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Items: 1 to 50 of 96


Magnetic Resonance-only Workflow: Implementation in a UK Centre.

Pearson RA, Brooks R, Driver S, Frew JA, Pedley ID, Pilling K, Richmond N, Walker C, West S, Wilkinson M, Wyatt J, McCallum H.

Clin Oncol (R Coll Radiol). 2019 Nov 27. pii: S0936-6555(19)30482-0. doi: 10.1016/j.clon.2019.10.009. [Epub ahead of print] No abstract available.


Rebuilding the Retina: Prospects for Müller Glial-mediated Self-repair.

Langhe R, Pearson RA.

Curr Eye Res. 2020 Mar;45(3):349-360. doi: 10.1080/02713683.2019.1669665. Epub 2019 Oct 2.


Conditional Dicer1 depletion using Chrnb4-Cre leads to cone cell death and impaired photopic vision.

Aldunate EZ, Di Foggia V, Di Marco F, Hervas LA, Ribeiro JC, Holder DL, Patel A, Jannini TB, Thompson DA, Martinez-Barbera JP, Pearson RA, Ali RR, Sowden JC.

Sci Rep. 2019 Feb 19;9(1):2314. doi: 10.1038/s41598-018-38294-9.


Unlocking the Potential for Endogenous Repair to Restore Sight.

Pearson RA, Ali RR.

Neuron. 2018 Nov 7;100(3):524-526. doi: 10.1016/j.neuron.2018.10.035. Review.


Müller Glia Reactivity and Development of Gliosis in Response to Pathological Conditions.

Graca AB, Hippert C, Pearson RA.

Adv Exp Med Biol. 2018;1074:303-308. doi: 10.1007/978-3-319-75402-4_37. Review.


Prevention of Photoreceptor Cell Loss in a Cln6nclf Mouse Model of Batten Disease Requires CLN6 Gene Transfer to Bipolar Cells.

Kleine Holthaus SM, Ribeiro J, Abelleira-Hervas L, Pearson RA, Duran Y, Georgiadis A, Sampson RD, Rizzi M, Hoke J, Maswood R, Azam S, Luhmann UFO, Smith AJ, Mole SE, Ali RR.

Mol Ther. 2018 May 2;26(5):1343-1353. doi: 10.1016/j.ymthe.2018.02.027. Epub 2018 Mar 2.


Assessment of AAV Vector Tropisms for Mouse and Human Pluripotent Stem Cell-Derived RPE and Photoreceptor Cells.

Gonzalez-Cordero A, Goh D, Kruczek K, Naeem A, Fernando M, Kleine Holthaus SM, Takaaki M, Blackford SJI, Kloc M, Agundez L, Sampson RD, Borooah S, Ovando-Roche P, Mehat MS, West EL, Smith AJ, Pearson RA, Ali RR.

Hum Gene Ther. 2018 Oct;29(10):1124-1139. doi: 10.1089/hum.2018.027. Epub 2018 May 14.


The effects of antimicrobial peptides WAM-1 and LL-37 on multidrug-resistant Acinetobacter baumannii.

Spencer JJ, Pitts RE, Pearson RA, King LB.

Pathog Dis. 2018 Mar 1;76(2). doi: 10.1093/femspd/fty007.


Transplanted Donor- or Stem Cell-Derived Cone Photoreceptors Can Both Integrate and Undergo Material Transfer in an Environment-Dependent Manner.

Waldron PV, Di Marco F, Kruczek K, Ribeiro J, Graca AB, Hippert C, Aghaizu ND, Kalargyrou AA, Barber AC, Grimaldi G, Duran Y, Blackford SJI, Kloc M, Goh D, Zabala Aldunate E, Sampson RD, Bainbridge JWB, Smith AJ, Gonzalez-Cordero A, Sowden JC, Ali RR, Pearson RA.

Stem Cell Reports. 2018 Feb 13;10(2):406-421. doi: 10.1016/j.stemcr.2017.12.008. Epub 2018 Jan 4.


Measurement of the bone endocortical region using clinical CT.

Pearson RA, Treece GM.

Med Image Anal. 2018 Feb;44:28-40. doi: 10.1016/ Epub 2017 Nov 16.


Recapitulation of Human Retinal Development from Human Pluripotent Stem Cells Generates Transplantable Populations of Cone Photoreceptors.

Gonzalez-Cordero A, Kruczek K, Naeem A, Fernando M, Kloc M, Ribeiro J, Goh D, Duran Y, Blackford SJI, Abelleira-Hervas L, Sampson RD, Shum IO, Branch MJ, Gardner PJ, Sowden JC, Bainbridge JWB, Smith AJ, West EL, Pearson RA, Ali RR.

Stem Cell Reports. 2017 Sep 12;9(3):820-837. doi: 10.1016/j.stemcr.2017.07.022. Epub 2017 Aug 24.


Integrating Soil Silicon Amendment into Management Programs for Insect Pests of Drill-Seeded Rice.

Villegas JM, Way MO, Pearson RA, Stout MJ.

Plants (Basel). 2017 Aug 13;6(3). pii: E33. doi: 10.3390/plants6030033.


Improving Staging in Bladder Cancer: The Increasing Role of Multiparametric Magnetic Resonance Imaging.

Panebianco V, Barchetti F, de Haas RJ, Pearson RA, Kennish SJ, Giannarini G, Catto JWF.

Eur Urol Focus. 2016 Jun;2(2):113-121. doi: 10.1016/j.euf.2016.04.010. Epub 2016 May 11. Review.


Harnessing the Potential of Human Pluripotent Stem Cells and Gene Editing for the Treatment of Retinal Degeneration.

Ovando-Roche P, Georgiadis A, Smith AJ, Pearson RA, Ali RR.

Curr Stem Cell Rep. 2017;3(2):112-123. doi: 10.1007/s40778-017-0078-4. Epub 2017 Apr 18. Review.


Pluripotent stem cells and their utility in treating photoreceptor degenerations.

Aghaizu ND, Kruczek K, Gonzalez-Cordero A, Ali RR, Pearson RA.

Prog Brain Res. 2017;231:191-223. doi: 10.1016/bs.pbr.2017.01.001. Epub 2017 Mar 21.


Differentiation and Transplantation of Embryonic Stem Cell-Derived Cone Photoreceptors into a Mouse Model of End-Stage Retinal Degeneration.

Kruczek K, Gonzalez-Cordero A, Goh D, Naeem A, Jonikas M, Blackford SJI, Kloc M, Duran Y, Georgiadis A, Sampson RD, Maswood RN, Smith AJ, Decembrini S, Arsenijevic Y, Sowden JC, Pearson RA, West EL, Ali RR.

Stem Cell Reports. 2017 Jun 6;8(6):1659-1674. doi: 10.1016/j.stemcr.2017.04.030. Epub 2017 May 25.


Rescue of mutant rhodopsin traffic by metformin-induced AMPK activation accelerates photoreceptor degeneration.

Athanasiou D, Aguila M, Opefi CA, South K, Bellingham J, Bevilacqua D, Munro PM, Kanuga N, Mackenzie FE, Dubis AM, Georgiadis A, Graca AB, Pearson RA, Ali RR, Sakami S, Palczewski K, Sherman MY, Reeves PJ, Cheetham ME.

Hum Mol Genet. 2017 Jan 15;26(2):305-319. doi: 10.1093/hmg/ddw387.


Evaluation of Host-Plant Resistance of Selected Rice Genotypes to the Rice Water Weevil (Coleoptera: Curculionidae).

Vyavhare SS, Gealy DR, Way MO, Tabien RE, Pearson RA.

Environ Entomol. 2016 Dec;45(6):1439-1444. doi: 10.1093/ee/nvw120. Epub 2016 Aug 30.


Donor and host photoreceptors engage in material transfer following transplantation of post-mitotic photoreceptor precursors.

Pearson RA, Gonzalez-Cordero A, West EL, Ribeiro JR, Aghaizu N, Goh D, Sampson RD, Georgiadis A, Waldron PV, Duran Y, Naeem A, Kloc M, Cristante E, Kruczek K, Warre-Cornish K, Sowden JC, Smith AJ, Ali RR.

Nat Commun. 2016 Oct 4;7:13029. doi: 10.1038/ncomms13029.


Nitrofurazone quantification in milk at the European Union minimum required performance limit of 1 ng g(-1): circumventing the semicarbazide problem.

Pearson RA, Evans C, Bendall JG.

Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2016 Aug;33(8):1324-36. doi: 10.1080/19440049.2016.1209692. Epub 2016 Jul 25.


Redbanded Stink Bug (Hemiptera: Pentatomidae) Infestation and Occurrence of Delayed Maturity in Soybean.

Vyavhare SS, Way MO, Pearson RA, Medina RF.

J Econ Entomol. 2015 Aug;108(4):1516-25. doi: 10.1093/jee/tov132. Epub 2015 May 26.


Gliosis Can Impede Integration Following Photoreceptor Transplantation into the Diseased Retina.

Hippert C, Graca AB, Pearson RA.

Adv Exp Med Biol. 2016;854:579-85. doi: 10.1007/978-3-319-17121-0_77. Review.


Transplantation of Photoreceptor Precursors Isolated via a Cell Surface Biomarker Panel From Embryonic Stem Cell-Derived Self-Forming Retina.

Lakowski J, Gonzalez-Cordero A, West EL, Han YT, Welby E, Naeem A, Blackford SJ, Bainbridge JW, Pearson RA, Ali RR, Sowden JC.

Stem Cells. 2015 Aug;33(8):2469-82. doi: 10.1002/stem.2051. Epub 2015 May 27.


Müller glia activation in response to inherited retinal degeneration is highly varied and disease-specific.

Hippert C, Graca AB, Barber AC, West EL, Smith AJ, Ali RR, Pearson RA.

PLoS One. 2015 Mar 20;10(3):e0120415. doi: 10.1371/journal.pone.0120415. eCollection 2015.


3'-Deoxy-3'-¹⁸F-fluorothymidine positron emission tomography as an early predictor of disease progression in patients with advanced and metastatic pancreatic cancer.

Challapalli A, Barwick T, Pearson RA, Merchant S, Mauri F, Howell EC, Sumpter K, Maxwell RJ, Aboagye EO, Sharma R.

Eur J Nucl Med Mol Imaging. 2015 May;42(6):831-40. doi: 10.1007/s00259-015-3000-2. Epub 2015 Feb 12.


Cellular strategies for retinal repair by photoreceptor replacement.

Jayakody SA, Gonzalez-Cordero A, Ali RR, Pearson RA.

Prog Retin Eye Res. 2015 May;46:31-66. doi: 10.1016/j.preteyeres.2015.01.003. Epub 2015 Feb 7. Review.


Photoreceptor replacement therapy: challenges presented by the diseased recipient retinal environment.

Pearson RA, Hippert C, Graca AB, Barber AC.

Vis Neurosci. 2014 Sep;31(4-5):333-44. doi: 10.1017/S0952523814000200. Epub 2014 Jun 19. Review.


Advances in repairing the degenerate retina by rod photoreceptor transplantation.

Pearson RA.

Biotechnol Adv. 2014 Mar-Apr;32(2):485-91. doi: 10.1016/j.biotechadv.2014.01.001. Epub 2014 Jan 8. Review.


Migration, integration and maturation of photoreceptor precursors following transplantation in the mouse retina.

Warre-Cornish K, Barber AC, Sowden JC, Ali RR, Pearson RA.

Stem Cells Dev. 2014 May 1;23(9):941-54. doi: 10.1089/scd.2013.0471. Epub 2014 Feb 18.


Outside-the-(cavity-prep)-box thinking.

Thompson VP, Watson TF, Marshall GW Jr, Blackman BR, Stansbury JW, Schadler LS, Pearson RA, Libanori R.

Adv Dent Res. 2013 Nov;25(1):24-32. doi: 10.1177/0022034513502207.


Photoreceptor precursors derived from three-dimensional embryonic stem cell cultures integrate and mature within adult degenerate retina.

Gonzalez-Cordero A, West EL, Pearson RA, Duran Y, Carvalho LS, Chu CJ, Naeem A, Blackford SJI, Georgiadis A, Lakowski J, Hubank M, Smith AJ, Bainbridge JWB, Sowden JC, Ali RR.

Nat Biotechnol. 2013 Aug;31(8):741-7. doi: 10.1038/nbt.2643. Epub 2013 Jul 21.


Repair of the degenerate retina by photoreceptor transplantation.

Barber AC, Hippert C, Duran Y, West EL, Bainbridge JW, Warre-Cornish K, Luhmann UF, Lakowski J, Sowden JC, Ali RR, Pearson RA.

Proc Natl Acad Sci U S A. 2013 Jan 2;110(1):354-9. doi: 10.1073/pnas.1212677110. Epub 2012 Dec 17.


Defining the integration capacity of embryonic stem cell-derived photoreceptor precursors.

West EL, Gonzalez-Cordero A, Hippert C, Osakada F, Martinez-Barbera JP, Pearson RA, Sowden JC, Takahashi M, Ali RR.

Stem Cells. 2012 Jul;30(7):1424-35. doi: 10.1002/stem.1123.


Restoration of vision after transplantation of photoreceptors.

Pearson RA, Barber AC, Rizzi M, Hippert C, Xue T, West EL, Duran Y, Smith AJ, Chuang JZ, Azam SA, Luhmann UF, Benucci A, Sung CH, Bainbridge JW, Carandini M, Yau KW, Sowden JC, Ali RR.

Nature. 2012 May 3;485(7396):99-103. doi: 10.1038/nature10997.


Manipulation of the recipient retinal environment by ectopic expression of neurotrophic growth factors can improve transplanted photoreceptor integration and survival.

West EL, Pearson RA, Duran Y, Gonzalez-Cordero A, MacLaren RE, Smith AJ, Sowden JC, Ali RR.

Cell Transplant. 2012;21(5):871-87. doi: 10.3727/096368911X623871. Epub 2012 Feb 2.


Isolation and culture of adult ciliary epithelial cells, previously identified as retinal stem cells, and retinal progenitor cells.

Gualdoni S, Baron M, Lakowski J, Decembrini S, Pearson RA, Ali RR, Sowden JC.

Curr Protoc Stem Cell Biol. 2011 Dec;Chapter 1:Unit 1H.4. doi: 10.1002/9780470151808.sc01h04s19.


Effective transplantation of photoreceptor precursor cells selected via cell surface antigen expression.

Lakowski J, Han YT, Pearson RA, Gonzalez-Cordero A, West EL, Gualdoni S, Barber AC, Hubank M, Ali RR, Sowden JC.

Stem Cells. 2011 Sep;29(9):1391-404. doi: 10.1002/stem.694.


Long-term preservation of cones and improvement in visual function following gene therapy in a mouse model of leber congenital amaurosis caused by guanylate cyclase-1 deficiency.

Mihelec M, Pearson RA, Robbie SJ, Buch PK, Azam SA, Bainbridge JW, Smith AJ, Ali RR.

Hum Gene Ther. 2011 Oct;22(10):1179-90. doi: 10.1089/hum.2011.069. Epub 2011 Aug 10.


Long-term and age-dependent restoration of visual function in a mouse model of CNGB3-associated achromatopsia following gene therapy.

Carvalho LS, Xu J, Pearson RA, Smith AJ, Bainbridge JW, Morris LM, Fliesler SJ, Ding XQ, Ali RR.

Hum Mol Genet. 2011 Aug 15;20(16):3161-75. doi: 10.1093/hmg/ddr218. Epub 2011 May 15.


Dominant cone-rod dystrophy: a mouse model generated by gene targeting of the GCAP1/Guca1a gene.

Buch PK, Mihelec M, Cottrill P, Wilkie SE, Pearson RA, Duran Y, West EL, Michaelides M, Ali RR, Hunt DM.

PLoS One. 2011 Mar 28;6(3):e18089. doi: 10.1371/journal.pone.0018089.


Comparative analysis of the retinal potential of embryonic stem cells and amniotic fluid-derived stem cells.

Decembrini S, Cananzi M, Gualdoni S, Battersby A, Allen N, Pearson RA, Ali RR, De Coppi P, Sowden JC.

Stem Cells Dev. 2011 May;20(5):851-63. doi: 10.1089/scd.2010.0291. Epub 2010 Dec 6.


Cone and rod photoreceptor transplantation in models of the childhood retinopathy Leber congenital amaurosis using flow-sorted Crx-positive donor cells.

Lakowski J, Baron M, Bainbridge J, Barber AC, Pearson RA, Ali RR, Sowden JC.

Hum Mol Genet. 2010 Dec 1;19(23):4545-59. doi: 10.1093/hmg/ddq378. Epub 2010 Sep 21.


Long-term survival of photoreceptors transplanted into the adult murine neural retina requires immune modulation.

West EL, Pearson RA, Barker SE, Luhmann UF, Maclaren RE, Barber AC, Duran Y, Smith AJ, Sowden JC, Ali RR.

Stem Cells. 2010 Nov;28(11):1997-2007. doi: 10.1002/stem.520.


Split-course hypofractionated palliative radiotherapy for patients with head and neck squamous cell carcinoma - a worthwhile treatment schedule in the UK?

Pearson RA, Bannister-Young RH, Ivison D, Kelly CG, Chatterjee S.

Clin Oncol (R Coll Radiol). 2010 Dec;22(10):890-1. doi: 10.1016/j.clon.2010.06.003. Epub 2010 Jun 26. No abstract available.


Adult ciliary epithelial cells, previously identified as retinal stem cells with potential for retinal repair, fail to differentiate into new rod photoreceptors.

Gualdoni S, Baron M, Lakowski J, Decembrini S, Smith AJ, Pearson RA, Ali RR, Sowden JC.

Stem Cells. 2010 Jun;28(6):1048-59. doi: 10.1002/stem.423.


Targeted disruption of outer limiting membrane junctional proteins (Crb1 and ZO-1) increases integration of transplanted photoreceptor precursors into the adult wild-type and degenerating retina.

Pearson RA, Barber AC, West EL, MacLaren RE, Duran Y, Bainbridge JW, Sowden JC, Ali RR.

Cell Transplant. 2010;19(4):487-503. doi: 10.3727/096368909X486057. Epub 2010 Jan 20.


Cell transplantation strategies for retinal repair.

West EL, Pearson RA, MacLaren RE, Sowden JC, Ali RR.

Prog Brain Res. 2009;175:3-21. doi: 10.1016/S0079-6123(09)17501-5. Review.


Neuron network activity scales exponentially with synapse density.

Brewer GJ, Boehler MD, Pearson RA, DeMaris AA, Ide AN, Wheeler BC.

J Neural Eng. 2009 Feb;6(1):014001. doi: 10.1088/1741-2560/6/1/014001. Epub 2008 Dec 22.


Isolation and characterisation of neural progenitor cells from the adult Chx10(orJ/orJ) central neural retina.

Kokkinopoulos I, Pearson RA, Macneil A, Dhomen NS, MacLaren RE, Ali RR, Sowden JC.

Mol Cell Neurosci. 2008 Jul;38(3):359-73. doi: 10.1016/j.mcn.2008.03.008. Epub 2008 Apr 10.


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