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Items: 1 to 50 of 66

1.

Polyamines and eIF5A Hypusination Modulate Mitochondrial Respiration and Macrophage Activation.

Puleston DJ, Buck MD, Klein Geltink RI, Kyle RL, Caputa G, O'Sullivan D, Cameron AM, Castoldi A, Musa Y, Kabat AM, Zhang Y, Flachsmann LJ, Field CS, Patterson AE, Scherer S, Alfei F, Baixauli F, Austin SK, Kelly B, Matsushita M, Curtis JD, Grzes KM, Villa M, Corrado M, Sanin DE, Qiu J, Pällman N, Paz K, Maccari ME, Blazar BR, Mittler G, Buescher JM, Zehn D, Rospert S, Pearce EJ, Balabanov S, Pearce EL.

Cell Metab. 2019 Aug 6;30(2):352-363.e8. doi: 10.1016/j.cmet.2019.05.003. Epub 2019 May 23.

2.

Acetate Promotes T Cell Effector Function during Glucose Restriction.

Qiu J, Villa M, Sanin DE, Buck MD, O'Sullivan D, Ching R, Matsushita M, Grzes KM, Winkler F, Chang CH, Curtis JD, Kyle RL, Van Teijlingen Bakker N, Corrado M, Haessler F, Alfei F, Edwards-Hicks J, Maggi LB Jr, Zehn D, Egawa T, Bengsch B, Klein Geltink RI, Jenuwein T, Pearce EJ, Pearce EL.

Cell Rep. 2019 May 14;27(7):2063-2074.e5. doi: 10.1016/j.celrep.2019.04.022.

3.

The importance of methionine metabolism.

Klein Geltink RI, Pearce EL.

Elife. 2019 May 2;8. pii: e47221. doi: 10.7554/eLife.47221.

4.

Potassium shapes antitumor immunity.

Baixauli F, Villa M, Pearce EL.

Science. 2019 Mar 29;363(6434):1395-1396. doi: 10.1126/science.aaw8800. No abstract available.

PMID:
30923211
5.

Inflammatory macrophage dependence on NAD+ salvage is a consequence of reactive oxygen species-mediated DNA damage.

Cameron AM, Castoldi A, Sanin DE, Flachsmann LJ, Field CS, Puleston DJ, Kyle RL, Patterson AE, Hässler F, Buescher JM, Kelly B, Pearce EL, Pearce EJ.

Nat Immunol. 2019 Apr;20(4):420-432. doi: 10.1038/s41590-019-0336-y. Epub 2019 Mar 11.

PMID:
30858618
6.

Metabolic interventions in the immune response to cancer.

O'Sullivan D, Sanin DE, Pearce EJ, Pearce EL.

Nat Rev Immunol. 2019 May;19(5):324-335. doi: 10.1038/s41577-019-0140-9. Review.

PMID:
30820043
7.

Mitochondrial Membrane Potential Regulates Nuclear Gene Expression in Macrophages Exposed to Prostaglandin E2.

Sanin DE, Matsushita M, Klein Geltink RI, Grzes KM, van Teijlingen Bakker N, Corrado M, Kabat AM, Buck MD, Qiu J, Lawless SJ, Cameron AM, Villa M, Baixauli F, Patterson AE, Hässler F, Curtis JD, O'Neill CM, O'Sullivan D, Wu D, Mittler G, Huang SC, Pearce EL, Pearce EJ.

Immunity. 2018 Dec 18;49(6):1021-1033.e6. doi: 10.1016/j.immuni.2018.10.011.

PMID:
30566880
8.

Memory CD8+ T Cells Use Cell-Intrinsic Lipolysis to Support the Metabolic Programming Necessary for Development.

O'Sullivan D, van der Windt GJW, Huang SC, Curtis JD, Chang CH, Buck MD, Qiu J, Smith AM, Lam WY, DiPlato LM, Hsu FF, Birnbaum MJ, Pearce EJ, Pearce EL.

Immunity. 2018 Aug 21;49(2):375-376. doi: 10.1016/j.immuni.2018.07.018. No abstract available.

9.

A metabolic interplay coordinated by HLX regulates myeloid differentiation and AML through partly overlapping pathways.

Piragyte I, Clapes T, Polyzou A, Klein Geltink RI, Lefkopoulos S, Yin N, Cauchy P, Curtis JD, Klaeylé L, Langa X, Beckmann CCA, Wlodarski MW, Müller P, Van Essen D, Rambold A, Kapp FG, Mione M, Buescher JM, Pearce EL, Polyzos A, Trompouki E.

Nat Commun. 2018 Aug 6;9(1):3090. doi: 10.1038/s41467-018-05311-4.

10.

Unraveling the Complex Interplay Between T Cell Metabolism and Function.

Geltink RIK, Kyle RL, Pearce EL.

Annu Rev Immunol. 2018 Apr 26;36:461-488. doi: 10.1146/annurev-immunol-042617-053019. Review.

11.

Oncogenic JAK2V617F causes PD-L1 expression, mediating immune escape in myeloproliferative neoplasms.

Prestipino A, Emhardt AJ, Aumann K, O'Sullivan D, Gorantla SP, Duquesne S, Melchinger W, Braun L, Vuckovic S, Boerries M, Busch H, Halbach S, Pennisi S, Poggio T, Apostolova P, Veratti P, Hettich M, Niedermann G, Bartholomä M, Shoumariyeh K, Jutzi JS, Wehrle J, Dierks C, Becker H, Schmitt-Graeff A, Follo M, Pfeifer D, Rohr J, Fuchs S, Ehl S, Hartl FA, Minguet S, Miething C, Heidel FH, Kröger N, Triviai I, Brummer T, Finke J, Illert AL, Ruggiero E, Bonini C, Duyster J, Pahl HL, Lane SW, Hill GR, Blazar BR, von Bubnoff N, Pearce EL, Zeiser R.

Sci Transl Med. 2018 Feb 21;10(429). pii: eaam7729. doi: 10.1126/scitranslmed.aam7729.

12.

Immunometabolism in 2017: Driving immunity: all roads lead to metabolism.

Pearce EJ, Pearce EL.

Nat Rev Immunol. 2018 Feb;18(2):81-82. doi: 10.1038/nri.2017.139. Epub 2017 Dec 11. No abstract available.

13.

A Sweet Deal for Diabetes.

Villa M, Qiu J, Pearce EL.

Trends Endocrinol Metab. 2018 Jan;29(1):1-2. doi: 10.1016/j.tem.2017.10.006.

PMID:
29102469
14.

Mitochondrial Dynamics at the Interface of Immune Cell Metabolism and Function.

Rambold AS, Pearce EL.

Trends Immunol. 2018 Jan;39(1):6-18. doi: 10.1016/j.it.2017.08.006. Epub 2017 Sep 8. Review.

PMID:
28923365
15.

Mitochondrial Priming by CD28.

Klein Geltink RI, O'Sullivan D, Corrado M, Bremser A, Buck MD, Buescher JM, Firat E, Zhu X, Niedermann G, Caputa G, Kelly B, Warthorst U, Rensing-Ehl A, Kyle RL, Vandersarren L, Curtis JD, Patterson AE, Lawless S, Grzes K, Qiu J, Sanin DE, Kretz O, Huber TB, Janssens S, Lambrecht BN, Rambold AS, Pearce EJ, Pearce EL.

Cell. 2017 Oct 5;171(2):385-397.e11. doi: 10.1016/j.cell.2017.08.018. Epub 2017 Sep 14.

16.

Ancillary Activity: Beyond Core Metabolism in Immune Cells.

Puleston DJ, Villa M, Pearce EL.

Cell Metab. 2017 Jul 5;26(1):131-141. doi: 10.1016/j.cmet.2017.06.019. Review.

17.

Metabolic Instruction of Immunity.

Buck MD, Sowell RT, Kaech SM, Pearce EL.

Cell. 2017 May 4;169(4):570-586. doi: 10.1016/j.cell.2017.04.004. Review.

18.

Caught in the cROSsfire: GSH Controls T Cell Metabolic Reprogramming.

Klein Geltink RI, O'Sullivan D, Pearce EL.

Immunity. 2017 Apr 18;46(4):525-527. doi: 10.1016/j.immuni.2017.03.022.

19.

The Colonic Crypt Protects Stem Cells from Microbiota-Derived Metabolites.

Kaiko GE, Ryu SH, Koues OI, Collins PL, Solnica-Krezel L, Pearce EJ, Pearce EL, Oltz EM, Stappenbeck TS.

Cell. 2016 Nov 3;167(4):1137. doi: 10.1016/j.cell.2016.10.034. No abstract available.

20.

Metabolic Reprogramming Mediated by the mTORC2-IRF4 Signaling Axis Is Essential for Macrophage Alternative Activation.

Huang SC, Smith AM, Everts B, Colonna M, Pearce EL, Schilling JD, Pearce EJ.

Immunity. 2016 Oct 18;45(4):817-830. doi: 10.1016/j.immuni.2016.09.016.

21.

When Hexokinase Gets that NAG-ing Feeling….

O'Sullivan D, Kelly B, Pearce EL.

Cell Metab. 2016 Aug 9;24(2):198-200. doi: 10.1016/j.cmet.2016.07.021.

22.

Mitochondrial Pyruvate Import Promotes Long-Term Survival of Antibody-Secreting Plasma Cells.

Lam WY, Becker AM, Kennerly KM, Wong R, Curtis JD, Llufrio EM, McCommis KS, Fahrmann J, Pizzato HA, Nunley RM, Lee J, Wolfgang MJ, Patti GJ, Finck BN, Pearce EL, Bhattacharya D.

Immunity. 2016 Jul 19;45(1):60-73. doi: 10.1016/j.immuni.2016.06.011. Epub 2016 Jul 5.

23.

Type 1 Interferons Induce Changes in Core Metabolism that Are Critical for Immune Function.

Wu D, Sanin DE, Everts B, Chen Q, Qiu J, Buck MD, Patterson A, Smith AM, Chang CH, Liu Z, Artyomov MN, Pearce EL, Cella M, Pearce EJ.

Immunity. 2016 Jun 21;44(6):1325-36. doi: 10.1016/j.immuni.2016.06.006.

24.

Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming.

Buck MD, O'Sullivan D, Klein Geltink RI, Curtis JD, Chang CH, Sanin DE, Qiu J, Kretz O, Braas D, van der Windt GJ, Chen Q, Huang SC, O'Neill CM, Edelson BT, Pearce EJ, Sesaki H, Huber TB, Rambold AS, Pearce EL.

Cell. 2016 Jun 30;166(1):63-76. doi: 10.1016/j.cell.2016.05.035. Epub 2016 Jun 9.

25.

The Colonic Crypt Protects Stem Cells from Microbiota-Derived Metabolites.

Kaiko GE, Ryu SH, Koues OI, Collins PL, Solnica-Krezel L, Pearce EJ, Pearce EL, Oltz EM, Stappenbeck TS.

Cell. 2016 Jun 16;165(7):1708-1720. doi: 10.1016/j.cell.2016.05.018. Epub 2016 Jun 2. Erratum in: Cell. 2016 Nov 3;167(4):1137.

26.

Arginase 1 is an innate lymphoid-cell-intrinsic metabolic checkpoint controlling type 2 inflammation.

Monticelli LA, Buck MD, Flamar AL, Saenz SA, Tait Wojno ED, Yudanin NA, Osborne LC, Hepworth MR, Tran SV, Rodewald HR, Shah H, Cross JR, Diamond JM, Cantu E, Christie JD, Pearce EL, Artis D.

Nat Immunol. 2016 Jun;17(6):656-65. doi: 10.1038/ni.3421. Epub 2016 Apr 4.

27.

Measuring Bioenergetics in T Cells Using a Seahorse Extracellular Flux Analyzer.

van der Windt GJ, Chang CH, Pearce EL.

Curr Protoc Immunol. 2016 Apr 1;113:3.16B.1-3.16B.14. doi: 10.1002/0471142735.im0316bs113.

28.

Emerging concepts of T cell metabolism as a target of immunotherapy.

Chang CH, Pearce EL.

Nat Immunol. 2016 Apr;17(4):364-8. doi: 10.1038/ni.3415.

29.

Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression.

Chang CH, Qiu J, O'Sullivan D, Buck MD, Noguchi T, Curtis JD, Chen Q, Gindin M, Gubin MM, van der Windt GJ, Tonc E, Schreiber RD, Pearce EJ, Pearce EL.

Cell. 2015 Sep 10;162(6):1229-41. doi: 10.1016/j.cell.2015.08.016. Epub 2015 Aug 27.

30.

T cell metabolism drives immunity.

Buck MD, O'Sullivan D, Pearce EL.

J Exp Med. 2015 Aug 24;212(9):1345-60. doi: 10.1084/jem.20151159. Epub 2015 Aug 10. Review.

31.

Immunology. Expanding the role of metabolism in T cells.

O'Sullivan D, Pearce EL.

Science. 2015 May 29;348(6238):976-7. doi: 10.1126/science.aac4997. No abstract available.

PMID:
26023125
32.

The energy sensor AMPK regulates T cell metabolic adaptation and effector responses in vivo.

Blagih J, Coulombe F, Vincent EE, Dupuy F, Galicia-Vázquez G, Yurchenko E, Raissi TC, van der Windt GJ, Viollet B, Pearce EL, Pelletier J, Piccirillo CA, Krawczyk CM, Divangahi M, Jones RG.

Immunity. 2015 Jan 20;42(1):41-54. doi: 10.1016/j.immuni.2014.12.030. Epub 2015 Jan 2.

33.

Targeting T cell metabolism for therapy.

O'Sullivan D, Pearce EL.

Trends Immunol. 2015 Feb;36(2):71-80. doi: 10.1016/j.it.2014.12.004. Epub 2015 Jan 15. Review.

34.

Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens.

Gubin MM, Zhang X, Schuster H, Caron E, Ward JP, Noguchi T, Ivanova Y, Hundal J, Arthur CD, Krebber WJ, Mulder GE, Toebes M, Vesely MD, Lam SS, Korman AJ, Allison JP, Freeman GJ, Sharpe AH, Pearce EL, Schumacher TN, Aebersold R, Rammensee HG, Melief CJ, Mardis ER, Gillanders WE, Artyomov MN, Schreiber RD.

Nature. 2014 Nov 27;515(7528):577-81. doi: 10.1038/nature13988.

35.

Fatty acid synthesis tips the TH17-Treg cell balance.

O'Sullivan D, Pearce EL.

Nat Med. 2014 Nov;20(11):1235-6. doi: 10.1038/nm.3744. No abstract available.

PMID:
25375921
36.

Autophagy is essential for effector CD8(+) T cell survival and memory formation.

Xu X, Araki K, Li S, Han JH, Ye L, Tan WG, Konieczny BT, Bruinsma MW, Martinez J, Pearce EL, Green DR, Jones DP, Virgin HW, Ahmed R.

Nat Immunol. 2014 Dec;15(12):1152-61. doi: 10.1038/ni.3025. Epub 2014 Nov 2.

37.

IL-18 synergizes with IL-7 to drive slow proliferation of naive CD8 T cells by costimulating self-peptide-mediated TCR signals.

Walsh MC, Pearce EL, Cejas PJ, Lee J, Wang LS, Choi Y.

J Immunol. 2014 Oct 15;193(8):3992-4001. doi: 10.4049/jimmunol.1400396. Epub 2014 Sep 8.

38.

Mechanistic target of rapamycin inhibition extends cellular lifespan in dendritic cells by preserving mitochondrial function.

Amiel E, Everts B, Fritz D, Beauchamp S, Ge B, Pearce EL, Pearce EJ.

J Immunol. 2014 Sep 15;193(6):2821-30. doi: 10.4049/jimmunol.1302498. Epub 2014 Aug 8.

39.

Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages.

Huang SC, Everts B, Ivanova Y, O'Sullivan D, Nascimento M, Smith AM, Beatty W, Love-Gregory L, Lam WY, O'Neill CM, Yan C, Du H, Abumrad NA, Urban JF Jr, Artyomov MN, Pearce EL, Pearce EJ.

Nat Immunol. 2014 Sep;15(9):846-55. doi: 10.1038/ni.2956. Epub 2014 Aug 3.

40.

c-Myc-induced transcription factor AP4 is required for host protection mediated by CD8+ T cells.

Chou C, Pinto AK, Curtis JD, Persaud SP, Cella M, Lin CC, Edelson BT, Allen PM, Colonna M, Pearce EL, Diamond MS, Egawa T.

Nat Immunol. 2014 Sep;15(9):884-93. doi: 10.1038/ni.2943. Epub 2014 Jul 13.

41.

Memory CD8(+) T cells use cell-intrinsic lipolysis to support the metabolic programming necessary for development.

O'Sullivan D, van der Windt GJ, Huang SC, Curtis JD, Chang CH, Buck MD, Qiu J, Smith AM, Lam WY, DiPlato LM, Hsu FF, Birnbaum MJ, Pearce EJ, Pearce EL.

Immunity. 2014 Jul 17;41(1):75-88. doi: 10.1016/j.immuni.2014.06.005. Epub 2014 Jul 4. Erratum in: Immunity. 2018 Aug 21;49(2):375-376.

42.

TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKɛ supports the anabolic demands of dendritic cell activation.

Everts B, Amiel E, Huang SC, Smith AM, Chang CH, Lam WY, Redmann V, Freitas TC, Blagih J, van der Windt GJ, Artyomov MN, Jones RG, Pearce EL, Pearce EJ.

Nat Immunol. 2014 Apr;15(4):323-32. doi: 10.1038/ni.2833. Epub 2014 Feb 23.

43.

Fueling immunity: insights into metabolism and lymphocyte function.

Pearce EL, Poffenberger MC, Chang CH, Jones RG.

Science. 2013 Oct 11;342(6155):1242454. doi: 10.1126/science.1242454. Review.

44.

CD8 memory T cells have a bioenergetic advantage that underlies their rapid recall ability.

van der Windt GJ, O'Sullivan D, Everts B, Huang SC, Buck MD, Curtis JD, Chang CH, Smith AM, Ai T, Faubert B, Jones RG, Pearce EJ, Pearce EL.

Proc Natl Acad Sci U S A. 2013 Aug 27;110(35):14336-41. doi: 10.1073/pnas.1221740110. Epub 2013 Aug 12.

45.

Posttranscriptional control of T cell effector function by aerobic glycolysis.

Chang CH, Curtis JD, Maggi LB Jr, Faubert B, Villarino AV, O'Sullivan D, Huang SC, van der Windt GJ, Blagih J, Qiu J, Weber JD, Pearce EJ, Jones RG, Pearce EL.

Cell. 2013 Jun 6;153(6):1239-51. doi: 10.1016/j.cell.2013.05.016.

46.

Metabolic pathways in immune cell activation and quiescence.

Pearce EL, Pearce EJ.

Immunity. 2013 Apr 18;38(4):633-43. doi: 10.1016/j.immuni.2013.04.005. Review.

47.

Fatty acid oxidation is essential for egg production by the parasitic flatworm Schistosoma mansoni.

Huang SC, Freitas TC, Amiel E, Everts B, Pearce EL, Lok JB, Pearce EJ.

PLoS Pathog. 2012;8(10):e1002996. doi: 10.1371/journal.ppat.1002996. Epub 2012 Oct 25.

48.

Metabolic switching and fuel choice during T-cell differentiation and memory development.

van der Windt GJ, Pearce EL.

Immunol Rev. 2012 Sep;249(1):27-42. doi: 10.1111/j.1600-065X.2012.01150.x. Review.

49.

Inhibition of mechanistic target of rapamycin promotes dendritic cell activation and enhances therapeutic autologous vaccination in mice.

Amiel E, Everts B, Freitas TC, King IL, Curtis JD, Pearce EL, Pearce EJ.

J Immunol. 2012 Sep 1;189(5):2151-8. doi: 10.4049/jimmunol.1103741. Epub 2012 Jul 23.

50.

Commitment to glycolysis sustains survival of NO-producing inflammatory dendritic cells.

Everts B, Amiel E, van der Windt GJ, Freitas TC, Chott R, Yarasheski KE, Pearce EL, Pearce EJ.

Blood. 2012 Aug 16;120(7):1422-31. doi: 10.1182/blood-2012-03-419747. Epub 2012 Jul 11.

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