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Items: 40


Trematode Genomics and Proteomics.

Sotillo J, Pearson MS, Loukas A.

Adv Exp Med Biol. 2019;1154:411-436. doi: 10.1007/978-3-030-18616-6_13.


In-depth proteomic characterization of Schistosoma haematobium: Towards the development of new tools for elimination.

Sotillo J, Pearson MS, Becker L, Mekonnen GG, Amoah AS, van Dam G, Corstjens PLAM, Murray J, Mduluza T, Mutapi F, Loukas A.

PLoS Negl Trop Dis. 2019 May 15;13(5):e0007362. doi: 10.1371/journal.pntd.0007362. eCollection 2019 May.


Flatworm-specific transcriptional regulators promote the specification of tegumental progenitors in Schistosoma mansoni.

Wendt GR, Collins JN, Pei J, Pearson MS, Bennett HM, Loukas A, Berriman M, Grishin NV, Collins JJ 3rd.

Elife. 2018 Mar 20;7. pii: e33221. doi: 10.7554/eLife.33221.


Polypyridylruthenium(II) complexes exert anti-schistosome activity and inhibit parasite acetylcholinesterases.

Sundaraneedi MK, Tedla BA, Eichenberger RM, Becker L, Pickering D, Smout MJ, Rajan S, Wangchuk P, Keene FR, Loukas A, Collins JG, Pearson MS.

PLoS Negl Trop Dis. 2017 Dec 14;11(12):e0006134. doi: 10.1371/journal.pntd.0006134. eCollection 2017 Dec.


Polypyridylruthenium(II) complexes exert in vitro and in vivo nematocidal activity and show significant inhibition of parasite acetylcholinesterases.

Sundaraneedi M, Eichenberger RM, Al-Hallaf R, Yang D, Sotillo J, Rajan S, Wangchuk P, Giacomin PR, Keene FR, Loukas A, Collins JG, Pearson MS.

Int J Parasitol Drugs Drug Resist. 2018 Apr;8(1):1-7. doi: 10.1016/j.ijpddr.2017.11.005. Epub 2017 Nov 29.


Identification of lead chemotherapeutic agents from medicinal plants against blood flukes and whipworms.

Wangchuk P, Giacomin PR, Pearson MS, Smout MJ, Loukas A.

Sci Rep. 2016 Aug 30;6:32101. doi: 10.1038/srep32101.


Compounds Derived from the Bhutanese Daisy, Ajania nubigena, Demonstrate Dual Anthelmintic Activity against Schistosoma mansoni and Trichuris muris.

Wangchuk P, Pearson MS, Giacomin PR, Becker L, Sotillo J, Pickering D, Smout MJ, Loukas A.

PLoS Negl Trop Dis. 2016 Aug 4;10(8):e0004908. doi: 10.1371/journal.pntd.0004908. eCollection 2016 Aug.


The parasite's new clothes.

Pearson MS, Loukas A.

Elife. 2016 Apr 15;5:e15957. doi: 10.7554/eLife.15957.


Lipopeptide Nanoparticles: Development of Vaccines against Hookworm Parasite.

Fuaad AA, Pearson MS, Pickering DA, Becker L, Zhao G, Loukas AC, Skwarczynski M, Toth I.

ChemMedChem. 2015 Oct;10(10):1647-54. doi: 10.1002/cmdc.201500227. Epub 2015 Aug 12.


Antibody Signatures Reflect Different Disease Pathologies in Patients With Schistosomiasis Due to Schistosoma japonicum.

Driguez P, Li Y, Gaze S, Pearson MS, Nakajima R, Trieu A, Doolan DL, Felgner PL, Hou X, Cardoso FC, Jasinskas A, Gobert GN, Loukas A, McManus DP.

J Infect Dis. 2016 Jan 1;213(1):122-30. doi: 10.1093/infdis/jiv356. Epub 2015 Jul 6.


Specific humoral response of hosts with variable schistosomiasis susceptibility.

Driguez P, McWilliam HE, Gaze S, Piedrafita D, Pearson MS, Nakajima R, Duke M, Trieu A, Doolan DL, Cardoso FC, Jasinskas A, Gobert GN, Felgner PL, Loukas A, Meeusen E, McManus DP.

Immunol Cell Biol. 2016 Jan;94(1):52-65. doi: 10.1038/icb.2015.61. Epub 2015 Jun 5.


New tools for NTD vaccines: A case study of quality control assays for product development of the human hookworm vaccine Na-APR-1M74.

Pearson MS, Jariwala AR, Abbenante G, Plieskatt J, Wilson D, Bottazzi ME, Hotez PJ, Keegan B, Bethony JM, Loukas A.

Hum Vaccin Immunother. 2015;11(5):1251-7. doi: 10.4161/21645515.2014.980199.


Of monkeys and men: immunomic profiling of sera from humans and non-human primates resistant to schistosomiasis reveals novel potential vaccine candidates.

Pearson MS, Becker L, Driguez P, Young ND, Gaze S, Mendes T, Li XH, Doolan DL, Midzi N, Mduluza T, McManus DP, Wilson RA, Bethony JM, Nausch N, Mutapi F, Felgner PL, Loukas A.

Front Immunol. 2015 May 5;6:213. doi: 10.3389/fimmu.2015.00213. eCollection 2015.


The use of a conformational cathepsin D-derived epitope for vaccine development against Schistosoma mansoni.

Ahmad Fuaad AA, Roubille R, Pearson MS, Pickering DA, Loukas AC, Skwarczynski M, Toth I.

Bioorg Med Chem. 2015 Mar 15;23(6):1307-12. doi: 10.1016/j.bmc.2015.01.033. Epub 2015 Jan 30.


An immunomics approach to schistosome antigen discovery: antibody signatures of naturally resistant and chronically infected individuals from endemic areas.

Gaze S, Driguez P, Pearson MS, Mendes T, Doolan DL, Trieu A, McManus DP, Gobert GN, Periago MV, Correa Oliveira R, Cardoso FC, Oliveira G, Nakajima R, Jasinskas A, Hung C, Liang L, Pablo J, Bethony JM, Felgner PL, Loukas A.

PLoS Pathog. 2014 Mar 27;10(3):e1004033. doi: 10.1371/journal.ppat.1004033. eCollection 2014 Mar.


Peptide-based subunit vaccine against hookworm infection.

Skwarczynski M, Dougall AM, Khoshnejad M, Chandrudu S, Pearson MS, Loukas A, Toth I.

PLoS One. 2012;7(10):e46870. doi: 10.1371/journal.pone.0046870. Epub 2012 Oct 3.


Molecular mechanisms of hookworm disease: stealth, virulence, and vaccines.

Pearson MS, Tribolet L, Cantacessi C, Periago MV, Valero MA, Jariwala AR, Hotez P, Diemert D, Loukas A, Bethony J.

J Allergy Clin Immunol. 2012 Jul;130(1):13-21. doi: 10.1016/j.jaci.2012.05.029. Review. Erratum in: J Allergy Clin Immunol. 2012 Oct;130(4):852. Valerio, Maria Adela [corrected to Valero, Maria Adela].


Enhanced protective efficacy of a chimeric form of the schistosomiasis vaccine antigen Sm-TSP-2.

Pearson MS, Pickering DA, McSorley HJ, Bethony JM, Tribolet L, Dougall AM, Hotez PJ, Loukas A.

PLoS Negl Trop Dis. 2012;6(3):e1564. doi: 10.1371/journal.pntd.0001564. Epub 2012 Mar 13.


Immune-mediated mechanisms of parasite tissue sequestration during experimental cerebral malaria.

Amante FH, Haque A, Stanley AC, Rivera Fde L, Randall LM, Wilson YA, Yeo G, Pieper C, Crabb BS, de Koning-Ward TF, Lundie RJ, Good MF, Pinzon-Charry A, Pearson MS, Duke MG, McManus DP, Loukas A, Hill GR, Engwerda CR.

J Immunol. 2010 Sep 15;185(6):3632-42. doi: 10.4049/jimmunol.1000944. Epub 2010 Aug 18.


Blunting the knife: development of vaccines targeting digestive proteases of blood-feeding helminth parasites.

Pearson MS, Ranjit N, Loukas A.

Biol Chem. 2010 Aug;391(8):901-11. doi: 10.1515/BC.2010.074. Review.


Neutralizing antibodies to the hookworm hemoglobinase Na-APR-1: implications for a multivalent vaccine against hookworm infection and schistosomiasis.

Pearson MS, Pickering DA, Tribolet L, Cooper L, Mulvenna J, Oliveira LM, Bethony JM, Hotez PJ, Loukas A.

J Infect Dis. 2010 May 15;201(10):1561-9. doi: 10.1086/651953.


Schistosoma mansoni proteins attenuate gastrointestinal motility disturbances during experimental colitis in mice.

Ruyssers NE, De Winter BY, De Man JG, Ruyssers ND, Van Gils AJ, Loukas A, Pearson MS, Weinstock JV, Pelckmans PA, Moreels TG.

World J Gastroenterol. 2010 Feb 14;16(6):703-12.


The spirocyclopropyl moiety as a methyl surrogate in the structure of l-fucosidase and l-rhamnosidase inhibitors.

Pearson MS, Floquet N, Bello C, Vogel P, Plantier-Royon R, Szymoniak J, Bertus P, Behr JB.

Bioorg Med Chem. 2009 Dec 1;17(23):8020-6. doi: 10.1016/j.bmc.2009.10.010. Epub 2009 Oct 12.


Studies toward the photochemical synthesis of functionalized [5]- and [6]carbohelicenes.

Pearson MS, Carbery DR.

J Org Chem. 2009 Aug 7;74(15):5320-5. doi: 10.1021/jo900785k.


An enzymatically inactivated hemoglobinase from Necator americanus induces neutralizing antibodies against multiple hookworm species and protects dogs against heterologous hookworm infection.

Pearson MS, Bethony JM, Pickering DA, de Oliveira LM, Jariwala A, Santiago H, Miles AP, Zhan B, Jiang D, Ranjit N, Mulvenna J, Tribolet L, Plieskatt J, Smith T, Bottazzi ME, Jones K, Keegan B, Hotez PJ, Loukas A.

FASEB J. 2009 Sep;23(9):3007-19. doi: 10.1096/fj.09-131433. Epub 2009 Apr 20.


Therapeutic potential of helminth soluble proteins in TNBS-induced colitis in mice.

Ruyssers NE, De Winter BY, De Man JG, Loukas A, Pearson MS, Weinstock JV, Van den Bossche RM, Martinet W, Pelckmans PA, Moreels TG.

Inflamm Bowel Dis. 2009 Apr;15(4):491-500. doi: 10.1002/ibd.20787.


Ov-APR-1, an aspartic protease from the carcinogenic liver fluke, Opisthorchis viverrini: functional expression, immunolocalization and subsite specificity.

Suttiprapa S, Mulvenna J, Huong NT, Pearson MS, Brindley PJ, Laha T, Wongkham S, Kaewkes S, Sripa B, Loukas A.

Int J Biochem Cell Biol. 2009 May;41(5):1148-56. doi: 10.1016/j.biocel.2008.10.013. Epub 2008 Oct 19.


A bioassessment approach for mid-continent great rivers: the Upper Mississippi, Missouri, and Ohio (USA).

Angradi TR, Bolgrien DW, Jicha TM, Pearson MS, Hill BH, Taylor DL, Schweiger EW, Shepard L, Batterman AR, Moffett MF, Elonen CM, Anderson LE.

Environ Monit Assess. 2009 May;152(1-4):425-42. doi: 10.1007/s10661-008-0327-1. Epub 2008 May 16.


Cloning and characterization of an orphan seven transmembrane receptor from Schistosoma mansoni.

Pearson MS, McManus DP, Smyth DJ, Jones MK, Sykes AM, Loukas A.

Parasitology. 2007 Dec;134(Pt.14):2001-8. Epub 2007 Aug 23.


Schistosome membrane proteins as vaccines.

Loukas A, Tran M, Pearson MS.

Int J Parasitol. 2007 Mar;37(3-4):257-63. Epub 2006 Dec 28. Review.


Tetraspanins on the surface of Schistosoma mansoni are protective antigens against schistosomiasis.

Tran MH, Pearson MS, Bethony JM, Smyth DJ, Jones MK, Duke M, Don TA, McManus DP, Correa-Oliveira R, Loukas A.

Nat Med. 2006 Jul;12(7):835-40. Epub 2006 Jun 18.


Pharmacology of 2-[4-(4-chloro-2-fluorophenoxy)phenyl]-pyrimidine-4-carboxamide: a potent, broad-spectrum state-dependent sodium channel blocker for treating pain states.

Ilyin VI, Pomonis JD, Whiteside GT, Harrison JE, Pearson MS, Mark L, Turchin PI, Gottshall S, Carter RB, Nguyen P, Hogenkamp DJ, Olanrewaju S, Benjamin E, Woodward RM.

J Pharmacol Exp Ther. 2006 Sep;318(3):1083-93. Epub 2006 May 25.


Flexible synthesis and biological evaluation of novel 5-deoxyadenophorine analogues.

Pearson MS, Saad RO, Dintinger T, Amri H, Mathé-Allainmat M, Lebreton J.

Bioorg Med Chem Lett. 2006 Jun 15;16(12):3262-7. Epub 2006 Apr 5.


A role for cannabinoid receptors, but not endogenous opioids, in the antinociceptive activity of the CB2-selective agonist, GW405833.

Whiteside GT, Gottshall SL, Boulet JM, Chaffer SM, Harrison JE, Pearson MS, Turchin PI, Mark L, Garrison AE, Valenzano KJ.

Eur J Pharmacol. 2005 Dec 28;528(1-3):65-72. Epub 2005 Nov 28.


In vitro and in silico analysis of signal peptides from the human blood fluke, Schistosoma mansoni.

Pearson MS, McManus DP, Smyth DJ, Lewis FA, Loukas A.

FEMS Immunol Med Microbiol. 2005 Aug 1;45(2):201-11.


Pharmacological and pharmacokinetic characterization of the cannabinoid receptor 2 agonist, GW405833, utilizing rodent models of acute and chronic pain, anxiety, ataxia and catalepsy.

Valenzano KJ, Tafesse L, Lee G, Harrison JE, Boulet JM, Gottshall SL, Mark L, Pearson MS, Miller W, Shan S, Rabadi L, Rotshteyn Y, Chaffer SM, Turchin PI, Elsemore DA, Toth M, Koetzner L, Whiteside GT.

Neuropharmacology. 2005 Apr;48(5):658-72.


A-317491, a selective P2X3/P2X2/3 receptor antagonist, reverses inflammatory mechanical hyperalgesia through action at peripheral receptors in rats.

Wu G, Whiteside GT, Lee G, Nolan S, Niosi M, Pearson MS, Ilyin VI.

Eur J Pharmacol. 2004 Nov 3;504(1-2):45-53.


DiPOA ([8-(3,3-diphenyl-propyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-3-yl]-acetic acid), a novel, systemically available, and peripherally restricted Mu opioid agonist with antihyperalgesic activity: II. In vivo pharmacological characterization in the rat.

Whiteside GT, Harrison JE, Pearson MS, Chen Z, Fundytus ME, Rotshteyn Y, Turchin PI, Pomonis JD, Mark L, Walker K, Broglé KC.

J Pharmacol Exp Ther. 2004 Aug;310(2):793-9. Epub 2004 Mar 30. Erratum in: J Pharmacol Exp Ther. 2005 Mar;312(3):1334. Fundytus, Marian E [added].


An efficient route to pyrimidine nucleoside analogues by [4 + 2] cycloaddition reaction.

Pearson MS, Robin A, Bourgougnon N, Meslin JC, Deniaud D.

J Org Chem. 2003 Oct 31;68(22):8583-7.


Complete mitochondrial genomes confirm the distinctiveness of the horse-dog and sheep-dog strains of Echinococcus granulosus.

Le TH, Pearson MS, Blair D, Dai N, Zhang LH, McManus DP.

Parasitology. 2002 Jan;124(Pt 1):97-112.


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