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Reply to Tran et al.: Dimeric KRAS protein-protein interaction stabilizers.

Kessler D, Gollner A, Gmachl M, Mantoulidis A, Martin LJ, Zoephel A, Mayer M, Covini D, Fischer S, Gerstberger T, Gmaschitz T, Goodwin C, Greb P, Häring D, Hela W, Hoffmann J, Karolyi-Oezguer J, Knesl P, Kornigg S, Koegl M, Kousek R, Lamarre L, Moser F, Munico-Martinez S, Peinsipp C, Phan J, Rinnenthal J, Sai J, Salamon C, Scherbantin Y, Schipany K, Schnitzer R, Schrenk A, Sharps B, Siszler G, Sun Q, Waterson A, Wolkerstorfer B, Zeeb M, Pearson M, Fesik SW, McConnell DB.

Proc Natl Acad Sci U S A. 2020 Feb 11. pii: 201921236. doi: 10.1073/pnas.1921236117. [Epub ahead of print] No abstract available.


Alcohol Use and Long-Term Outcomes Among U.S. Veterans Who Received Direct-Acting Antivirals for Hepatitis C Treatment.

Kim NJ, Pearson M, Vutien P, Su F, Moon AM, Berry K, Green PK, Williams EC, Ioannou GN.

Hepatol Commun. 2020 Jan 2;4(2):314-324. doi: 10.1002/hep4.1464. eCollection 2020 Feb.


Selective and potent CDK8/19 inhibitors enhance NK cell activity and promote tumor surveillance.

Hofmann MH, Mani R, Engelhardt H, Impagnatiello MA, Carotta S, Kerenyi M, Lorenzo-Herrero S, Böttcher J, Scharn D, Arnhof H, Zoephel A, Schnitzer R, Gerstberger T, Sanderson MP, Rajgolikar G, Goswami S, Vasu S, Ettmayer P, Gonzalez S, Pearson M, McConnell DB, Kraut N, Muthusamy N, Moll J.

Mol Cancer Ther. 2020 Feb 5. pii: molcanther.0789.2019. doi: 10.1158/1535-7163.MCT-19-0789. [Epub ahead of print]


"Are you doing your pelvic floor?" An ethnographic exploration of the interaction between women and midwives about pelvic floor muscle exercises (PFME) during pregnancy.

Terry R, Jarvie R, Hay-Smith J, Salmon V, Pearson M, Boddy K, MacArthur C, Dean S.

Midwifery. 2020 Jan 22;83:102647. doi: 10.1016/j.midw.2020.102647. [Epub ahead of print]


Proteomic analysis of two populations of Schistosoma mansoni-derived extracellular vesicles: 15k pellet and 120k pellet vesicles.

Kifle DW, Pearson MS, Becker L, Pickering D, Loukas A, Sotillo J.

Mol Biochem Parasitol. 2020 Jan 31;236:111264. doi: 10.1016/j.molbiopara.2020.111264. [Epub ahead of print]


Evidence of Intrinsic Impairment of Osteoblast Phenotype at the Curve Apex in Girls With Adolescent Idiopathic Scoliosis.

Pearson MJ, Philp AM, Haq H, Cooke ME, Nicholson T, Grover LM, Newton Ede M, Jones SW.

Spine Deform. 2019 Jul;7(4):533-542. doi: 10.1016/j.jspd.2018.11.016. Epub 2019 Dec 30.


The Addictions Neuroclinical Assessment Negative Emotionality Domain Among Treatment-Seekers with Alcohol Use Disorder: Construct Validity and Measurement Invariance.

Votaw VR, Pearson MR, Stein E, Witkiewitz K.

Alcohol Clin Exp Res. 2020 Jan 19. doi: 10.1111/acer.14283. [Epub ahead of print]


Predictors of cognitive function in pediatric brain tumor patients: pre-surgery through 24-month follow-up.

Fraley CE, Thigpen JC, Pearson MM, Kuttesch JF Jr, Desjardins L, Hoskinson KR, Alvarado-Gonzalez A, Esbenshade AJ, Pastakia D, Friedman DL, Wellons JC, McNally CM, Siciliano RE, Compas BE.

Appl Neuropsychol Child. 2019 Dec 30:1-8. doi: 10.1080/21622965.2019.1706179. [Epub ahead of print]


Fast and accurate quantification of insertion-site specific transgene levels from raw seed samples using solid-state nanopore technology.

Pearson MD, Nguyen L, Zhao Y, McKenna WL, Morin TJ, Dunbar WB.

PLoS One. 2019 Dec 27;14(12):e0226719. doi: 10.1371/journal.pone.0226719. eCollection 2019.


Cross-cultural examination of the Big Five Personality Trait Short Questionnaire: Measurement invariance testing and associations with mental health.

Mezquita L, Bravo AJ, Morizot J, Pilatti A, Pearson MR, Ibáñez MI, Ortet G, Cross-Cultural Addictions Study Team.

PLoS One. 2019 Dec 17;14(12):e0226223. doi: 10.1371/journal.pone.0226223. eCollection 2019.


Implementing pelvic floor muscle training in women's childbearing years: A critical interpretive synthesis of individual, professional, and service issues.

Salmon VE, Hay-Smith EJC, Jarvie R, Dean S, Terry R, Frawley H, Oborn E, Bayliss SE, Bick D, Davenport C, MacArthur C, Pearson M.

Neurourol Urodyn. 2020 Feb;39(2):863-870. doi: 10.1002/nau.24256. Epub 2019 Dec 17. Review.


A mother's bond: An ecological momentary assessment study of posttraumatic stress disorder symptoms and substance craving during pregnancy.

Sanjuan PM, Pearson MR, Fokas K, Leeman LM.

Psychol Addict Behav. 2019 Dec 12. doi: 10.1037/adb0000543. [Epub ahead of print]


The Relationship between Negative Affect and Alcohol and Marijuana Use Outcomes among Dual Users.

Bravo AJ, Pearson MR, Baumgardner SF; Protective Strategies Study Team.

Subst Use Misuse. 2019 Dec 9:1-8. doi: 10.1080/10826084.2019.1696820. [Epub ahead of print]


Novel cholinesterase paralogs of Schistosoma mansoni have perceived roles in cholinergic signalling and drug detoxification and are essential for parasite survival.

Tedla BA, Sotillo J, Pickering D, Eichenberger RM, Ryan S, Becker L, Loukas A, Pearson MS.

PLoS Pathog. 2019 Dec 6;15(12):e1008213. doi: 10.1371/journal.ppat.1008213. eCollection 2019 Dec.


Balancing the scales-Nurses' attempts at meeting family and employer needs in a work-intensified environment.

Harvey C, Baldwin A, Thompson S, Willis E, Meyer A, Pearson M, Otis E.

J Nurs Manag. 2019 Nov 27. doi: 10.1111/jonm.12913. [Epub ahead of print]


Estimating the government health-care costs of treating pesticide poisoned and pesticide self-poisoned patients in Sri Lanka.

Ahrensberg H, Madsen LB, Pearson M, Weerasinghe M, Eddleston M, Jayamanne S, Hansen KS, Ariyarathna V, Rajapaksha S, Konradsen F.

Glob Health Action. 2019;12(1):1692616. doi: 10.1080/16549716.2019.1692616.


An evidence-based analysis of managing hypertension with isometric resistance exercise-are the guidelines current?

Smart NA, Gow J, Bleile B, Van der Touw T, Pearson MJ.

Hypertens Res. 2019 Nov 22. doi: 10.1038/s41440-019-0360-1. [Epub ahead of print] Review.


Protective behavioral strategies predict alcohol-related problems among injured patients following a brief intervention.

Richards DK, Pearson MR, Morera OF, Field CA.

Drug Alcohol Depend. 2019 Dec 1;205:107535. doi: 10.1016/j.drugalcdep.2019.06.037. Epub 2019 Oct 22.


Obese osteoarthritis patients exhibit an inflammatory synovial fibroblast phenotype, which is regulated by the long non coding RNA MALAT1.

Nanus DE, Wijesinghe SN, Pearson MJ, Hadjicharalambous MR, Rosser A, Davis ET, Lindsay MA, Jones SW.

Arthritis Rheumatol. 2019 Nov 4. doi: 10.1002/art.41158. [Epub ahead of print]


Clinical management in mixed gonadal dysgenesis with chromosomal mosaicism: Considerations in newborns and adolescents.

Weidler EM, Pearson M, van Leeuwen K, Garvey E.

Semin Pediatr Surg. 2019 Oct;28(5):150841. doi: 10.1016/j.sempedsurg.2019.150841. Epub 2019 Sep 19.


Effect of vitamin D supplementation on endothelial function - An updated systematic review with meta-analysis and meta-regression.

Pincombe NL, Pearson MJ, Smart NA, King N, Dieberg G.

Nutr Metab Cardiovasc Dis. 2019 Dec;29(12):1261-1272. doi: 10.1016/j.numecd.2019.08.005. Epub 2019 Aug 19.


A randomized evaluation of on-site monitoring nested in a multinational randomized trial.

Wyman Engen N, Huppler Hullsiek K, Belloso WH, Finley E, Hudson F, Denning E, Carey C, Pearson M, Kagan J.

Clin Trials. 2020 Feb;17(1):3-14. doi: 10.1177/1740774519881616. Epub 2019 Oct 24.


Fast, Flexible Closed-Loop Feedback: Tracking Movement in "Real-Millisecond-Time".

Sehara K, Bahr V, Mitchinson B, Pearson MJ, Larkum ME, Sachdev RNS.

eNeuro. 2019 Nov 1;6(6). pii: ENEURO.0147-19.2019. doi: 10.1523/ENEURO.0147-19.2019. Print 2019 Nov/Dec.


Mucosal Immune Response to Feline Enteric Coronavirus Infection.

Pearson M, LaVoy A, Evans S, Vilander A, Webb C, Graham B, Musselman E, LeCureux J, VandeWoude S, Dean GA.

Viruses. 2019 Sep 27;11(10). pii: E906. doi: 10.3390/v11100906.


Bi-Arrhenius Diffusion and Surface Trapping of ^{8}Li^{+} in Rutile TiO_{2}.

Chatzichristos A, McFadden RML, Dehn MH, Dunsiger SR, Fujimoto D, Karner VL, McKenzie I, Morris GD, Pearson MR, Stachura M, Sugiyama J, Ticknor JO, MacFarlane WA, Kiefl RF.

Phys Rev Lett. 2019 Aug 30;123(9):095901. doi: 10.1103/PhysRevLett.123.095901.


Emergence of dominant toxigenic M1T1 Streptococcus pyogenes clone during increased scarlet fever activity in England: a population-based molecular epidemiological study.

Lynskey NN, Jauneikaite E, Li HK, Zhi X, Turner CE, Mosavie M, Pearson M, Asai M, Lobkowicz L, Chow JY, Parkhill J, Lamagni T, Chalker VJ, Sriskandan S.

Lancet Infect Dis. 2019 Nov;19(11):1209-1218. doi: 10.1016/S1473-3099(19)30446-3. Epub 2019 Sep 10.


PolyMOF Nanoparticles: Dual Roles of a Multivalent polyMOF Ligand in Size Control and Surface Functionalization.

Gu Y, Huang M, Zhang W, Pearson MA, Johnson JA.

Angew Chem Int Ed Engl. 2019 Nov 11;58(46):16676-16681. doi: 10.1002/anie.201910542. Epub 2019 Sep 30. Review.


Discovery of MK-8719, a Potent O-GlcNAcase Inhibitor as a Potential Treatment for Tauopathies.

Selnick HG, Hess JF, Tang C, Liu K, Schachter JB, Ballard JE, Marcus J, Klein DJ, Wang X, Pearson M, Savage MJ, Kaul R, Li TS, Vocadlo DJ, Zhou Y, Zhu Y, Mu C, Wang Y, Wei Z, Bai C, Duffy JL, McEachern EJ.

J Med Chem. 2019 Nov 27;62(22):10062-10097. doi: 10.1021/acs.jmedchem.9b01090. Epub 2019 Sep 29.


SMARCA2-deficiency confers sensitivity to targeted inhibition of SMARCA4 in esophageal squamous cell carcinoma cell lines.

Ehrenhöfer-Wölfer K, Puchner T, Schwarz C, Rippka J, Blaha-Ostermann S, Strobl U, Hörmann A, Bader G, Kornigg S, Zahn S, Sommergruber W, Schweifer N, Zichner T, Schlattl A, Neumüller RA, Shi J, Vakoc CR, Kögl M, Petronczki M, Kraut N, Pearson MA, Wöhrle S.

Sci Rep. 2019 Aug 12;9(1):11661. doi: 10.1038/s41598-019-48152-x.


Ancient pigs reveal a near-complete genomic turnover following their introduction to Europe.

Frantz LAF, Haile J, Lin AT, Scheu A, Geörg C, Benecke N, Alexander M, Linderholm A, Mullin VE, Daly KG, Battista VM, Price M, Gron KJ, Alexandri P, Arbogast RM, Arbuckle B, Bӑlӑşescu A, Barnett R, Bartosiewicz L, Baryshnikov G, Bonsall C, Borić D, Boroneanţ A, Bulatović J, Çakirlar C, Carretero JM, Chapman J, Church M, Crooijmans R, De Cupere B, Detry C, Dimitrijevic V, Dumitraşcu V, du Plessis L, Edwards CJ, Erek CM, Erim-Özdoğan A, Ervynck A, Fulgione D, Gligor M, Götherström A, Gourichon L, Groenen MAM, Helmer D, Hongo H, Horwitz LK, Irving-Pease EK, Lebrasseur O, Lesur J, Malone C, Manaseryan N, Marciniak A, Martlew H, Mashkour M, Matthews R, Matuzeviciute GM, Maziar S, Meijaard E, McGovern T, Megens HJ, Miller R, Mohaseb AF, Orschiedt J, Orton D, Papathanasiou A, Pearson MP, Pinhasi R, Radmanović D, Ricaut FX, Richards M, Sabin R, Sarti L, Schier W, Sheikhi S, Stephan E, Stewart JR, Stoddart S, Tagliacozzo A, Tasić N, Trantalidou K, Tresset A, Valdiosera C, van den Hurk Y, Van Poucke S, Vigne JD, Yanevich A, Zeeb-Lanz A, Triantafyllidis A, Gilbert MTP, Schibler J, Rowley-Conwy P, Zeder M, Peters J, Cucchi T, Bradley DG, Dobney K, Burger J, Evin A, Girdland-Flink L, Larson G.

Proc Natl Acad Sci U S A. 2019 Aug 27;116(35):17231-17238. doi: 10.1073/pnas.1901169116. Epub 2019 Aug 12.


Intracellular Trapping of the Selective Phosphoglycerate Dehydrogenase (PHGDH) Inhibitor BI-4924 Disrupts Serine Biosynthesis.

Weinstabl H, Treu M, Rinnenthal J, Zahn SK, Ettmayer P, Bader G, Dahmann G, Kessler D, Rumpel K, Mischerikow N, Savarese F, Gerstberger T, Mayer M, Zoephel A, Schnitzer R, Sommergruber W, Martinelli P, Arnhof H, Peric-Simov B, Hofbauer KS, Garavel G, Scherbantin Y, Mitzner S, Fett TN, Scholz G, Bruchhaus J, Burkard M, Kousek R, Ciftci T, Sharps B, Schrenk A, Harrer C, Haering D, Wolkerstorfer B, Zhang X, Lv X, Du A, Li D, Li Y, Quant J, Pearson M, McConnell DB.

J Med Chem. 2019 Sep 12;62(17):7976-7997. doi: 10.1021/acs.jmedchem.9b00718. Epub 2019 Aug 14.


Post-traumatic stress and marijuana outcomes: The mediating role of marijuana protective behavioral strategies.

Jordan HR, Madson MB, Bravo AJ, Pearson MR; Protective Strategies Study Team.

Subst Abus. 2019 Jul 30:1-7. doi: 10.1080/08897077.2019.1635965. [Epub ahead of print]


Caregiver Interventions for Adults Discharged from the Hospital: Systematic Review and Meta-Analysis.

Smith TO, Pearson M, Pfeiffer K, Crotty M, Lamb SE.

J Am Geriatr Soc. 2019 Sep;67(9):1960-1969. doi: 10.1111/jgs.16048. Epub 2019 Jul 27. Review.


Drugging an undruggable pocket on KRAS.

Kessler D, Gmachl M, Mantoulidis A, Martin LJ, Zoephel A, Mayer M, Gollner A, Covini D, Fischer S, Gerstberger T, Gmaschitz T, Goodwin C, Greb P, Häring D, Hela W, Hoffmann J, Karolyi-Oezguer J, Knesl P, Kornigg S, Koegl M, Kousek R, Lamarre L, Moser F, Munico-Martinez S, Peinsipp C, Phan J, Rinnenthal J, Sai J, Salamon C, Scherbantin Y, Schipany K, Schnitzer R, Schrenk A, Sharps B, Siszler G, Sun Q, Waterson A, Wolkerstorfer B, Zeeb M, Pearson M, Fesik SW, McConnell DB.

Proc Natl Acad Sci U S A. 2019 Aug 6;116(32):15823-15829. doi: 10.1073/pnas.1904529116. Epub 2019 Jul 22.


Phase Variation of the mrp Fimbrial Promoter.

Pearson MM.

Methods Mol Biol. 2019;2021:121-127. doi: 10.1007/978-1-4939-9601-8_12.


Using Hemagglutination, Surface Shearing, and Acid Treatment to Study Fimbriae in Proteus mirabilis.

Himpsl SD, Pearson MM, Mobley HLT.

Methods Mol Biol. 2019;2021:109-120. doi: 10.1007/978-1-4939-9601-8_11.


Insertional Mutagenesis Protocol for Constructing Single or Sequential Mutations.

Pearson MM, Himpsl SD, Mobley HLT.

Methods Mol Biol. 2019;2021:61-76. doi: 10.1007/978-1-4939-9601-8_7.


Methods for Studying Swarming and Swimming Motility.

Pearson MM.

Methods Mol Biol. 2019;2021:15-25. doi: 10.1007/978-1-4939-9601-8_3.


Culture Methods for Proteus mirabilis.

Pearson MM.

Methods Mol Biol. 2019;2021:5-13. doi: 10.1007/978-1-4939-9601-8_2.


Trematode Genomics and Proteomics.

Sotillo J, Pearson MS, Loukas A.

Adv Exp Med Biol. 2019;1154:411-436. doi: 10.1007/978-3-030-18616-6_13.


Knowing antmicrobial resistance in practice: a multi-country qualitative study with human and animal healthcare professionals.

Pearson M, Chandler C.

Glob Health Action. 2019;12(1):1599560. doi: 10.1080/16549716.2019.1599560.


Fragment-based discovery of a chemical probe for the PWWP1 domain of NSD3.

Böttcher J, Dilworth D, Reiser U, Neumüller RA, Schleicher M, Petronczki M, Zeeb M, Mischerikow N, Allali-Hassani A, Szewczyk MM, Li F, Kennedy S, Vedadi M, Barsyte-Lovejoy D, Brown PJ, Huber KVM, Rogers CM, Wells CI, Fedorov O, Rumpel K, Zoephel A, Mayer M, Wunberg T, Böse D, Zahn S, Arnhof H, Berger H, Reiser C, Hörmann A, Krammer T, Corcokovic M, Sharps B, Winkler S, Häring D, Cockcroft XL, Fuchs JE, Müllauer B, Weiss-Puxbaum A, Gerstberger T, Boehmelt G, Vakoc CR, Arrowsmith CH, Pearson M, McConnell DB.

Nat Chem Biol. 2019 Aug;15(8):822-829. doi: 10.1038/s41589-019-0310-x. Epub 2019 Jul 8.


Teaching primary care teamwork: a conceptual model of primary care team performance.

Warde CM, Giannitrapani KF, Pearson ML.

Clin Teach. 2019 Jul 7. doi: 10.1111/tct.13037. [Epub ahead of print] No abstract available.


Perspectives on Heavy Metal Soil Testing Among Community Gardeners in the United States: A Mixed Methods Approach.

Hunter CM, Williamson DHZ, Gribble MO, Bradshaw H, Pearson M, Saikawa E, Ryan PB, Kegler M.

Int J Environ Res Public Health. 2019 Jul 3;16(13). pii: E2350. doi: 10.3390/ijerph16132350.


Targeting a ceramide double bond improves insulin resistance and hepatic steatosis.

Chaurasia B, Tippetts TS, Mayoral Monibas R, Liu J, Li Y, Wang L, Wilkerson JL, Sweeney CR, Pereira RF, Sumida DH, Maschek JA, Cox JE, Kaddai V, Lancaster GI, Siddique MM, Poss A, Pearson M, Satapati S, Zhou H, McLaren DG, Previs SF, Chen Y, Qian Y, Petrov A, Wu M, Shen X, Yao J, Nunes CN, Howard AD, Wang L, Erion MD, Rutter J, Holland WL, Kelley DE, Summers SA.

Science. 2019 Jul 26;365(6451):386-392. doi: 10.1126/science.aav3722. Epub 2019 Jul 4.


Risk of suicide and repeat self-harm after hospital attendance for non-fatal self-harm in Sri Lanka: a cohort study.

Knipe D, Metcalfe C, Hawton K, Pearson M, Dawson A, Jayamanne S, Konradsen F, Eddleston M, Gunnell D.

Lancet Psychiatry. 2019 Aug;6(8):659-666. doi: 10.1016/S2215-0366(19)30214-7. Epub 2019 Jul 1.


Publisher Correction: BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design.

Farnaby W, Koegl M, Roy MJ, Whitworth C, Diers E, Trainor N, Zollman D, Steurer S, Karolyi-Oezguer J, Riedmueller C, Gmaschitz T, Wachter J, Dank C, Galant M, Sharps B, Rumpel K, Traxler E, Gerstberger T, Schnitzer R, Petermann O, Greb P, Weinstabl H, Bader G, Zoephel A, Weiss-Puxbaum A, Ehrenhöfer-Wölfer K, Wöhrle S, Boehmelt G, Rinnenthal J, Arnhof H, Wiechens N, Wu MY, Owen-Hughes T, Ettmayer P, Pearson M, McConnell DB, Ciulli A.

Nat Chem Biol. 2019 Aug;15(8):846. doi: 10.1038/s41589-019-0329-z.


Metabolomic profiling of the excretory-secretory products of hookworm and whipworm.

Wangchuk P, Kouremenos K, Eichenberger RM, Pearson M, Susianto A, Wishart DS, McConville MJ, Loukas A.

Metabolomics. 2019 Jun 28;15(7):101. doi: 10.1007/s11306-019-1561-y.


Evidence of Intrinsic Impairment of Osteoblast Phenotype at the Curve Apex in Girls With Adolescent Idiopathic Scoliosis.

Pearson MJ, Philp AM, Haq H, Cooke ME, Nicholson T, Grover LM, Newton Ede M, Jones SW.

Spine Deform. 2019 Jul;7(4):533-542. doi: 10.1016/j.jspd.2018.11.016.


EF-G-induced ribosome sliding along the noncoding mRNA.

Klimova M, Senyushkina T, Samatova E, Peng BZ, Pearson M, Peske F, Rodnina MV.

Sci Adv. 2019 Jun 5;5(6):eaaw9049. doi: 10.1126/sciadv.aaw9049. eCollection 2019 Jun.

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