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Using the concordance of in vitro and in vivo data to evaluate extrapolation assumptions.

Honda GS, Pearce RG, Pham LL, Setzer RW, Wetmore BA, Sipes NS, Gilbert J, Franz B, Thomas RS, Wambaugh JF.

PLoS One. 2019 May 28;14(5):e0217564. doi: 10.1371/journal.pone.0217564. eCollection 2019.


Ontogeny of Hepatic Sulfotransferases and Prediction of Age-Dependent Fractional Contribution of Sulfation in Acetaminophen Metabolism.

Ladumor MK, Bhatt DK, Gaedigk A, Sharma S, Thakur A, Pearce RE, Leeder JS, Bolger MB, Singh S, Prasad B.

Drug Metab Dispos. 2019 Aug;47(8):818-831. doi: 10.1124/dmd.119.086462. Epub 2019 May 17.


An Image Analysis Solution For Quantification and Determination of Immunohistochemistry Staining Reproducibility.

Chlipala EA, Bendzinski CM, Dorner C, Sartan R, Copeland K, Pearce R, Doherty F, Bolon B.

Appl Immunohistochem Mol Morphol. 2019 May 16. doi: 10.1097/PAI.0000000000000776. [Epub ahead of print]


LOMETS2: improved meta-threading server for fold-recognition and structure-based function annotation for distant-homology proteins.

Zheng W, Zhang C, Wuyun Q, Pearce R, Li Y, Zhang Y.

Nucleic Acids Res. 2019 Jul 2;47(W1):W429-W436. doi: 10.1093/nar/gkz384.


Hippocampal CA2 Lewy pathology is associated with cholinergic degeneration in Parkinson's disease with cognitive decline.

Liu AKL, Chau TW, Lim EJ, Ahmed I, Chang RC, Kalaitzakis ME, Graeber MB, Gentleman SM, Pearce RKB.

Acta Neuropathol Commun. 2019 Apr 25;7(1):61. doi: 10.1186/s40478-019-0717-3.


EvoDesign: Designing Protein-Protein Binding Interactions Using Evolutionary Interface Profiles in Conjunction with an Optimized Physical Energy Function.

Pearce R, Huang X, Setiawan D, Zhang Y.

J Mol Biol. 2019 Jun 14;431(13):2467-2476. doi: 10.1016/j.jmb.2019.02.028. Epub 2019 Mar 7.


β-Arrestins Regulate Stem Cell-Like Phenotype and Response to Chemotherapy in Bladder Cancer.

Kallifatidis G, Smith DK, Morera DS, Gao J, Hennig MJ, Hoy JJ, Pearce RF, Dabke IR, Li J, Merseburger AS, Kuczyk MA, Lokeshwar VB, Lokeshwar BL.

Mol Cancer Ther. 2019 Apr;18(4):801-811. doi: 10.1158/1535-7163.MCT-18-1167. Epub 2019 Feb 20.


Impairments in cognitive performance in chronic fatigue syndrome are common, not related to co-morbid depression but do associate with autonomic dysfunction.

Robinson LJ, Gallagher P, Watson S, Pearce R, Finkelmeyer A, Maclachlan L, Newton JL.

PLoS One. 2019 Feb 5;14(2):e0210394. doi: 10.1371/journal.pone.0210394. eCollection 2019.


Monitoring melanoma recurrence with circulating tumor DNA: a proof of concept from three case studies.

McEvoy AC, Pereira MR, Reid A, Pearce R, Cowell L, Al-Ogaili Z, Khattak MA, Millward M, Meniawy TM, Gray ES, Ziman M.

Oncotarget. 2019 Jan 4;10(2):113-122. doi: 10.18632/oncotarget.26451. eCollection 2019 Jan 4.


Wake Up, Neurons! Astrocytes Calling.

Perouansky M, MacIver MB, Pearce RA.

Anesthesiology. 2019 Mar;130(3):361-363. doi: 10.1097/ALN.0000000000002589. No abstract available.


Evaluating metronidazole as a novel, safe CYP2A6 phenotyping probe in healthy adults.

Stancil SL, Pearce RE, Tyndale RF, Kearns GL, Vyhlidal CA, Leeder JS, Abdel-Rahman S.

Br J Clin Pharmacol. 2019 May;85(5):960-969. doi: 10.1111/bcp.13884. Epub 2019 Mar 12.


Outcome of allografting for AML-CR2 is equivalent across BSBMT and EBMT and is associated with encouraging OS and DFS across all age groups.

Byrne J, Pearce R, Perry J, Crawley C, Jackson G.

Bone Marrow Transplant. 2019 Jul;54(7):1151-1154. doi: 10.1038/s41409-019-0439-y. Epub 2019 Jan 24. No abstract available.


Assessment of medication for opioid use disorder as delivered within the Vermont hub and spoke system.

Rawson R, Cousins SJ, McCann M, Pearce R, Van Donsel A.

J Subst Abuse Treat. 2019 Feb;97:84-90. doi: 10.1016/j.jsat.2018.11.003. Epub 2018 Nov 19.


Prognostic Relevance of CCDC88C (Daple) Transcripts in the Peripheral Blood of Patients with Cutaneous Melanoma.

Dunkel Y, Reid AL, Ear J, Aznar N, Millward M, Gray E, Pearce R, Ziman M, Ghosh P.

Sci Rep. 2018 Dec 21;8(1):18036. doi: 10.1038/s41598-018-36173-x.


Acceptability of non-drug therapies in older people with orthostatic hypotension: a qualitative study.

Robinson LJ, Pearce RM, Frith J.

BMC Geriatr. 2018 Dec 17;18(1):315. doi: 10.1186/s12877-018-0999-5.


Xenophyophores (Rhizaria, Foraminifera) from the Eastern Clarion-Clipperton Zone (equatorial Pacific): the Genus Psammina.

Gooday AJ, Holzmann M, Goineau A, Kamenskaya O, Melnik VF, Pearce RB, Weber AA, Pawlowski J.

Protist. 2018 Dec;169(6):926-957. doi: 10.1016/j.protis.2018.09.003. Epub 2018 Oct 5.


Phylogeny and Classification of Novel Diversity in Sainouroidea (Cercozoa, Rhizaria) Sheds Light on a Highly Diverse and Divergent Clade.

Schuler GA, Tice AK, Pearce RA, Foreman E, Stone J, Gammill S, Willson JD, Reading C, Silberman JD, Brown MW.

Protist. 2018 Dec;169(6):853-874. doi: 10.1016/j.protis.2018.08.002. Epub 2018 Aug 22.


Evaluation of three commercial PCR kits for the direct detection of Mycobacterium avium subsp. paratuberculosis (MAP) in bovine faeces.

Prendergast DM, Pearce RA, Yearsley D, Ramovic E, Egan J.

Vet J. 2018 Nov;241:52-57. doi: 10.1016/j.tvjl.2018.09.013. Epub 2018 Sep 27.


Lean body weight dosing avoids excessive systemic exposure to proton pump inhibitors for children with obesity.

Shakhnovich V, Abdel-Rahman S, Friesen CA, Weigel J, Pearce RE, Gaedigk A, Leeder JS, Kearns GL.

Pediatr Obes. 2019 Jan;14(1). doi: 10.1111/ijpo.12459. Epub 2018 Sep 26.


A diagnostic autoantibody signature for primary cutaneous melanoma.

Zaenker P, Lo J, Pearce R, Cantwell P, Cowell L, Lee M, Quirk C, Law H, Gray E, Ziman M.

Oncotarget. 2018 Jul 17;9(55):30539-30551. doi: 10.18632/oncotarget.25669. eCollection 2018 Jul 17.


Review: Revisiting the human cholinergic nucleus of the diagonal band of Broca.

Liu AKL, Lim EJ, Ahmed I, Chang RC, Pearce RKB, Gentleman SM.

Neuropathol Appl Neurobiol. 2018 Dec;44(7):647-662. doi: 10.1111/nan.12513. Epub 2018 Aug 13. Review.


Axonal myelin decrease in the splenium in major depressive disorder.

Williams MR, Sharma P, Macdonald C, Pearce RKB, Hirsch SR, Maier M.

Eur Arch Psychiatry Clin Neurosci. 2019 Jun;269(4):387-395. doi: 10.1007/s00406-018-0904-4. Epub 2018 Jul 6.


Development of a UPLC-MS/MS method for quantitation of metronidazole and 2-hydroxy metronidazole in human plasma and its application to a pharmacokinetic study.

Stancil SL, van Haandel L, Abdel-Rahman S, Pearce RE.

J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Aug 15;1092:272-278. doi: 10.1016/j.jchromb.2018.06.024. Epub 2018 Jun 14.


Doc2-mediated superpriming supports synaptic augmentation.

Xue R, Ruhl DA, Briguglio JS, Figueroa AG, Pearce RA, Chapman ER.

Proc Natl Acad Sci U S A. 2018 Jun 12;115(24):E5605-E5613. doi: 10.1073/pnas.1802104115. Epub 2018 May 29.


Predicting Return to Work in a Heterogeneous Sample of Recently Injured Workers Using the Brief ÖMPSQ-SF.

Nicholas MK, Costa DSJ, Linton SJ, Main CJ, Shaw WS, Pearce R, Gleeson M, Pinto RZ, Blyth FM, McCauley JH, Maher CG, Smeets RJEM, McGarity A.

J Occup Rehabil. 2019 Jun;29(2):295-302. doi: 10.1007/s10926-018-9784-8.


Age- and Genotype-Dependent Variability in the Protein Abundance and Activity of Six Major Uridine Diphosphate-Glucuronosyltransferases in Human Liver.

Bhatt DK, Mehrotra A, Gaedigk A, Chapa R, Basit A, Zhang H, Choudhari P, Boberg M, Pearce RE, Gaedigk R, Broeckel U, Leeder JS, Prasad B.

Clin Pharmacol Ther. 2019 Jan;105(1):131-141. doi: 10.1002/cpt.1109. Epub 2018 Jul 12.


Electronic medication management: is it a silver bullet?

Pearce R, Whyte I.

Aust Prescr. 2018 Apr;41(2):32-33. doi: 10.18773/austprescr.2018.012. Epub 2018 Apr 3. No abstract available.


Hepatic Abundance and Activity of Androgen- and Drug-Metabolizing Enzyme UGT2B17 Are Associated with Genotype, Age, and Sex.

Bhatt DK, Basit A, Zhang H, Gaedigk A, Lee SB, Claw KG, Mehrotra A, Chaudhry AS, Pearce RE, Gaedigk R, Broeckel U, Thornton TA, Nickerson DA, Schuetz EG, Amory JK, Leeder JS, Prasad B.

Drug Metab Dispos. 2018 Jun;46(6):888-896. doi: 10.1124/dmd.118.080952. Epub 2018 Mar 30.


Evaluating In Vitro-In Vivo Extrapolation of Toxicokinetics.

Wambaugh JF, Hughes MF, Ring CL, MacMillan DK, Ford J, Fennell TR, Black SR, Snyder RW, Sipes NS, Wetmore BA, Westerhout J, Setzer RW, Pearce RG, Simmons JE, Thomas RS.

Toxicol Sci. 2018 May 1;163(1):152-169. doi: 10.1093/toxsci/kfy020.


Droplet Digital PCR for Mutation Detection in Formalin-Fixed, Paraffin-Embedded Melanoma Tissues: A Comparison with Sanger Sequencing and Pyrosequencing.

McEvoy AC, Wood BA, Ardakani NM, Pereira MR, Pearce R, Cowell L, Robinson C, Grieu-Iacopetta F, Spicer AJ, Amanuel B, Ziman M, Gray ES.

J Mol Diagn. 2018 Mar;20(2):240-252. doi: 10.1016/j.jmoldx.2017.11.009. Epub 2018 Jan 2.


Persistent organic pollutants (POPs) in blood and blubber of common bottlenose dolphins (Tursiops truncatus) at three northern Gulf of Mexico sites following the Deepwater Horizon oil spill.

Balmer JE, Ylitalo GM, Rowles TK, Mullin KD, Wells RS, Townsend FI, Pearce RW, Bolton JL, Zolman ES, Balmer BC, Schwacke LH.

Sci Total Environ. 2018 Apr 15;621:130-137. doi: 10.1016/j.scitotenv.2017.11.209. Epub 2017 Nov 23.


Guidance and Ethical Considerations for Undertaking Transgender Health Research and Institutional Review Boards Adjudicating this Research.

Adams N, Pearce R, Veale J, Radix A, Castro D, Sarkar A, Thom KC.

Transgend Health. 2017 Oct 1;2(1):165-175. doi: 10.1089/trgh.2017.0012. eCollection 2017. Review.


Long-lived immunity to canine core vaccine antigens in UK dogs as assessed by an in-practice test kit.

Killey R, Mynors C, Pearce R, Nell A, Prentis A, Day MJ.

J Small Anim Pract. 2018 Jan;59(1):27-31. doi: 10.1111/jsap.12775. Epub 2017 Oct 31.


Evaluation and calibration of high-throughput predictions of chemical distribution to tissues.

Pearce RG, Setzer RW, Davis JL, Wambaugh JF.

J Pharmacokinet Pharmacodyn. 2017 Dec;44(6):549-565. doi: 10.1007/s10928-017-9548-7. Epub 2017 Oct 14.


Variants in the CYP2B6 3'UTR Alter In Vitro and In Vivo CYP2B6 Activity: Potential Role of MicroRNAs.

Burgess KS, Ipe J, Swart M, Metzger IF, Lu J, Gufford BT, Thong N, Desta Z, Gaedigk R, Pearce RE, Gaedigk A, Liu Y, Skaar TC.

Clin Pharmacol Ther. 2018 Jul;104(1):130-138. doi: 10.1002/cpt.892. Epub 2017 Oct 25.


Flow characterization and patch clamp dose responses using jet microfluidics in a tubeless microfluidic device.

Resto PJ, Bhat A, Stava E, Lor C, Merriam E, Diaz-Rivera RE, Pearce R, Blick R, Williams JC.

J Neurosci Methods. 2017 Nov 1;291:182-189. doi: 10.1016/j.jneumeth.2017.08.025. Epub 2017 Aug 23.


Genetic and Nongenetic Factors Associated with Protein Abundance of Flavin-Containing Monooxygenase 3 in Human Liver.

Xu M, Bhatt DK, Yeung CK, Claw KG, Chaudhry AS, Gaedigk A, Pearce RE, Broeckel U, Gaedigk R, Nickerson DA, Schuetz E, Rettie AE, Leeder JS, Thummel KE, Prasad B.

J Pharmacol Exp Ther. 2017 Nov;363(2):265-274. doi: 10.1124/jpet.117.243113. Epub 2017 Aug 17.


An Intuitive Approach for Predicting Potential Human Health Risk with the Tox21 10k Library.

Sipes NS, Wambaugh JF, Pearce R, Auerbach SS, Wetmore BA, Hsieh JH, Shapiro AJ, Svoboda D, DeVito MJ, Ferguson SS.

Environ Sci Technol. 2017 Sep 19;51(18):10786-10796. doi: 10.1021/acs.est.7b00650. Epub 2017 Sep 6.


Graphene gas sensing using a non-contact microwave method.

Black N, Liu CG, Pearce R, Li B, Maier SA, Cohen LF, Gallop JC, Hao L.

Nanotechnology. 2017 Sep 29;28(39):395501. doi: 10.1088/1361-6528/aa80f7. Epub 2017 Jul 20.


httk: R Package for High-Throughput Toxicokinetics.

Pearce RG, Setzer RW, Strope CL, Wambaugh JF, Sipes NS.

J Stat Softw. 2017 Jul 17;79(4):1-26. doi: 10.18637/jss.v079.i04.


Identifying populations sensitive to environmental chemicals by simulating toxicokinetic variability.

Ring CL, Pearce RG, Setzer RW, Wetmore BA, Wambaugh JF.

Environ Int. 2017 Sep;106:105-118. doi: 10.1016/j.envint.2017.06.004. Epub 2017 Jun 16.


Age-dependent Protein Abundance of Cytosolic Alcohol and Aldehyde Dehydrogenases in Human Liver.

Bhatt DK, Gaedigk A, Pearce RE, Leeder JS, Prasad B.

Drug Metab Dispos. 2017 Sep;45(9):1044-1048. doi: 10.1124/dmd.117.076463. Epub 2017 Jun 12.


Target-distractor synchrony affects performance in a novel motor task for studying action selection.

James S, Bell OA, Nazli MAM, Pearce RE, Spencer J, Tyrrell K, Paine PJ, Heaton TJ, Anderson S, Da Lio M, Gurney K.

PLoS One. 2017 May 5;12(5):e0176945. doi: 10.1371/journal.pone.0176945. eCollection 2017.


Travel and the emergence of high-level drug resistance in Plasmodium falciparum in southwest Uganda: results from a population-based study.

Lynch CA, Pearce R, Pota H, Egwang C, Egwang T, Bhasin A, Cox J, Abeku TA, Roper C.

Malar J. 2017 Apr 17;16(1):150. doi: 10.1186/s12936-017-1812-1.


Bumblebees can discriminate between scent-marks deposited by conspecifics.

Pearce RF, Giuggioli L, Rands SA.

Sci Rep. 2017 Mar 7;7:43872. doi: 10.1038/srep43872.


Allogeneic stem cell transplantation for refractory acute myeloid leukemia in pediatric patients: the UK experience.

O'Hare P, Lucchini G, Cummins M, Veys P, Potter M, Lawson S, Vora A, Wynn R, Peniket A, Kirkland K, Pearce R, Perry J, Amrolia PJ.

Bone Marrow Transplant. 2017 Jun;52(6):825-831. doi: 10.1038/bmt.2017.3. Epub 2017 Feb 20.


Age-Dependent Absolute Abundance of Hepatic Carboxylesterases (CES1 and CES2) by LC-MS/MS Proteomics: Application to PBPK Modeling of Oseltamivir In Vivo Pharmacokinetics in Infants.

Boberg M, Vrana M, Mehrotra A, Pearce RE, Gaedigk A, Bhatt DK, Leeder JS, Prasad B.

Drug Metab Dispos. 2017 Feb;45(2):216-223. doi: 10.1124/dmd.116.072652. Epub 2016 Nov 28.


Measuring and communicating meaningful outcomes in neonatology: A family perspective.

Janvier A, Farlow B, Baardsnes J, Pearce R, Barrington KJ.

Semin Perinatol. 2016 Dec;40(8):571-577. doi: 10.1053/j.semperi.2016.09.009. Epub 2016 Oct 26. Review.


Metronidazole Metabolism in Neonates and the Interplay Between Ontogeny and Genetic Variation.

Wang LA, Gonzalez D, Leeder JS, Tyndale RF, Pearce RE, Benjamin DK Jr, Kearns GL, Cohen-Wolkowiez M; Best Pharmaceuticals for Children Act-Pediatric Trials Network Steering Committee.

J Clin Pharmacol. 2017 Feb;57(2):230-234. doi: 10.1002/jcph.797. Epub 2016 Aug 23. No abstract available.

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