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Items: 1 to 50 of 96


Obese osteoarthritis patients exhibit an inflammatory synovial fibroblast phenotype, which is regulated by the long non coding RNA MALAT1.

Nanus DE, Wijesinghe SN, Pearson MJ, Hadjicharalambous MR, Rosser A, Davis ET, Lindsay MA, Jones SW.

Arthritis Rheumatol. 2019 Nov 4. doi: 10.1002/art.41158. [Epub ahead of print]


Effect of vitamin D supplementation on endothelial function - An updated systematic review with meta-analysis and meta-regression.

Pincombe NL, Pearson MJ, Smart NA, King N, Dieberg G.

Nutr Metab Cardiovasc Dis. 2019 Dec;29(12):1261-1272. doi: 10.1016/j.numecd.2019.08.005. Epub 2019 Aug 19.


Fast, Flexible Closed-Loop Feedback: Tracking Movement in "Real-Millisecond-Time".

Sehara K, Bahr V, Mitchinson B, Pearson MJ, Larkum ME, Sachdev RNS.

eNeuro. 2019 Nov 1;6(6). pii: ENEURO.0147-19.2019. doi: 10.1523/ENEURO.0147-19.2019. Print 2019 Nov/Dec.


Evidence of Intrinsic Impairment of Osteoblast Phenotype at the Curve Apex in Girls With Adolescent Idiopathic Scoliosis.

Pearson MJ, Philp AM, Haq H, Cooke ME, Nicholson T, Grover LM, Newton Ede M, Jones SW.

Spine Deform. 2019 Jul;7(4):533-542. doi: 10.1016/j.jspd.2018.11.016.


Exercise-based cardiac rehabilitation improves exercise capacity and health-related quality of life in people with atrial fibrillation: a systematic review and meta-analysis of randomised and non-randomised trials.

Smart NA, King N, Lambert JD, Pearson MJ, Campbell JL, Risom SS, Taylor RS.

Open Heart. 2018 Dec 20;5(2):e000880. doi: 10.1136/openhrt-2018-000880. eCollection 2018.


Endogenous Galectin-9 Suppresses Apoptosis in Human Rheumatoid Arthritis Synovial Fibroblasts.

Pearson MJ, Bik MA, Ospelt C, Naylor AJ, Wehmeyer C, Jones SW, Buckley CD, Gay S, Filer A, Lord JM.

Sci Rep. 2018 Aug 27;8(1):12887. doi: 10.1038/s41598-018-31173-3.


Effect of exercise therapy on established and emerging circulating biomarkers in patients with heart failure: a systematic review and meta-analysis.

Pearson MJ, King N, Smart NA.

Open Heart. 2018 Jul 11;5(2):e000819. doi: 10.1136/openhrt-2018-000819. eCollection 2018.


Glucagon Receptor Antagonism Improves Glucose Metabolism and Cardiac Function by Promoting AMP-Mediated Protein Kinase in Diabetic Mice.

Sharma AX, Quittner-Strom EB, Lee Y, Johnson JA, Martin SA, Yu X, Li J, Lu J, Cai Z, Chen S, Wang MY, Zhang Y, Pearson MJ, Dorn AC, McDonald JG, Gordillo R, Yan H, Thai D, Wang ZV, Unger RH, Holland WL.

Cell Rep. 2018 Feb 13;22(7):1760-1773. doi: 10.1016/j.celrep.2018.01.065.


Effect of aerobic and resistance training on inflammatory markers in heart failure patients: systematic review and meta-analysis.

Pearson MJ, Mungovan SF, Smart NA.

Heart Fail Rev. 2018 Mar;23(2):209-223. doi: 10.1007/s10741-018-9677-0.


Exercise therapy and autonomic function in heart failure patients: a systematic review and meta-analysis.

Pearson MJ, Smart NA.

Heart Fail Rev. 2018 Jan;23(1):91-108. doi: 10.1007/s10741-017-9662-z.


Geometric confinement is required for recovery and maintenance of chondrocyte phenotype in alginate.

Cooke ME, Pearson MJ, Moakes RJA, Weston CJ, Davis ET, Jones SW, Grover LM.

APL Bioeng. 2017 Oct 9;1(1):016104. doi: 10.1063/1.5006752. eCollection 2017 Dec.


Directing visceral white adipocyte precursors to a thermogenic adipocyte fate improves insulin sensitivity in obese mice.

Hepler C, Shao M, Xia JY, Ghaben AL, Pearson MJ, Vishvanath L, Sharma AX, Morley TS, Holland WL, Gupta RK.

Elife. 2017 Jul 19;6. pii: e27669. doi: 10.7554/eLife.27669.


IL-6 secretion in osteoarthritis patients is mediated by chondrocyte-synovial fibroblast cross-talk and is enhanced by obesity.

Pearson MJ, Herndler-Brandstetter D, Tariq MA, Nicholson TA, Philp AM, Smith HL, Davis ET, Jones SW, Lord JM.

Sci Rep. 2017 Jun 14;7(1):3451. doi: 10.1038/s41598-017-03759-w.


High-Mobility Group Box 1 Disrupts Metabolic Function with Cigarette Smoke Exposure in a Ceramide-Dependent Manner.

Taylor OJ, Thatcher MO, Carr ST, Gibbs JL, Trumbull AM, Harrison ME, Winden DR, Pearson MJ, Tippetts TS, Holland WL, Reynolds PR, Bikman BT.

Int J Mol Sci. 2017 May 20;18(5). pii: E1099. doi: 10.3390/ijms18051099.


Aerobic Training Intensity for Improved Endothelial Function in Heart Failure Patients: A Systematic Review and Meta-Analysis.

Pearson MJ, Smart NA.

Cardiol Res Pract. 2017;2017:2450202. doi: 10.1155/2017/2450202. Epub 2017 Feb 27.


Inducible overexpression of adiponectin receptors highlight the roles of adiponectin-induced ceramidase signaling in lipid and glucose homeostasis.

Holland WL, Xia JY, Johnson JA, Sun K, Pearson MJ, Sharma AX, Quittner-Strom E, Tippetts TS, Gordillo R, Scherer PE.

Mol Metab. 2017 Jan 12;6(3):267-275. doi: 10.1016/j.molmet.2017.01.002. eCollection 2017 Mar.


Effect of exercise on diastolic function in heart failure patients: a systematic review and meta-analysis.

Pearson MJ, Mungovan SF, Smart NA.

Heart Fail Rev. 2017 Mar;22(2):229-242. doi: 10.1007/s10741-017-9600-0. Review.


Bearings in Hip Arthroplasty: Joint Registries vs Precision Medicine: Review Article.

Pearson MJ, Grover LM, Lord JM, Jones SW, Davis ET.

HSS J. 2017 Feb;13(1):20-27. doi: 10.1007/s11420-016-9531-7. Epub 2016 Nov 14. Review.


Effect of exercise training on endothelial function in heart failure patients: A systematic review meta-analysis.

Pearson MJ, Smart NA.

Int J Cardiol. 2017 Mar 15;231:234-243. doi: 10.1016/j.ijcard.2016.12.145. Epub 2016 Dec 28. Review.


Review: Long Noncoding RNAs in the Regulation of Inflammatory Pathways in Rheumatoid Arthritis and Osteoarthritis.

Pearson MJ, Jones SW.

Arthritis Rheumatol. 2016 Nov;68(11):2575-2583. doi: 10.1002/art.39759. Review. No abstract available.


11╬▓-Hydroxysteroid dehydrogenase type 1 within muscle protects against the adverse effects of local inflammation.

Hardy RS, Doig CL, Hussain Z, O'Leary M, Morgan SA, Pearson MJ, Naylor A, Jones SW, Filer A, Stewart PM, Buckley CD, Lavery GG, Cooper MS, Raza K.

J Pathol. 2016 Dec;240(4):472-483. doi: 10.1002/path.4806. Epub 2016 Oct 18.


Cerebellar-inspired algorithm for adaptive control of nonlinear dielectric elastomer-based artificial muscle.

Wilson ED, Assaf T, Pearson MJ, Rossiter JM, Anderson SR, Porrill J, Dean P.

J R Soc Interface. 2016 Sep;13(122). pii: 20160547.


Clinical Trials, Triumphs, and Tribulations of Glucagon Receptor Antagonists.

Pearson MJ, Unger RH, Holland WL.

Diabetes Care. 2016 Jul;39(7):1075-7. doi: 10.2337/dci15-0033. No abstract available.


Long Intergenic Noncoding RNAs Mediate the Human Chondrocyte Inflammatory Response and Are Differentially Expressed in Osteoarthritis Cartilage.

Pearson MJ, Philp AM, Heward JA, Roux BT, Walsh DA, Davis ET, Lindsay MA, Jones SW.

Arthritis Rheumatol. 2016 Apr;68(4):845-56. doi: 10.1002/art.39520.


Biohybrid Control of General Linear Systems Using the Adaptive Filter Model of Cerebellum.

Wilson ED, Assaf T, Pearson MJ, Rossiter JM, Dean P, Anderson SR, Porrill J.

Front Neurorobot. 2015 Jul 20;9:5. doi: 10.3389/fnbot.2015.00005. eCollection 2015.


Release of Active Peptidyl Arginine Deiminases by Neutrophils Can Explain Production of Extracellular Citrullinated Autoantigens in Rheumatoid Arthritis Synovial Fluid.

Spengler J, Lugonja B, Ytterberg AJ, Zubarev RA, Creese AJ, Pearson MJ, Grant MM, Milward M, Lundberg K, Buckley CD, Filer A, Raza K, Cooper PR, Chapple IL, Scheel-Toellner D.

Arthritis Rheumatol. 2015 Dec;67(12):3135-45. doi: 10.1002/art.39313.


The effects of cobalt-chromium-molybdenum wear debris in vitro on serum cytokine profiles and T cell repertoire.

Pearson MJ, Williams RL, Floyd H, Bodansky D, Grover LM, Davis ET, Lord JM.

Biomaterials. 2015 Oct;67:232-9. doi: 10.1016/j.biomaterials.2015.07.034. Epub 2015 Jul 20.


Targeted Induction of Ceramide Degradation Leads to Improved Systemic Metabolism and Reduced Hepatic Steatosis.

Xia JY, Holland WL, Kusminski CM, Sun K, Sharma AX, Pearson MJ, Sifuentes AJ, McDonald JG, Gordillo R, Scherer PE.

Cell Metab. 2015 Aug 4;22(2):266-278. doi: 10.1016/j.cmet.2015.06.007. Epub 2015 Jul 16.


Stromal transcriptional profiles reveal hierarchies of anatomical site, serum response and disease and identify disease specific pathways.

Filer A, Antczak P, Parsonage GN, Legault HM, O'Toole M, Pearson MJ, Thomas AM, Scheel-Toellner D, Raza K, Buckley CD, Falciani F.

PLoS One. 2015 Mar 25;10(3):e0120917. doi: 10.1371/journal.pone.0120917. eCollection 2015.


The hallmarks of osteoarthritis and the potential to develop personalised disease-modifying pharmacological therapeutics.

Tonge DP, Pearson MJ, Jones SW.

Osteoarthritis Cartilage. 2014 May;22(5):609-21. doi: 10.1016/j.joca.2014.03.004. Epub 2014 Mar 12. Review.


Interventions for schizophrenia: integrative approaches to group therapy.

Pearson MJ, Burlingame GM.

Int J Group Psychother. 2013 Oct;63(4):603-8. doi: 10.1521/ijgp.2013.63.4.603. No abstract available.


Cognitive approaches to group therapy: prevention of relapse in major depressive and bipolar disorders.

Pearson MJ, Burlingame GM.

Int J Group Psychother. 2013 Apr;63(2):303-9. doi: 10.1521/ijgp.2013.63.2.303. No abstract available.


The effect of whisker movement on radial distance estimation: a case study in comparative robotics.

Evans MH, Fox CW, Lepora NF, Pearson MJ, Sullivan JC, Prescott TJ.

Front Neurorobot. 2013 Jan 2;6:12. doi: 10.3389/fnbot.2012.00012. eCollection 2012.


CUG binding protein 1 binds to a specific region within the human albumin 3' untranslated region.

Khaziapoul S, Pearson MJ, Pryme IF, Stern B, Hesketh JE.

Biochem Biophys Res Commun. 2012 Oct 5;426(4):539-43. doi: 10.1016/j.bbrc.2012.08.123. Epub 2012 Sep 7.


An internal model architecture for novelty detection: implications for cerebellar and collicular roles in sensory processing.

Anderson SR, Porrill J, Pearson MJ, Pipe AG, Prescott TJ, Dean P.

PLoS One. 2012;7(9):e44560. doi: 10.1371/journal.pone.0044560. Epub 2012 Sep 5.


Albumin 3'untranslated region facilitates increased recombinant protein production from Chinese hamster ovary cells.

Pearson MJ, Khazaipoul S, Optun A, Pryme IF, Stern B, Hesketh JE.

Biotechnol J. 2012 Nov;7(11):1405-11. doi: 10.1002/biot.201200044. Epub 2012 Jun 29.


Biomimetic vibrissal sensing for robots.

Pearson MJ, Mitchinson B, Sullivan JC, Pipe AG, Prescott TJ.

Philos Trans R Soc Lond B Biol Sci. 2011 Nov 12;366(1581):3085-96. doi: 10.1098/rstb.2011.0164. Review.


A Phase I Study using low-dose fractionated whole abdominal radiotherapy as a chemopotentiator to full-dose cisplatin for optimally debulked stage III/IV carcinoma of the endometrium.

Wrenn DC, Saigal K, Lucci JA 3rd, Pearson MJ, Simpkins F, Schuman S, Twiggs LB, Walker GR, Wolfson AH.

Gynecol Oncol. 2011 Jul;122(1):59-62. doi: 10.1016/j.ygyno.2011.03.007. Epub 2011 Apr 6.


Comparison of a simple dose-guided intervention technique for prostate radiotherapy with existing anatomical image guidance methods.

Smyth G, McCallum HM, Pearson MJ, Lawrence GP.

Br J Radiol. 2012 Feb;85(1010):127-34. doi: 10.1259/bjr/13032912. Epub 2011 Mar 8.


Validity and inter-rater reliability of the Lindop Parkinson's Disease Mobility Assessment: a preliminary study.

Pearson MJ, Lindop FA, Mockett SP, Saunders L.

Physiotherapy. 2009 Jun;95(2):126-33. doi: 10.1016/ Epub 2009 Apr 23.


Implementing spiking neural networks for real-time signal-processing and control applications: a model-validated FPGA approach.

Pearson MJ, Pipe AG, Mitchinson B, Gurney K, Melhuish C, Gilhespy I, Nibouche M.

IEEE Trans Neural Netw. 2007 Sep;18(5):1472-87.


Inheritance of persistent foramen ovale and atrial septal defects and the relation to familial migraine with aura.

Wilmshurst PT, Pearson MJ, Nightingale S, Walsh KP, Morrison WL.

Heart. 2004 Nov;90(11):1315-20.


Effect of fibrinogen on leukocyte margination and adhesion in postcapillary venules.

Pearson MJ, Lipowsky HH.

Microcirculation. 2004 Apr-May;11(3):295-306.


Pleuromutilins. Part 1. The identification of novel mutilin 14-carbamates.

Brooks G, Burgess W, Colthurst D, Hinks JD, Hunt E, Pearson MJ, Shea B, Takle AK, Wilson JM, Woodnutt G.

Bioorg Med Chem. 2001 May;9(5):1221-31.


Relationship between right-to-left shunts and cutaneous decompression illness.

Wilmshurst PT, Pearson MJ, Walsh KP, Morrison WL, Bryson P.

Clin Sci (Lond). 2001 May;100(5):539-42.


Influence of erythrocyte aggregation on leukocyte margination in postcapillary venules of rat mesentery.

Pearson MJ, Lipowsky HH.

Am J Physiol Heart Circ Physiol. 2000 Oct;279(4):H1460-71.


The clinical role of clinical biochemists.

Pearson MJ.

Ann Clin Biochem. 1999 Nov;36 ( Pt 6):691-9.


Antibacterial activity of some (C2)-heterobicyclyl carbapenem derivatives.

Burton G, Coulton S, Harrington FP, Hinks JD, Holland RK, Hunt E, Pearson MJ.

J Antibiot (Tokyo). 1998 Jun;51(6):599-601. No abstract available.


Novel C-2 substituted carbapenem derivatives. Part IV. Synthesis and biological activity of five membered heteroaromatic derivatives.

Branch CL, Burton G, Clarke GJ, Coulton S, Douglas JD, Eglington AJ, Guest AW, Hinks JD, Hird NW, Holland RK, Hunt E, Knott SJ, Moss SF, Naylor A, Pearson MJ, Takle AK.

J Antibiot (Tokyo). 1998 Feb;51(2):210-20.

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