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Items: 23


Cancer Immunotherapy.

Pearce OMT, Läubli H.

Glycobiology. 2018 Sep 1;28(9):638-639. doi: 10.1093/glycob/cwy069. No abstract available.


Cancer glycan epitopes: biosynthesis, structure and function.

Pearce OMT.

Glycobiology. 2018 Sep 1;28(9):670-696. doi: 10.1093/glycob/cwy023. Review.


Deconstruction of a Metastatic Tumor Microenvironment Reveals a Common Matrix Response in Human Cancers.

Pearce OMT, Delaine-Smith RM, Maniati E, Nichols S, Wang J, Böhm S, Rajeeve V, Ullah D, Chakravarty P, Jones RR, Montfort A, Dowe T, Gribben J, Jones JL, Kocher HM, Serody JS, Vincent BG, Connelly J, Brenton JD, Chelala C, Cutillas PR, Lockley M, Bessant C, Knight MM, Balkwill FR.

Cancer Discov. 2018 Mar;8(3):304-319. doi: 10.1158/2159-8290.CD-17-0284. Epub 2017 Dec 1.


N-glycolyl groups of nonhuman chondroitin sulfates survive in ancient fossils.

Bergfeld AK, Lawrence R, Diaz SL, Pearce OMT, Ghaderi D, Gagneux P, Leakey MG, Varki A.

Proc Natl Acad Sci U S A. 2017 Sep 26;114(39):E8155-E8164. doi: 10.1073/pnas.1706306114. Epub 2017 Sep 11.


Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.

Naba A, Pearce OMT, Del Rosario A, Ma D, Ding H, Rajeeve V, Cutillas PR, Balkwill FR, Hynes RO.

J Proteome Res. 2017 Aug 4;16(8):3083-3091. doi: 10.1021/acs.jproteome.7b00191. Epub 2017 Jul 19.


Relationships between Exciton Dissociation and Slow Recombination within ZnSe/CdS and CdSe/CdS Dot-in-Rod Heterostructures.

Grennell AN, Utterback JK, Pearce OM, Wilker MB, Dukovic G.

Nano Lett. 2017 Jun 14;17(6):3764-3774. doi: 10.1021/acs.nanolett.7b01101. Epub 2017 Jun 1.


Observation of trapped-hole diffusion on the surfaces of CdS nanorods.

Utterback JK, Grennell AN, Wilker MB, Pearce OM, Eaves JD, Dukovic G.

Nat Chem. 2016 Nov;8(11):1061-1066. doi: 10.1038/nchem.2566. Epub 2016 Jul 11.


Neoadjuvant Chemotherapy Modulates the Immune Microenvironment in Metastases of Tubo-Ovarian High-Grade Serous Carcinoma.

Böhm S, Montfort A, Pearce OM, Topping J, Chakravarty P, Everitt GL, Clear A, McDermott JR, Ennis D, Dowe T, Fitzpatrick A, Brockbank EC, Lawrence AC, Jeyarajah A, Faruqi AZ, McNeish IA, Singh N, Lockley M, Balkwill FR.

Clin Cancer Res. 2016 Jun 15;22(12):3025-36. doi: 10.1158/1078-0432.CCR-15-2657.


Sialic acids in cancer biology and immunity.

Pearce OM, Läubli H.

Glycobiology. 2016 Feb;26(2):111-28. doi: 10.1093/glycob/cwv097. Epub 2015 Oct 30. Review.


Interleukin-6 Stimulates Defective Angiogenesis.

Gopinathan G, Milagre C, Pearce OM, Reynolds LE, Hodivala-Dilke K, Leinster DA, Zhong H, Hollingsworth RE, Thompson R, Whiteford JR, Balkwill F.

Cancer Res. 2015 Aug 1;75(15):3098-107. doi: 10.1158/0008-5472.CAN-15-1227. Epub 2015 Jun 16.


Siglec receptors impact mammalian lifespan by modulating oxidative stress.

Schwarz F, Pearce OM, Wang X, Samraj AN, Läubli H, Garcia JO, Lin H, Fu X, Garcia-Bingman A, Secrest P, Romanoski CE, Heyser C, Glass CK, Hazen SL, Varki N, Varki A, Gagneux P.

Elife. 2015 Apr 7;4. doi: 10.7554/eLife.06184.


Rapid Trimming of Cell Surface Polysialic Acid (PolySia) by Exovesicular Sialidase Triggers Release of Preexisting Surface Neurotrophin.

Sumida M, Hane M, Yabe U, Shimoda Y, Pearce OM, Kiso M, Miyagi T, Sawada M, Varki A, Kitajima K, Sato C.

J Biol Chem. 2015 May 22;290(21):13202-14. doi: 10.1074/jbc.M115.638759. Epub 2015 Mar 6.


Reply to Mackenzie: A comparison of Neu5Gc and α-gal xenoantigens.

Pearce OM, Samraj AN, Läubli H, Varki NM, Varki A.

Proc Natl Acad Sci U S A. 2015 Mar 24;112(12):E1405. doi: 10.1073/pnas.1500880112. Epub 2015 Feb 20. No abstract available.


A red meat-derived glycan promotes inflammation and cancer progression.

Samraj AN, Pearce OM, Läubli H, Crittenden AN, Bergfeld AK, Banda K, Gregg CJ, Bingman AE, Secrest P, Diaz SL, Varki NM, Varki A.

Proc Natl Acad Sci U S A. 2015 Jan 13;112(2):542-7. doi: 10.1073/pnas.1417508112. Epub 2014 Dec 29.


Engagement of myelomonocytic Siglecs by tumor-associated ligands modulates the innate immune response to cancer.

Läubli H, Pearce OM, Schwarz F, Siddiqui SS, Deng L, Stanczak MA, Deng L, Verhagen A, Secrest P, Lusk C, Schwartz AG, Varki NM, Bui JD, Varki A.

Proc Natl Acad Sci U S A. 2014 Sep 30;111(39):14211-6. doi: 10.1073/pnas.1409580111. Epub 2014 Sep 15.


Hormesis in cancer immunology: Does the quantity of an immune reactant matter?

Pearce OM, Läubli H, Bui J, Varki A.

Oncoimmunology. 2014 Jun 25;3:e29312. eCollection 2014.


Inverse hormesis of cancer growth mediated by narrow ranges of tumor-directed antibodies.

Pearce OM, Läubli H, Verhagen A, Secrest P, Zhang J, Varki NM, Crocker PR, Bui JD, Varki A.

Proc Natl Acad Sci U S A. 2014 Apr 22;111(16):5998-6003. doi: 10.1073/pnas.1209067111. Epub 2014 Apr 7.


Enhanced T cell function in a mouse model of human glycosylation.

Buchlis G, Odorizzi P, Soto PC, Pearce OM, Hui DJ, Jordan MS, Varki A, Wherry EJ, High KA.

J Immunol. 2013 Jul 1;191(1):228-37. doi: 10.4049/jimmunol.1202905. Epub 2013 May 24.


Metabolism of vertebrate amino sugars with N-glycolyl groups: resistance of α2-8-linked N-glycolylneuraminic acid to enzymatic cleavage.

Davies LR, Pearce OM, Tessier MB, Assar S, Smutova V, Pajunen M, Sumida M, Sato C, Kitajima K, Finne J, Gagneux P, Pshezhetsky A, Woods R, Varki A.

J Biol Chem. 2012 Aug 17;287(34):28917-31. doi: 10.1074/jbc.M112.365056. Epub 2012 Jun 12.


Metabolism of vertebrate amino sugars with N-glycolyl groups: elucidating the intracellular fate of the non-human sialic acid N-glycolylneuraminic acid.

Bergfeld AK, Pearce OM, Diaz SL, Pham T, Varki A.

J Biol Chem. 2012 Aug 17;287(34):28865-81. doi: 10.1074/jbc.M112.363549. Epub 2012 Jun 12.


Metabolism of vertebrate amino sugars with N-glycolyl groups: incorporation of N-glycolylhexosamines into mammalian glycans by feeding N-glycolylgalactosamine.

Bergfeld AK, Pearce OM, Diaz SL, Lawrence R, Vocadlo DJ, Choudhury B, Esko JD, Varki A.

J Biol Chem. 2012 Aug 17;287(34):28898-916. doi: 10.1074/jbc.M112.363499. Epub 2012 Jun 12.


Chemo-enzymatic synthesis of the carbohydrate antigen N-glycolylneuraminic acid from glucose.

Pearce OM, Varki A.

Carbohydr Res. 2010 Jun 16;345(9):1225-9. doi: 10.1016/j.carres.2010.04.003. Epub 2010 Apr 9.


Glycoviruses: chemical glycosylation retargets adenoviral gene transfer.

Pearce OM, Fisher KD, Humphries J, Seymour LW, Smith A, Davis BG.

Angew Chem Int Ed Engl. 2005 Feb 4;44(7):1057-61. No abstract available.


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