML358, a Selective Small Molecule Inhibitor of the SKN-1 Pathway Involved in Drug Detoxification and Resistance in Nematodes.

Peddibhotla S, Fontaine P, Leung CK, Maloney P, Hershberger PM, Wang Y, Bousquet MS, Luesch H, Mangravita-Novo A, Pinkerton AB, Smith LH, Malany S, Choe K.

ACS Chem Biol. 2015 Aug 21;10(8):1871-9. doi: 10.1021/acschembio.5b00304. Epub 2015 May 22.

PMID:
25946346
11.

Inhibitors of Myocyte Triacylglyceride Accumulation.

Hershberger PM, Sugarman E, Maloney P, Peddibhotla S, Koo A, Suyama E, Ruidiaz ME, Heynen-Genel S, Nguyen KH, Vasile S, Mangravita-Novo A, Smith LH, Soundarapandian MM, Salaniwal S, Kung P, Vega RB, Chung TDY, Pinkerton AB, Malany S, Kelly DP.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2013 Dec 15 [updated 2015 Feb 11].

12.

A high throughput screen for inhibitors of nematode detoxification genes.

Peddibhotla S, Leung CK, Maloney P, Hershberger PM, Nguyen K, Vasile S, Suyama E, Kane A, Bousquet MS, Leusch H, Stonich D, Mangravita-Novo A, Salaniwal S, Kung P, Diwan J, Smith LH, Chung TDY, Pinkerton AB, Malany S, Choe K.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2013 Apr 11 [updated 2014 Jan 13].

13.

Probing the CXCR6/CXCL16 Axis: Targeting Prevention of Prostate Cancer Metastasis.

Hershberger PM, Peddibhotla S, Sugarman E, Maloney P, Key D, Suyama E, Nguyen K, Vasile S, Kraft M, Stonich D, Mangravita-Novo A, Vicchiarelli M, Gosalia P, Milewski M, Li L, Hedrick M, Sun Q, Sergienko E, Cheltsov A, Salanawil S, Diwan J, Smith LH, Taichman RS, Chung TDY, Pinkerton AB, Malany S, Roth GP.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2012 Dec 15 [updated 2014 May 13].

14.

Delineation of candidate genes responsible for structural brain abnormalities in patients with terminal deletions of chromosome 6q27.

Peddibhotla S, Nagamani SC, Erez A, Hunter JV, Holder JL Jr, Carlin ME, Bader PI, Perras HM, Allanson JE, Newman L, Simpson G, Immken L, Powell E, Mohanty A, Kang SH, Stankiewicz P, Bacino CA, Bi W, Patel A, Cheung SW.

Eur J Hum Genet. 2015 Jan;23(1):54-60. doi: 10.1038/ejhg.2014.51. Epub 2014 Apr 16. Review.

15.

Discovery of ML314, a Brain Penetrant Non-Peptidic β-Arrestin Biased Agonist of the Neurotensin NTR1 Receptor.

Peddibhotla S, Hedrick MP, Hershberger P, Maloney PR, Li Y, Milewski M, Gosalia P, Gray W, Mehta A, Sugarman E, Hood B, Suyama E, Nguyen K, Heynen-Genel S, Vasile S, Salaniwal S, Stonich D, Su Y, Mangravita-Novo A, Vicchiarelli M, Roth GP, Smith LH, Chung TD, Hanson GR, Thomas JB, Caron MG, Barak LS, Pinkerton AB.

ACS Med Chem Lett. 2013 Jul 20;4(9):846-851.

16.

Small Molecule Agonists for the Neurotensin 1 Receptor (NTR1 Agonists).

Hershberger P, Hedrick M, Peddibhotla S, Maloney P, Li Y, Milewski M, Gosalia P, Gray W, Mehta A, Sugarman E, Hood B, Suyama E, Nguyen K, Heynen-Genel S, Vasile S, Salaniwal S, Stonich D, Su Y, Mangravita-Novo A, Vicchiarelli M, Smith LH, Roth G, Diwan J, Chung TDY, Caron MG, Thomas JB, Pinkerton AB, Barak LR.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2012 Apr 8 [updated 2013 Mar 7].

17.

A 2nd Selective Inhibitor of Plasmodium falciparum Glucose-6-Phosphate Dehydrogenase (PfG6PDH) - Probe 2.

Maloney P, Hedrick M, Peddibhotla S, Hershberger P, Milewski M, Gosalia P, Li L, Preuss J, Sugarman E, Hood B, Suyama E, Nguyen K, Vasile S, Sergienko E, Salanawil S, Stonich D, Su Y, Dahl R, Mangravita-Novo A, Vicchiarelli M, McAnally D, Smith LH, Roth G, Diwan J, Chung TDY, Pinkerton AB, Bode L, Becker K.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2012 Mar 28 [updated 2013 Mar 14].

18.

Cardioprotective inhibitors of reperfusion injury.

Kane A, Peddibhotla S, Maloney P, Mehta A, Hood B, Suyama E, Nguyen K, Vasile S, Leavitt L, Cheltsov A, Salaiwal S, Stonich D, Mangravita-Novo A, Vicchiarelli M, Smith LH, Diwan J, Chung TDY, Pinkerton AB, Hershberger P, Malany S, Kitsis RN.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2012 Dec 10 [updated 2013 Mar 22].

19.

Imidazole-derived agonists for the neurotensin 1 receptor.

Hershberger PM, Hedrick MP, Peddibhotla S, Mangravita-Novo A, Gosalia P, Li Y, Gray W, Vicchiarelli M, Smith LH, Chung TD, Thomas JB, Caron MG, Pinkerton AB, Barak LS, Roth GP.

Bioorg Med Chem Lett. 2014 Jan 1;24(1):262-7. doi: 10.1016/j.bmcl.2013.11.026. Epub 2013 Nov 21.

20.

Expanding the genotype-phenotype correlation in subtelomeric 19p13.3 microdeletions using high resolution clinical chromosomal microarray analysis.

Peddibhotla S, Khalifa M, Probst FJ, Stein J, Harris LL, Kearney DL, Vance GH, Bull MJ, Grange DK, Scharer GH, Kang SH, Stankiewicz P, Bacino CA, Cheung SW, Patel A.

Am J Med Genet A. 2013 Dec;161A(12):2953-63. doi: 10.1002/ajmg.a.35886. Epub 2013 Oct 2.

PMID:
24123848
21.

Synthesis and physicochemical characterization of novel phenotypic probes targeting the nuclear factor-kappa B signaling pathway.

Hershberger PM, Peddibhotla S, Sessions EH, Divlianska DB, Correa RG, Pinkerton AB, Reed JC, Roth GP.

Beilstein J Org Chem. 2013 May 8;9:900-7. doi: 10.3762/bjoc.9.103. Print 2013.

22.

A Selective Inhibitor of Plasmodium falciparum Glucose-6-Phosphate Dehydrogenase (PfG6PDH).

Maloney P, Hedrick M, Peddibhotla S, Hershberger P, Milewski M, Gosalia P, Li L, Preuss J, Sugarman E, Hood B, Suyama E, Nguyen K, Vasile S, Sergienko E, Salanawil S, Stonich D, Su Y, Dahl R, Mangravita-Novo A, Vicchiarelli M, McAnally D, Smith LH, Roth G, Diwan J, Chung TDY, Pinkerton AB, Bode L, Becker K.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2011 Dec 16 [updated 2013 Mar 7].

23.

Tetraspanin CD9 links junctional adhesion molecule-A to αvβ3 integrin to mediate basic fibroblast growth factor-specific angiogenic signaling.

Peddibhotla SS, Brinkmann BF, Kummer D, Tuncay H, Nakayama M, Adams RH, Gerke V, Ebnet K.

Mol Biol Cell. 2013 Apr;24(7):933-44. doi: 10.1091/mbc.E12-06-0481. Epub 2013 Feb 6.

24.

Discovery of a Plasmodium falciparum glucose-6-phosphate dehydrogenase 6-phosphogluconolactonase inhibitor (R,Z)-N-((1-ethylpyrrolidin-2-yl)methyl)-2-(2-fluorobenzylidene)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazine-6-carboxamide (ML276) that reduces parasite growth in vitro.

Preuss J, Maloney P, Peddibhotla S, Hedrick MP, Hershberger P, Gosalia P, Milewski M, Li YL, Sugarman E, Hood B, Suyama E, Nguyen K, Vasile S, Sergienko E, Mangravita-Novo A, Vicchiarelli M, McAnally D, Smith LH, Roth GP, Diwan J, Chung TD, Jortzik E, Rahlfs S, Becker K, Pinkerton AB, Bode L.

J Med Chem. 2012 Aug 23;55(16):7262-72. doi: 10.1021/jm300833h. Epub 2012 Aug 6.

25.

P190B RhoGAP Regulates Chromosome Segregation in Cancer Cells.

Hwang M, Peddibhotla S, McHenry P, Chang P, Yochum Z, Park KU, Sears JC, Vargo-Gogola T.

Cancers (Basel). 2012 Jun;4(2):475-89. doi: 10.3390/cancers4020475. Epub 2012 Apr 25.

26.

aPKC phosphorylates JAM-A at Ser285 to promote cell contact maturation and tight junction formation.

Iden S, Misselwitz S, Peddibhotla SS, Tuncay H, Rehder D, Gerke V, Robenek H, Suzuki A, Ebnet K.

J Cell Biol. 2012 Mar 5;196(5):623-39. doi: 10.1083/jcb.201104143. Epub 2012 Feb 27.

27.

Identification of Inhibitors of NOD1-Induced Nuclear Factor-κB Activation.

Khan PM, Correa RG, Divlianska DB, Peddibhotla S, Sessions EH, Magnuson G, Brown B, Suyama E, Yuan H, Mangravita-Novo A, Vicchiarelli M, Su Y, Vasile S, Smith LH, Diaz PW, Reed JC, Roth GP.

ACS Med Chem Lett. 2011 Oct 13;2(10):780-785. Epub 2011 Aug 5.

28.

The DNA damage effector Chk1 kinase regulates Cdc14B nucleolar shuttling during cell cycle progression.

Peddibhotla S, Wei Z, Papineni R, Lam MH, Rosen JM, Zhang P.

Cell Cycle. 2011 Feb 15;10(4):671-9. Epub 2011 Feb 15.

29.

Early-onset aging and defective DNA damage response in Cdc14b-deficient mice.

Wei Z, Peddibhotla S, Lin H, Fang X, Li M, Rosen JM, Zhang P.

Mol Cell Biol. 2011 Apr;31(7):1470-7. doi: 10.1128/MCB.01330-10. Epub 2011 Jan 24.

30.

Thermal enhancement with optically activated gold nanoshells sensitizes breast cancer stem cells to radiation therapy.

Atkinson RL, Zhang M, Diagaradjane P, Peddibhotla S, Contreras A, Hilsenbeck SG, Woodward WA, Krishnan S, Chang JC, Rosen JM.

Sci Transl Med. 2010 Oct 27;2(55):55ra79. doi: 10.1126/scitranslmed.3001447.

31.

miR-145-dependent targeting of junctional adhesion molecule A and modulation of fascin expression are associated with reduced breast cancer cell motility and invasiveness.

Götte M, Mohr C, Koo CY, Stock C, Vaske AK, Viola M, Ibrahim SA, Peddibhotla S, Teng YH, Low JY, Ebnet K, Kiesel L, Yip GW.

Oncogene. 2010 Dec 16;29(50):6569-80. doi: 10.1038/onc.2010.386. Epub 2010 Sep 6.

PMID:
20818426
32.

Inhibition of protein kinase C-driven nuclear factor-kappaB activation: synthesis, structure-activity relationship, and pharmacological profiling of pathway specific benzimidazole probe molecules.

Peddibhotla S, Shi R, Khan P, Smith LH, Mangravita-Novo A, Vicchiarelli M, Su Y, Okolotowicz KJ, Cashman JR, Reed JC, Roth GP.

J Med Chem. 2010 Jun 24;53(12):4793-7. doi: 10.1021/jm1000248.

33.

Mild arming and derivatization of natural products via an In(OTf)3-catalyzed arene iodination.

Zhou CY, Li J, Peddibhotla S, Romo D.

Org Lett. 2010 May 7;12(9):2104-7. doi: 10.1021/ol100587j.

PMID:
20387852
34.

Chemical biology strategy reveals pathway-selective inhibitor of NF-kappaB activation induced by protein kinase C.

Shi R, Re D, Dudl E, Cuddy M, Okolotowicz KJ, Dahl R, Su Y, Hurder A, Kitada S, Peddibhotla S, Roth GP, Smith LH, Kipps TJ, Cosford N, Cashman J, Reed JC.

ACS Chem Biol. 2010 Mar 19;5(3):287-99. doi: 10.1021/cb9003089.

35.

Defining the ATM-mediated barrier to tumorigenesis in somatic mammary cells following ErbB2 activation.

Reddy JP, Peddibhotla S, Bu W, Zhao J, Haricharan S, Du YC, Podsypanina K, Rosen JM, Donehower LA, Li Y.

Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3728-33. doi: 10.1073/pnas.0910665107. Epub 2010 Feb 3.

36.

Chk1 haploinsufficiency results in anemia and defective erythropoiesis.

Boles NC, Peddibhotla S, Chen AJ, Goodell MA, Rosen JM.

PLoS One. 2010 Jan 5;5(1):e8581. doi: 10.1371/journal.pone.0008581.

37.

Chking and executing cell division to prevent genomic instability.

Peddibhotla S, Rosen JM.

Cell Cycle. 2009 Aug;8(15):2339-42. Epub 2009 Aug 3.

PMID:
19571679
38.

The DNA-damage effector checkpoint kinase 1 is essential for chromosome segregation and cytokinesis.

Peddibhotla S, Lam MH, Gonzalez-Rimbau M, Rosen JM.

Proc Natl Acad Sci U S A. 2009 Mar 31;106(13):5159-64. doi: 10.1073/pnas.0806671106. Epub 2009 Mar 16.

39.

Small molecules can selectively inhibit ephrin binding to the EphA4 and EphA2 receptors.

Noberini R, Koolpe M, Peddibhotla S, Dahl R, Su Y, Cosford ND, Roth GP, Pasquale EB.

J Biol Chem. 2008 Oct 24;283(43):29461-72. doi: 10.1074/jbc.M804103200. Epub 2008 Aug 26.

40.
41.

Wnt/beta-catenin mediates radiation resistance of Sca1+ progenitors in an immortalized mammary gland cell line.

Chen MS, Woodward WA, Behbod F, Peddibhotla S, Alfaro MP, Buchholz TA, Rosen JM.

J Cell Sci. 2007 Feb 1;120(Pt 3):468-77. Epub 2007 Jan 16.

42.

Sensitization of cancer cells to DNA damaging agents by imidazolines.

Sharma V, Peddibhotla S, Tepe JJ.

J Am Chem Soc. 2006 Jul 19;128(28):9137-43.

PMID:
16834387
43.

Sensitization of tumor cells toward chemotherapy: enhancing the efficacy of camptothecin with imidazolines.

Sharma V, Lansdell TA, Peddibhotla S, Tepe JJ.

Chem Biol. 2004 Dec;11(12):1689-99.

44.
45.

Highly diastereoselective multicomponent synthesis of unsymmetrical imidazolines.

Peddibhotla S, Jayakumar S, Tepe JJ.

Org Lett. 2002 Oct 3;4(20):3533-5.

PMID:
12323062

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