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Items: 1 to 50 of 148

1.

Targeting Multiple Myeloma with AMG 424, a Novel Anti-CD38/CD3 Bispecific T-cell-recruiting Antibody Optimized for Cytotoxicity and Cytokine Release.

Zuch de Zafra CL, Fajardo F, Zhong W, Bernett MJ, Muchhal US, Moore GL, Stevens J, Case R, Pearson JT, Liu S, McElroy PL, Canon J, Desjarlais JR, Coxon A, Balazs M, Nolan-Stevaux O.

Clin Cancer Res. 2019 Mar 27. doi: 10.1158/1078-0432.CCR-18-2752. [Epub ahead of print]

PMID:
30918018
2.

Liraglutide Improves Renal Endothelial Function in Obese Zucker Rats on a High-Salt Diet.

Sukumaran V, Tsuchimochi H, Sonobe T, Shirai M, Pearson JT.

J Pharmacol Exp Ther. 2019 Jun;369(3):375-388. doi: 10.1124/jpet.118.254821. Epub 2019 Mar 25.

PMID:
30910920
3.

Accentuated antagonism of vagal heart rate control and less potent prejunctional inhibition of vagal acetylcholine release during sympathetic nerve stimulation in the rat.

Kawada T, Sonobe T, Hayama Y, Nishikawa T, Miyamoto T, Akiyama T, Pearson JT, Sugimachi M.

Auton Neurosci. 2019 May;218:25-30. doi: 10.1016/j.autneu.2019.02.005. Epub 2019 Feb 18.

PMID:
30890345
4.

Metformin intervention prevents cardiac dysfunction in a murine model of adult congenital heart disease.

Wilmanns JC, Pandey R, Hon O, Chandran A, Schilling JM, Forte E, Wu Q, Cagnone G, Bais P, Philip V, Coleman D, Kocalis H, Archer SK, Pearson JT, Ramialison M, Heineke J, Patel HH, Rosenthal NA, Furtado MB, Costa MW.

Mol Metab. 2019 Feb;20:102-114. doi: 10.1016/j.molmet.2018.11.002. Epub 2018 Nov 15.

5.

Central activation of cardiac vagal nerve by α2-adrenergic stimulation is impaired in streptozotocin-induced type 1 diabetic rats.

Kawada T, Akiyama T, Sonobe T, Shimizu S, Hayama Y, Pearson JT, Shishido T, Sugimachi M.

Auton Neurosci. 2019 Jan;216:39-45. doi: 10.1016/j.autneu.2018.09.001. Epub 2018 Sep 8.

PMID:
30220605
6.

Progressive Decrease in Coronary Vascular Function Associated With Type 2 Diabetic Heart Disease.

Katare R, Pearson JT, Lew JK, Wei M, Tsuchimouchi H, Du CK, Zhan DY, Umetani K, Shirai M, Schwenke DO.

Front Physiol. 2018 Jun 6;9:696. doi: 10.3389/fphys.2018.00696. eCollection 2018.

7.

Ghrelin Pre-treatment Attenuates Local Oxidative Stress and End Organ Damage During Cardiopulmonary Bypass in Anesthetized Rats.

Sukumaran V, Tsuchimochi H, Fujii Y, Hosoda H, Kangawa K, Akiyama T, Shirai M, Tatsumi E, Pearson JT.

Front Physiol. 2018 Mar 9;9:196. doi: 10.3389/fphys.2018.00196. eCollection 2018.

8.

Drinking by amphibious fish: convergent evolution of thirst mechanisms during vertebrate terrestrialization.

Katayama Y, Sakamoto T, Saito K, Tsuchimochi H, Kaiya H, Watanabe T, Pearson JT, Takei Y.

Sci Rep. 2018 Jan 12;8(1):625. doi: 10.1038/s41598-017-18611-4.

9.

Ghrelin, MicroRNAs, and Critical Limb Ischemia: Hungering for a Novel Treatment Option.

Neale JPH, Pearson JT, Katare R, Schwenke DO.

Front Endocrinol (Lausanne). 2017 Dec 13;8:350. doi: 10.3389/fendo.2017.00350. eCollection 2017. Review.

10.

Ghrelin Preserves Ischemia-Induced Vasodilation of Male Rat Coronary Vessels Following β-Adrenergic Receptor Blockade.

Pearson JT, Collie N, Lamberts RR, Inagaki T, Yoshimoto M, Umetani K, Davis P, Wilkins G, Jones PP, Shirai M, Schwenke DO.

Endocrinology. 2018 Apr 1;159(4):1763-1773. doi: 10.1210/en.2017-03070.

PMID:
29325034
11.

Widespread Coronary Dysfunction in the Absence of HDL Receptor SR-B1 in an Ischemic Cardiomyopathy Mouse Model.

Pearson JT, Yoshimoto M, Chen YC, Sultani R, Edgley AJ, Nakaoka H, Nishida M, Umetani K, Waddingham MT, Jin HL, Zhang Y, Kelly DJ, Schwenke DO, Inagaki T, Tsuchimochi H, Komuro I, Yamashita S, Shirai M.

Sci Rep. 2017 Dec 22;7(1):18108. doi: 10.1038/s41598-017-18485-6.

12.

Diffusion tensor imaging detects ventilation-induced brain injury in preterm lambs.

Alahmari DM, Chan KYY, Stojanovska V, LaRosa D, Barton SK, Nitsos I, Zahra V, Barbuto J, Farrell M, Yamaoka S, Pearson JT, Polglase GR.

PLoS One. 2017 Dec 6;12(12):e0188737. doi: 10.1371/journal.pone.0188737. eCollection 2017.

13.

Homeostatic plasticity shapes the visual system's first synapse.

Johnson RE, Tien NW, Shen N, Pearson JT, Soto F, Kerschensteiner D.

Nat Commun. 2017 Oct 31;8(1):1220. doi: 10.1038/s41467-017-01332-7.

14.

Immunoaffinity capture coupled with capillary electrophoresis - mass spectrometry to study therapeutic protein stability in vivo.

Han M, Pearson JT, Wang Y, Winters D, Soto M, Rock DA, Rock BM.

Anal Biochem. 2017 Dec 15;539:118-126. doi: 10.1016/j.ab.2017.10.005. Epub 2017 Oct 10.

PMID:
29029979
15.

Three-dimensional morphometric analysis of the renal vasculature.

Khan Z, Ngo JP, Le B, Evans RG, Pearson JT, Gardiner BS, Smith DW.

Am J Physiol Renal Physiol. 2018 May 1;314(5):F715-F725. doi: 10.1152/ajprenal.00339.2017. Epub 2017 Sep 20.

16.

Analysis of the microvascular morphology and hemodynamics of breast cancer in mice using SPring-8 synchrotron radiation microangiography.

Torii M, Fukui T, Inoue M, Kanao S, Umetani K, Shirai M, Inagaki T, Tsuchimochi H, Pearson JT, Toi M.

J Synchrotron Radiat. 2017 Sep 1;24(Pt 5):1039-1047. doi: 10.1107/S1600577517008372. Epub 2017 Aug 2.

17.

Influence of coronary architecture on the variability in myocardial infarction induced by coronary ligation in rats.

Kainuma S, Miyagawa S, Fukushima S, Tsuchimochi H, Sonobe T, Fujii Y, Pearson JT, Saito A, Harada A, Toda K, Shirai M, Sawa Y.

PLoS One. 2017 Aug 24;12(8):e0183323. doi: 10.1371/journal.pone.0183323. eCollection 2017.

18.

Micro-computed tomographic analysis of the radial geometry of intrarenal artery-vein pairs in rats and rabbits: Comparison with light microscopy.

Ngo JP, Le B, Khan Z, Kett MM, Gardiner BS, Smith DW, Melhem MM, Maksimenko A, Pearson JT, Evans RG.

Clin Exp Pharmacol Physiol. 2017 Dec;44(12):1241-1253. doi: 10.1111/1440-1681.12842. Epub 2017 Sep 5.

PMID:
28795785
19.

Azilsartan ameliorates diabetic cardiomyopathy in young db/db mice through the modulation of ACE-2/ANG 1-7/Mas receptor cascade.

Sukumaran V, Tsuchimochi H, Tatsumi E, Shirai M, Pearson JT.

Biochem Pharmacol. 2017 Nov 15;144:90-99. doi: 10.1016/j.bcp.2017.07.022. Epub 2017 Aug 5.

PMID:
28789938
20.

Beyond proof of concepts for ideal cardiac regenerative therapy.

Mochizuki N, Pearson JT, Kitamura S.

J Thorac Cardiovasc Surg. 2017 Sep;154(3):964-965. doi: 10.1016/j.jtcvs.2017.05.015. Epub 2017 May 17. No abstract available.

PMID:
28645824
21.

Diffusion Tensor Imaging Colour Mapping Threshold for Identification of Ventilation-Induced Brain Injury after Intrauterine Inflammation in Preterm Lambs.

Alahmari DM, Skiöld B, Barton SK, Nitsos I, McDonald C, Miller SL, Zahra V, Galinsky R, Wu Q, Farrell MJ, Moss TJ, Hooper SB, Pearson JT, Polglase GR.

Front Pediatr. 2017 Apr 5;5:70. doi: 10.3389/fped.2017.00070. eCollection 2017.

22.

Lung hypoplasia in newborn rabbits with a diaphragmatic hernia affects pulmonary ventilation but not perfusion.

Flemmer AW, Thio M, Wallace MJ, Lee K, Kitchen MJ, Kerr L, Roehr CC, Fouras A, Carnibella R, Jani JC, DeKoninck P, Te Pas AB, Pearson JT, Hooper SB.

Pediatr Res. 2017 Sep;82(3):536-543. doi: 10.1038/pr.2017.91. Epub 2017 May 31.

23.

Point mutations in murine Nkx2-5 phenocopy human congenital heart disease and induce pathogenic Wnt signaling.

Furtado MB, Wilmanns JC, Chandran A, Perera J, Hon O, Biben C, Willow TJ, Nim HT, Kaur G, Simonds S, Wu Q, Willians D, Salimova E, Plachta N, Denegre JM, Murray SA, Fatkin D, Cowley M, Pearson JT, Kaye D, Ramialison M, Harvey RP, Rosenthal NA, Costa MW.

JCI Insight. 2017 Mar 23;2(6):e88271. doi: 10.1172/jci.insight.88271.

24.

Cardiac vagal control in a knock-in mouse model of dilated cardiomyopathy with a troponin mutation.

Zhan DY, Du CK, Akiyama T, Morimoto S, Shimizu S, Kawada T, Shirai M, Pearson JT.

Auton Neurosci. 2017 Jul;205:33-40. doi: 10.1016/j.autneu.2017.03.002. Epub 2017 Mar 16.

PMID:
28344023
25.

Microvascular leakage in acute myocardial infarction: characterization by histology, biochemistry, and magnetic resonance imaging.

Gao XM, Wu QZ, Kiriazis H, Su Y, Han LP, Pearson JT, Taylor AJ, Du XJ.

Am J Physiol Heart Circ Physiol. 2017 May 1;312(5):H1068-H1075. doi: 10.1152/ajpheart.00073.2017. Epub 2017 Mar 24.

26.

Exercise mediated protection of diabetic heart through modulation of microRNA mediated molecular pathways.

Lew JK, Pearson JT, Schwenke DO, Katare R.

Cardiovasc Diabetol. 2017 Jan 13;16(1):10. doi: 10.1186/s12933-016-0484-4. Review.

27.

Vagal denervation inhibits the increase in pulmonary blood flow during partial lung aeration at birth.

Lang JA, Pearson JT, Binder-Heschl C, Wallace MJ, Siew ML, Kitchen MJ, Te Pas AB, Lewis RA, Polglase GR, Shirai M, Hooper SB.

J Physiol. 2017 Mar 1;595(5):1593-1606. doi: 10.1113/JP273682. Epub 2017 Feb 14.

28.

Technical Note: Contrast free angiography of the pulmonary vasculature in live mice using a laboratory x-ray source.

Samarage CR, Carnibella R, Preissner M, Jones HD, Pearson JT, Fouras A, Dubsky S.

Med Phys. 2016 Nov;43(11):6017.

29.

Diffusive shunting of gases and other molecules in the renal vasculature: physiological and evolutionary significance.

Ngo JP, Ow CP, Gardiner BS, Kar S, Pearson JT, Smith DW, Evans RG.

Am J Physiol Regul Integr Comp Physiol. 2016 Nov 1;311(5):R797-R810. doi: 10.1152/ajpregu.00246.2016. Epub 2016 Aug 3. Review.

30.

Myocardial interstitial levels of serotonin and its major metabolite 5-hydroxyindole acetic acid during ischemia-reperfusion.

Du CK, Zhan DY, Akiyama T, Inagaki T, Shishido T, Shirai M, Pearson JT.

Am J Physiol Heart Circ Physiol. 2017 Jan 1;312(1):H60-H67. doi: 10.1152/ajpheart.00471.2016. Epub 2016 Oct 28.

31.

Chronic intermittent hypoxia accelerates coronary microcirculatory dysfunction in insulin-resistant Goto-Kakizaki rats.

Chen YC, Inagaki T, Fujii Y, Schwenke DO, Tsuchimochi H, Edgley AJ, Umetani K, Zhang Y, Kelly DJ, Yoshimoto M, Nagai H, Evans RG, Kuwahira I, Shirai M, Pearson JT.

Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1.

32.

A novel conditional mouse model for Nkx2-5 reveals transcriptional regulation of cardiac ion channels.

Furtado MB, Wilmanns JC, Chandran A, Tonta M, Biben C, Eichenlaub M, Coleman HA, Berger S, Bouveret R, Singh R, Harvey RP, Ramialison M, Pearson JT, Parkington HC, Rosenthal NA, Costa MW.

Differentiation. 2016 Jan-Mar;91(1-3):29-41. doi: 10.1016/j.diff.2015.12.003. Epub 2016 Feb 17.

PMID:
26897459
33.

Intact mass analysis of monoclonal antibodies by capillary electrophoresis-Mass spectrometry.

Han M, Rock BM, Pearson JT, Rock DA.

J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Feb 1;1011:24-32. doi: 10.1016/j.jchromb.2015.12.045. Epub 2015 Dec 28.

PMID:
26751590
34.

Changes in inflammatory response during and after cardiopulmonary bypass using a rat extracorporeal circulation model.

Fujii Y, Shirai M, Pearson JT, Takewa Y, Tatsumi E.

Conf Proc IEEE Eng Med Biol Soc. 2015 Aug;2015:957-60. doi: 10.1109/EMBC.2015.7318522.

PMID:
26736422
35.

Bioanalytical approaches to assess the proteolytic stability of therapeutic fusion proteins.

Pearson JT, Rock DA.

Bioanalysis. 2015 Dec;7(23):3035-51. doi: 10.4155/bio.15.217. Epub 2015 Nov 30. Review.

PMID:
26617274
36.

Cardiac responses to hypoxia and reoxygenation in Drosophila. New insights into evolutionarily conserved gene responses. Focus on "Cardiac responses to hypoxia and reoxygenation in Drosophila".

Pearson JT.

Am J Physiol Regul Integr Comp Physiol. 2015 Dec 1;309(11):R1344-6. doi: 10.1152/ajpregu.00419.2015. Epub 2015 Oct 7. No abstract available.

37.

Increase in pulmonary blood flow at birth: role of oxygen and lung aeration.

Lang JA, Pearson JT, Binder-Heschl C, Wallace MJ, Siew ML, Kitchen MJ, te Pas AB, Fouras A, Lewis RA, Polglase GR, Shirai M, Hooper SB.

J Physiol. 2016 Mar 1;594(5):1389-98. doi: 10.1113/JP270926. Epub 2015 Sep 10.

38.

Genetically Identified Suppressed-by-Contrast Retinal Ganglion Cells Reliably Signal Self-Generated Visual Stimuli.

Tien NW, Pearson JT, Heller CR, Demas J, Kerschensteiner D.

J Neurosci. 2015 Jul 29;35(30):10815-20. doi: 10.1523/JNEUROSCI.1521-15.2015.

39.

Chronic Rho-kinase inhibition improves left ventricular contractile dysfunction in early type-1 diabetes by increasing myosin cross-bridge extension.

Waddingham MT, Edgley AJ, Astolfo A, Inagaki T, Fujii Y, Du CK, Zhan DY, Tsuchimochi H, Yagi N, Kelly DJ, Shirai M, Pearson JT.

Cardiovasc Diabetol. 2015 Jul 22;14:92. doi: 10.1186/s12933-015-0256-6.

40.

Contractile apparatus dysfunction early in the pathophysiology of diabetic cardiomyopathy.

Waddingham MT, Edgley AJ, Tsuchimochi H, Kelly DJ, Shirai M, Pearson JT.

World J Diabetes. 2015 Jul 10;6(7):943-60. doi: 10.4239/wjd.v6.i7.943. Review.

41.

Pulmonary Macrophages Attenuate Hypoxic Pulmonary Vasoconstriction via β3AR/iNOS Pathway in Rats Exposed to Chronic Intermittent Hypoxia.

Nagai H, Kuwahira I, Schwenke DO, Tsuchimochi H, Nara A, Ogura S, Sonobe T, Inagaki T, Fujii Y, Yamaguchi R, Wingenfeld L, Umetani K, Shimosawa T, Yoshida K, Uemura K, Pearson JT, Shirai M.

PLoS One. 2015 Jul 1;10(7):e0131923. doi: 10.1371/journal.pone.0131923. eCollection 2015.

42.

Interleukin-21 receptor blockade inhibits secondary humoral responses and halts the progression of preestablished disease in the (NZB × NZW)F1 systemic lupus erythematosus model.

Zhang M, Yu G, Chan B, Pearson JT, Rathanaswami P, Delaney J, Ching Lim A, Babcook J, Hsu H, Gavin MA.

Arthritis Rheumatol. 2015 Oct;67(10):2723-31. doi: 10.1002/art.39233.

43.

Ambient illumination switches contrast preference of specific retinal processing streams.

Pearson JT, Kerschensteiner D.

J Neurophysiol. 2015 Jul;114(1):540-50. doi: 10.1152/jn.00360.2015. Epub 2015 May 20.

44.

Treadmill running improves hindlimb arteriolar endothelial function in type 1 diabetic mice as visualized by X-ray microangiography.

Sonobe T, Tsuchimochi H, Schwenke DO, Pearson JT, Shirai M.

Cardiovasc Diabetol. 2015 May 13;14:51. doi: 10.1186/s12933-015-0217-0.

45.

Importance of tissue preparation methods in FTIR micro-spectroscopical analysis of biological tissues: 'traps for new users'.

Zohdi V, Whelan DR, Wood BR, Pearson JT, Bambery KR, Black MJ.

PLoS One. 2015 Feb 24;10(2):e0116491. doi: 10.1371/journal.pone.0116491. eCollection 2015.

46.

Functional and Electrical Integration of Induced Pluripotent Stem Cell-Derived Cardiomyocytes in a Myocardial Infarction Rat Heart.

Higuchi T, Miyagawa S, Pearson JT, Fukushima S, Saito A, Tsuchimochi H, Sonobe T, Fujii Y, Yagi N, Astolfo A, Shirai M, Sawa Y.

Cell Transplant. 2015;24(12):2479-89. doi: 10.3727/096368914X685799. Epub 2015 Jan 20.

PMID:
25606821
47.
48.

β2-Adrenergic receptor-dependent attenuation of hypoxic pulmonary vasoconstriction prevents progression of pulmonary arterial hypertension in intermittent hypoxic rats.

Nagai H, Kuwahira I, Schwenke DO, Tsuchimochi H, Nara A, Inagaki T, Ogura S, Fujii Y, Umetani K, Shimosawa T, Yoshida K, Pearson JT, Uemura K, Shirai M.

PLoS One. 2014 Oct 28;9(10):e110693. doi: 10.1371/journal.pone.0110693. eCollection 2014.

49.

Vascular geometry and oxygen diffusion in the vicinity of artery-vein pairs in the kidney.

Ngo JP, Kar S, Kett MM, Gardiner BS, Pearson JT, Smith DW, Ludbrook J, Bertram JF, Evans RG.

Am J Physiol Renal Physiol. 2014 Nov 15;307(10):F1111-22. doi: 10.1152/ajprenal.00382.2014. Epub 2014 Sep 10.

50.

Pulmonary vascular tone is dependent on the central modulation of sympathetic nerve activity following chronic intermittent hypoxia.

Shirai M, Tsuchimochi H, Nagai H, Gray E, Pearson JT, Sonobe T, Yoshimoto M, Inagaki T, Fujii Y, Umetani K, Kuwahira I, Schwenke DO.

Basic Res Cardiol. 2014;109(5):432. doi: 10.1007/s00395-014-0432-y. Epub 2014 Aug 20.

PMID:
25139633

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