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Improved in vivo targeting of BCL-2 phenotypic conversion through hollow gold nanoshell delivery.

Morgan E, Gamble JT, Pearce MC, Elson DJ, Tanguay RL, Kolluri SK, Reich NO.

Apoptosis. 2019 Jun;24(5-6):529-537. doi: 10.1007/s10495-019-01531-1.


Cancer therapeutics based on BCL-2 functional conversion.

Pearce MC, Satterthwait AC, Zhang XK, Kolluri SK.

Apoptosis. 2019 Feb;24(1-2):1-2. doi: 10.1007/s10495-018-1504-5. No abstract available.


Clinics in diagnostic imaging (191). Multiple system atrophy-cerebellar type (MSA-C).

Pearce MC, Choy G, Chen RC.

Singapore Med J. 2018 Oct;59(10):550-554. doi: 10.11622/smedj.2018128.


Clinics in diagnostic imaging (190). Subacute combined degeneration of the spinal cord (SCD).

Pearce MC, Choy G, Chen RC.

Singapore Med J. 2018 Sep;59(9):460-464. doi: 10.11622/smedj.2018109.


Clinics in diagnostic imaging (188). Transient global amnesia (TGA).

Pearce MC, Choy G, Chen RC.

Singapore Med J. 2018 Jul;59(7):351-355. doi: 10.11622/smedj.2018087.


Induction of apoptosis and suppression of tumor growth by Nur77-derived Bcl-2 converting peptide in chemoresistant lung cancer cells.

Pearce MC, Gamble JT, Kopparapu PR, O'Donnell EF, Mueller MJ, Jang HS, Greenwood JA, Satterthwait AC, Tanguay RL, Zhang XK, Kolluri SK.

Oncotarget. 2018 May 25;9(40):26072-26085. doi: 10.18632/oncotarget.25437. eCollection 2018 May 25.


Using Patient Flow Information to Determine Risk of Hospital Presentation: Protocol for a Proof-of-Concept Study.

Pearce CM, McLeod A, Patrick J, Boyle D, Shearer M, Eustace P, Pearce MC.

JMIR Res Protoc. 2016 Dec 20;5(4):e241. doi: 10.2196/resprot.5894.


Prevalence of antibodies to Leptospira hardjo in bulk tank milk from unvaccinated dairy herds in the south-west region of Poland.

Rypuła K, Płoneczka-Janeczko K, Bierowiec K, Chorbiński P, Pearce MC, Lesiak M.

Berl Munch Tierarztl Wochenschr. 2014 May-Jun;127(5-6):247-50.


E. coli O157 on Scottish cattle farms: evidence of local spread and persistence using repeat cross-sectional data.

Herbert LJ, Vali L, Hoyle DV, Innocent G, McKendrick IJ, Pearce MC, Mellor D, Porphyre T, Locking M, Allison L, Hanson M, Matthews L, Gunn GJ, Woolhouse ME, Chase-Topping ME.

BMC Vet Res. 2014 Apr 26;10:95. doi: 10.1186/1746-6148-10-95.


Effects of early vaccination with a gonadotropin releasing factor analog-diphtheria toxoid conjugate on boar taint and growth performance of male pigs.

Kantas D, Papatsiros V, Tassis P, Tzika E, Pearce MC, Wilson S.

J Anim Sci. 2014 May;92(5):2251-8. doi: 10.2527/jas.2013-6924. Epub 2014 Mar 18.


The roles of helix I and strand 5A in the folding, function and misfolding of α1-antitrypsin.

Knaupp AS, Keleher S, Yang L, Dai W, Bottomley SP, Pearce MC.

PLoS One. 2013;8(1):e54766. doi: 10.1371/journal.pone.0054766. Epub 2013 Jan 29.


Fatty acid composition and lipogenic enzyme protein expression in subcutaneous adipose tissue of male pigs vaccinated against boar taint, barrows, and entire boars.

Mackay J, Pearce MC, Thevasagayam S, Doran O.

J Anim Sci. 2013 Jan;91(1):395-404. doi: 10.2527/jas.2011-4685. Epub 2012 Oct 9.


Efficacy of major anthelmintics against horse cyathostomins in France.

Traversa D, Castagna G, von Samson-Himmelstjerna G, Meloni S, Bartolini R, Geurden T, Pearce MC, Woringer E, Besognet B, Milillo P, D'Espois M.

Vet Parasitol. 2012 Sep 10;188(3-4):294-300. doi: 10.1016/j.vetpar.2012.03.048. Epub 2012 Apr 3.


Pathogenic potential to humans of bovine Escherichia coli O26, Scotland.

Chase-Topping ME, Rosser T, Allison LJ, Courcier E, Evans J, McKendrick IJ, Pearce MC, Handel I, Caprioli A, Karch H, Hanson MF, Pollock KG, Locking ME, Woolhouse ME, Matthews L, Low JC, Gally DL.

Emerg Infect Dis. 2012 Mar;18(3):439-48. doi: 10.3201/eid1803.111236.


Effect of vaccination against gonadotrophin-releasing factor on growth performance, carcass, meat and fat quality of male Duroc pigs for dry-cured ham production.

Font-I-Furnols M, Gispert M, Soler J, Diaz M, Garcia-Regueiro JA, Diaz I, Pearce MC.

Meat Sci. 2012 Jun;91(2):148-54. doi: 10.1016/j.meatsci.2012.01.008. Epub 2012 Jan 21.


The conjugation protein TcpC from Clostridium perfringens is structurally related to the type IV secretion system protein VirB8 from Gram-negative bacteria.

Porter CJ, Bantwal R, Bannam TL, Rosado CJ, Pearce MC, Adams V, Lyras D, Whisstock JC, Rood JI.

Mol Microbiol. 2012 Jan;83(2):275-88. doi: 10.1111/j.1365-2958.2011.07930.x. Epub 2011 Dec 11.


Production of recombinant serpins in Escherichia coli.

Pearce MC, Cabrita LD.

Methods Enzymol. 2011;501:13-28. doi: 10.1016/B978-0-12-385950-1.00002-X.


Molecular basis of α1-antitrypsin deficiency revealed by the structure of a domain-swapped trimer.

Yamasaki M, Sendall TJ, Pearce MC, Whisstock JC, Huntington JA.

EMBO Rep. 2011 Sep 30;12(10):1011-7. doi: 10.1038/embor.2011.171.


Ultrasensitive electrochemical immunosensor employing glucose oxidase catalyzed deposition of gold nanoparticles for signal amplification.

Zhang J, Pearce MC, Ting BP, Ying JY.

Biosens Bioelectron. 2011 Sep 15;27(1):53-7. doi: 10.1016/j.bios.2011.06.007. Epub 2011 Jun 17.


Identification and characterization of a misfolded monomeric serpin formed at physiological temperature.

Pearce MC, Powers GA, Feil SC, Hansen G, Parker MW, Bottomley SP.

J Mol Biol. 2010 Oct 29;403(3):459-67. doi: 10.1016/j.jmb.2010.09.007. Epub 2010 Sep 17.


Pt nanoparticle label-mediated deposition of Pt catalyst for ultrasensitive electrochemical immunosensors.

Zhang J, Ting BP, Khan M, Pearce MC, Yang Y, Gao Z, Ying JY.

Biosens Bioelectron. 2010 Oct 15;26(2):418-23. doi: 10.1016/j.bios.2010.07.112. Epub 2010 Aug 11.


Application of the Three Rs to challenge assays used in vaccine testing: tenth report of the BVAAWF/FRAME/RSPCA/UFAW Joint Working Group on Refinement.

Jennings M, Morton DB, Charton E, Cooper J, Hendriksen C, Martin S, Pearce MC, Price S, Redhead K, Reed N, Simmons H, Spencer S, Willingale H.

Biologicals. 2010 Nov;38(6):684-95. doi: 10.1016/j.biologicals.2010.04.004. Epub 2010 Aug 17.


Temporal and spatial patterns of bovine Escherichia coli O157 prevalence and comparison of temporal changes in the patterns of phage types associated with bovine shedding and human E. coli O157 cases in Scotland between 1998-2000 and 2002-2004.

Pearce MC, Chase-Topping ME, McKendrick IJ, Mellor DJ, Locking ME, Allison L, Ternent HE, Matthews L, Knight HI, Smith AW, Synge BA, Reilly W, Low JC, Reid SW, Gunn GJ, Woolhouse ME.

BMC Microbiol. 2009 Dec 29;9:276. doi: 10.1186/1471-2180-9-276.


Kinetic instability of the serpin Z alpha1-antitrypsin promotes aggregation.

Knaupp AS, Levina V, Robertson AL, Pearce MC, Bottomley SP.

J Mol Biol. 2010 Feb 19;396(2):375-83. doi: 10.1016/j.jmb.2009.11.048. Epub 2009 Nov 26.


Exploiting strain diversity to expose transmission heterogeneities and predict the impact of targeting supershedding.

Matthews L, Reeve R, Woolhouse ME, Chase-Topping M, Mellor DJ, Pearce MC, Allison LJ, Gunn GJ, Low JC, Reid SW.

Epidemics. 2009 Dec;1(4):221-9. doi: 10.1016/j.epidem.2009.10.002. Epub 2009 Oct 27.


Expression, purification and characterization of recombinant Z alpha(1)-antitrypsin--the most common cause of alpha(1)-antitrypsin deficiency.

Levina V, Dai W, Knaupp AS, Kaiserman D, Pearce MC, Cabrita LD, Bird PI, Bottomley SP.

Protein Expr Purif. 2009 Dec;68(2):226-32. doi: 10.1016/j.pep.2009.06.011. Epub 2009 Jun 23.


Cefixime-tellurite rhamnose MacConkey agar for isolation of Vero cytotoxin-producing Escherichia coli serogroup O26 from Scottish cattle and sheep faeces.

Evans J, Knight HI, Smith AW, Pearce MC, Hall M, Foster G, Low JC, Gunn GJ.

Lett Appl Microbiol. 2008 Sep;47(3):148-52. doi: 10.1111/j.1472-765X.2008.02402.x.


Conformational change in the chromatin remodelling protein MENT.

Ong PC, Golding SJ, Pearce MC, Irving JA, Grigoryev SA, Pike D, Langendorf CG, Bashtannyk-Puhalovich TA, Bottomley SP, Whisstock JC, Pike RN, McGowan S.

PLoS One. 2009;4(3):e4727. doi: 10.1371/journal.pone.0004727. Epub 2009 Mar 6.


Preventing serpin aggregation: the molecular mechanism of citrate action upon antitrypsin unfolding.

Pearce MC, Morton CJ, Feil SC, Hansen G, Adams JJ, Parker MW, Bottomley SP.

Protein Sci. 2008 Dec;17(12):2127-33. doi: 10.1110/ps.037234.108. Epub 2008 Sep 9.


DNA accelerates the inhibition of human cathepsin V by serpins.

Ong PC, McGowan S, Pearce MC, Irving JA, Kan WT, Grigoryev SA, Turk B, Silverman GA, Brix K, Bottomley SP, Whisstock JC, Pike RN.

J Biol Chem. 2007 Dec 21;282(51):36980-6. Epub 2007 Oct 8.


A common fold mediates vertebrate defense and bacterial attack.

Rosado CJ, Buckle AM, Law RH, Butcher RE, Kan WT, Bird CH, Ung K, Browne KA, Baran K, Bashtannyk-Puhalovich TA, Faux NG, Wong W, Porter CJ, Pike RN, Ellisdon AM, Pearce MC, Bottomley SP, Emsley J, Smith AI, Rossjohn J, Hartland EL, Voskoboinik I, Trapani JA, Bird PI, Dunstone MA, Whisstock JC.

Science. 2007 Sep 14;317(5844):1548-51. Epub 2007 Aug 23.


Aeropin from the extremophile Pyrobaculum aerophilum bypasses the serpin misfolding trap.

Cabrita LD, Irving JA, Pearce MC, Whisstock JC, Bottomley SP.

J Biol Chem. 2007 Sep 14;282(37):26802-9. Epub 2007 Jul 16.


The loss of tryptophan 194 in antichymotrypsin lowers the kinetic barrier to misfolding.

Pearce MC, Cabrita LD, Ellisdon AM, Bottomley SP.

FEBS J. 2007 Jul;274(14):3622-3632. doi: 10.1111/j.1742-4658.2007.05897.x. Epub 2007 Jul 3.


The N terminus of the serpin, tengpin, functions to trap the metastable native state.

Zhang Q, Buckle AM, Law RH, Pearce MC, Cabrita LD, Lloyd GJ, Irving JA, Smith AI, Ruzyla K, Rossjohn J, Bottomley SP, Whisstock JC.

EMBO Rep. 2007 Jul;8(7):658-63. Epub 2007 Jun 8.


Short-term endocrine and metabolic reactions before and after second immunization against GnRH in boars.

Claus R, Lacorn M, Danowski K, Pearce MC, Bauer A.

Vaccine. 2007 Jun 11;25(24):4689-96. Epub 2007 Apr 20.


Mechanisms of ataxin-3 misfolding and fibril formation: kinetic analysis of a disease-associated polyglutamine protein.

Ellisdon AM, Pearce MC, Bottomley SP.

J Mol Biol. 2007 Apr 27;368(2):595-605. Epub 2007 Feb 22.


Risk factors for the presence of high-level shedders of Escherichia coli O157 on Scottish farms.

Chase-Topping ME, McKendrick IJ, Pearce MC, MacDonald P, Matthews L, Halliday J, Allison L, Fenlon D, Low JC, Gunn G, Woolhouse ME.

J Clin Microbiol. 2007 May;45(5):1594-603. Epub 2007 Mar 14.


Antibiotic resistance and molecular epidemiology of Escherichia coli O26, O103 and O145 shed by two cohorts of Scottish beef cattle.

Vali L, Hamouda A, Hoyle DV, Pearce MC, Whitaker LH, Jenkins C, Knight HI, Smith AW, Amyes SG.

J Antimicrob Chemother. 2007 Mar;59(3):403-10. Epub 2007 Feb 8.


Modelling the epidemiology and transmission of Verocytotoxin-producing Escherichia coli serogroups O26 and O103 in two different calf cohorts.

Liu WC, Shaw DJ, Matthews L, Hoyle DV, Pearce MC, Yates CM, Low JC, Amyes SG, Gunn GJ, Woolhouse ME.

Epidemiol Infect. 2007 Nov;135(8):1316-23. Epub 2007 Jan 15.


Serpin acceleration of amyloid fibril formation: a role for accessory proteins.

Powers GA, Pham CL, Pearce MC, Howlett GJ, Bottomley SP.

J Mol Biol. 2007 Feb 16;366(2):666-76. Epub 2006 Nov 22.


Herd-level risk factors associated with the presence of Phage type 21/28 E. coli O157 on Scottish cattle farms.

Halliday JE, Chase-Topping ME, Pearce MC, McKendrick IJ, Allison L, Fenlon D, Low C, Mellor DJ, Gunn GJ, Woolhouse ME.

BMC Microbiol. 2006 Dec 2;6:99.


Sensitivity of an immunomagnetic-separation-based test for detecting Escherichia coli O26 in bovine feces.

Hall LM, Evans J, Smith AW, Pearce MC, Knight HI, Foster G, Low JC, Gunn GJ.

Appl Environ Microbiol. 2006 Nov;72(11):7260-3. Epub 2006 Sep 15.


Heterogeneous shedding of Escherichia coli O157 in cattle and its implications for control.

Matthews L, Low JC, Gally DL, Pearce MC, Mellor DJ, Heesterbeek JA, Chase-Topping M, Naylor SW, Shaw DJ, Reid SW, Gunn GJ, Woolhouse ME.

Proc Natl Acad Sci U S A. 2006 Jan 17;103(3):547-52. Epub 2006 Jan 9.


Prevalence and virulence factors of Escherichia coli serogroups O26, O103, O111, and O145 shed by cattle in Scotland.

Pearce MC, Evans J, McKendrick IJ, Smith AW, Knight HI, Mellor DJ, Woolhouse ME, Gunn GJ, Low JC.

Appl Environ Microbiol. 2006 Jan;72(1):653-9.


Modelling the epidemiology of Verocytotoxin-producing Escherichia coli serogroups in young calves.

Liu WC, Jenkins C, Shaw DJ, Matthews L, Pearce MC, Low JC, Gunn GJ, Smith HR, Frankel G, Woolhouse ME.

Epidemiol Infect. 2005 Jun;133(3):449-58.


Comparison of diversities of Escherichia coli O157 shed from a cohort of spring-born beef calves at pasture and in housing.

Vali L, Pearce MC, Wisely KA, Hamouda A, Knight HI, Smith AW, Amyes SG.

Appl Environ Microbiol. 2005 Mar;71(3):1648-52.


Shedding patterns of verocytotoxin-producing Escherichia coli strains in a cohort of calves and their dams on a Scottish beef farm.

Shaw DJ, Jenkins C, Pearce MC, Cheasty T, Gunn GJ, Dougan G, Smith HR, Woolhouse ME, Frankel G.

Appl Environ Microbiol. 2004 Dec;70(12):7456-65.


Age-related decline in carriage of ampicillin-resistant Escherichia coli in young calves.

Hoyle DV, Shaw DJ, Knight HI, Davison HC, Pearce MC, Low JC, Gunn GJ, Woolhouse ME.

Appl Environ Microbiol. 2004 Nov;70(11):6927-30.


Identification of residual structure within denatured antichymotrypsin: implications for serpin folding and misfolding.

Pearce MC, Cabrita LD, Rubin H, Gore MG, Bottomley SP.

Biochem Biophys Res Commun. 2004 Nov 12;324(2):729-35.


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