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Biogeographical patterns in soil bacterial communities across the Arctic region.

Malard LA, Anwar MZ, Jacobsen CS, Pearce DA.

FEMS Microbiol Ecol. 2019 Aug 20. pii: fiz128. doi: 10.1093/femsec/fiz128. [Epub ahead of print]


Microbial community drivers of PK/NRP gene diversity in selected global soils.

Borsetto C, Amos GCA, da Rocha UN, Mitchell AL, Finn RD, Laidi RF, Vallin C, Pearce DA, Newsham KK, Wellington EMH.

Microbiome. 2019 May 22;7(1):78. doi: 10.1186/s40168-019-0692-8.


Spatial Variability of Antarctic Surface Snow Bacterial Communities.

Malard LA, Šabacká M, Magiopoulos I, Mowlem M, Hodson A, Tranter M, Siegert MJ, Pearce DA.

Front Microbiol. 2019 Mar 26;10:461. doi: 10.3389/fmicb.2019.00461. eCollection 2019.


Therapeutic landscape for Batten disease: current treatments and future prospects.

Johnson TB, Cain JT, White KA, Ramirez-Montealegre D, Pearce DA, Weimer JM.

Nat Rev Neurol. 2019 Mar;15(3):161-178. doi: 10.1038/s41582-019-0138-8. Review.


Molecular changes during extended neoadjuvant letrozole treatment of breast cancer: distinguishing acquired resistance from dormant tumours.

Selli C, Turnbull AK, Pearce DA, Li A, Fernando A, Wills J, Renshaw L, Thomas JS, Dixon JM, Sims AH.

Breast Cancer Res. 2019 Jan 7;21(1):2. doi: 10.1186/s13058-018-1089-5.


Characterization of a novel N-acylhomoserine lactonase, AidP, from Antarctic Planococcus sp.

See-Too WS, Convey P, Pearce DA, Chan KG.

Microb Cell Fact. 2018 Nov 17;17(1):179. doi: 10.1186/s12934-018-1024-6.


Searching for novel biomarkers using a mouse model of CLN3-Batten disease.

Timm D, Cain JT, Geraets RD, White KA, Koh SY, Kielian T, Pearce DA, Hastings ML, Weimer JM.

PLoS One. 2018 Aug 7;13(8):e0201470. doi: 10.1371/journal.pone.0201470. eCollection 2018.


Microbial diversity and biogeography in Arctic soils.

Malard LA, Pearce DA.

Environ Microbiol Rep. 2018 Dec;10(6):611-625. doi: 10.1111/1758-2229.12680. Epub 2018 Aug 20. Review.


Toxic Cyanobacteria in Svalbard: Chemical Diversity of Microcystins Detected Using a Liquid Chromatography Mass Spectrometry Precursor Ion Screening Method.

Kleinteich J, Puddick J, Wood SA, Hildebrand F, Laughinghouse HD IV, Pearce DA, Dietrich DR, Wilmotte A.

Toxins (Basel). 2018 Apr 3;10(4). pii: E147. doi: 10.3390/toxins10040147.


Microbial metabolism directly affects trace gases in (sub) polar snowpacks.

Redeker KR, Chong JPJ, Aguion A, Hodson A, Pearce DA.

J R Soc Interface. 2017 Dec;14(137). pii: 20170729. doi: 10.1098/rsif.2017.0729.


Defective synaptic transmission causes disease signs in a mouse model of juvenile neuronal ceroid lipofuscinosis.

Grünewald B, Lange MD, Werner C, O'Leary A, Weishaupt A, Popp S, Pearce DA, Wiendl H, Reif A, Pape HC, Toyka KV, Sommer C, Geis C.

Elife. 2017 Nov 14;6. pii: e28685. doi: 10.7554/eLife.28685.


Lack of specificity of antibodies raised against CLN3, the lysosomal/endosomal transmembrane protein mutated in juvenile Batten disease.

Nelson T, Pearce DA, Kovács AD.

Biosci Rep. 2017 Nov 23;37(6). pii: BSR20171229. doi: 10.1042/BSR20171229. Print 2017 Dec 22.


Complete genome of Arthrobacter alpinus strain R3.8, bioremediation potential unraveled with genomic analysis.

See-Too WS, Ee R, Lim YL, Convey P, Pearce DA, Mohidin TBM, Yin WF, Chan KG.

Stand Genomic Sci. 2017 Sep 6;12:52. doi: 10.1186/s40793-017-0264-0. eCollection 2017.


Extenuating Circumstances: Data Sharing: Leading Data-Driven Population Health.

Griese ER, Hsu BS, Pearce DA.

S D Med. 2017 Aug;70(8):374-375. No abstract available.


Pharmacological Effects on Ceroid Lipofuscin and Neuronal Structure in Cln3 ∆ex7/8 Mouse Brain Cultures.

Brenneman DE, Pearce DA, Kovacs A, DeFrees S.

J Mol Neurosci. 2017 Sep;63(1):100-114. doi: 10.1007/s12031-017-0962-5. Epub 2017 Aug 15.


Genetic ataxia telangiectasia porcine model phenocopies the multisystemic features of the human disease.

Beraldi R, Meyerholz DK, Savinov A, Kovács AD, Weimer JM, Dykstra JA, Geraets RD, Pearce DA.

Biochim Biophys Acta Mol Basis Dis. 2017 Nov;1863(11):2862-2870. doi: 10.1016/j.bbadis.2017.07.020. Epub 2017 Jul 23.


Detailed Clinical Phenotype and Molecular Genetic Findings in CLN3-Associated Isolated Retinal Degeneration.

Ku CA, Hull S, Arno G, Vincent A, Carss K, Kayton R, Weeks D, Anderson GW, Geraets R, Parker C, Pearce DA, Michaelides M, MacLaren RE, Robson AG, Holder GE, Heon E, Raymond FL, Moore AT, Webster AR, Pennesi ME.

JAMA Ophthalmol. 2017 Jul 1;135(7):749-760. doi: 10.1001/jamaophthalmol.2017.1401.


Characterisation of Arctic Bacterial Communities in the Air above Svalbard.

Cuthbertson L, Amores-Arrocha H, Malard LA, Els N, Sattler B, Pearce DA.

Biology (Basel). 2017 May 6;6(2). pii: E29. doi: 10.3390/biology6020029.


A tailored mouse model of CLN2 disease: A nonsense mutant for testing personalized therapies.

Geraets RD, Langin LM, Cain JT, Parker CM, Beraldi R, Kovacs AD, Weimer JM, Pearce DA.

PLoS One. 2017 May 2;12(5):e0176526. doi: 10.1371/journal.pone.0176526. eCollection 2017.


Role of the Lysosomal Membrane Protein, CLN3, in the Regulation of Cathepsin D Activity.

Cárcel-Trullols J, Kovács AD, Pearce DA.

J Cell Biochem. 2017 Nov;118(11):3883-3890. doi: 10.1002/jcb.26039. Epub 2017 May 23.


AidP, a novel N-Acyl homoserine lactonase gene from Antarctic Planococcus sp.

See-Too WS, Ee R, Lim YL, Convey P, Pearce DA, Yin WF, Chan KG.

Sci Rep. 2017 Feb 22;7:42968. doi: 10.1038/srep42968.


Planococcus versutus sp. nov., isolated from soil.

See-Too WS, Ee R, Madhaiyan M, Kwon SW, Tan JY, Lim YL, Convey P, Pearce DA, Yin WF, Chan KG.

Int J Syst Evol Microbiol. 2017 Apr;67(4):944-950. doi: 10.1099/ijsem.0.001721. Epub 2017 May 5.


Decreased sensitivity of palmitoyl protein thioesterase 1-deficient neurons to chemical anoxia.

Meyer M, Kovács AD, Pearce DA.

Metab Brain Dis. 2017 Feb;32(1):275-279. doi: 10.1007/s11011-016-9919-6. Epub 2016 Oct 8.


Extremophiles in an Antarctic Marine Ecosystem.

Dickinson I, Goodall-Copestake W, Thorne MA, Schlitt T, Ávila-Jiménez ML, Pearce DA.

Microorganisms. 2016 Jan 11;4(1). pii: E8. doi: 10.3390/microorganisms4010008.


Diagnosis of neuronal ceroid lipofuscinosis type 2 (CLN2 disease): Expert recommendations for early detection and laboratory diagnosis.

Fietz M, AlSayed M, Burke D, Cohen-Pfeffer J, Cooper JD, Dvořáková L, Giugliani R, Izzo E, Jahnová H, Lukacs Z, Mole SE, Noher de Halac I, Pearce DA, Poupetova H, Schulz A, Specchio N, Xin W, Miller N.

Mol Genet Metab. 2016 Sep;119(1-2):160-7. doi: 10.1016/j.ymgme.2016.07.011. Epub 2016 Jul 25.


Differential expression of store-operated calcium- and proliferation-related genes in hepatocellular carcinoma cells following TRPC1 ion channel silencing.

Selli C, Pearce DA, Sims AH, Tosun M.

Mol Cell Biochem. 2016 Sep;420(1-2):129-40. doi: 10.1007/s11010-016-2776-0. Epub 2016 Jul 22.


Tumour sampling method can significantly influence gene expression profiles derived from neoadjuvant window studies.

Pearce DA, Arthur LM, Turnbull AK, Renshaw L, Sabine VS, Thomas JS, Bartlett JM, Dixon JM, Sims AH.

Sci Rep. 2016 Jul 7;6:29434. doi: 10.1038/srep29434.


Disruption of a cystine transporter downregulates expression of genes involved in sulfur regulation and cellular respiration.

Simpkins JA, Rickel KE, Madeo M, Ahlers BA, Carlisle GB, Nelson HJ, Cardillo AL, Weber EA, Vitiello PF, Pearce DA, Vitiello SP.

Biol Open. 2016 Jun 15;5(6):689-97. doi: 10.1242/bio.017517.


De novo assembly of complete genome sequence of Planococcus kocurii ATCC 43650(T), a potential plant growth promoting bacterium.

See-Too WS, Tan JY, Ee R, Lim YL, Convey P, Pearce DA, Yin WF, Chan KG.

Mar Genomics. 2016 Aug;28:33-35. doi: 10.1016/j.margen.2016.04.007. Epub 2016 Apr 23.


Antigen presenting cell abnormalities in the Cln3(-/-) mouse model of juvenile neuronal ceroid lipofuscinosis.

Hersrud SL, Kovács AD, Pearce DA.

Biochim Biophys Acta. 2016 Jul;1862(7):1324-36. doi: 10.1016/j.bbadis.2016.04.011. Epub 2016 Apr 19.


Moving towards effective therapeutic strategies for Neuronal Ceroid Lipofuscinosis.

Geraets RD, Koh Sy, Hastings ML, Kielian T, Pearce DA, Weimer JM.

Orphanet J Rare Dis. 2016 Apr 16;11:40. doi: 10.1186/s13023-016-0414-2. Review.


Composition and Interactions among Bacterial, Microeukaryotic, and T4-like Viral Assemblages in Lakes from Both Polar Zones.

Daniel Ade C, Pedrós-Alió C, Pearce DA, Alcamí A.

Front Microbiol. 2016 Mar 18;7:337. doi: 10.3389/fmicb.2016.00337. eCollection 2016.


Aerobiology Over Antarctica - A New Initiative for Atmospheric Ecology.

Pearce DA, Alekhina IA, Terauds A, Wilmotte A, Quesada A, Edwards A, Dommergue A, Sattler B, Adams BJ, Magalhães C, Chu WL, Lau MC, Cary C, Smith DJ, Wall DH, Eguren G, Matcher G, Bradley JA, de Vera JP, Elster J, Hughes KA, Cuthbertson L, Benning LG, Gunde-Cimerman N, Convey P, Hong SG, Pointing SB, Pellizari VH, Vincent WF.

Front Microbiol. 2016 Feb 16;7:16. doi: 10.3389/fmicb.2016.00016. eCollection 2016.


Complete genome of Pseudomonas sp. strain L10.10, a psychrotolerant biofertilizer that could promote plant growth.

See-Too WS, Lim YL, Ee R, Convey P, Pearce DA, Yin WF, Chan KG.

J Biotechnol. 2016 Mar 20;222:84-5. doi: 10.1016/j.jbiotec.2016.02.017. Epub 2016 Feb 11.


Planetary Protection and Mars Special Regions--A Suggestion for Updating the Definition.

Rettberg P, Anesio AM, Baker VR, Baross JA, Cady SL, Detsis E, Foreman CM, Hauber E, Ori GG, Pearce DA, Renno NO, Ruvkun G, Sattler B, Saunders MP, Smith DH, Wagner D, Westall F.

Astrobiology. 2016 Feb;16(2):119-25. doi: 10.1089/ast.2016.1472. Epub 2016 Feb 5.


Complete genome of Planococcus rifietoensis M8(T), a halotolerant and potentially plant growth promoting bacterium.

See-Too WS, Convey P, Pearce DA, Lim YL, Ee R, Yin WF, Chan KG.

J Biotechnol. 2016 Mar 10;221:114-5. doi: 10.1016/j.jbiotec.2016.01.026. Epub 2016 Jan 22.


Microbiology: lessons from a first attempt at Lake Ellsworth.

Pearce DA, Magiopoulos I, Mowlem M, Tranter M, Holt G, Woodward J, Siegert MJ.

Philos Trans A Math Phys Eng Sci. 2016 Jan 28;374(2059). pii: 20140291. doi: 10.1098/rsta.2014.0291.


Tissue-specific variation in nonsense mutant transcript level and drug-induced read-through efficiency in the Cln1(R151X) mouse model of INCL.

Thada V, Miller JN, Kovács AD, Pearce DA.

J Cell Mol Med. 2016 Feb;20(2):381-5. doi: 10.1111/jcmm.12744. Epub 2015 Dec 9.


Evaluating the effectiveness of a laboratory-based professional development program for science educators.

Amolins MW, Ezrailson CM, Pearce DA, Elliott AJ, Vitiello PF.

Adv Physiol Educ. 2015 Dec;39(4):341-51. doi: 10.1152/advan.00088.2015.


Biodiversity and distribution of polar freshwater DNA viruses.

Aguirre de Cárcer D, López-Bueno A, Pearce DA, Alcamí A.

Sci Adv. 2015 Jun 19;1(5):e1400127. doi: 10.1126/sciadv.1400127. eCollection 2015 Jun.


Plasma biomarkers for neuronal ceroid lipofuscinosis.

Hersrud SL, Geraets RD, Weber KL, Chan CH, Pearce DA.

FEBS J. 2016 Feb;283(3):459-71. doi: 10.1111/febs.13593. Epub 2015 Dec 17.


Emerging spatial patterns in Antarctic prokaryotes.

Chong CW, Pearce DA, Convey P.

Front Microbiol. 2015 Sep 30;6:1058. doi: 10.3389/fmicb.2015.01058. eCollection 2015. Review.


Designing and Implementing an Assay for the Detection of Rare and Divergent NRPS and PKS Clones in European, Antarctic and Cuban Soils.

Amos GC, Borsetto C, Laskaris P, Krsek M, Berry AE, Newsham KK, Calvo-Bado L, Pearce DA, Vallin C, Wellington EM.

PLoS One. 2015 Sep 23;10(9):e0138327. doi: 10.1371/journal.pone.0138327. eCollection 2015.


Abnormally increased surface expression of AMPA receptors in the cerebellum, cortex and striatum of Cln3(-/-) mice.

Kovács AD, Hof C, Pearce DA.

Neurosci Lett. 2015 Oct 21;607:29-34. doi: 10.1016/j.neulet.2015.09.012. Epub 2015 Sep 12.


A novel porcine model of ataxia telangiectasia reproduces neurological features and motor deficits of human disease.

Beraldi R, Chan CH, Rogers CS, Kovács AD, Meyerholz DK, Trantzas C, Lambertz AM, Darbro BW, Weber KL, White KA, Rheeden RV, Kruer MC, Dacken BA, Wang XJ, Davis BT, Rohret JA, Struzynski JT, Rohret FA, Weimer JM, Pearce DA.

Hum Mol Genet. 2015 Nov 15;24(22):6473-84. doi: 10.1093/hmg/ddv356. Epub 2015 Sep 15.


Cell biology of the NCL proteins: What they do and don't do.

Cárcel-Trullols J, Kovács AD, Pearce DA.

Biochim Biophys Acta. 2015 Oct;1852(10 Pt B):2242-55. doi: 10.1016/j.bbadis.2015.04.027. Epub 2015 May 8. Review.


Nonsense-mediated decay in genetic disease: friend or foe?

Miller JN, Pearce DA.

Mutat Res Rev Mutat Res. 2014 Oct-Dec;762:52-64. doi: 10.1016/j.mrrev.2014.05.001. Epub 2014 May 28. Review.


The human synaptic vesicle protein, SV2A, functions as a galactose transporter in Saccharomyces cerevisiae.

Madeo M, Kovács AD, Pearce DA.

J Biol Chem. 2014 Nov 28;289(48):33066-71. doi: 10.1074/jbc.C114.584516. Epub 2014 Oct 17.


The novel Cln1(R151X) mouse model of infantile neuronal ceroid lipofuscinosis (INCL) for testing nonsense suppression therapy.

Miller JN, Kovács AD, Pearce DA.

Hum Mol Genet. 2015 Jan 1;24(1):185-96. doi: 10.1093/hmg/ddu428. Epub 2014 Sep 8.

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