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Items: 1 to 50 of 160

1.

Letter: studies of salivary pepsin in patients with gastro-oesophageal reflux disease.

Dettmar PW, Woodcock AD, Wilcox MD, Chater PI, Pearson JP.

Aliment Pharmacol Ther. 2019 May;49(9):1248-1249. doi: 10.1111/apt.15213. No abstract available.

PMID:
30977170
2.

Encapsulation of stevia rebaudiana Bertoni aqueous crude extracts by ionic gelation - Effects of alginate blends and gelling solutions on the polyphenolic profile.

Arriola NDA, Chater PI, Wilcox M, Lucini L, Rocchetti G, Dalmina M, Pearson JP, de Mello Castanho Amboni RD.

Food Chem. 2019 Mar 1;275:123-134. doi: 10.1016/j.foodchem.2018.09.086. Epub 2018 Sep 14.

PMID:
30724178
3.

The effect of thiamine-coating nanoparticles on their biodistribution and fate following oral administration.

Inchaurraga L, Martínez-López AL, Cattoz B, Griffiths PC, Wilcox M, Pearson JP, Quincoces G, Peñuelas I, Martin-Arbella N, Irache JM.

Eur J Pharm Sci. 2019 Feb 1;128:81-90. doi: 10.1016/j.ejps.2018.11.025. Epub 2018 Nov 23.

PMID:
30472222
4.

Reflux in idiopathic pulmonary fibrosis: treatment informed by an integrated approach.

Jones R, Krishnan A, Zeybel GL, Dookun E, Pearson JP, Simpson AJ, Griffin SM, Ward C, Forrest IA.

ERJ Open Res. 2018 Nov 5;4(4). pii: 00051-2018. doi: 10.1183/23120541.00051-2018. eCollection 2018 Oct.

5.

A qualitative synthesis of gastro-oesophageal reflux in bronchiectasis: Current understanding and future risk.

McDonnell MJ, O'Toole D, Ward C, Pearson JP, Lordan JL, De Soyza A, Loebinger M, Chalmers JD, Laffey JG, Rutherford RM.

Respir Med. 2018 Aug;141:132-143. doi: 10.1016/j.rmed.2018.06.031. Epub 2018 Jun 30. Review.

PMID:
30053958
6.

Evolutionary conservation of the antimicrobial function of mucus: a first defence against infection.

Bakshani CR, Morales-Garcia AL, Althaus M, Wilcox MD, Pearson JP, Bythell JC, Burgess JG.

NPJ Biofilms Microbiomes. 2018 Jul 4;4:14. doi: 10.1038/s41522-018-0057-2. eCollection 2018. Review.

7.

Response.

Murphy DM, Ward C, Hunt EB, MacSharry J, Pearson JP.

Chest. 2018 Apr;153(4):1077-1078. doi: 10.1016/j.chest.2017.12.023. No abstract available.

PMID:
29626956
8.

Efficacy and safety concerns over the use of mucus modulating agents for drug delivery using nanoscale systems.

Chater PI, Wilcox MD, Pearson JP.

Adv Drug Deliv Rev. 2018 Jan 15;124:184-192. doi: 10.1016/j.addr.2017.12.006. Epub 2017 Dec 13. Review.

PMID:
29247764
9.

ζ potential changing nanoparticles as cystic fibrosis transmembrane conductance regulator gene delivery system: an in vitro evaluation.

Prüfert F, Bonengel S, Köllner S, Griesser J, Wilcox MD, Chater PI, Pearson JP, Bernkop-Schnürch A.

Nanomedicine (Lond). 2017 Nov;12(22):2713-2724. doi: 10.2217/nnm-2017-0115. Epub 2017 Sep 29.

PMID:
28960133
10.

The Potential Role of Aspiration in the Asthmatic Airway.

Hunt EB, Ward C, Power S, Sullivan A, Pearson JP, Lapthorne S, O'Byrne PM, Eustace J, Plant BJ, Maher MM, MacSharry J, Murphy DM.

Chest. 2017 Jun;151(6):1272-1278. doi: 10.1016/j.chest.2017.03.005. Epub 2017 Mar 11.

PMID:
28300572
11.

Ivacaftor and symptoms of extra-oesophageal reflux in patients with cystic fibrosis and G551D mutation.

Zeybel GL, Pearson JP, Krishnan A, Bourke SJ, Doe S, Anderson A, Faruqi S, Morice AH, Jones R, McDonnell M, Zeybel M, Dettmar PW, Brodlie M, Ward C.

J Cyst Fibros. 2017 Jan;16(1):124-131. doi: 10.1016/j.jcf.2016.07.004. Epub 2016 Jul 27.

12.

The properties of the mucus barrier, a unique gel--how can nanoparticles cross it?

Pearson JP, Chater PI, Wilcox MD.

Ther Deliv. 2016;7(4):229-44. doi: 10.4155/tde-2015-0002. Review.

PMID:
27010985
13.

Bile acid aspiration in people with cystic fibrosis before and after lung transplantation.

Brodlie M, Aseeri A, Lordan JL, Robertson AG, McKean MC, Corris PA, Griffin SM, Manning NJ, Pearson JP, Ward C.

Eur Respir J. 2015 Dec;46(6):1820-3. doi: 10.1183/13993003.00891-2015. Epub 2015 Oct 22. No abstract available.

14.

The role of seaweed bioactives in the control of digestion: implications for obesity treatments.

Chater PI, Wilcox MD, Houghton D, Pearson JP.

Food Funct. 2015 Nov;6(11):3420-7. doi: 10.1039/c5fo00293a. Epub 2015 Sep 29. Review.

PMID:
26416783
15.

Optimal design for studying mucoadhesive polymers interaction with gastric mucin using a quartz crystal microbalance with dissipation (QCM-D): Comparison of two different mucin origins.

Oh S, Wilcox M, Pearson JP, Borrós S.

Eur J Pharm Biopharm. 2015 Oct;96:477-83. doi: 10.1016/j.ejpb.2015.08.002. Epub 2015 Aug 10.

PMID:
26272125
16.

Alginate as a protease inhibitor in vitro and in a model gut system; selective inhibition of pepsin but not trypsin.

Chater PI, Wilcox MD, Brownlee IA, Pearson JP.

Carbohydr Polym. 2015 Oct 20;131:142-51. doi: 10.1016/j.carbpol.2015.05.062. Epub 2015 Jun 4.

17.

Biological activity of alginate and its effect on pancreatic lipase inhibition as a potential treatment for obesity.

Houghton D, Wilcox MD, Chater PI, Brownlee IA, Seal CJ, Pearson JP.

Food Hydrocoll. 2015 Jul;49:18-24.

18.

The effect of nanoparticle permeation on the bulk rheological properties of mucus from the small intestine.

Wilcox MD, Van Rooij LK, Chater PI, Pereira de Sousa I, Pearson JP.

Eur J Pharm Biopharm. 2015 Oct;96:484-7. doi: 10.1016/j.ejpb.2015.02.029. Epub 2015 Mar 7.

PMID:
25758122
19.

More than one disease process in chronic sinusitis based on mucin fragmentation patterns and amino Acid analysis.

Ali Mel-S, Pearson JP.

Int J Otolaryngol. 2015;2015:708475. doi: 10.1155/2015/708475. Epub 2015 Jan 26.

20.

Mucus permeating carriers: formulation and characterization of highly densely charged nanoparticles.

Pereira de Sousa I, Steiner C, Schmutzler M, Wilcox MD, Veldhuis GJ, Pearson JP, Huck CW, Salvenmoser W, Bernkop-Schnürch A.

Eur J Pharm Biopharm. 2015 Nov;97(Pt A):273-9. doi: 10.1016/j.ejpb.2014.12.024. Epub 2015 Jan 7.

PMID:
25576256
21.

Effects of repeated dosing with mechanistically distinct antinociceptive ligands in a rat model of neuropathic spinal cord injury pain.

Hama AT, Pearson JP, Sagen J.

Pharmacol Res Perspect. 2014 Apr;2(2):e00034. doi: 10.1002/prp2.34. Epub 2014 Mar 13.

22.

Attenuation of persistent pain-related behavior by fatty acid amide hydrolase (FAAH) inhibitors in a rat model of HIV sensory neuropathy.

Nasirinezhad F, Jergova S, Pearson JP, Sagen J.

Neuropharmacology. 2015 Aug;95:100-9. doi: 10.1016/j.neuropharm.2014.11.024. Epub 2014 Dec 5.

23.

Mucin gene expression in reflux laryngeal mucosa: histological and in situ hybridization observations.

Ali Mel-S, Bulmer DM, Dettmar PW, Pearson JP.

Int J Otolaryngol. 2014;2014:264075. doi: 10.1155/2014/264075. Epub 2014 Mar 24.

24.

Fatty acid amide hydrolase (FAAH) inhibitors exert pharmacological effects, but lack antinociceptive efficacy in rats with neuropathic spinal cord injury pain.

Hama AT, Germano P, Varghese MS, Cravatt BF, Milne GT, Pearson JP, Sagen J.

PLoS One. 2014 May 2;9(5):e96396. doi: 10.1371/journal.pone.0096396. eCollection 2014.

25.

Method for quantifying alginate and determining release from a food vehicle in gastrointestinal digesta.

Houghton D, Wilcox MD, Brownlee IA, Chater P, Seal CJ, Pearson JP.

Food Chem. 2014 May 15;151:352-7. doi: 10.1016/j.foodchem.2013.11.070. Epub 2013 Nov 20.

PMID:
24423543
26.

Development and evaluation of a novel mucus diffusion test system approved by self-nanoemulsifying drug delivery systems.

Friedl H, Dünnhaupt S, Hintzen F, Waldner C, Parikh S, Pearson JP, Wilcox MD, Bernkop-Schnürch A.

J Pharm Sci. 2013 Dec;102(12):4406-13. doi: 10.1002/jps.23757. Epub 2013 Oct 28.

PMID:
24258284
27.

The modulation of pancreatic lipase activity by alginates.

Wilcox MD, Brownlee IA, Richardson JC, Dettmar PW, Pearson JP.

Food Chem. 2014 Mar 1;146:479-84. doi: 10.1016/j.foodchem.2013.09.075. Epub 2013 Sep 20.

28.

Aspiration and allograft injury secondary to gastroesophageal reflux occur in the immediate post-lung transplantation period (prospective clinical trial).

Griffin SM, Robertson AG, Bredenoord AJ, Brownlee IA, Stovold R, Brodlie M, Forrest I, Dark JH, Pearson JP, Ward C.

Ann Surg. 2013 Nov;258(5):705-11; discussion 711-2. doi: 10.1097/SLA.0b013e3182a6589b.

PMID:
24121257
29.

Are the enzymatic methods currently being used to measure bronchoalveolar lavage bile salt levels fit for purpose?

Parikh S, Brownlee IA, Robertson AG, Manning NT, Johnson GE, Brodlie M, Corris PA, Ward C, Pearson JP.

J Heart Lung Transplant. 2013 Apr;32(4):418-23. doi: 10.1016/j.healun.2012.12.008. Epub 2013 Feb 4.

PMID:
23384888
30.

Bile acids in laryngopharyngeal refluxate: will they enhance or attenuate the action of pepsin?

Ali MS, Parikh S, Chater P, Pearson JP.

Laryngoscope. 2013 Feb;123(2):434-9. doi: 10.1002/lary.23619. Epub 2012 Oct 15.

PMID:
23070961
31.

Systematic review and UK-based study of PARK2 (parkin), PINK1, PARK7 (DJ-1) and LRRK2 in early-onset Parkinson's disease.

Kilarski LL, Pearson JP, Newsway V, Majounie E, Knipe MD, Misbahuddin A, Chinnery PF, Burn DJ, Clarke CE, Marion MH, Lewthwaite AJ, Nicholl DJ, Wood NW, Morrison KE, Williams-Gray CH, Evans JR, Sawcer SJ, Barker RA, Wickremaratchi MM, Ben-Shlomo Y, Williams NM, Morris HR.

Mov Disord. 2012 Oct;27(12):1522-9. doi: 10.1002/mds.25132. Epub 2012 Sep 6. Review.

PMID:
22956510
32.

Presentation of the candidate rheumatoid arthritis autoantigen aggrecan by antigen-specific B cells induces enhanced CD4(+) T helper type 1 subset differentiation.

Wilson CL, Hine DW, Pradipta A, Pearson JP, van Eden W, Robinson JH, Knight AM.

Immunology. 2012 Apr;135(4):344-54. doi: 10.1111/j.1365-2567.2011.03548.x.

33.

Anti-reflux surgery in lung transplant recipients: outcomes and effects on quality of life.

Robertson AG, Krishnan A, Ward C, Pearson JP, Small T, Corris PA, Dark JH, Karat D, Shenfine J, Griffin SM.

Eur Respir J. 2012 Mar;39(3):691-7. doi: 10.1183/09031936.00061811. Epub 2011 Jul 20.

34.

Sheep intelectin-2 co-purifies with the mucin Muc5ac from gastric mucus.

Pemberton AD, Verdon B, Inglis NF, Pearson JP.

Res Vet Sci. 2011 Dec;91(3):e53-7. doi: 10.1016/j.rvsc.2011.03.004. Epub 2011 Mar 31.

PMID:
21453947
35.

Review article: reflux and its consequences--the laryngeal, pulmonary and oesophageal manifestations. Conference held in conjunction with the 9th International Symposium on Human Pepsin (ISHP) Kingston-upon-Hull, UK, 21-23 April 2010.

Pearson JP, Parikh S, Orlando RC, Johnston N, Allen J, Tinling SP, Johnston N, Belafsky P, Arevalo LF, Sharma N, Castell DO, Fox M, Harding SM, Morice AH, Watson MG, Shields MD, Bateman N, McCallion WA, van Wijk MP, Wenzl TG, Karkos PD, Belafsky PC.

Aliment Pharmacol Ther. 2011 Apr;33 Suppl 1:1-71. doi: 10.1111/j.1365-2036.2011.04581.x. Review.

36.

The interaction of large bowel microflora with the colonic mucus barrier.

Pearson JP, Brownlee IA.

Int J Inflam. 2010 Oct 3;2010:321426. doi: 10.4061/2010/321426.

37.

Familial frontotemporal dementia with amyotrophic lateral sclerosis and a shared haplotype on chromosome 9p.

Pearson JP, Williams NM, Majounie E, Waite A, Stott J, Newsway V, Murray A, Hernandez D, Guerreiro R, Singleton AB, Neal J, Morris HR.

J Neurol. 2011 Apr;258(4):647-55. doi: 10.1007/s00415-010-5815-x. Epub 2010 Nov 12.

38.

Dissection of the genetics of Parkinson's disease identifies an additional association 5' of SNCA and multiple associated haplotypes at 17q21.

UK Parkinson's Disease Consortium; Wellcome Trust Case Control Consortium 2, Spencer CC, Plagnol V, Strange A, Gardner M, Paisan-Ruiz C, Band G, Barker RA, Bellenguez C, Bhatia K, Blackburn H, Blackwell JM, Bramon E, Brown MA, Brown MA, Burn D, Casas JP, Chinnery PF, Clarke CE, Corvin A, Craddock N, Deloukas P, Edkins S, Evans J, Freeman C, Gray E, Hardy J, Hudson G, Hunt S, Jankowski J, Langford C, Lees AJ, Markus HS, Mathew CG, McCarthy MI, Morrison KE, Palmer CN, Pearson JP, Peltonen L, Pirinen M, Plomin R, Potter S, Rautanen A, Sawcer SJ, Su Z, Trembath RC, Viswanathan AC, Williams NW, Morris HR, Donnelly P, Wood NW.

Hum Mol Genet. 2011 Jan 15;20(2):345-53. doi: 10.1093/hmg/ddq469. Epub 2010 Nov 2.

39.

Fatty acid amide hydrolase (FAAH) inhibition reduces L-3,4-dihydroxyphenylalanine-induced hyperactivity in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned non-human primate model of Parkinson's disease.

Johnston TH, Huot P, Fox SH, Wakefield JD, Sykes KA, Bartolini WP, Milne GT, Pearson JP, Brotchie JM.

J Pharmacol Exp Ther. 2011 Feb;336(2):423-30. doi: 10.1124/jpet.110.169532. Epub 2010 Oct 21.

PMID:
20966038
40.

From gastric aspiration to airway inflammation.

Brownlee IA, Aseeri A, Ward C, Pearson JP.

Monaldi Arch Chest Dis. 2010 Jun;73(2):54-63. Review.

PMID:
20957772
41.

Laryngeal mucosa: its susceptibility to damage by acid and pepsin.

Bulmer DM, Ali MS, Brownlee IA, Dettmar PW, Pearson JP.

Laryngoscope. 2010 Apr;120(4):777-82. doi: 10.1002/lary.20665.

PMID:
20213655
42.

Primary bronchial epithelial cell culture from explanted cystic fibrosis lungs.

Brodlie M, McKean MC, Johnson GE, Perry JD, Nicholson A, Verdon B, Gray MA, Dark JH, Pearson JP, Fisher AJ, Corris PA, Lordan J, Ward C.

Exp Lung Res. 2010 Mar;36(2):101-10. doi: 10.3109/01902140903165265.

PMID:
20205595
43.

Coral mucus: the properties of its constituent mucins.

Jatkar AA, Brown BE, Bythell JC, Guppy R, Morris NJ, Pearson JP.

Biomacromolecules. 2010 Apr 12;11(4):883-8. doi: 10.1021/bm9012106.

PMID:
20199018
44.

Physiological parameters governing the action of pancreatic lipase.

Brownlee IA, Forster DJ, Wilcox MD, Dettmar PW, Seal CJ, Pearson JP.

Nutr Res Rev. 2010 Jun;23(1):146-54. doi: 10.1017/S0954422410000028. Epub 2010 Mar 1. Review.

PMID:
20193096
45.

Lung transplantation, gastroesophageal reflux, and fundoplication.

Robertson AG, Ward C, Pearson JP, Corris PA, Dark JH, Griffin SM.

Ann Thorac Surg. 2010 Feb;89(2):653-60. doi: 10.1016/j.athoracsur.2009.09.001. Review.

PMID:
20103377
46.

Longitudinal changes in gastro-oesophageal reflux from 3 months to 6 months after lung transplantation.

Robertson AG, Ward C, Pearson JP, Small T, Lordan J, Fisher AJ, Bredenoord AJ, Dark J, Griffin SM, Corris PA.

Thorax. 2009 Nov;64(11):1005-7. doi: 10.1136/thx.2009.117879. No abstract available.

PMID:
19864545
47.

Targeting allograft injury and inflammation in the management of post-lung transplant bronchiolitis obliterans syndrome.

Robertson AG, Griffin SM, Murphy DM, Pearson JP, Forrest IA, Dark JH, Corris PA, Ward C.

Am J Transplant. 2009 Jun;9(6):1272-8. doi: 10.1111/j.1600-6143.2009.02648.x. Epub 2009 May 20. Review.

48.

A call for standardization of antireflux surgery in the lung transplantation population.

Robertson AG, Shenfine J, Ward C, Pearson JP, Dark JH, Corris PA, Griffin SM.

Transplantation. 2009 Apr 27;87(8):1112-4. doi: 10.1097/TP.0b013e31819f7010. Review.

PMID:
19384154
49.

Thickness and continuity of the adherent colonic mucus barrier in active and quiescent ulcerative colitis and Crohn's disease.

Strugala V, Dettmar PW, Pearson JP.

Int J Clin Pract. 2008 May;62(5):762-9. doi: 10.1111/j.1742-1241.2007.01665.x. Epub 2008 Jan 8.

PMID:
18194279
50.

Mucin gene expression in hypertrophic adenoids.

Ali MS, Wilson JA, Bennett M, Pearson JP.

Acta Otolaryngol. 2007 Oct;127(10):1080-5.

PMID:
17851936

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