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Speleothem growth intervals reflect New Zealand montane vegetation response to temperature change over the last glacial cycle.

Hellstrom J, Sniderman K, Drysdale R, Couchoud I, Hartland A, Pearson A, Bajo P.

Sci Rep. 2020 Feb 12;10(1):2492. doi: 10.1038/s41598-020-58317-8.


In silico models accurately predict in vivo response for IL-6 blockade in head and neck cancer.

Nazari F, Oklejas AE, Nör JE, Pearson AT, Jackson TL.

Cancer Res. 2020 Feb 10. pii: canres.1846.2019. doi: 10.1158/0008-5472.CAN-19-1846. [Epub ahead of print]


Discovery of a Gatekeeper Residue in the C-Terminal Tail of the Extracellular Signal-Regulated Protein Kinase 5 (ERK5).

Pearson AJ, Fullwood P, Toro Tapia G, Prise I, Smith MP, Xu Q, Jordan A, Giurisato E, Whitmarsh AJ, Francavilla C, Tournier C.

Int J Mol Sci. 2020 Jan 31;21(3). pii: E929. doi: 10.3390/ijms21030929.


Radio-frequency optomechanical characterization of a silicon nitride drum.

Pearson AN, Khosla KE, Mergenthaler M, Briggs GAD, Laird EA, Ares N.

Sci Rep. 2020 Feb 3;10(1):1654. doi: 10.1038/s41598-020-58554-x.


A conserved intratumoral regulatory T cell signature identifies 4-1BB as a pan-cancer target.

Freeman ZT, Nirschl TR, Hovelson DH, Johnston RJ, Engelhardt JJ, Selby MJ, Kochel CM, Lan RY, Zhai J, Ghasemzadeh A, Gupta A, Skaist AM, Wheelan SJ, Jiang H, Pearson AT, Snyder LA, Korman AJ, Tomlins SA, Yegnasubramanian S, Drake CG.

J Clin Invest. 2020 Feb 4. pii: 128672. doi: 10.1172/JCI128672. [Epub ahead of print]


Investigation of the Role of Dinutuximab Beta-Based Immunotherapy in the SIOPEN High-Risk Neuroblastoma 1 Trial (HR-NBL1).

Ladenstein R, Pötschger U, Valteau-Couanet D, Luksch R, Castel V, Ash S, Laureys G, Brock P, Michon JM, Owens C, Trahair T, Chi Fung Chan G, Ruud E, Schroeder H, Beck-Popovic M, Schreier G, Loibner H, Ambros P, Holmes K, Castellani MR, Gaze MN, Garaventa A, Pearson ADJ, Lode HN.

Cancers (Basel). 2020 Jan 28;12(2). pii: E309. doi: 10.3390/cancers12020309.


The iron chelator Deferasirox causes severe mitochondrial swelling without depolarization due to a specific effect on inner membrane permeability.

Gottwald EM, Schuh CD, Drücker P, Haenni D, Pearson A, Ghazi S, Bugarski M, Polesel M, Duss M, Landau EM, Kaech A, Ziegler U, Lundby AKM, Lundby C, Dittrich PS, Hall AM.

Sci Rep. 2020 Jan 31;10(1):1577. doi: 10.1038/s41598-020-58386-9.


ACCELERATE and European Medicines Agency Paediatric Strategy Forum for medicinal product development of checkpoint inhibitors for use in combination therapy in paediatric patients.

Pearson ADJ, Rossig C, Lesa G, Diede SJ, Weiner S, Anderson J, Gray J, Geoerger B, Minard-Colin V, Marshall LV, Smith M, Sondel P, Bajars M, Baldazzi C, Barry E, Blackman S, Blanc P, Capdeville R, Caron H, Cole PD, Jiménez JC, Demolis P, Donoghue M, Elgadi M, Gajewski T, Galluzzo S, Ilaria R Jr, Jenkner A, Karres D, Kieran M, Ligas F, Lowy I, Meyers M, Oprea C, Peddareddigari VGR, Sterba J, Stockman PK, Suenaert P, Tabori U, van Tilburg C, Yancey T, Weigel B, Norga K, Reaman G, Vassal G.

Eur J Cancer. 2020 Mar;127:52-66. doi: 10.1016/j.ejca.2019.12.029. Epub 2020 Jan 24.


Machine learning can identify newly diagnosed patients with CLL at high risk of infection.

Agius R, Brieghel C, Andersen MA, Pearson AT, Ledergerber B, Cozzi-Lepri A, Louzoun Y, Andersen CL, Bergstedt J, von Stemann JH, Jørgensen M, Tang ME, Fontes M, Bahlo J, Herling CD, Hallek M, Lundgren J, MacPherson CR, Larsen J, Niemann CU.

Nat Commun. 2020 Jan 17;11(1):363. doi: 10.1038/s41467-019-14225-8.


Pancreatic resection in patients with synchronous extra-pancreatic malignancy: outcomes and complications.

Mehta S, Tan GI, Nahm CB, Chua TC, Pearson A, Gill AJ, Samra JS, Mittal A.

ANZ J Surg. 2020 Jan 13. doi: 10.1111/ans.15651. [Epub ahead of print]


Demographics of a Large International Population of Patients Affected by Leber's Hereditary Optic Neuropathy.

Poincenot L, Pearson AL, Karanjia R.

Ophthalmology. 2019 Nov 25. pii: S0161-6420(19)32295-X. doi: 10.1016/j.ophtha.2019.11.014. [Epub ahead of print]


Motherhood and Anesthesiology: A Survey of the American Society of Anesthesiologists.

Kraus MB, Dexter F, Patel PV, Dodd SE, Thomson HM, Girardo ME, Hertzberg LB, Pearson ACS.

Anesth Analg. 2020 Jan 8. doi: 10.1213/ANE.0000000000004615. [Epub ahead of print]


Progress in treating inherited retinal diseases: Early subretinal gene therapy clinical trials and candidates for future initiatives.

Garafalo AV, Cideciyan AV, Héon E, Sheplock R, Pearson A, WeiYang Yu C, Sumaroka A, Aguirre GD, Jacobson SG.

Prog Retin Eye Res. 2019 Dec 30:100827. doi: 10.1016/j.preteyeres.2019.100827. [Epub ahead of print] Review.


Structural Kinetics of MsbA Investigated by Stopped-Flow Time-Resolved Small-Angle X-Ray Scattering.

Josts I, Gao Y, Monteiro DCF, Niebling S, Nitsche J, Veith K, Gräwert TW, Blanchet CE, Schroer MA, Huse N, Pearson AR, Svergun DI, Tidow H.

Structure. 2019 Dec 17. pii: S0969-2126(19)30439-3. doi: 10.1016/j.str.2019.12.001. [Epub ahead of print]


Risk assessment of antimony, barium, beryllium, boron, bromine, lithium, nickel, strontium, thallium and uranium concentrations in the New Zealand diet.

Pearson AJ, Ashmore E.

Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2019 Dec 27:1-14. doi: 10.1080/19440049.2019.1704445. [Epub ahead of print]


Release of Carbohydrate-Metal Adducts from Electrospray Droplets: Insight into Glycan Ionization by Electrospray.

Calixte EI, Liyanage OT, Kim HJ, Ziperman ED, Pearson AJ, Gallagher ES.

J Phys Chem B. 2020 Jan 23;124(3):479-486. doi: 10.1021/acs.jpcb.9b10369. Epub 2020 Jan 9.


Cash water expenditures are associated with household water insecurity, food insecurity, and perceived stress in study sites across 20 low- and middle-income countries.

Stoler J, Pearson AL, Staddon C, Wutich A, Mack E, Brewis A, Rosinger AY; Household Water Insecurity Experiences (HWISE) Research Coordination Network.

Sci Total Environ. 2019 Dec 2:135881. doi: 10.1016/j.scitotenv.2019.135881. [Epub ahead of print]


Comparison of a manometric tear duct irrigation test with dacryoscintigraphy in the investigation of epiphora.

Sipkova Z, Obi EE, Olurin O, Mota PM, Vonica O, Pearson AR.

Orbit. 2019 Dec 20:1-5. doi: 10.1080/01676830.2019.1704033. [Epub ahead of print]


Identification, Characterization, and Application of a Highly Sensitive Lactam Biosensor from Pseudomonas putida.

Thompson MG, Pearson AN, Barajas JF, Cruz-Morales P, Sedaghatian N, Costello Z, Garber ME, Incha MR, Valencia LE, Baidoo EEK, Martin HG, Mukhopadhyay A, Keasling JD.

ACS Synth Biol. 2020 Jan 17;9(1):53-62. doi: 10.1021/acssynbio.9b00292. Epub 2020 Jan 2.


Somatic mitochondrial mutation discovery using ultra-deep sequencing of the mitochondrial genome reveals spatial tumor heterogeneity in head and neck squamous cell carcinoma.

Schubert AD, Channah Broner E, Agrawal N, London N, Pearson A, Gupta A, Wali N, Seiwert TY, Wheelan S, Lingen M, Macleod K, Allen H, Chatterjee A, Vassiliki S, Gaykalova D, Hoque MO, Sidransky D, Suresh K, Izumchenko E.

Cancer Lett. 2020 Feb 28;471:49-60. doi: 10.1016/j.canlet.2019.12.006. Epub 2019 Dec 10.


Reducing Radiation and Lowering Costs With a Standardized Care Pathway for Nonoperative Thoracolumbar Fractures.

Hanson G, Lyons KW, Fournier DA, Lollis SS, Martin ED, Rhynhart KK, Handel WJ, McGuire KJ, Abdu WA, Pearson AM.

Global Spine J. 2019 Dec;9(8):813-819. doi: 10.1177/2192568219831687. Epub 2019 Mar 5.


Point of View: Surgeons Looking for a Crystal Ball.

Pearson AM.

Spine (Phila Pa 1976). 2019 Nov 19. doi: 10.1097/BRS.0000000000003342. [Epub ahead of print] No abstract available.


Fundamentally different global marine nitrogen cycling in response to severe ocean deoxygenation.

Naafs BDA, Monteiro FM, Pearson A, Higgins MB, Pancost RD, Ridgwell A.

Proc Natl Acad Sci U S A. 2019 Dec 10;116(50):24979-24984. doi: 10.1073/pnas.1905553116. Epub 2019 Nov 25.


Illuminating microbial species-specific effects on organic matter remineralization in marine sediments.

Mahmoudi N, Enke TN, Beaupré SR, Teske AP, Cordero OX, Pearson A.

Environ Microbiol. 2019 Nov 24. doi: 10.1111/1462-2920.14871. [Epub ahead of print]


Omics-driven identification and elimination of valerolactam catabolism in Pseudomonas putida KT2440 for increased product titer.

Thompson MG, Valencia LE, Blake-Hedges JM, Cruz-Morales P, Velasquez AE, Pearson AN, Sermeno LN, Sharpless WA, Benites VT, Chen Y, Baidoo EEK, Petzold CJ, Deutschbauer AM, Keasling JD.

Metab Eng Commun. 2019 Aug 10;9:e00098. doi: 10.1016/j.mec.2019.e00098. eCollection 2019 Dec.


Annual Number of Spinal Cord Stimulation Procedures Performed in the State of Florida During 2018: Implications for Establishing Neuromodulation Centers of Excellence.

Epstein RH, Dexter F, Podgorski EM 3rd, Pearson ACS.

Neuromodulation. 2019 Nov 11. doi: 10.1111/ner.13066. [Epub ahead of print]


The population randomization observation process (PROP) assessment method: using systematic habitation observations of street segments to establish household-level epidemiologic population samples.

Smart M, Sadler R, Harris A, Buchalski Z, Pearson A, Debra Furr-Holden C.

Int J Health Geogr. 2019 Nov 8;18(1):24. doi: 10.1186/s12942-019-0190-z.


Energy flux controls tetraether lipid cyclization in Sulfolobus acidocaldarius.

Zhou A, Weber Y, Chiu BK, Elling FJ, Cobban AB, Pearson A, Leavitt WD.

Environ Microbiol. 2020 Jan;22(1):343-353. doi: 10.1111/1462-2920.14851. Epub 2019 Nov 25.


Child Antisocial Behavior Is more Environmental in Origin in Disadvantaged Neighborhoods: Evidence Across Residents' Perceptions and Geographic Scales in Two Samples.

Burt SA, Pearson AL, Carroll S, Klump KL, Neiderhiser JM.

J Abnorm Child Psychol. 2020 Feb;48(2):265-276. doi: 10.1007/s10802-019-00587-6.


Resolving a piece of the archaeal lipid puzzle.

Pearson A.

Proc Natl Acad Sci U S A. 2019 Nov 5;116(45):22423-22425. doi: 10.1073/pnas.1916583116. Epub 2019 Oct 18. No abstract available.


Spatial equity and realised access to healthcare - a geospatial analysis of general practitioner enrolments in Waikato, New Zealand.

Whitehead J, Pearson AL, Lawrenson R, Atatoa-Carr P.

Rural Remote Health. 2019 Oct;19(4):5349. doi: 10.22605/RRH5349. Epub 2019 Oct 18.


Lucitanib for the Treatment of HR+/HER2- Metastatic Breast Cancer: Results from the Multicohort Phase II FINESSE Study.

Hui R, Pearson A, Cortes J, Campbell C, Poirot C, Azim HA Jr, Fumagalli D, Lambertini M, Daly F, Arahmani A, Perez-Garcia J, Aftimos P, Bedard PL, Xuereb L, Scheepers ED, Vicente M, Goulioti T, Loibl S, Loi S, Pierrat MJ, Turner NC, Andre F, Curigliano G.

Clin Cancer Res. 2020 Jan 15;26(2):354-363. doi: 10.1158/1078-0432.CCR-19-1164. Epub 2019 Oct 16.


Inactivating NF1 Mutations Are Enriched in Advanced Breast Cancer and Contribute to Endocrine Therapy Resistance.

Pearson A, Proszek P, Pascual J, Fribbens C, Shamsher MK, Kingston B, O'Leary B, Herrera-Abreu MT, Cutts RJ, Garcia-Murillas I, Bye H, Walker BA, Gonzalez De Castro D, Yuan L, Jamal S, Hubank M, Lopez-Knowles E, Schuster EF, Dowsett M, Osin P, Nerurkar A, Parton M, Okines AFC, Johnston SRD, Ring A, Turner NC.

Clin Cancer Res. 2020 Feb 1;26(3):608-622. doi: 10.1158/1078-0432.CCR-18-4044. Epub 2019 Oct 7.


Archaeal lipid biomarker constraints on the Paleocene-Eocene carbon isotope excursion.

Elling FJ, Gottschalk J, Doeana KD, Kusch S, Hurley SJ, Pearson A.

Nat Commun. 2019 Oct 4;10(1):4519. doi: 10.1038/s41467-019-12553-3.


Assessing the assessment strategies: A medical student perspective.

Rowley W, Greene C, Pearson A, Uwhubetine O, Chung B.

Med Teach. 2019 Oct 3:1. doi: 10.1080/0142159X.2019.1671968. [Epub ahead of print] No abstract available.


Spatial variability in Polonium-210 and Lead-210 activity concentration in New Zealand shellfish and dose assessment.

Guy S, Gaw S, Pearson AJ, Golovko O, Lechermann M.

J Environ Radioact. 2020 Jan;211:106043. doi: 10.1016/j.jenvrad.2019.106043. Epub 2019 Sep 23.


A tailored molecular profiling programme for children with cancer to identify clinically actionable genetic alterations.

George SL, Izquierdo E, Campbell J, Koutroumanidou E, Proszek P, Jamal S, Hughes D, Yuan L, Marshall LV, Carceller F, Chisholm JC, Vaidya S, Mandeville H, Angelini P, Wasti A, Bexelius T, Thway K, Gatz SA, Clarke M, Al-Lazikani B, Barone G, Anderson J, Tweddle DA, Gonzalez D, Walker BA, Barton J, Depani S, Eze J, Ahmed SW, Moreno L, Pearson A, Shipley J, Jones C, Hargrave D, Jacques TS, Hubank M, Chesler L.

Eur J Cancer. 2019 Nov;121:224-235. doi: 10.1016/j.ejca.2019.07.027. Epub 2019 Sep 19.


A 5-Year Review of Hospital Costs and Reimbursement in the Surgical Management of Degenerative Spondylolisthesis.

Lyons KW, Klare CM, Kunkel ST, Lemire JR, Bao M, McGuire KJ, Pearson AM, Abdu WA.

Int J Spine Surg. 2019 Aug 31;13(4):378-385. doi: 10.14444/6052. eCollection 2019 Aug.


Liquid application method for time-resolved analyses by serial synchrotron crystallography.

Mehrabi P, Schulz EC, Agthe M, Horrell S, Bourenkov G, von Stetten D, Leimkohl JP, Schikora H, Schneider TR, Pearson AR, Tellkamp F, Miller RJD.

Nat Methods. 2019 Oct;16(10):979-982. doi: 10.1038/s41592-019-0553-1. Epub 2019 Sep 16.


Robust Characterization of Two Distinct Glutarate Sensing Transcription Factors of Pseudomonas putida l-Lysine Metabolism.

Thompson MG, Costello Z, Hummel NFC, Cruz-Morales P, Blake-Hedges JM, Krishna RN, Skyrud W, Pearson AN, Incha MR, Shih PM, Garcia-Martin H, Keasling JD.

ACS Synth Biol. 2019 Oct 18;8(10):2385-2396. doi: 10.1021/acssynbio.9b00255. Epub 2019 Sep 25.


A Phase I and Pharmacokinetic Study of Oral Dabrafenib in Children and Adolescent Patients with Recurrent or Refractory BRAF V600 Mutation-Positive Solid Tumors.

Kieran MW, Geoerger B, Dunkel IJ, Broniscer A, Hargrave D, Hingorani P, Aerts I, Bertozzi AI, Cohen KJ, Hummel TR, Shen V, Bouffet E, Pratilas CA, Pearson ADJ, Tseng L, Nebot N, Green S, Russo MW, Whitlock JA.

Clin Cancer Res. 2019 Dec 15;25(24):7294-7302. doi: 10.1158/1078-0432.CCR-17-3572. Epub 2019 Sep 10.


Formulation of Broccoli Sprout Powder in Gastro-Resistant Capsules Protects against the Acidic pH of the Stomach In Vitro but Does Not Increase Isothiocyanate Bioavailability In Vivo.

Zawari M, Poller B, Walker G, Pearson A, Hampton M, Carr AC.

Antioxidants (Basel). 2019 Sep 1;8(9). pii: E359. doi: 10.3390/antiox8090359.


Effects of freshwater blue spaces may be beneficial for mental health: A first, ecological study in the North American Great Lakes region.

Pearson AL, Shortridge A, Delamater PL, Horton TH, Dahlin K, Rzotkiewicz A, Marchiori MJ.

PLoS One. 2019 Aug 30;14(8):e0221977. doi: 10.1371/journal.pone.0221977. eCollection 2019.


Characteristics of physicians who prescribe opioids for chronic pain: a meta-narrative systematic review.

Hooten WM, Dvorkin J, Warner NS, Pearson AC, Murad MH, Warner DO.

J Pain Res. 2019 Jul 24;12:2261-2289. doi: 10.2147/JPR.S202376. eCollection 2019.


Inorganic arsenic in rice and rice products in New Zealand and Australia.

Ashmore E, Molyneux S, Watson S, Miles G, Pearson A.

Food Addit Contam Part B Surveill. 2019 Dec;12(4):275-279. doi: 10.1080/19393210.2019.1651403. Epub 2019 Aug 13.


Space-time analysis of unhealthy food advertising: New Zealand children's exposure and health policy options.

Liu W, Barr M, Pearson AL, Chambers T, Pfeiffer KA, Smith M, Signal L.

Health Promot Int. 2019 Aug 13. pii: daz083. doi: 10.1093/heapro/daz083. [Epub ahead of print]


Scotland's efforts to improve the lives of trainee doctors.

Pearson AC, Colvin JR.

BMJ. 2019 Aug 9;366:l5060. doi: 10.1136/bmj.l5060. No abstract available.


Vaginal CO2 laser for the treatment of vulvovaginal atrophy in women with breast cancer: LAAVA pilot study.

Pearson A, Booker A, Tio M, Marx G.

Breast Cancer Res Treat. 2019 Nov;178(1):135-140. doi: 10.1007/s10549-019-05384-9. Epub 2019 Aug 3.


A permethrin metabolite is associated with adaptive immune responses in Gulf War Illness.

Joshi U, Pearson A, Evans JE, Langlois H, Saltiel N, Ojo J, Klimas N, Sullivan K, Keegan AP, Oberlin S, Darcey T, Cseresznye A, Raya B, Paris D, Hammock B, Vasylieva N, Hongsibsong S, Stern LJ, Crawford F, Mullan M, Abdullah L.

Brain Behav Immun. 2019 Oct;81:545-559. doi: 10.1016/j.bbi.2019.07.015. Epub 2019 Jul 17.

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