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Items: 1 to 50 of 199

1.

Stochastic changes in gene expression promote chaotic dysregulation of homeostasis in clonal breast tumors.

Felts SJ, Tang X, Willett B, Van Keulen VP, Hansen MJ, Kalari KR, Pease LR.

Commun Biol. 2019 Jun 14;2:206. doi: 10.1038/s42003-019-0460-0. eCollection 2019.

2.

The early proximal αβ TCR signalosome specifies thymic selection outcome through a quantitative protein interaction network.

Neier SC, Ferrer A, Wilton KM, Smith SEP, Kelcher AMH, Pavelko KD, Canfield JM, Davis TR, Stiles RJ, Chen Z, McCluskey J, Burrows SR, Rossjohn J, Hebrink DM, Carmona EM, Limper AH, Kappes DJ, Wettstein PJ, Johnson AJ, Pease LR, Daniels MA, Neuhauser C, Gil D, Schrum AG.

Sci Immunol. 2019 Feb 15;4(32). pii: eaal2201. doi: 10.1126/sciimmunol.aal2201.

PMID:
30770409
3.

Breaking tolerance with engineered class I antigen-presenting molecules.

Parks CA, Henning KR, Pavelko KD, Hansen MJ, Van Keulen VP, Reed BK, Stone JD, Schrum AG, Gil D, Kranz DM, Bordner AJ, Barry MA, Pease LR.

Proc Natl Acad Sci U S A. 2019 Feb 19;116(8):3136-3145. doi: 10.1073/pnas.1807465116. Epub 2019 Feb 6.

4.

Exploring the effect of library preparation on RNA sequencing experiments.

Wang L, Felts SJ, Van Keulen VP, Pease LR, Zhang Y.

Genomics. 2018 Dec 6. pii: S0888-7543(18)30367-7. doi: 10.1016/j.ygeno.2018.11.030. [Epub ahead of print]

PMID:
30529531
5.

GM-CSF inhibition reduces cytokine release syndrome and neuroinflammation but enhances CAR-T cell function in xenografts.

Sterner RM, Sakemura R, Cox MJ, Yang N, Khadka RH, Forsman CL, Hansen MJ, Jin F, Ayasoufi K, Hefazi M, Schick KJ, Walters DK, Ahmed O, Chappell D, Sahmoud T, Durrant C, Nevala WK, Patnaik MM, Pease LR, Hedin KE, Kay NE, Johnson AJ, Kenderian SS.

Blood. 2019 Feb 14;133(7):697-709. doi: 10.1182/blood-2018-10-881722. Epub 2018 Nov 21.

PMID:
30463995
6.

Integrative Genome-Wide Analysis of Long Noncoding RNAs in Diverse Immune Cell Types of Melanoma Patients.

Wang L, Felts SJ, Van Keulen VP, Scheid AD, Block MS, Markovic SN, Pease LR, Zhang Y.

Cancer Res. 2018 Aug 1;78(15):4411-4423. doi: 10.1158/0008-5472.CAN-18-0529. Epub 2018 Jun 12.

7.

Non-equivalent antigen presenting capabilities of dendritic cells and macrophages in generating brain-infiltrating CD8 + T cell responses.

Malo CS, Huggins MA, Goddery EN, Tolcher HMA, Renner DN, Jin F, Hansen MJ, Pease LR, Pavelko KD, Johnson AJ.

Nat Commun. 2018 Feb 12;9(1):633. doi: 10.1038/s41467-018-03037-x.

8.

Gene Expression Signatures Characterized by Longitudinal Stability and Interindividual Variability Delineate Baseline Phenotypic Groups with Distinct Responses to Immune Stimulation.

Scheid AD, Van Keulen VP, Felts SJ, Neier SC, Middha S, Nair AA, Techentin RW, Gilbert BK, Jen J, Neuhauser C, Zhang Y, Pease LR.

J Immunol. 2018 Mar 1;200(5):1917-1928. doi: 10.4049/jimmunol.1701099. Epub 2018 Jan 19.

9.

Human perforin gene variation is geographically distributed.

Willenbring RC, Ikeda Y, Pease LR, Johnson AJ.

Mol Genet Genomic Med. 2018 Jan;6(1):44-55. doi: 10.1002/mgg3.344. Epub 2017 Dec 7.

10.

Replicating Single-Cycle Adenovirus Vectors Generate Amplified Influenza Vaccine Responses.

Crosby CM, Matchett WE, Anguiano-Zarate SS, Parks CA, Weaver EA, Pease LR, Webby RJ, Barry MA.

J Virol. 2017 Jan 3;91(2). pii: e00720-16. doi: 10.1128/JVI.00720-16. Print 2017 Jan 15.

11.

Definitive activation of endogenous antitumor immunity by repetitive cycles of cyclophosphamide with interspersed Toll-like receptor agonists.

Manrique SZ, Dominguez AL, Mirza N, Spencer CD, Bradley JM, Finke JH, Lee JJ, Pease LR, Gendler SJ, Cohen PA.

Oncotarget. 2016 Jul 12;7(28):42919-42942. doi: 10.18632/oncotarget.10190.

12.

Co-potentiation of antigen recognition: A mechanism to boost weak T cell responses and provide immunotherapy in vivo.

Hoffmann MM, Molina-Mendiola C, Nelson AD, Parks CA, Reyes EE, Hansen MJ, Rajagopalan G, Pease LR, Schrum AG, Gil D.

Sci Adv. 2015 Oct 2;1(9):e1500415. doi: 10.1126/sciadv.1500415. eCollection 2015 Oct.

13.

Calcium-Modulating Cyclophilin Ligand Is Essential for the Survival of Activated T Cells and for Adaptive Immunity.

Chan SL, Lindquist LD, Hansen MJ, Girtman MA, Pease LR, Bram RJ.

J Immunol. 2015 Dec 15;195(12):5648-56. doi: 10.4049/jimmunol.1500308. Epub 2015 Nov 11.

14.

A Versatile Simple Capture Assay for Assessing the Structural Integrity of MHC Multimer Reagents.

Reed BK, Chopp LB, Malo CS, Renner DN, Van Keulen VS, Girtman MA, Nevala WN, Pavelko KD, Gil D, Schrum AG, Johnson AJ, Pease LR.

PLoS One. 2015 Sep 21;10(9):e0137984. doi: 10.1371/journal.pone.0137984. eCollection 2015.

15.

Gene expression patterns in CD4+ peripheral blood cells in healthy subjects and stage IV melanoma patients.

Felts SJ, Van Keulen VP, Scheid AD, Allen KS, Bradshaw RK, Jen J, Peikert T, Middha S, Zhang Y, Block MS, Markovic SN, Pease LR.

Cancer Immunol Immunother. 2015 Nov;64(11):1437-47. doi: 10.1007/s00262-015-1745-x. Epub 2015 Aug 6.

16.

A natural human IgM that binds to gangliosides is therapeutic in murine models of amyotrophic lateral sclerosis.

Xu X, Denic A, Jordan LR, Wittenberg NJ, Warrington AE, Wootla B, Papke LM, Zoecklein LJ, Yoo D, Shaver J, Oh SH, Pease LR, Rodriguez M.

Dis Model Mech. 2015 Aug 1;8(8):831-42. doi: 10.1242/dmm.020727. Epub 2015 May 28.

17.

Combinatorial Immunoprofiling in Latent Tuberculosis Infection. Toward Better Risk Stratification.

Escalante P, Peikert T, Van Keulen VP, Erskine CL, Bornhorst CL, Andrist BR, McCoy K, Pease LR, Abraham RS, Knutson KL, Kita H, Schrum AG, Limper AH.

Am J Respir Crit Care Med. 2015 Sep 1;192(5):605-17. doi: 10.1164/rccm.201412-2141OC.

18.

Widespread Non-Canonical Epigenetic Modifications in MMTV-NeuT Breast Cancer.

Felts SJ, Van Keulen VP, Hansen MJ, Bell MP, Allen K, Belachew AA, Vile RG, Cunningham JM, Hoskin TL, Pankratz VS, Pease LR.

Neoplasia. 2015 Apr;17(4):348-57. doi: 10.1016/j.neo.2015.02.006.

19.

Gene splicing by overlap extension: tailor-made genes using the polymerase chain reaction. BioTechniques 8(5):528-535 (November 1990).

Horton RM, Cai Z, Ho SM, Pease LR.

Biotechniques. 2013 Mar;54(3):129-33. No abstract available.

20.

The epitope integration site for vaccine antigens determines virus control while maintaining efficacy in an engineered cancer vaccine.

Pavelko KD, Bell MP, Karyampudi L, Hansen MJ, Allen KS, Knutson KL, Pease LR.

Mol Ther. 2013 May;21(5):1087-95. doi: 10.1038/mt.2013.52. Epub 2013 Apr 9.

21.

Naturally occurring antibodies as therapeutics for neurologic disease: can human monoclonal IgMs replace the limited resource IVIG?

Warrington AE, Van Keulen V, Pease LR, Rodriguez M.

Adv Exp Med Biol. 2012;750:44-55. doi: 10.1007/978-1-4614-3461-0_4.

PMID:
22903665
22.

Two discreet subsets of CD8 T cells modulate PLP(91-110) induced experimental autoimmune encephalomyelitis in HLA-DR3 transgenic mice.

Mangalam AK, Luckey D, Giri S, Smart M, Pease LR, Rodriguez M, David CS.

J Autoimmun. 2012 Jun;38(4):344-53. doi: 10.1016/j.jaut.2012.02.004. Epub 2012 Mar 28.

23.

Nonequivalence of classical MHC class I loci in ability to direct effective antiviral immunity.

Pavelko KD, Mendez-Fernandez Y, Bell MP, Hansen MJ, Johnson AJ, David CS, Rodriguez M, Pease LR.

PLoS Pathog. 2012 Feb;8(2):e1002541. doi: 10.1371/journal.ppat.1002541. Epub 2012 Feb 23.

24.

Lineage(-)Sca1+c-Kit(-)CD25+ cells are IL-33-responsive type 2 innate cells in the mouse bone marrow.

Brickshawana A, Shapiro VS, Kita H, Pease LR.

J Immunol. 2011 Dec 1;187(11):5795-804. doi: 10.4049/jimmunol.1102242. Epub 2011 Nov 2.

25.

A single dose of neuron-binding human monoclonal antibody improves spontaneous activity in a murine model of demyelination.

Denic A, Macura SI, Warrington AE, Pirko I, Grossardt BR, Pease LR, Rodriguez M.

PLoS One. 2011;6(10):e26001. doi: 10.1371/journal.pone.0026001. Epub 2011 Oct 12.

26.

A human IgM signals axon outgrowth: coupling lipid raft to microtubules.

Xu X, Warrington AE, Wright BR, Bieber AJ, Van Keulen V, Pease LR, Rodriguez M.

J Neurochem. 2011 Oct;119(1):100-12. doi: 10.1111/j.1471-4159.2011.07416.x. Epub 2011 Sep 1.

27.

Theiler's murine encephalomyelitis virus as a vaccine candidate for immunotherapy.

Pavelko KD, Girtman MA, Mitsunaga Y, Mendez-Fernandez YV, Bell MP, Hansen MJ, Allen KS, Rodriguez M, Pease LR.

PLoS One. 2011;6(5):e20217. doi: 10.1371/journal.pone.0020217. Epub 2011 May 20.

28.

Transgenic expression of viral capsid proteins predisposes to axonal injury in a murine model of multiple sclerosis.

Denic A, Zoecklein L, Kerkvliet J, Papke L, Edukulla R, Warrington A, Bieber A, Pease LR, David CS, Rodriguez M.

Brain Pathol. 2011 Sep;21(5):501-15. doi: 10.1111/j.1750-3639.2011.00474.x. Epub 2011 Feb 11.

29.

Retraction: CTL activation using the natural low-affinity epitope 222-229 from tyrosinase-related protein 1 leads to tumor rejection.

Pavelko KD, Hansen MJ, Pease LR.

Cancer Res. 2010 Nov 15;70(22):9529. doi: 10.1158/0008-5472.CAN-10-3463. Epub 2010 Nov 2. No abstract available.

30.

Retraction: An effective vaccine strategy protective against antigenically distinct tumor variants.

Pavelko KD, Hansen MJ, Pease LR, Heckman KL.

Cancer Res. 2010 Nov 15;70(22):9528. doi: 10.1158/0008-5472.CAN-10-3462. Epub 2010 Nov 2. No abstract available.

31.

Retraction: Immunotherapeutic potential of B7-DC (PD-L2) cross-linking antibody in conferring antitumor immunity.

Nguyen LT, Ciric B, Van Keulen VP, Rodriguez M, Pease LR, Tamada K, Flies DB, Chen L.

Cancer Res. 2010 Nov 15;70(22):9528. doi: 10.1158/0008-5472.CAN-10-3461. Epub 2010 Nov 2. No abstract available.

32.
33.

Retraction: TREM-2 mediated signaling induces antigen uptake and retention in mature myeloid dendritic cells.

Arneson LN, Upshaw JL, Howe CL, Felts SJ, Rodriguez M, Pease LR, Colonna M.

J Immunol. 2010 Jun 1;184(11):6557. doi: 10.4049/jimmunol.1090036. No abstract available.

34.

Retraction: Reprogrammed FoxP3+ T regulatory cells become IL-17+ antigen-specific autoimmune effectors in vitro and in vivo.

Cabrera R, Schenk EL, Nava-Parada P, Bell MP, Van Keulen VP, Marler RJ, Felts SJ, Pease LR.

J Immunol. 2010 Jun 1;184(11):6556. doi: 10.4049/jimmunol.1090035. No abstract available.

35.

Retraction: Induction of a Th1 response from Th2-polarized T cells by activated dendritic cells: dependence on TCR:peptide-MHC interaction, ICAM-1, IL-12, and IFN-gamma.

Wiehagen KR, Pulko V, Van Keulen V, Faubion WA, Knutson KL, Pease LR.

J Immunol. 2010 Jun 1;184(11):6555. doi: 10.4049/jimmunol.1090034. No abstract available.

36.

Retraction: B7-DC/PD-L2 cross-linking induces NF-kappaB-dependent protection of dendritic cells from cell death.

Nguyen LT, Ciric B, Van Keulen VP, Pease LR.

J Immunol. 2010 Jun 1;184(11):6554. doi: 10.4049/jimmunol.1090033. No abstract available.

37.

Retraction: Blockade of allergic airway inflammation following systemic treatment with a B7-dendritic cell (PD-L2) cross-linking human antibody.

Iijima K, Kobayashi T, Rodriguez M, Kita H, Pease LR.

J Immunol. 2010 Jun 1;184(11):6553. doi: 10.4049/jimmunol.1090032. No abstract available.

38.

Retraction: Naturally occurring human IgM antibody that binds B7-DC and potentiates T cell stimulation by dendritic cells.

Nguyen LT, Ciric B, Ure DR, Zhou B, Tamada K, Tseng SY, Shin T, Chen L, Dong H, Kyle RA, Rodriguez M, Pease LR.

J Immunol. 2010 Jun 1;184(11):6552. doi: 10.4049/jimmunol.1090031. No abstract available.

39.

Retraction for Radhakrishnan et al., B7-DC cross-linking restores antigen uptake and augments antigen-presenting cell function by matured dendritic cells.

Radhakrishnan S, Celis E, Pease LR.

Proc Natl Acad Sci U S A. 2010 May 4;107(18):8498. doi: 10.1073/pnas.1003319107. Epub 2010 Apr 7. No abstract available.

40.

Allelic variation in the Tyk2 and EGF genes as potential genetic determinants of CNS repair.

Bieber AJ, Suwansrinon K, Kerkvliet J, Zhang W, Pease LR, Rodriguez M.

Proc Natl Acad Sci U S A. 2010 Jan 12;107(2):792-7. doi: 10.1073/pnas.0906589107. Epub 2009 Dec 22.

41.

Transgenic expression of the 3D polymerase inhibits Theiler's virus infection and demyelination.

Kerkvliet J, Zoecklein L, Papke L, Denic A, Bieber AJ, Pease LR, David CS, Rodriguez M.

J Virol. 2009 Dec;83(23):12279-89. doi: 10.1128/JVI.00664-09. Epub 2009 Sep 16.

42.

Indirect recruitment of a CD40 signaling pathway in dendritic cells by B7-DC cross-linking antibody modulates T cell functions.

Radhakrishnan S, Cabrera R, Bruns KM, Van Keulen VP, Hansen MJ, Felts SJ, Pease LR.

PLoS One. 2009;4(4):e5373. doi: 10.1371/journal.pone.0005373. Epub 2009 Apr 28. Retraction in: PLoS One. 2010;5(3). doi: 10.1371/annotation/36ac4b2c-cf27-41d9-90e2-e5d58d307896.

43.

Invited article: human natural autoantibodies in the treatment of neurologic disease.

Rodriguez M, Warrington AE, Pease LR.

Neurology. 2009 Apr 7;72(14):1269-76. doi: 10.1212/01.wnl.0000345662.05861.e4. Review.

44.

CTL activation using the natural low-affinity epitope 222-229 from tyrosinase-related protein 1 leads to tumor rejection.

Pavelko KD, Hansen MJ, Pease LR.

Cancer Res. 2009 Apr 1;69(7):3114-20. doi: 10.1158/0008-5472.CAN-08-2448. Epub 2009 Mar 10. Retraction in: Pavelko KD, Hansen MJ, Pease LR. Cancer Res. 2010 Nov 15;70(22):9529.

45.

Asthma-related environmental fungus, Alternaria, activates dendritic cells and produces potent Th2 adjuvant activity.

Kobayashi T, Iijima K, Radhakrishnan S, Mehta V, Vassallo R, Lawrence CB, Cyong JC, Pease LR, Oguchi K, Kita H.

J Immunol. 2009 Feb 15;182(4):2502-10. doi: 10.4049/jimmunol.0802773.

46.

TREM-2 mediated signaling induces antigen uptake and retention in mature myeloid dendritic cells.

Radhakrishnan S, Arneson LN, Upshaw JL, Howe CL, Felts SJ, Colonna M, Leibson PJ, Rodriguez M, Pease LR.

J Immunol. 2008 Dec 1;181(11):7863-72. Retraction in: Arneson LN, Upshaw JL, Howe CL, Felts SJ, Rodriguez M, Pease LR, Colonna M. J Immunol. 2010 Jun 1;184(11):6557.

47.

T-bet expression by dendritic cells is required for the repolarization of allergic airway inflammation.

Heckman KL, Radhakrishnan S, Peikert T, Iijima K, McGregor HC, Bell MP, Kita H, Pease LR.

Eur J Immunol. 2008 Sep;38(9):2464-74. doi: 10.1002/eji.200737952.

48.
49.

An effective vaccine strategy protective against antigenically distinct tumor variants.

Pavelko KD, Heckman KL, Hansen MJ, Pease LR.

Cancer Res. 2008 Apr 1;68(7):2471-8. doi: 10.1158/0008-5472.CAN-07-5937. Retraction in: Pavelko KD, Hansen MJ, Pease LR, Heckman KL. Cancer Res. 2010 Nov 15;70(22):9528.

50.

Human HLA-DR transgenes protect mice from fatal virus-induced encephalomyelitis and chronic demyelination.

Rodriguez M, Zoecklein L, Kerkvliet JG, Pavelko KD, Papke L, Howe CL, Pease LR, David C.

J Virol. 2008 Apr;82(7):3369-80. doi: 10.1128/JVI.02243-07. Epub 2008 Jan 30.

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