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Items: 26


Redundant and Antagonistic Roles of XTP3B and OS9 in Decoding Glycan and Non-glycan Degrons in ER-Associated Degradation.

van der Goot AT, Pearce MMP, Leto DE, Shaler TA, Kopito RR.

Mol Cell. 2018 May 3;70(3):516-530.e6. doi: 10.1016/j.molcel.2018.03.026. Epub 2018 Apr 26.


Monitoring Cell-to-cell Transmission of Prion-like Protein Aggregates in Drosophila Melanogaster.

Donnelly KM, Pearce MMP.

J Vis Exp. 2018 Mar 12;(133). doi: 10.3791/56906.


Prion-like transmission of pathogenic protein aggregates in genetic models of neurodegenerative disease.

Pearce MM.

Curr Opin Genet Dev. 2017 Jun;44:149-155. doi: 10.1016/j.gde.2017.03.011. Epub 2017 Apr 22. Review.


Prion-Like Characteristics of Polyglutamine-Containing Proteins.

Pearce MMP, Kopito RR.

Cold Spring Harb Perspect Med. 2018 Feb 1;8(2). pii: a024257. doi: 10.1101/cshperspect.a024257. Review.


Incontinence medication response relates to the female urinary microbiota.

Thomas-White KJ, Hilt EE, Fok C, Pearce MM, Mueller ER, Kliethermes S, Jacobs K, Zilliox MJ, Brincat C, Price TK, Kuffel G, Schreckenberger P, Gai X, Brubaker L, Wolfe AJ.

Int Urogynecol J. 2016 May;27(5):723-33. doi: 10.1007/s00192-015-2847-x. Epub 2015 Sep 30.


The female urinary microbiome in urgency urinary incontinence.

Pearce MM, Zilliox MJ, Rosenfeld AB, Thomas-White KJ, Richter HE, Nager CW, Visco AG, Nygaard IE, Barber MD, Schaffer J, Moalli P, Sung VW, Smith AL, Rogers R, Nolen TL, Wallace D, Meikle SF, Gai X, Wolfe AJ, Brubaker L; Pelvic Floor Disorders Network.

Am J Obstet Gynecol. 2015 Sep;213(3):347.e1-11. doi: 10.1016/j.ajog.2015.07.009. Epub 2015 Jul 23.


Prion-like transmission of neuronal huntingtin aggregates to phagocytic glia in the Drosophila brain.

Pearce MMP, Spartz EJ, Hong W, Luo L, Kopito RR.

Nat Commun. 2015 Apr 13;6:6768. doi: 10.1038/ncomms7768.


IL22 regulates human urothelial cell sensory and innate functions through modulation of the acetylcholine response, immunoregulatory cytokines and antimicrobial peptides: assessment of an in vitro model.

Le PT, Pearce MM, Zhang S, Campbell EM, Fok CS, Mueller ER, Brincat CA, Wolfe AJ, Brubaker L.

PLoS One. 2014 Oct 29;9(10):e111375. doi: 10.1371/journal.pone.0111375. eCollection 2014.


The female urinary microbiome: a comparison of women with and without urgency urinary incontinence.

Pearce MM, Hilt EE, Rosenfeld AB, Zilliox MJ, Thomas-White K, Fok C, Kliethermes S, Schreckenberger PC, Brubaker L, Gai X, Wolfe AJ.

MBio. 2014 Jul 8;5(4):e01283-14. doi: 10.1128/mBio.01283-14.


Factors influencing parents' decision to donate their healthy infant's DNA for minimal-risk genetic research.

Hatfield LA, Pearce MM.

J Nurs Scholarsh. 2014 Nov;46(6):398-407. doi: 10.1111/jnu.12096. Epub 2014 Jun 19.


Urine is not sterile: use of enhanced urine culture techniques to detect resident bacterial flora in the adult female bladder.

Hilt EE, McKinley K, Pearce MM, Rosenfeld AB, Zilliox MJ, Mueller ER, Brubaker L, Gai X, Wolfe AJ, Schreckenberger PC.

J Clin Microbiol. 2014 Mar;52(3):871-6. doi: 10.1128/JCM.02876-13. Epub 2013 Dec 26.


Unassembled CD147 is an endogenous endoplasmic reticulum-associated degradation substrate.

Tyler RE, Pearce MM, Shaler TA, Olzmann JA, Greenblatt EJ, Kopito RR.

Mol Biol Cell. 2012 Dec;23(24):4668-78. doi: 10.1091/mbc.E12-06-0428. Epub 2012 Oct 24.


Differential regulation of HMG-CoA reductase and Insig-1 by enzymes of the ubiquitin-proteasome system.

Tsai YC, Leichner GS, Pearce MM, Wilson GL, Wojcikiewicz RJ, Roitelman J, Weissman AM.

Mol Biol Cell. 2012 Dec;23(23):4484-94. doi: 10.1091/mbc.E12-08-0631. Epub 2012 Oct 19.


Fibrillar structure and charge determine the interaction of polyglutamine protein aggregates with the cell surface.

Trevino RS, Lauckner JE, Sourigues Y, Pearce MM, Bousset L, Melki R, Kopito RR.

J Biol Chem. 2012 Aug 24;287(35):29722-8. doi: 10.1074/jbc.M112.372474. Epub 2012 Jun 29.


Legionella cardiaca sp. nov., isolated from a case of native valve endocarditis in a human heart.

Pearce MM, Theodoropoulos N, Mandel MJ, Brown E, Reed KD, Cianciotto NP.

Int J Syst Evol Microbiol. 2012 Dec;62(Pt 12):2946-54. doi: 10.1099/ijs.0.039248-0. Epub 2012 Jan 27.


Native valve endocarditis due to a novel strain of Legionella.

Pearce MM, Theodoropoulos N, Noskin GA, Flaherty JP, Stemper ME, Aspeslet T, Cianciotto NP, Reed KD.

J Clin Microbiol. 2011 Sep;49(9):3340-2. doi: 10.1128/JCM.01066-11. Epub 2011 Jul 27.


RNF170 protein, an endoplasmic reticulum membrane ubiquitin ligase, mediates inositol 1,4,5-trisphosphate receptor ubiquitination and degradation.

Lu JP, Wang Y, Sliter DA, Pearce MM, Wojcikiewicz RJ.

J Biol Chem. 2011 Jul 8;286(27):24426-33. doi: 10.1074/jbc.M111.251983. Epub 2011 May 24.


Legionella pneumophila secretes an endoglucanase that belongs to the family-5 of glycosyl hydrolases and is dependent upon type II secretion.

Pearce MM, Cianciotto NP.

FEMS Microbiol Lett. 2009 Nov;300(2):256-64. doi: 10.1111/j.1574-6968.2009.01801.x. Epub 2009 Sep 21.


SPFH1 and SPFH2 mediate the ubiquitination and degradation of inositol 1,4,5-trisphosphate receptors in muscarinic receptor-expressing HeLa cells.

Wang Y, Pearce MM, Sliter DA, Olzmann JA, Christianson JC, Kopito RR, Boeckmann S, Gagen C, Leichner GS, Roitelman J, Wojcikiewicz RJ.

Biochim Biophys Acta. 2009 Nov;1793(11):1710-8. doi: 10.1016/j.bbamcr.2009.09.004. Epub 2009 Sep 12.


When worlds collide: IP(3) receptors and the ERAD pathway.

Wojcikiewicz RJ, Pearce MM, Sliter DA, Wang Y.

Cell Calcium. 2009 Sep;46(3):147-53. doi: 10.1016/j.ceca.2009.05.002. Epub 2009 Aug 25. Review.


An endoplasmic reticulum (ER) membrane complex composed of SPFH1 and SPFH2 mediates the ER-associated degradation of inositol 1,4,5-trisphosphate receptors.

Pearce MM, Wormer DB, Wilkens S, Wojcikiewicz RJ.

J Biol Chem. 2009 Apr 17;284(16):10433-45. doi: 10.1074/jbc.M809801200. Epub 2009 Feb 24.


SPFH2 mediates the endoplasmic reticulum-associated degradation of inositol 1,4,5-trisphosphate receptors and other substrates in mammalian cells.

Pearce MM, Wang Y, Kelley GG, Wojcikiewicz RJ.

J Biol Chem. 2007 Jul 13;282(28):20104-15. Epub 2007 May 14.


Phylogenetic diversity and cosymbiosis in the bioluminescent symbioses of "Photobacterium mandapamensis".

Kaeding AJ, Ast JC, Pearce MM, Urbanczyk H, Kimura S, Endo H, Nakamura M, Dunlap PV.

Appl Environ Microbiol. 2007 May;73(10):3173-82. Epub 2007 Mar 16.


Genomic polymorphism in symbiotic populations of Photobacterium leiognathi.

Dunlap PV, Jiemjit A, Ast JC, Pearce MM, Marques RR, Lavilla-Pitogo CR.

Environ Microbiol. 2004 Feb;6(2):145-58.


A tour of the ADA's dental artifact collection.

Pearce MM.

Dentistry. 1987 Dec;7(4):18-20. No abstract available.


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