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Positive Response to Galcanezumab Following Treatment Failure to OnabotulinumtoxinA in Patients With Migraine: Post hoc Analyses of 3 Randomized Double-Blind Studies.

Ailani J, Pearlman E, Zhang Q, Nagy AJ, Schuh K, Aurora SK.

Eur J Neurol. 2019 Oct 8. doi: 10.1111/ene.14102. [Epub ahead of print]


Delineating the role of MITF isoforms in pigmentation and tissue homeostasis.

Flesher JL, Paterson-Coleman EK, Vasudeva P, Ruiz-Vega R, Marshall M, Pearlman E, MacGregor GR, Neumann J, Ganesan AK.

Pigment Cell Melanoma Res. 2019 Sep 28. doi: 10.1111/pcmr.12828. [Epub ahead of print]


Interim results of a prospective, randomized, open-label, Phase 3 study of the long-term safety and efficacy of lasmiditan for acute treatment of migraine (the GLADIATOR study).

Brandes JL, Klise S, Krege JH, Case M, Khanna R, Vasudeva R, Raskin J, Pearlman EM, Kudrow D.

Cephalalgia. 2019 Oct;39(11):1343-1357. doi: 10.1177/0333102419864132. Epub 2019 Aug 21.


Linked Toll-Like Receptor Triagonists Stimulate Distinct, Combination-Dependent Innate Immune Responses.

Albin TJ, Tom JK, Manna S, Gilkes AP, Stetkevich SA, Katz BB, Supnet M, Felgner J, Jain A, Nakajima R, Jasinskas A, Zlotnik A, Pearlman E, Davies DH, Felgner PL, Burkhardt AM, Esser-Kahn AP.

ACS Cent Sci. 2019 Jul 24;5(7):1137-1145. doi: 10.1021/acscentsci.8b00823. Epub 2019 Jun 27.


NLRP3, NLRP12, and IFI16 Inflammasomes Induction and Caspase-1 Activation Triggered by Virulent HSV-1 Strains Are Associated With Severe Corneal Inflammatory Herpetic Disease.

Coulon PG, Dhanushkodi N, Prakash S, Srivastava R, Roy S, Alomari NI, Nguyen AM, Warsi WR, Ye C, Carlos-Cruz EA, Mai UT, Cruel AC, Ekmekciyan KM, Pearlman E, BenMohamed L.

Front Immunol. 2019 Jul 16;10:1631. doi: 10.3389/fimmu.2019.01631. eCollection 2019.


EphA2 Is a Neutrophil Receptor for Candida albicans that Stimulates Antifungal Activity during Oropharyngeal Infection.

Swidergall M, Solis NV, Wang Z, Phan QT, Marshall ME, Lionakis MS, Pearlman E, Filler SG.

Cell Rep. 2019 Jul 9;28(2):423-433.e5. doi: 10.1016/j.celrep.2019.06.020.


Breaching bacterial biofilm with neutrophil α-mannosidase.

Abbondante S, Pearlman E.

J Leukoc Biol. 2019 Jun;105(6):1085. doi: 10.1002/JLB.4CE0419-139R. Epub 2019 May 22. No abstract available.


Efficacy of galcanezumab in patients with chronic migraine and a history of preventive treatment failure.

Ruff DD, Ford JH, Tockhorn-Heidenreich A, Sexson M, Govindan S, Pearlman EM, Wang SJ, Khan A, Aurora SK.

Cephalalgia. 2019 Jul;39(8):931-944. doi: 10.1177/0333102419847957. Epub 2019 May 19.


Response to Misused and Misleading: 100% Response Rate to Galcanezumab in Patients With Episodic Migraine.

Rosen N, Pearlman E, Ruff D, Day K, Nagy AJ.

Headache. 2019 Apr;59(4):627-628. doi: 10.1111/head.13514. No abstract available.


Aspergillus fumigatus corneal infection is regulated by chitin synthases and by neutrophil-derived acidic mammalian chitinase.

de Jesus Carrion S, Abbondante S, Clark HL, Marshall ME, Mouyna I, Beauvais A, Sun Y, Taylor PR, Leal SM Jr, Armstrong B, Carrera W, Latge JP, Pearlman E.

Eur J Immunol. 2019 Jun;49(6):918-927. doi: 10.1002/eji.201847851. Epub 2019 May 14.


Sustained release of decorin to the surface of the eye enables scarless corneal regeneration.

Hill LJ, Moakes RJA, Vareechon C, Butt G, Ng A, Brock K, Chouhan G, Vincent RC, Abbondante S, Williams RL, Barnes NM, Pearlman E, Wallace GR, Rauz S, Logan A, Grover LM.

NPJ Regen Med. 2018 Dec 21;3:23. doi: 10.1038/s41536-018-0061-4. eCollection 2018.


Basic Considerations for the Use of Monoclonal Antibodies in Migraine.

Levin M, Silberstein SD, Gilbert R, Lucas S, Munsie L, Garrelts A, Kennedy K, Everman N, Pearlman E.

Headache. 2018 Nov;58(10):1689-1696. doi: 10.1111/head.13439. Epub 2018 Nov 13.


Neutrophil Caspase-11 Is Required for Cleavage of Caspase-1 and Secretion of IL-1β in Aspergillus fumigatus Infection.

Sun Y, Abbondante S, Karmakar M, de Jesus Carrion S, Che C, Hise AG, Pearlman E.

J Immunol. 2018 Nov 1;201(9):2767-2775. doi: 10.4049/jimmunol.1701195. Epub 2018 Sep 28.


Protein Deiminase 4 and CR3 Regulate Aspergillus fumigatus and β-Glucan-Induced Neutrophil Extracellular Trap Formation, but Hyphal Killing Is Dependent Only on CR3.

Clark HL, Abbondante S, Minns MS, Greenberg EN, Sun Y, Pearlman E.

Front Immunol. 2018 May 29;9:1182. doi: 10.3389/fimmu.2018.01182. eCollection 2018.


Atovaquone Impairs Growth of Aspergillus and Fusarium Keratitis Isolates by Modulating Mitochondrial Function and Zinc Homeostasis.

Clark HL, Minns MS, Sun Y, de Jesus T, Ghannoum MG, Pearlman E.

Invest Ophthalmol Vis Sci. 2018 Mar 1;59(3):1589-1598. doi: 10.1167/iovs.17-22585.


Neutrophils Cause an Intravascular Traffic Jam.

Minns MS, Pearlman E.

Cell Host Microbe. 2018 Jan 10;23(1):6-8. doi: 10.1016/j.chom.2017.12.011.


GADD34 Function in Protein Trafficking Promotes Adaptation to Hyperosmotic Stress in Human Corneal Cells.

Krokowski D, Guan BJ, Wu J, Zheng Y, Pattabiraman PP, Jobava R, Gao XH, Di XJ, Snider MD, Mu TW, Liu S, Storrie B, Pearlman E, Blumental-Perry A, Hatzoglou M.

Cell Rep. 2017 Dec 5;21(10):2895-2910. doi: 10.1016/j.celrep.2017.11.027.


Pseudomonas aeruginosa Effector ExoS Inhibits ROS Production in Human Neutrophils.

Vareechon C, Zmina SE, Karmakar M, Pearlman E, Rietsch A.

Cell Host Microbe. 2017 May 10;21(5):611-618.e5. doi: 10.1016/j.chom.2017.04.001.


The impact of lens care solutions on corneal epithelial changes during daily silicone hydrogel contact lens wear as measured by in vivo confocal microscopy.

Zhang X, Marchetti C, Lee J, Sun Y, Debanne S, Jiang Y, Kern J, Harrod M, Benetz BA, Pearlman E, Szczotka-Flynn L.

Cont Lens Anterior Eye. 2017 Feb;40(1):33-41. doi: 10.1016/j.clae.2016.11.006. Epub 2016 Nov 19.


Polymeric Nanofiber/Antifungal Formulations Using a Novel Co-extrusion Approach.

Mofidfar M, Wang J, Long L, Hager CL, Vareechon C, Pearlman E, Baer E, Ghannoum M, Wnek GE.

AAPS PharmSciTech. 2017 Aug;18(6):1917-1924. doi: 10.1208/s12249-016-0664-2. Epub 2016 Nov 17.


Interleukin-17 Pathophysiology and Therapeutic Intervention in Cystic Fibrosis Lung Infection and Inflammation.

Hsu D, Taylor P, Fletcher D, van Heeckeren R, Eastman J, van Heeckeren A, Davis P, Chmiel JF, Pearlman E, Bonfield TL.

Infect Immun. 2016 Aug 19;84(9):2410-21. doi: 10.1128/IAI.00284-16. Print 2016 Sep.


Neutrophils from F508del cystic fibrosis patients produce IL-17A and express IL-23 - dependent IL-17RC.

Taylor PR, Bonfield TL, Chmiel JF, Pearlman E.

Clin Immunol. 2016 Sep;170:53-60. doi: 10.1016/j.clim.2016.03.016. Epub 2016 May 4.


JAK/STAT regulation of Aspergillus fumigatus corneal infections and IL-6/23-stimulated neutrophil, IL-17, elastase, and MMP9 activity.

Taylor PR, Roy S, Meszaros EC, Sun Y, Howell SJ, Malemud CJ, Pearlman E.

J Leukoc Biol. 2016 Jul;100(1):213-22. doi: 10.1189/jlb.4A1015-483R. Epub 2016 Mar 31.


Neutrophil P2X7 receptors mediate NLRP3 inflammasome-dependent IL-1β secretion in response to ATP.

Karmakar M, Katsnelson MA, Dubyak GR, Pearlman E.

Nat Commun. 2016 Feb 15;7:10555. doi: 10.1038/ncomms10555.


Histidine biosynthesis plays a crucial role in metal homeostasis and virulence of Aspergillus fumigatus.

Dietl AM, Amich J, Leal S, Beckmann N, Binder U, Beilhack A, Pearlman E, Haas H.

Virulence. 2016 May 18;7(4):465-76. doi: 10.1080/21505594.2016.1146848. Epub 2016 Feb 6.


Immune Interactions with Pathogenic and Commensal Fungi: A Two-Way Street.

Underhill DM, Pearlman E.

Immunity. 2015 Nov 17;43(5):845-58. doi: 10.1016/j.immuni.2015.10.023. Review.


Zinc and Manganese Chelation by Neutrophil S100A8/A9 (Calprotectin) Limits Extracellular Aspergillus fumigatus Hyphal Growth and Corneal Infection.

Clark HL, Jhingran A, Sun Y, Vareechon C, de Jesus Carrion S, Skaar EP, Chazin WJ, Calera JA, Hohl TM, Pearlman E.

J Immunol. 2016 Jan 1;196(1):336-44. doi: 10.4049/jimmunol.1502037. Epub 2015 Nov 18.


IL-17A production by neutrophils.

Taylor PR, Pearlman E.

Immunol Lett. 2016 Jan;169:104-5. doi: 10.1016/j.imlet.2015.11.006. Epub 2015 Nov 12. No abstract available.


Tyrosine phosphatase SHP-2 mediates C-type lectin receptor-induced activation of the kinase Syk and anti-fungal TH17 responses.

Deng Z, Ma S, Zhou H, Zang A, Fang Y, Li T, Shi H, Liu M, Du M, Taylor PR, Zhu HH, Chen J, Meng G, Li F, Chen C, Zhang Y, Jia XM, Lin X, Zhang X, Pearlman E, Li X, Feng GS, Xiao H.

Nat Immunol. 2015 Jun;16(6):642-52. doi: 10.1038/ni.3155. Epub 2015 Apr 27.


Inhibition of Corneal Inflammation by the Resolvin E1.

Lee JE, Sun Y, Gjorstrup P, Pearlman E.

Invest Ophthalmol Vis Sci. 2015 Apr;56(4):2728-36. doi: 10.1167/iovs.14-15982. Erratum in: Invest Ophthalmol Vis Sci. 2015 Sep;56(10):5739.


Neutrophil IL-1β processing induced by pneumolysin is mediated by the NLRP3/ASC inflammasome and caspase-1 activation and is dependent on K+ efflux.

Karmakar M, Katsnelson M, Malak HA, Greene NG, Howell SJ, Hise AG, Camilli A, Kadioglu A, Dubyak GR, Pearlman E.

J Immunol. 2015 Feb 15;194(4):1763-75. doi: 10.4049/jimmunol.1401624. Epub 2015 Jan 21.


Randomized controlled trial of the CGRP receptor antagonist telcagepant for migraine prevention.

Ho TW, Connor KM, Zhang Y, Pearlman E, Koppenhaver J, Fan X, Lines C, Edvinsson L, Goadsby PJ, Michelson D.

Neurology. 2014 Sep 9;83(11):958-66. doi: 10.1212/WNL.0000000000000771. Epub 2014 Aug 8.


Interleukin 17 expression in peripheral blood neutrophils from fungal keratitis patients and healthy cohorts in southern India.

Karthikeyan RS, Vareechon C, Prajna NV, Dharmalingam K, Pearlman E, Lalitha P.

J Infect Dis. 2015 Jan 1;211(1):130-4. doi: 10.1093/infdis/jiu381. Epub 2014 Jul 7.


Animal models to investigate fungal biofilm formation.

Chandra J, Pearlman E, Ghannoum MA.

Methods Mol Biol. 2014;1147:141-57. doi: 10.1007/978-1-4939-0467-9_10.


CCL3 production by microglial cells modulates disease severity in murine models of retinal degeneration.

Kohno H, Maeda T, Perusek L, Pearlman E, Maeda A.

J Immunol. 2014 Apr 15;192(8):3816-27. doi: 10.4049/jimmunol.1301738. Epub 2014 Mar 17.


The protein phosphatase PhzA of A. fumigatus is involved in oxidative stress tolerance and fungal virulence.

Muszkieta L, Carrion Sde J, Robinet P, Beau R, Elbim C, Pearlman E, Latgé JP.

Fungal Genet Biol. 2014 May;66:79-85. doi: 10.1016/j.fgb.2014.02.009. Epub 2014 Mar 12.


Aspergillus and Fusarium corneal infections are regulated by Th17 cells and IL-17-producing neutrophils.

Taylor PR, Leal SM Jr, Sun Y, Pearlman E.

J Immunol. 2014 Apr 1;192(7):3319-27. doi: 10.4049/jimmunol.1302235. Epub 2014 Mar 3.


Diversity of virulence phenotypes among type III secretion negative Pseudomonas aeruginosa clinical isolates.

Toska J, Sun Y, Carbonell DA, Foster AN, Jacobs MR, Pearlman E, Rietsch A.

PLoS One. 2014 Jan 23;9(1):e86829. doi: 10.1371/journal.pone.0086829. eCollection 2014.


Activation of neutrophils by autocrine IL-17A-IL-17RC interactions during fungal infection is regulated by IL-6, IL-23, RORγt and dectin-2.

Taylor PR, Roy S, Leal SM Jr, Sun Y, Howell SJ, Cobb BA, Li X, Pearlman E.

Nat Immunol. 2014 Feb;15(2):143-51. doi: 10.1038/ni.2797. Epub 2013 Dec 22. Erratum in: Nat Immunol. 2015 Feb;16(2):214.


Mgat2 ablation in the myeloid lineage leads to defective glycoantigen T cell responses.

Ryan SO, Leal SM Jr, Abbott DW, Pearlman E, Cobb BA.

Glycobiology. 2014 Mar;24(3):262-71. doi: 10.1093/glycob/cwt107. Epub 2013 Dec 4.


The RodA hydrophobin on Aspergillus fumigatus spores masks dectin-1- and dectin-2-dependent responses and enhances fungal survival in vivo.

Carrion Sde J, Leal SM Jr, Ghannoum MA, Aimanianda V, Latgé JP, Pearlman E.

J Immunol. 2013 Sep 1;191(5):2581-8. doi: 10.4049/jimmunol.1300748. Epub 2013 Aug 7.


MyD88-dependent pathways in leukocytes affect the retina in diabetes.

Tang J, Allen Lee C, Du Y, Sun Y, Pearlman E, Sheibani N, Kern TS.

PLoS One. 2013 Jul 11;8(7):e68871. doi: 10.1371/journal.pone.0068871. Print 2013.


Targeting iron acquisition blocks infection with the fungal pathogens Aspergillus fumigatus and Fusarium oxysporum.

Leal SM Jr, Roy S, Vareechon C, Carrion Sd, Clark H, Lopez-Berges MS, Di Pietro A, Schrettl M, Beckmann N, Redl B, Haas H, Pearlman E.

PLoS Pathog. 2013;9(7):e1003436. doi: 10.1371/journal.ppat.1003436. Epub 2013 Jul 11. Erratum in: PLoS Pathog. 2013 Jul;9(7). doi:10.1371/annotation/4f388450-90fe-4c65-9b9b-71a2b7935ac0. diPietro, Antonio [corrected to Di Pietro, Antonio].


Host response and bacterial virulence factor expression in Pseudomonas aeruginosa and Streptococcus pneumoniae corneal ulcers.

Karthikeyan RS, Priya JL, Leal SM Jr, Toska J, Rietsch A, Prajna V, Pearlman E, Lalitha P.

PLoS One. 2013 Jun 4;8(6):e64867. doi: 10.1371/journal.pone.0064867. Print 2013.


Photoreceptor proteins initiate microglial activation via Toll-like receptor 4 in retinal degeneration mediated by all-trans-retinal.

Kohno H, Chen Y, Kevany BM, Pearlman E, Miyagi M, Maeda T, Palczewski K, Maeda A.

J Biol Chem. 2013 May 24;288(21):15326-41. doi: 10.1074/jbc.M112.448712. Epub 2013 Apr 9.


Host defense at the ocular surface.

Pearlman E, Sun Y, Roy S, Karmakar M, Hise AG, Szczotka-Flynn L, Ghannoum M, Chinnery HR, McMenamin PG, Rietsch A.

Int Rev Immunol. 2013 Feb;32(1):4-18. doi: 10.3109/08830185.2012.749400. Review.


Monosodium Urate and Tumor Necrosis Factor-α Increase Apoptosis in Human Chondrocyte Cultures.

Malemud CJ, Sun Y, Pearlman E, Ginley NM, Awadallah A, Wisler BA, Dennis JE.

Rheumatology (Sunnyvale). 2012 Dec 26;2:113.

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