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Items: 9

1.

Functional characterization of obesity-associated variants involving the α and β isoforms of human SH2B1.

Pearce LR, Joe R, Doche ME, Su HW, Keogh JM, Henning E, Argetsinger LS, Bochukova EG, Cline JM, Garg S, Saeed S, Shoelson S, O'Rahilly S, Barroso I, Rui L, Farooqi IS, Carter-Su C.

Endocrinology. 2014 Sep;155(9):3219-26. doi: 10.1210/en.2014-1264. Epub 2014 Jun 27.

2.

A homozygous mutation in the TUB gene associated with retinal dystrophy and obesity.

Borman AD, Pearce LR, Mackay DS, Nagel-Wolfrum K, Davidson AE, Henderson R, Garg S, Waseem NH, Webster AR, Plagnol V, Wolfrum U, Farooqi IS, Moore AT.

Hum Mutat. 2014 Mar;35(3):289-93. doi: 10.1002/humu.22482. Epub 2013 Dec 20.

3.

KSR2 mutations are associated with obesity, insulin resistance, and impaired cellular fuel oxidation.

Pearce LR, Atanassova N, Banton MC, Bottomley B, van der Klaauw AA, Revelli JP, Hendricks A, Keogh JM, Henning E, Doree D, Jeter-Jones S, Garg S, Bochukova EG, Bounds R, Ashford S, Gayton E, Hindmarsh PC, Shield JP, Crowne E, Barford D, Wareham NJ; UK10K consortium, O'Rahilly S, Murphy MP, Powell DR, Barroso I, Farooqi IS.

Cell. 2013 Nov 7;155(4):765-77.

4.

Human SH2B1 mutations are associated with maladaptive behaviors and obesity.

Doche ME, Bochukova EG, Su HW, Pearce LR, Keogh JM, Henning E, Cline JM, Saeed S, Dale A, Cheetham T, Barroso I, Argetsinger LS, O'Rahilly S, Rui L, Carter-Su C, Farooqi IS.

J Clin Invest. 2012 Dec;122(12):4732-6. doi: 10.1172/JCI62696. Epub 2012 Nov 19. Erratum in: J Clin Invest. 2013 Jan 2;123(1):526. Saeed, Sadia [added].

5.

Protor-1 is required for efficient mTORC2-mediated activation of SGK1 in the kidney.

Pearce LR, Sommer EM, Sakamoto K, Wullschleger S, Alessi DR.

Biochem J. 2011 May 15;436(1):169-79. doi: 10.1042/BJ20102103.

PMID:
21413931
6.

Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1).

Pearce LR, Alton GR, Richter DT, Kath JC, Lingardo L, Chapman J, Hwang C, Alessi DR.

Biochem J. 2010 Oct 15;431(2):245-55. doi: 10.1042/BJ20101024.

PMID:
20704563
7.

The nuts and bolts of AGC protein kinases.

Pearce LR, Komander D, Alessi DR.

Nat Rev Mol Cell Biol. 2010 Jan;11(1):9-22. doi: 10.1038/nrm2822. Review.

PMID:
20027184
8.

New insights into mTOR signaling: mTORC2 and beyond.

Alessi DR, Pearce LR, García-Martínez JM.

Sci Signal. 2009 Apr 21;2(67):pe27. doi: 10.1126/scisignal.267pe27.

PMID:
19383978
9.

Identification of Protor as a novel Rictor-binding component of mTOR complex-2.

Pearce LR, Huang X, Boudeau J, Pawłowski R, Wullschleger S, Deak M, Ibrahim AF, Gourlay R, Magnuson MA, Alessi DR.

Biochem J. 2007 Aug 1;405(3):513-22.

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