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Items: 19


Evaluation of the Possibility to Detect Circulating Tumor DNA From Pituitary Adenoma.

Megnis K, Peculis R, Rovite V, Laksa P, Niedra H, Balcere I, Caune O, Breiksa A, Nazarovs J, Stukens J, Konrade I, Pirags V, Klovins J.

Front Endocrinol (Lausanne). 2019 Sep 18;10:615. doi: 10.3389/fendo.2019.00615. eCollection 2019.


Significantly altered peripheral blood cell DNA methylation profile as a result of immediate effect of metformin use in healthy individuals.

Elbere I, Silamikelis I, Ustinova M, Kalnina I, Zaharenko L, Peculis R, Konrade I, Ciuculete DM, Zhukovsky C, Gudra D, Radovica-Spalvina I, Fridmanis D, Pirags V, Schiöth HB, Klovins J.

Clin Epigenetics. 2018 Dec 13;10(1):156. doi: 10.1186/s13148-018-0593-x.


A widely used sampling device in colorectal cancer screening programmes allows for large-scale microbiome studies.

Gudra D, Shoaie S, Fridmanis D, Klovins J, Wefer H, Silamikelis I, Peculis R, Kalnina I, Elbere I, Radovica-Spalvina I, Hultcrantz R, Šķenders Ģ, Leja M, Engstrand L.

Gut. 2019 Sep;68(9):1723-1725. doi: 10.1136/gutjnl-2018-316225. Epub 2018 Sep 21. No abstract available.


Single nucleotide polymorphisms in the intergenic region between metformin transporter OCT2 and OCT3 coding genes are associated with short-term response to metformin monotherapy in type 2 diabetes mellitus patients.

Zaharenko L, Kalnina I, Geldnere K, Konrade I, Grinberga S, Židzik J, Javorský M, Lejnieks A, Nikitina-Zake L, Fridmanis D, Peculis R, Radovica-Spalvina I, Hartmane D, Pugovics O, Tkáč I, Klimčáková L, Pīrāgs V, Klovins J.

Eur J Endocrinol. 2016 Dec;175(6):531-540. Epub 2016 Sep 8.


Genetic linkage studies of a North Carolina macular dystrophy family.

Audere M, Rutka K, Inaskina I, Peculis R, Sepetiene S, Valeina S, Lāce B.

Medicina (Kaunas). 2016;52(3):180-6. doi: 10.1016/j.medici.2016.04.001. Epub 2016 Apr 19.


Functional Characteristics of Multipotent Mesenchymal Stromal Cells from Pituitary Adenomas.

Megnis K, Mandrika I, Petrovska R, Stukens J, Rovite V, Balcere I, Jansone LS, Peculis R, Pirags V, Klovins J.

Stem Cells Int. 2016;2016:7103720. doi: 10.1155/2016/7103720. Epub 2016 Jun 2.


Polymorphisms in MEN1 and DRD2 genes are associated with the occurrence and characteristics of pituitary adenomas.

Peculis R, Balcere I, Rovite V, Megnis K, Valtere A, Stukens J, Arnicane L, Nikitina-Zake L, Lejnieks A, Pirags V, Klovins J.

Eur J Endocrinol. 2016 Aug;175(2):145-53. doi: 10.1530/EJE-15-0879. Epub 2016 May 16.


Association of F11 polymorphism rs2289252 with deep vein thrombosis and related phenotypes in population of Latvia.

Rovite V, Maurins U, Megnis K, Vaivade I, Pečulis R, Rits J, Prave S, Klovins J.

Thromb Res. 2014 Sep;134(3):659-63. doi: 10.1016/j.thromres.2014.07.011. Epub 2014 Jul 18.


Role of genetic factors on the effect of additional loading doses and two maintenance doses used to overcome clopidogrel hyporesponsiveness.

Latkovskis G, Urtane I, Knipse A, Peculis R, Cakstina I, Klovins J, Erglis A.

Medicina (Kaunas). 2014;50(1):19-27. doi: 10.1016/j.medici.2014.05.004. Epub 2014 Jun 6.


HFE-related hemochromatosis risk mutations in Latvian population.

Peculis R, Lace B, Putnina A, Nikitina-Zake L, Klovins J.

Ann Hematol. 2015 Feb;94(2):343-4. No abstract available.


BRCA1 gene-related hereditary susceptibility to breast and ovarian cancer in Latvia.

Tihomirova L, Vaivade I, Fokina O, Peculis R, Mandrika I, Sinicka O, Stengrevics A, Krilova A, Keire G, Petrevics J, Eglitis J, Timofejevs M, Leja M.

Adv Med Sci. 2014 Mar;59(1):114-9. doi: 10.1016/j.advms.2013.09.002. Epub 2014 Mar 20.


The role of common and rare MC4R variants and FTO polymorphisms in extreme form of obesity.

Rovite V, Petrovska R, Vaivade I, Kalnina I, Fridmanis D, Zaharenko L, Peculis R, Pirags V, Schioth HB, Klovins J.

Mol Biol Rep. 2014 Mar;41(3):1491-500. doi: 10.1007/s11033-013-2994-4. Epub 2014 Jan 3.


Polymorphisms in FTO and near TMEM18 associate with type 2 diabetes and predispose to younger age at diagnosis of diabetes.

Kalnina I, Zaharenko L, Vaivade I, Rovite V, Nikitina-Zake L, Peculis R, Fridmanis D, Geldnere K, Jacobsson JA, Almen MS, Pirags V, Schiöth HB, Klovins J.

Gene. 2013 Sep 25;527(2):462-8. doi: 10.1016/j.gene.2013.06.079. Epub 2013 Jul 13.


Identification of glyoxalase 1 polymorphisms associated with enzyme activity.

Peculis R, Konrade I, Skapare E, Fridmanis D, Nikitina-Zake L, Lejnieks A, Pirags V, Dambrova M, Klovins J.

Gene. 2013 Feb 15;515(1):140-3. doi: 10.1016/j.gene.2012.11.009. Epub 2012 Nov 29.


Stronger association of common variants in TCF7L2 gene with nonobese type 2 diabetes in the Latvian population.

Kalnina I, Geldnere K, Tarasova L, Nikitina-Zake L, Peculis R, Fridmanis D, Pirags V, Klovins J.

Exp Clin Endocrinol Diabetes. 2012 Sep;120(8):466-8. doi: 10.1055/s-0032-1306298. Epub 2012 Mar 22.


Identification of somatostatin receptor type 5 gene polymorphisms associated with acromegaly.

Ciganoka D, Balcere I, Kapa I, Peculis R, Valtere A, Nikitina-Zake L, Lase I, Schiöth HB, Pirags V, Klovins J.

Eur J Endocrinol. 2011 Oct;165(4):517-25. doi: 10.1530/EJE-11-0416. Epub 2011 Aug 2.


A nonsynonymous variant I248L of the adenosine A3 receptor is associated with coronary heart disease in a Latvian population.

Peculis R, Latkovskis G, Tarasova L, Pirags V, Erglis A, Klovins J.

DNA Cell Biol. 2011 Nov;30(11):907-11. doi: 10.1089/dna.2011.1230. Epub 2011 Jun 15.


Single nucleotide polymorphisms of the purinergic 1 receptor are not associated with myocardial infarction in a Latvian population.

Ignatovica V, Latkovskis G, Peculis R, Megnis K, Schioth HB, Vaivade I, Fridmanis D, Pirags V, Erglis A, Klovins J.

Mol Biol Rep. 2012 Feb;39(2):1917-25. doi: 10.1007/s11033-011-0938-4. Epub 2011 Jun 4.


Identification of domains responsible for specific membrane transport and ligand specificity of the ACTH receptor (MC2R).

Fridmanis D, Petrovska R, Kalnina I, Slaidina M, Peculis R, Schiöth HB, Klovins J.

Mol Cell Endocrinol. 2010 Jun 10;321(2):175-83. doi: 10.1016/j.mce.2010.02.032. Epub 2010 Mar 3.


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