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Items: 1 to 50 of 83

1.

Synthesis of novel tellurides bearing benzensulfonamide moiety as carbonic anhydrase inhibitors with antitumor activity.

Tanini D, Ricci L, Capperucci A, Di Cesare Mannelli L, Ghelardini C, Peat TS, Carta F, Angeli A, Supuran CT.

Eur J Med Chem. 2019 Aug 5;181:111586. doi: 10.1016/j.ejmech.2019.111586. [Epub ahead of print]

PMID:
31401537
2.

Structures of the transcriptional regulator BgaR, a lactose sensor.

Newman J, Caron K, Nebl T, Peat TS.

Acta Crystallogr D Struct Biol. 2019 Jul 1;75(Pt 7):639-646. doi: 10.1107/S2059798319008131. Epub 2019 Jun 26.

PMID:
31282473
3.

Benzensulfonamides bearing spyrohydantoin moieties act as potent inhibitors of human carbonic anhydrases II and VII and show neuropathic pain attenuating effects.

Angeli A, Di Cesare Mannelli L, Ghelardini C, Peat TS, Bartolucci G, Menicatti M, Carta F, Supuran CT.

Eur J Med Chem. 2019 Sep 1;177:188-197. doi: 10.1016/j.ejmech.2019.05.058. Epub 2019 May 21.

PMID:
31136893
4.

A novel decarboxylating amidohydrolase involved in avoiding metabolic dead ends during cyanuric acid catabolism in Pseudomonas sp. strain ADP.

Esquirol L, Peat TS, Wilding M, Hartley CJ, Newman J, Scott C.

PLoS One. 2018 Nov 6;13(11):e0206949. doi: 10.1371/journal.pone.0206949. eCollection 2018.

5.

Cryo-EM structure of the active, Gs-protein complexed, human CGRP receptor.

Liang YL, Khoshouei M, Deganutti G, Glukhova A, Koole C, Peat TS, Radjainia M, Plitzko JM, Baumeister W, Miller LJ, Hay DL, Christopoulos A, Reynolds CA, Wootten D, Sexton PM.

Nature. 2018 Sep;561(7724):492-497. doi: 10.1038/s41586-018-0535-y. Epub 2018 Sep 12.

6.

Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth.

Baell JB, Leaver DJ, Hermans SJ, Kelly GL, Brennan MS, Downer NL, Nguyen N, Wichmann J, McRae HM, Yang Y, Cleary B, Lagiakos HR, Mieruszynski S, Pacini G, Vanyai HK, Bergamasco MI, May RE, Davey BK, Morgan KJ, Sealey AJ, Wang B, Zamudio N, Wilcox S, Garnham AL, Sheikh BN, Aubrey BJ, Doggett K, Chung MC, de Silva M, Bentley J, Pilling P, Hattarki M, Dolezal O, Dennis ML, Falk H, Ren B, Charman SA, White KL, Rautela J, Newbold A, Hawkins ED, Johnstone RW, Huntington ND, Peat TS, Heath JK, Strasser A, Parker MW, Smyth GK, Street IP, Monahan BJ, Voss AK, Thomas T.

Nature. 2018 Aug;560(7717):253-257. doi: 10.1038/s41586-018-0387-5. Epub 2018 Aug 1.

PMID:
30069049
7.

Design, synthesis and X-ray crystallography of selenides bearing benzenesulfonamide moiety with neuropathic pain modulating effects.

Angeli A, di Cesare Mannelli L, Lucarini E, Peat TS, Ghelardini C, Supuran CT.

Eur J Med Chem. 2018 Jun 25;154:210-219. doi: 10.1016/j.ejmech.2018.05.026. Epub 2018 May 19.

PMID:
29803994
8.

Design, Synthesis, and X-ray of Selenides as New Class of Agents for Prevention of Diabetic Cerebrovascular Pathology.

Angeli A, di Cesare Mannelli L, Trallori E, Peat TS, Ghelardini C, Carta F, Supuran CT.

ACS Med Chem Lett. 2018 Apr 9;9(5):462-467. doi: 10.1021/acsmedchemlett.8b00076. eCollection 2018 May 10.

9.

Synthesis, structure and bioactivity of primary sulfamate-containing natural products.

Mujumdar P, Bua S, Supuran CT, Peat TS, Poulsen SA.

Bioorg Med Chem Lett. 2018 Sep 15;28(17):3009-3013. doi: 10.1016/j.bmcl.2018.04.038. Epub 2018 Apr 16.

PMID:
29685656
10.

An unexpected vestigial protein complex reveals the evolutionary origins of an s-triazine catabolic enzyme.

Esquirol L, Peat TS, Wilding M, Liu JW, French NG, Hartley CJ, Onagi H, Nebl T, Easton CJ, Newman J, Scott C.

J Biol Chem. 2018 May 18;293(20):7880-7891. doi: 10.1074/jbc.RA118.001996. Epub 2018 Mar 9.

11.

Structural and biochemical characterization of the biuret hydrolase (BiuH) from the cyanuric acid catabolism pathway of Rhizobium leguminasorum bv. viciae 3841.

Esquirol L, Peat TS, Wilding M, Lucent D, French NG, Hartley CJ, Newman J, Scott C.

PLoS One. 2018 Feb 9;13(2):e0192736. doi: 10.1371/journal.pone.0192736. eCollection 2018.

12.

Structural characterization of a novel monotreme-specific protein with antimicrobial activity from the milk of the platypus.

Newman J, Sharp JA, Enjapoori AK, Bentley J, Nicholas KR, Adams TE, Peat TS.

Acta Crystallogr F Struct Biol Commun. 2018 Jan 1;74(Pt 1):39-45. doi: 10.1107/S2053230X17017708. Epub 2018 Jan 1.

PMID:
29372906
13.

8-Mercaptoguanine Derivatives as Inhibitors of Dihydropteroate Synthase.

Dennis ML, Lee MD, Harjani JR, Ahmed M, DeBono AJ, Pitcher NP, Wang ZC, Chhabra S, Barlow N, Rahmani R, Cleary B, Dolezal O, Hattarki M, Aurelio L, Shonberg J, Graham B, Peat TS, Baell JB, Swarbrick JD.

Chemistry. 2018 Feb 6;24(8):1922-1930. doi: 10.1002/chem.201704730. Epub 2018 Jan 9.

PMID:
29171692
14.

Discovery of New Selenoureido Analogues of 4-(4-Fluorophenylureido)benzenesulfonamide as Carbonic Anhydrase Inhibitors.

Angeli A, Tanini D, Peat TS, Di Cesare Mannelli L, Bartolucci G, Capperucci A, Ghelardini C, Supuran CT, Carta F.

ACS Med Chem Lett. 2017 Aug 10;8(9):963-968. doi: 10.1021/acsmedchemlett.7b00280. eCollection 2017 Sep 14.

15.

Identification of a New Zinc Binding Chemotype by Fragment Screening.

Chrysanthopoulos PK, Mujumdar P, Woods LA, Dolezal O, Ren B, Peat TS, Poulsen SA.

J Med Chem. 2017 Sep 14;60(17):7333-7349. doi: 10.1021/acs.jmedchem.7b00606. Epub 2017 Sep 1.

PMID:
28817930
16.

T-dependent B cell responses to Plasmodium induce antibodies that form a high-avidity multivalent complex with the circumsporozoite protein.

Fisher CR, Sutton HJ, Kaczmarski JA, McNamara HA, Clifton B, Mitchell J, Cai Y, Dups JN, D'Arcy NJ, Singh M, Chuah A, Peat TS, Jackson CJ, Cockburn IA.

PLoS Pathog. 2017 Jul 31;13(7):e1006469. doi: 10.1371/journal.ppat.1006469. eCollection 2017 Jul.

17.

High-Resolution X-Ray Structures of Two Functionally Distinct Members of the Cyclic Amide Hydrolase Family of Toblerone Fold Enzymes.

Peat TS, Balotra S, Wilding M, Hartley CJ, Newman J, Scott C.

Appl Environ Microbiol. 2017 Apr 17;83(9). pii: e03365-16. doi: 10.1128/AEM.03365-16. Print 2017 May 1.

18.

Crystal structure of a putrescine aminotransferase from Pseudomonas sp. strain AAC.

Wilding M, Scott C, Newman J, Peat TS.

Acta Crystallogr F Struct Biol Commun. 2017 Jan 1;73(Pt 1):29-35. doi: 10.1107/S2053230X16019658. Epub 2017 Jan 1.

19.

X-ray crystal structure of a malonate-semialdehyde dehydrogenase from Pseudomonas sp. strain AAC.

Wilding M, Scott C, Peat TS, Newman J.

Acta Crystallogr F Struct Biol Commun. 2017 Jan 1;73(Pt 1):24-28. doi: 10.1107/S2053230X16020008. Epub 2017 Jan 1.

20.

The nanoscience behind the art of in-meso crystallization of membrane proteins.

Zabara A, Meikle TG, Newman J, Peat TS, Conn CE, Drummond CJ.

Nanoscale. 2017 Jan 5;9(2):754-763. doi: 10.1039/c6nr07634c.

PMID:
27976759
21.

Intramolecular oxidative deselenization of acylselenoureas: a facile synthesis of benzoxazole amides and carbonic anhydrase inhibitors.

Angeli A, Peat TS, Bartolucci G, Nocentini A, Supuran CT, Carta F.

Org Biomol Chem. 2016 Dec 28;14(48):11353-11356. Epub 2016 Nov 28.

PMID:
27892589
22.

Structural basis for ligand recognition by a Cache chemosensory domain that mediates carboxylate sensing in Pseudomonas syringae.

Brewster JL, McKellar JL, Finn TJ, Newman J, Peat TS, Gerth ML.

Sci Rep. 2016 Oct 13;6:35198. doi: 10.1038/srep35198.

23.

An Unusual Natural Product Primary Sulfonamide: Synthesis, Carbonic Anhydrase Inhibition, and Protein X-ray Structures of Psammaplin C.

Mujumdar P, Teruya K, Tonissen KF, Vullo D, Supuran CT, Peat TS, Poulsen SA.

J Med Chem. 2016 Jun 9;59(11):5462-70. doi: 10.1021/acs.jmedchem.6b00443. Epub 2016 May 23.

PMID:
27172398
24.

A β-Alanine Catabolism Pathway Containing a Highly Promiscuous ω-Transaminase in the 12-Aminododecanate-Degrading Pseudomonas sp. Strain AAC.

Wilding M, Peat TS, Newman J, Scott C.

Appl Environ Microbiol. 2016 Jun 13;82(13):3846-3856. doi: 10.1128/AEM.00665-16. Print 2016 Jul 1.

25.

Structural Basis for the Selective Binding of Inhibitors to 6-Hydroxymethyl-7,8-dihydropterin Pyrophosphokinase from Staphylococcus aureus and Escherichia coli.

Dennis ML, Pitcher NP, Lee MD, DeBono AJ, Wang ZC, Harjani JR, Rahmani R, Cleary B, Peat TS, Baell JB, Swarbrick JD.

J Med Chem. 2016 Jun 9;59(11):5248-63. doi: 10.1021/acs.jmedchem.6b00002. Epub 2016 Apr 26.

PMID:
27094768
26.

Native State Mass Spectrometry, Surface Plasmon Resonance, and X-ray Crystallography Correlate Strongly as a Fragment Screening Combination.

Woods LA, Dolezal O, Ren B, Ryan JH, Peat TS, Poulsen SA.

J Med Chem. 2016 Mar 10;59(5):2192-204. doi: 10.1021/acs.jmedchem.5b01940. Epub 2016 Feb 29.

PMID:
26882437
27.

Rational engineering of a mesohalophilic carbonic anhydrase to an extreme halotolerant biocatalyst.

Warden AC, Williams M, Peat TS, Seabrook SA, Newman J, Dojchinov G, Haritos VS.

Nat Commun. 2015 Dec 21;6:10278. doi: 10.1038/ncomms10278.

28.

Some of the most interesting CASP11 targets through the eyes of their authors.

Kryshtafovych A, Moult J, Baslé A, Burgin A, Craig TK, Edwards RA, Fass D, Hartmann MD, Korycinski M, Lewis RJ, Lorimer D, Lupas AN, Newman J, Peat TS, Piepenbrink KH, Prahlad J, van Raaij MJ, Rohwer F, Segall AM, Seguritan V, Sundberg EJ, Singh AK, Wilson MA, Schwede T.

Proteins. 2016 Sep;84 Suppl 1:34-50. doi: 10.1002/prot.24942. Epub 2015 Nov 16.

29.

X-Ray Structure and Mutagenesis Studies of the N-Isopropylammelide Isopropylaminohydrolase, AtzC.

Balotra S, Warden AC, Newman J, Briggs LJ, Scott C, Peat TS.

PLoS One. 2015 Sep 21;10(9):e0137700. doi: 10.1371/journal.pone.0137700. eCollection 2015.

30.

Structural and biochemical analyses of a Clostridium perfringens sortase D transpeptidase.

Suryadinata R, Seabrook SA, Adams TE, Nuttall SD, Peat TS.

Acta Crystallogr D Biol Crystallogr. 2015 Jul;71(Pt 7):1505-13. doi: 10.1107/S1399004715009219. Epub 2015 Jun 30.

31.

The structure of the hexameric atrazine chlorohydrolase AtzA.

Peat TS, Newman J, Balotra S, Lucent D, Warden AC, Scott C.

Acta Crystallogr D Biol Crystallogr. 2015 Mar;71(Pt 3):710-20. doi: 10.1107/S1399004715000619. Epub 2015 Feb 26.

32.

Carbonic anhydrase inhibitors with dual-tail moieties to match the hydrophobic and hydrophilic halves of the carbonic anhydrase active site.

Tanpure RP, Ren B, Peat TS, Bornaghi LF, Vullo D, Supuran CT, Poulsen SA.

J Med Chem. 2015 Feb 12;58(3):1494-501. doi: 10.1021/jm501798g. Epub 2015 Jan 27.

PMID:
25581127
33.

Crystallization: digging into the past to learn lessons for the future.

Fazio VJ, Peat TS, Newman J.

Methods Mol Biol. 2015;1261:141-56. doi: 10.1007/978-1-4939-2230-7_8.

PMID:
25502198
34.

The structure of vanin 1: a key enzyme linking metabolic disease and inflammation.

Boersma YL, Newman J, Adams TE, Cowieson N, Krippner G, Bozaoglu K, Peat TS.

Acta Crystallogr D Biol Crystallogr. 2014 Dec 1;70(Pt 12):3320-9. doi: 10.1107/S1399004714022767. Epub 2014 Nov 28.

PMID:
25478849
35.

X-ray structure of the amidase domain of AtzF, the allophanate hydrolase from the cyanuric acid-mineralizing multienzyme complex.

Balotra S, Newman J, Cowieson NP, French NG, Campbell PM, Briggs LJ, Warden AC, Easton CJ, Peat TS, Scott C.

Appl Environ Microbiol. 2015 Jan;81(2):470-80. doi: 10.1128/AEM.02783-14. Epub 2014 Oct 31.

36.

Structure-based design and development of functionalized Mercaptoguanine derivatives as inhibitors of the folate biosynthesis pathway enzyme 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase from Staphylococcus aureus.

Dennis ML, Chhabra S, Wang ZC, Debono A, Dolezal O, Newman J, Pitcher NP, Rahmani R, Cleary B, Barlow N, Hattarki M, Graham B, Peat TS, Baell JB, Swarbrick JD.

J Med Chem. 2014 Nov 26;57(22):9612-26. doi: 10.1021/jm501417f. Epub 2014 Nov 12.

PMID:
25357262
37.

A drunken search in crystallization space.

Fazio VJ, Peat TS, Newman J.

Acta Crystallogr F Struct Biol Commun. 2014 Oct;70(Pt 10):1303-11. doi: 10.1107/S2053230X1401841X. Epub 2014 Sep 30.

38.

Unprecedented conformational flexibility revealed in the ligand-binding domains of the Bovicola ovis ecdysone receptor (EcR) and ultraspiracle (USP) subunits.

Ren B, Peat TS, Streltsov VA, Pollard M, Fernley R, Grusovin J, Seabrook S, Pilling P, Phan T, Lu L, Lovrecz GO, Graham LD, Hill RJ.

Acta Crystallogr D Biol Crystallogr. 2014 Jul;70(Pt 7):1954-64. doi: 10.1107/S1399004714009626. Epub 2014 Jun 29.

PMID:
25004972
39.

300-Fold increase in production of the Zn2+-dependent dechlorinase TrzN in soluble form via apoenzyme stabilization.

Jackson CJ, Coppin CW, Carr PD, Aleksandrov A, Wilding M, Sugrue E, Ubels J, Paks M, Newman J, Peat TS, Russell RJ, Field M, Weik M, Oakeshott JG, Scott C.

Appl Environ Microbiol. 2014 Jul;80(13):4003-11. doi: 10.1128/AEM.00916-14. Epub 2014 Apr 25.

40.

Cyclic secondary sulfonamides: unusually good inhibitors of cancer-related carbonic anhydrase enzymes.

Moeker J, Peat TS, Bornaghi LF, Vullo D, Supuran CT, Poulsen SA.

J Med Chem. 2014 Apr 24;57(8):3522-31. doi: 10.1021/jm500255y. Epub 2014 Apr 11.

PMID:
24689792
41.

Crystallization and preliminary X-ray diffraction analysis of the amidase domain of allophanate hydrolase from Pseudomonas sp. strain ADP.

Balotra S, Newman J, French NG, Briggs LJ, Peat TS, Scott C.

Acta Crystallogr F Struct Biol Commun. 2014 Mar;70(Pt 3):310-5. doi: 10.1107/S2053230X13034705. Epub 2014 Feb 19.

42.

Interrogating HIV integrase for compounds that bind--a SAMPL challenge.

Peat TS, Dolezal O, Newman J, Mobley D, Deadman JJ.

J Comput Aided Mol Des. 2014 Apr;28(4):347-62. doi: 10.1007/s10822-014-9721-7. Epub 2014 Feb 16.

43.

Nitrate in the active site of protein tyrosine phosphatase 1B is a putative mimetic of the transition state.

Kenny PW, Newman J, Peat TS.

Acta Crystallogr D Biol Crystallogr. 2014 Feb;70(Pt 2):565-71. doi: 10.1107/S1399004713031052. Epub 2014 Jan 31.

PMID:
24531490
44.

Crystallization reports are the backbone of Acta Cryst. F, but do they have any spine?

Newman J, Burton DR, Caria S, Desbois S, Gee CL, Fazio VJ, Kvansakul M, Marshall B, Mills G, Richter V, Seabrook SA, Wu M, Peat TS.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Jul;69(Pt 7):712-8. doi: 10.1107/S1744309113014152. Epub 2013 Jun 30.

45.

Characterization of the novel broad-spectrum kinase inhibitor CTx-0294885 as an affinity reagent for mass spectrometry-based kinome profiling.

Zhang L, Holmes IP, Hochgräfe F, Walker SR, Ali NA, Humphrey ES, Wu J, de Silva M, Kersten WJ, Connor T, Falk H, Allan L, Street IP, Bentley JD, Pilling PA, Monahan BJ, Peat TS, Daly RJ.

J Proteome Res. 2013 Jul 5;12(7):3104-16. doi: 10.1021/pr3008495. Epub 2013 Jun 25.

PMID:
23692254
46.

Cyanuric acid hydrolase: evolutionary innovation by structural concatenation.

Peat TS, Balotra S, Wilding M, French NG, Briggs LJ, Panjikar S, Cowieson N, Newman J, Scott C.

Mol Microbiol. 2013 Jun;88(6):1149-63. doi: 10.1111/mmi.12249. Epub 2013 May 20.

47.

Exploring the chemical space around 8-mercaptoguanine as a route to new inhibitors of the folate biosynthesis enzyme HPPK.

Chhabra S, Barlow N, Dolezal O, Hattarki MK, Newman J, Peat TS, Graham B, Swarbrick JD.

PLoS One. 2013;8(4):e59535. doi: 10.1371/journal.pone.0059535. Epub 2013 Apr 2.

48.

Expression, purification, crystallization and preliminary X-ray diffraction analysis of a lactococcal bacteriophage small terminase subunit.

Ren B, Pham TM, Surjadi R, Robinson CP, Le TK, Chandry PS, Peat TS, McKinstry WJ.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Mar 1;69(Pt 3):275-9. doi: 10.1107/S174430911300184X. Epub 2013 Feb 22.

49.

Determination of the structure of the catabolic N-succinylornithine transaminase (AstC) from Escherichia coli.

Newman J, Seabrook S, Surjadi R, Williams CC, Lucent D, Wilding M, Scott C, Peat TS.

PLoS One. 2013;8(3):e58298. doi: 10.1371/journal.pone.0058298. Epub 2013 Mar 6.

50.

Parallel screening of low molecular weight fragment libraries: do differences in methodology affect hit identification?

Wielens J, Headey SJ, Rhodes DI, Mulder RJ, Dolezal O, Deadman JJ, Newman J, Chalmers DK, Parker MW, Peat TS, Scanlon MJ.

J Biomol Screen. 2013 Feb;18(2):147-59. doi: 10.1177/1087057112465979. Epub 2012 Nov 8.

PMID:
23139382

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