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Items: 32

1.

Discovery of imidazo[1,2-a]-pyridine inhibitors of pan-PI3 kinases that are efficacious in a mouse xenograft model.

Han W, Menezes DL, Xu Y, Knapp MS, Elling R, Burger MT, Ni ZJ, Smith A, Lan J, Williams TE, Verhagen J, Huh K, Merritt H, Chan J, Kaufman S, Voliva CF, Pecchi S.

Bioorg Med Chem Lett. 2016 Feb 1;26(3):742-746. doi: 10.1016/j.bmcl.2016.01.003. Epub 2016 Jan 5.

PMID:
26774655
2.

Optimization of a Dibenzodiazepine Hit to a Potent and Selective Allosteric PAK1 Inhibitor.

Karpov AS, Amiri P, Bellamacina C, Bellance MH, Breitenstein W, Daniel D, Denay R, Fabbro D, Fernandez C, Galuba I, Guerro-Lagasse S, Gutmann S, Hinh L, Jahnke W, Klopp J, Lai A, Lindvall MK, Ma S, Möbitz H, Pecchi S, Rummel G, Shoemaker K, Trappe J, Voliva C, Cowan-Jacob SW, Marzinzik AL.

ACS Med Chem Lett. 2015 May 22;6(7):776-81. doi: 10.1021/acsmedchemlett.5b00102. eCollection 2015 Jul 9.

3.

Microbiological Assessment of Freshly-Shot Wild Boars Meat in Lazio Region, Viterbo Territory: a Preliminary Study.

Rodas EM, Bogdanova T, Bossù T, Pecchi S, Tomassetti F, De Santis P, Tolli R, Condoleo R, Greco S, Brozzi A, Bilei S, Micarelli G, Martini E, Palazzetti M.

Ital J Food Saf. 2014 Mar 4;3(1):1711. eCollection 2014 Jan 21. Italian. No abstract available.

PMID:
27800318
Free PMC Article
4.

Structure guided optimization of a fragment hit to imidazopyridine inhibitors of PI3K.

Pecchi S, Ni ZJ, Han W, Smith A, Lan J, Burger M, Merritt H, Wiesmann M, Chan J, Kaufman S, Knapp MS, Janssen J, Huh K, Voliva CF.

Bioorg Med Chem Lett. 2013 Aug 15;23(16):4652-6. doi: 10.1016/j.bmcl.2013.06.010. Epub 2013 Jun 12.

PMID:
23820386
5.

Identification and characterization of NVP-BKM120, an orally available pan-class I PI3-kinase inhibitor.

Maira SM, Pecchi S, Huang A, Burger M, Knapp M, Sterker D, Schnell C, Guthy D, Nagel T, Wiesmann M, Brachmann S, Fritsch C, Dorsch M, Chène P, Shoemaker K, De Pover A, Menezes D, Martiny-Baron G, Fabbro D, Wilson CJ, Schlegel R, Hofmann F, García-Echeverría C, Sellers WR, Voliva CF.

Mol Cancer Ther. 2012 Feb;11(2):317-28. doi: 10.1158/1535-7163.MCT-11-0474. Epub 2011 Dec 21.

6.

Identification of NVP-BKM120 as a Potent, Selective, Orally Bioavailable Class I PI3 Kinase Inhibitor for Treating Cancer.

Burger MT, Pecchi S, Wagman A, Ni ZJ, Knapp M, Hendrickson T, Atallah G, Pfister K, Zhang Y, Bartulis S, Frazier K, Ng S, Smith A, Verhagen J, Haznedar J, Huh K, Iwanowicz E, Xin X, Menezes D, Merritt H, Lee I, Wiesmann M, Kaufman S, Crawford K, Chin M, Bussiere D, Shoemaker K, Zaror I, Maira SM, Voliva CF.

ACS Med Chem Lett. 2011 Aug 26;2(10):774-9. doi: 10.1021/ml200156t. eCollection 2011 Oct 13.

7.

Synthesis and in Vitro and in Vivo Evaluation of Phosphoinositide-3-kinase Inhibitors.

Burger MT, Knapp M, Wagman A, Ni ZJ, Hendrickson T, Atallah G, Zhang Y, Frazier K, Verhagen J, Pfister K, Ng S, Smith A, Bartulis S, Merrit H, Weismann M, Xin X, Haznedar J, Voliva CF, Iwanowicz E, Pecchi S.

ACS Med Chem Lett. 2010 Oct 13;2(1):34-8. doi: 10.1021/ml1001932. eCollection 2011 Jan 13.

8.

Identification and structure-activity relationship of 2-morpholino 6-(3-hydroxyphenyl) pyrimidines, a class of potent and selective PI3 kinase inhibitors.

Pecchi S, Renhowe PA, Taylor C, Kaufman S, Merritt H, Wiesmann M, Shoemaker KR, Knapp MS, Ornelas E, Hendrickson TF, Fantl W, Voliva CF.

Bioorg Med Chem Lett. 2010 Dec 1;20(23):6895-8. doi: 10.1016/j.bmcl.2010.10.021. Epub 2010 Oct 13.

PMID:
21035331
9.

Design, structure-activity relationships and in vivo characterization of 4-amino-3-benzimidazol-2-ylhydroquinolin-2-ones: a novel class of receptor tyrosine kinase inhibitors.

Renhowe PA, Pecchi S, Shafer CM, Machajewski TD, Jazan EM, Taylor C, Antonios-McCrea W, McBride CM, Frazier K, Wiesmann M, Lapointe GR, Feucht PH, Warne RL, Heise CC, Menezes D, Aardalen K, Ye H, He M, Le V, Vora J, Jansen JM, Wernette-Hammond ME, Harris AL.

J Med Chem. 2009 Jan 22;52(2):278-92. doi: 10.1021/jm800790t.

PMID:
19113866
10.

4-(Aminoalkylamino)-3-benzimidazole-quinolinones as potent CHK-1 inhibitors.

Ni ZJ, Barsanti P, Brammeier N, Diebes A, Poon DJ, Ng S, Pecchi S, Pfister K, Renhowe PA, Ramurthy S, Wagman AS, Bussiere DE, Le V, Zhou Y, Jansen JM, Ma S, Gesner TG.

Bioorg Med Chem Lett. 2006 Jun 15;16(12):3121-4. Epub 2006 Apr 5.

PMID:
16603354
11.

Design and structure-activity relationship of heterocyclic analogs of 4-amino-3-benzimidazol-2-ylhydroquinolin-2-ones as inhibitors of receptor tyrosine kinases.

Frazier K, Jazan E, McBride CM, Pecchi S, Renhowe PA, Shafer CM, Taylor C, Bussiere D, He MM, Jansen JM, Lapointe G, Ma S, Vora J, Wiesmann M.

Bioorg Med Chem Lett. 2006 Apr 15;16(8):2247-51. Epub 2006 Jan 30.

PMID:
16446087
12.

A New Bromo Trienyne: Synthesis of all-E, Conjugated Tetra-, Penta-, and Hexaenes Common to Oxo Polyene Macrolide Antibiotics.

Lipshutz BH, Ullman B, Lindsley C, Pecchi S, Buzard DJ, Dickson D.

J Org Chem. 1998 Sep 4;63(18):6092-6093. No abstract available.

PMID:
11672230
13.

A Selective and General Access to Trisubstituted Oxetanes.

Mordini A, Bindi S, Pecchi S, Capperucci A, Degl'Innocenti A, Reginato G.

J Org Chem. 1996 Jun 26;61(13):4466-4468. No abstract available.

PMID:
11667355
14.

Different Pathways in the Base-Promoted Isomerization of Benzyl Oxiranyl Ethers.

Mordini A, Bindi S, Pecchi S, Degl'Innocenti A, Reginato G, Serci A.

J Org Chem. 1996 Jun 26;61(13):4374-4378.

PMID:
11667340
15.

Evidence of an adenosine-dependent mechanism in the hypotensive effect of L-arginine in man.

Laghi Pasini F, Frigerio C, Blardi P, Domini L, De Giorgi L, Borgogni G, Pecchi S, Cati G, Franchi M, Volpi L, et al.

Clin Exp Pharmacol Physiol. 1995 Apr;22(4):254-9.

PMID:
7671437
16.

Hemodynamic and hemorheologic effects of i.v. Dilevalol in hypertensive patients.

Pasini FL, Pecchi S, Guideri F, DeFranco V, Damiani P, Galigani C, Saletti M, Verzuri MS, Blardi P, Di Perri T.

Angiology. 1991 Sep;42(9):703-10.

PMID:
1928811
17.

Plethysmographic evaluation of the vascular effects of human calcitonin gene-related peptide in man.

Gennari C, Nami R, Pecchi S, De Franco V, Panza F, Pavese G.

Angiology. 1991 Jun;42(6):462-7.

PMID:
2042794
18.

[The effects of the acute administration of vinburnine on blood rheology, oxygen transport and regional circulation under normal conditions and in hypoxemia. In vivo research].

Domini L, Acciavatti A, Galigani C, Saletti M, De Franco V, Pecchi S, Auteri A, Di Perri T.

Recenti Prog Med. 1990 Nov;81(11):716-23. Italian.

PMID:
2287808
19.

[Calcium dobesilate in the treatment of primary venous insufficiency of the lower limbs. A controlled clinical study].

Pecchi S, De Franco V, Damiani P, Guerrini M, Di Perri T.

Clin Ter. 1990 Mar 31;132(6):409-17. Italian.

PMID:
2139387
20.

In vivo and in vitro evidence of an adenosine-mediated mechanism of calcium entry blocker activities.

Di Perri T, Pasini FL, Pecchi S, De Franco V, Damiani P, Pasqui AL, Capecchi PL, Orrico A, Materazzi M, Domini L, et al.

Angiology. 1989 Mar;40(3):190-8.

PMID:
2537050
21.

Pharmacological basis and therapeutic efficacy of flunarizine in peripheral artery disease.

Di Perri T, Laghi Pasini F, Pecchi S, Domini L, Ralli L, Materazzi M, De Franco V, Monaci A, Ceccatelli L.

Ann N Y Acad Sci. 1988;522:491-501. No abstract available.

PMID:
3377375
22.

Efficacy of O-(beta-hydroxyethyl)-rutosides at high dosage in counteracting the unwanted activity of oral contraceptives on venous function.

Cappelli R, Pecchi S, Oberhauser V, Forconi S, Di Perri T.

Int J Clin Pharmacol Res. 1987;7(4):291-9.

PMID:
3596872
23.

[Can normovolemic hemodilution really modify blood flow in the limbs?].

Guerrini M, Pieragalli D, Acciavatti A, Cappelli R, Pecchi S, Forconi S, Di Perri T.

Ric Clin Lab. 1983;13 Suppl 3:439-44. Italian.

PMID:
6673027
24.

Influence of non-selective and selective beta adrenoceptor blockade on isoxsuprine-dependent hemodynamic and rheologic changes.

Di Perri T, Forconi S, Guerrini M, Pecchi S, Pieragalli D, Cappelli R, Acciavatti A.

Angiology. 1981 Apr;32(4):257-65.

PMID:
7224236
25.

[Effects of pentoxifylline on blood viscosity and peripheral hemodynamics in patients with peripheral occlusive arteriopathies].

Guerrini M, Pecchi S, Rossi C, Cappelli R, Pieragalli D, Acciavatti A.

Ric Clin Lab. 1981;11 Suppl 1:265-79. Italian. No abstract available.

PMID:
7188114
27.

Arterial and venous blood viscosity in ischemic lower limbs in patients affected by peripheral obliterative arterial disease.

Forconi S, Guerrini M, Ravelli P, Rossi C, Ferrozzi C, Pecchi S, Biasi G.

J Cardiovasc Surg (Torino). 1979 Jul-Aug;20(4):379-84.

PMID:
479273
28.

Strain gauge plethysmography in the study of circulation of the limbs.

Forconi S, Jageneau A, Guerrini M, Pecchi S, Cappelli R.

Angiology. 1979 Jul;30(7):487-97. No abstract available.

PMID:
464339
29.

Local increase of blood viscosity during cold-induced Raynaud's phenomenon.

Forconi S, Guerrini M, Rossi C, Pecchi S.

Vasa. 1979;8(2):116-20. No abstract available.

PMID:
463282
30.

[Changes in systemic blood viscosity in subjects with regional chronic vasculopathies during spontaneous and induced ischemia].

Di Perri T, Forconi S, Guerrini M, Rossi C, Pecchi S.

Boll Soc Ital Cardiol. 1977;22(7):1138-50. Italian. No abstract available.

PMID:
618247
31.

[Changes in systemic blood viscosity during induced intermittent claudication in peripheral obliterating arteriopathy].

Forconi S, Guerrini M, Rossi C, Pecchi S, Di Perri T.

Boll Soc Ital Cardiol. 1977;22(4):441-6. Italian. No abstract available.

PMID:
617290
32.

[Changes in systemic blood viscosity during the exercise test in angina pectoris].

Forconi S, Guerrini M, Rossi C, Pecchi S, Di Perri T.

Boll Soc Ital Cardiol. 1977;22(4):435-40. Italian. No abstract available.

PMID:
617289

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