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Items: 1 to 50 of 199

1.

Metabolic adaptations of tissue-resident immune cells.

Caputa G, Castoldi A, Pearce EJ.

Nat Immunol. 2019 Jul;20(7):793-801. doi: 10.1038/s41590-019-0407-0. Epub 2019 Jun 18. Review.

PMID:
31213715
2.

Polyamines and eIF5A Hypusination Modulate Mitochondrial Respiration and Macrophage Activation.

Puleston DJ, Buck MD, Klein Geltink RI, Kyle RL, Caputa G, O'Sullivan D, Cameron AM, Castoldi A, Musa Y, Kabat AM, Zhang Y, Flachsmann LJ, Field CS, Patterson AE, Scherer S, Alfei F, Baixauli F, Austin SK, Kelly B, Matsushita M, Curtis JD, Grzes KM, Villa M, Corrado M, Sanin DE, Qiu J, Pällman N, Paz K, Maccari ME, Blazar BR, Mittler G, Buescher JM, Zehn D, Rospert S, Pearce EJ, Balabanov S, Pearce EL.

Cell Metab. 2019 Aug 6;30(2):352-363.e8. doi: 10.1016/j.cmet.2019.05.003. Epub 2019 May 23.

3.

Acetate Promotes T Cell Effector Function during Glucose Restriction.

Qiu J, Villa M, Sanin DE, Buck MD, O'Sullivan D, Ching R, Matsushita M, Grzes KM, Winkler F, Chang CH, Curtis JD, Kyle RL, Van Teijlingen Bakker N, Corrado M, Haessler F, Alfei F, Edwards-Hicks J, Maggi LB Jr, Zehn D, Egawa T, Bengsch B, Klein Geltink RI, Jenuwein T, Pearce EJ, Pearce EL.

Cell Rep. 2019 May 14;27(7):2063-2074.e5. doi: 10.1016/j.celrep.2019.04.022.

4.

Inflammatory macrophage dependence on NAD+ salvage is a consequence of reactive oxygen species-mediated DNA damage.

Cameron AM, Castoldi A, Sanin DE, Flachsmann LJ, Field CS, Puleston DJ, Kyle RL, Patterson AE, Hässler F, Buescher JM, Kelly B, Pearce EL, Pearce EJ.

Nat Immunol. 2019 Apr;20(4):420-432. doi: 10.1038/s41590-019-0336-y. Epub 2019 Mar 11.

PMID:
30858618
5.

Metabolic interventions in the immune response to cancer.

O'Sullivan D, Sanin DE, Pearce EJ, Pearce EL.

Nat Rev Immunol. 2019 May;19(5):324-335. doi: 10.1038/s41577-019-0140-9. Review.

PMID:
30820043
6.

Mitochondrial Membrane Potential Regulates Nuclear Gene Expression in Macrophages Exposed to Prostaglandin E2.

Sanin DE, Matsushita M, Klein Geltink RI, Grzes KM, van Teijlingen Bakker N, Corrado M, Kabat AM, Buck MD, Qiu J, Lawless SJ, Cameron AM, Villa M, Baixauli F, Patterson AE, Hässler F, Curtis JD, O'Neill CM, O'Sullivan D, Wu D, Mittler G, Huang SC, Pearce EL, Pearce EJ.

Immunity. 2018 Dec 18;49(6):1021-1033.e6. doi: 10.1016/j.immuni.2018.10.011.

PMID:
30566880
7.

Schistosoma mansoni Infection-Induced Transcriptional Changes in Hepatic Macrophage Metabolism Correlate With an Athero-Protective Phenotype.

Cortes-Selva D, Elvington AF, Ready A, Rajwa B, Pearce EJ, Randolph GJ, Fairfax KC.

Front Immunol. 2018 Nov 12;9:2580. doi: 10.3389/fimmu.2018.02580. eCollection 2018.

8.

Memory CD8+ T Cells Use Cell-Intrinsic Lipolysis to Support the Metabolic Programming Necessary for Development.

O'Sullivan D, van der Windt GJW, Huang SC, Curtis JD, Chang CH, Buck MD, Qiu J, Smith AM, Lam WY, DiPlato LM, Hsu FF, Birnbaum MJ, Pearce EJ, Pearce EL.

Immunity. 2018 Aug 21;49(2):375-376. doi: 10.1016/j.immuni.2018.07.018. No abstract available.

9.

Disrupting metabolism to treat autoimmunity.

Matsushita M, Pearce EJ.

Science. 2018 Apr 27;360(6387):377-378. doi: 10.1126/science.aat4984. No abstract available.

PMID:
29700251
10.

Immunometabolism in 2017: Driving immunity: all roads lead to metabolism.

Pearce EJ, Pearce EL.

Nat Rev Immunol. 2018 Feb;18(2):81-82. doi: 10.1038/nri.2017.139. Epub 2017 Dec 11. No abstract available.

11.

Mitochondrial Priming by CD28.

Klein Geltink RI, O'Sullivan D, Corrado M, Bremser A, Buck MD, Buescher JM, Firat E, Zhu X, Niedermann G, Caputa G, Kelly B, Warthorst U, Rensing-Ehl A, Kyle RL, Vandersarren L, Curtis JD, Patterson AE, Lawless S, Grzes K, Qiu J, Sanin DE, Kretz O, Huber TB, Janssens S, Lambrecht BN, Rambold AS, Pearce EJ, Pearce EL.

Cell. 2017 Oct 5;171(2):385-397.e11. doi: 10.1016/j.cell.2017.08.018. Epub 2017 Sep 14.

12.

Treg Cells Survive and Thrive in Inhospitable Environments.

Grzes KM, Field CS, Pearce EJ.

Cell Metab. 2017 Jun 6;25(6):1213-1215. doi: 10.1016/j.cmet.2017.05.012.

13.

MenTORing Immunity: mTOR Signaling in the Development and Function of Tissue-Resident Immune Cells.

Jones RG, Pearce EJ.

Immunity. 2017 May 16;46(5):730-742. doi: 10.1016/j.immuni.2017.04.028. Review.

14.

Inflammation by way of macrophage metabolism.

Kabat AM, Pearce EJ.

Science. 2017 May 5;356(6337):488-489. doi: 10.1126/science.aan2691. No abstract available.

PMID:
28473549
15.

Metabolism and acetylation in innate immune cell function and fate.

Cameron AM, Lawless SJ, Pearce EJ.

Semin Immunol. 2016 Oct;28(5):408-416. doi: 10.1016/j.smim.2016.10.003. Epub 2016 Oct 27. Review.

PMID:
28340958
16.

The Colonic Crypt Protects Stem Cells from Microbiota-Derived Metabolites.

Kaiko GE, Ryu SH, Koues OI, Collins PL, Solnica-Krezel L, Pearce EJ, Pearce EL, Oltz EM, Stappenbeck TS.

Cell. 2016 Nov 3;167(4):1137. doi: 10.1016/j.cell.2016.10.034. No abstract available.

17.

Metabolic Reprogramming Mediated by the mTORC2-IRF4 Signaling Axis Is Essential for Macrophage Alternative Activation.

Huang SC, Smith AM, Everts B, Colonna M, Pearce EL, Schilling JD, Pearce EJ.

Immunity. 2016 Oct 18;45(4):817-830. doi: 10.1016/j.immuni.2016.09.016.

18.

The Transcriptional Repressor Polycomb Group Factor 6, PCGF6, Negatively Regulates Dendritic Cell Activation and Promotes Quiescence.

Boukhaled GM, Cordeiro B, Deblois G, Dimitrov V, Bailey SD, Holowka T, Domi A, Guak H, Chiu HH, Everts B, Pearce EJ, Lupien M, White JH, Krawczyk CM.

Cell Rep. 2016 Aug 16;16(7):1829-37. doi: 10.1016/j.celrep.2016.07.026. Epub 2016 Aug 4.

19.

TPL-2 Regulates Macrophage Lipid Metabolism and M2 Differentiation to Control TH2-Mediated Immunopathology.

Kannan Y, Perez-Lloret J, Li Y, Entwistle LJ, Khoury H, Papoutsopoulou S, Mahmood R, Mansour NR, Ching-Cheng Huang S, Pearce EJ, Pedro S de Carvalho L, Ley SC, Wilson MS.

PLoS Pathog. 2016 Aug 3;12(8):e1005783. doi: 10.1371/journal.ppat.1005783. eCollection 2016 Aug.

20.

Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation.

Lampropoulou V, Sergushichev A, Bambouskova M, Nair S, Vincent EE, Loginicheva E, Cervantes-Barragan L, Ma X, Huang SC, Griss T, Weinheimer CJ, Khader S, Randolph GJ, Pearce EJ, Jones RG, Diwan A, Diamond MS, Artyomov MN.

Cell Metab. 2016 Jul 12;24(1):158-66. doi: 10.1016/j.cmet.2016.06.004. Epub 2016 Jun 30.

21.

Type 1 Interferons Induce Changes in Core Metabolism that Are Critical for Immune Function.

Wu D, Sanin DE, Everts B, Chen Q, Qiu J, Buck MD, Patterson A, Smith AM, Chang CH, Liu Z, Artyomov MN, Pearce EL, Cella M, Pearce EJ.

Immunity. 2016 Jun 21;44(6):1325-36. doi: 10.1016/j.immuni.2016.06.006.

22.

Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming.

Buck MD, O'Sullivan D, Klein Geltink RI, Curtis JD, Chang CH, Sanin DE, Qiu J, Kretz O, Braas D, van der Windt GJ, Chen Q, Huang SC, O'Neill CM, Edelson BT, Pearce EJ, Sesaki H, Huber TB, Rambold AS, Pearce EL.

Cell. 2016 Jun 30;166(1):63-76. doi: 10.1016/j.cell.2016.05.035. Epub 2016 Jun 9.

23.

The Colonic Crypt Protects Stem Cells from Microbiota-Derived Metabolites.

Kaiko GE, Ryu SH, Koues OI, Collins PL, Solnica-Krezel L, Pearce EJ, Pearce EL, Oltz EM, Stappenbeck TS.

Cell. 2016 Jun 16;165(7):1708-1720. doi: 10.1016/j.cell.2016.05.018. Epub 2016 Jun 2. Erratum in: Cell. 2016 Nov 3;167(4):1137.

24.

GAM: a web-service for integrated transcriptional and metabolic network analysis.

Sergushichev AA, Loboda AA, Jha AK, Vincent EE, Driggers EM, Jones RG, Pearce EJ, Artyomov MN.

Nucleic Acids Res. 2016 Jul 8;44(W1):W194-200. doi: 10.1093/nar/gkw266. Epub 2016 Apr 20.

25.

Migratory CD103+ dendritic cells suppress helminth-driven type 2 immunity through constitutive expression of IL-12.

Everts B, Tussiwand R, Dreesen L, Fairfax KC, Huang SC, Smith AM, O'Neill CM, Lam WY, Edelson BT, Urban JF Jr, Murphy KM, Pearce EJ.

J Exp Med. 2016 Jan 11;213(1):35-51. doi: 10.1084/jem.20150235. Epub 2015 Dec 28.

26.

Immunometabolism governs dendritic cell and macrophage function.

O'Neill LA, Pearce EJ.

J Exp Med. 2016 Jan 11;213(1):15-23. doi: 10.1084/jem.20151570. Epub 2015 Dec 22. Review.

27.

The cell identity of cytotoxic T lymphocytes.

Sanin DE, Pearce EJ.

Nat Immunol. 2016 Jan;17(1):45-6. doi: 10.1038/ni.3350. No abstract available.

PMID:
26681463
28.

Helminth-induced arginase-1 exacerbates lung inflammation and disease severity in tuberculosis.

Monin L, Griffiths KL, Lam WY, Gopal R, Kang DD, Ahmed M, Rajamanickam A, Cruz-Lagunas A, Zúñiga J, Babu S, Kolls JK, Mitreva M, Rosa BA, Ramos-Payan R, Morrison TE, Murray PJ, Rangel-Moreno J, Pearce EJ, Khader SA.

J Clin Invest. 2015 Dec;125(12):4699-713. doi: 10.1172/JCI77378. Epub 2015 Nov 16.

29.

Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression.

Chang CH, Qiu J, O'Sullivan D, Buck MD, Noguchi T, Curtis JD, Chen Q, Gindin M, Gubin MM, van der Windt GJ, Tonc E, Schreiber RD, Pearce EJ, Pearce EL.

Cell. 2015 Sep 10;162(6):1229-41. doi: 10.1016/j.cell.2015.08.016. Epub 2015 Aug 27.

30.

Klf4 expression in conventional dendritic cells is required for T helper 2 cell responses.

Tussiwand R, Everts B, Grajales-Reyes GE, Kretzer NM, Iwata A, Bagaitkar J, Wu X, Wong R, Anderson DA, Murphy TL, Pearce EJ, Murphy KM.

Immunity. 2015 May 19;42(5):916-28. doi: 10.1016/j.immuni.2015.04.017.

31.

The metabolic control of schistosome egg production.

Pearce EJ, Huang SC.

Cell Microbiol. 2015 Jun;17(6):796-801. doi: 10.1111/cmi.12444. Epub 2015 Apr 30. Review.

32.

Network integration of parallel metabolic and transcriptional data reveals metabolic modules that regulate macrophage polarization.

Jha AK, Huang SC, Sergushichev A, Lampropoulou V, Ivanova Y, Loginicheva E, Chmielewski K, Stewart KM, Ashall J, Everts B, Pearce EJ, Driggers EM, Artyomov MN.

Immunity. 2015 Mar 17;42(3):419-30. doi: 10.1016/j.immuni.2015.02.005.

33.

IL-4-secreting secondary T follicular helper (Tfh) cells arise from memory T cells, not persisting Tfh cells, through a B cell-dependent mechanism.

Fairfax KC, Everts B, Amiel E, Smith AM, Schramm G, Haas H, Randolph GJ, Taylor JJ, Pearce EJ.

J Immunol. 2015 Apr 1;194(7):2999-3010. doi: 10.4049/jimmunol.1401225. Epub 2015 Feb 23.

34.

Dendritic cell metabolism.

Pearce EJ, Everts B.

Nat Rev Immunol. 2015 Jan;15(1):18-29. doi: 10.1038/nri3771. Review.

35.

For macrophages, Ndufs is enough.

Huang SC, Pearce EJ.

Immunity. 2014 Sep 18;41(3):351-353. doi: 10.1016/j.immuni.2014.09.004.

PMID:
25238092
36.

Ly6Chi monocyte recruitment is responsible for Th2 associated host-protective macrophage accumulation in liver inflammation due to schistosomiasis.

Nascimento M, Huang SC, Smith A, Everts B, Lam W, Bassity E, Gautier EL, Randolph GJ, Pearce EJ.

PLoS Pathog. 2014 Aug 21;10(8):e1004282. doi: 10.1371/journal.ppat.1004282. eCollection 2014 Aug.

37.

Mechanistic target of rapamycin inhibition extends cellular lifespan in dendritic cells by preserving mitochondrial function.

Amiel E, Everts B, Fritz D, Beauchamp S, Ge B, Pearce EL, Pearce EJ.

J Immunol. 2014 Sep 15;193(6):2821-30. doi: 10.4049/jimmunol.1302498. Epub 2014 Aug 8.

38.

Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages.

Huang SC, Everts B, Ivanova Y, O'Sullivan D, Nascimento M, Smith AM, Beatty W, Love-Gregory L, Lam WY, O'Neill CM, Yan C, Du H, Abumrad NA, Urban JF Jr, Artyomov MN, Pearce EL, Pearce EJ.

Nat Immunol. 2014 Sep;15(9):846-55. doi: 10.1038/ni.2956. Epub 2014 Aug 3.

39.

Gata6 regulates aspartoacylase expression in resident peritoneal macrophages and controls their survival.

Gautier EL, Ivanov S, Williams JW, Huang SC, Marcelin G, Fairfax K, Wang PL, Francis JS, Leone P, Wilson DB, Artyomov MN, Pearce EJ, Randolph GJ.

J Exp Med. 2014 Jul 28;211(8):1525-31. doi: 10.1084/jem.20140570. Epub 2014 Jul 14.

40.

Memory CD8(+) T cells use cell-intrinsic lipolysis to support the metabolic programming necessary for development.

O'Sullivan D, van der Windt GJ, Huang SC, Curtis JD, Chang CH, Buck MD, Qiu J, Smith AM, Lam WY, DiPlato LM, Hsu FF, Birnbaum MJ, Pearce EJ, Pearce EL.

Immunity. 2014 Jul 17;41(1):75-88. doi: 10.1016/j.immuni.2014.06.005. Epub 2014 Jul 4. Erratum in: Immunity. 2018 Aug 21;49(2):375-376.

41.

Helminth infection reactivates latent γ-herpesvirus via cytokine competition at a viral promoter.

Reese TA, Wakeman BS, Choi HS, Hufford MM, Huang SC, Zhang X, Buck MD, Jezewski A, Kambal A, Liu CY, Goel G, Murray PJ, Xavier RJ, Kaplan MH, Renne R, Speck SH, Artyomov MN, Pearce EJ, Virgin HW.

Science. 2014 Aug 1;345(6196):573-7. doi: 10.1126/science.1254517. Epub 2014 Jun 26.

42.

Metabolic control of dendritic cell activation and function: recent advances and clinical implications.

Everts B, Pearce EJ.

Front Immunol. 2014 May 8;5:203. doi: 10.3389/fimmu.2014.00203. eCollection 2014. Review.

43.

TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKɛ supports the anabolic demands of dendritic cell activation.

Everts B, Amiel E, Huang SC, Smith AM, Chang CH, Lam WY, Redmann V, Freitas TC, Blagih J, van der Windt GJ, Artyomov MN, Jones RG, Pearce EL, Pearce EJ.

Nat Immunol. 2014 Apr;15(4):323-32. doi: 10.1038/ni.2833. Epub 2014 Feb 23.

44.

Regulation of the development of the hepatic B cell compartment during Schistosoma mansoni infection.

Fairfax KC, Everts B, Smith AM, Pearce EJ.

J Immunol. 2013 Oct 15;191(8):4202-10. doi: 10.4049/jimmunol.1301357. Epub 2013 Sep 13.

45.

CD8 memory T cells have a bioenergetic advantage that underlies their rapid recall ability.

van der Windt GJ, O'Sullivan D, Everts B, Huang SC, Buck MD, Curtis JD, Chang CH, Smith AM, Ai T, Faubert B, Jones RG, Pearce EJ, Pearce EL.

Proc Natl Acad Sci U S A. 2013 Aug 27;110(35):14336-41. doi: 10.1073/pnas.1221740110. Epub 2013 Aug 12.

46.

Discovery of anthelmintic drug targets and drugs using chokepoints in nematode metabolic pathways.

Taylor CM, Wang Q, Rosa BA, Huang SC, Powell K, Schedl T, Pearce EJ, Abubucker S, Mitreva M.

PLoS Pathog. 2013;9(8):e1003505. doi: 10.1371/journal.ppat.1003505. Epub 2013 Aug 1.

47.

Imaging trematode and nematode parasites.

Pearce EJ, Lok JB.

Parasite Immunol. 2013 Sep-Oct;35(9-10):248-55. doi: 10.1111/pim.12051. Review.

48.

Posttranscriptional control of T cell effector function by aerobic glycolysis.

Chang CH, Curtis JD, Maggi LB Jr, Faubert B, Villarino AV, O'Sullivan D, Huang SC, van der Windt GJ, Blagih J, Qiu J, Weber JD, Pearce EJ, Jones RG, Pearce EL.

Cell. 2013 Jun 6;153(6):1239-51. doi: 10.1016/j.cell.2013.05.016.

49.

Metabolic pathways in immune cell activation and quiescence.

Pearce EL, Pearce EJ.

Immunity. 2013 Apr 18;38(4):633-43. doi: 10.1016/j.immuni.2013.04.005. Review.

50.

Parasitology: Rejuvenation through stem cells.

Pearce EJ.

Nature. 2013 Feb 28;494(7438):438-9. doi: 10.1038/nature11953. Epub 2013 Feb 20. No abstract available.

PMID:
23426259

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