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Items: 1 to 50 of 144

1.

Trib1 regulates eosinophil lineage commitment and identity by restraining the neutrophil program.

Mack EA, Stein SJ, Rome KS, Xu L, Wertheim GB, Melo RCN, Pear WS.

Blood. 2019 May 30;133(22):2413-2426. doi: 10.1182/blood.2018872218. Epub 2019 Mar 27.

PMID:
30917956
2.

Oncogenic Notch Promotes Long-Range Regulatory Interactions within Hyperconnected 3D Cliques.

Petrovic J, Zhou Y, Fasolino M, Goldman N, Schwartz GW, Mumbach MR, Nguyen SC, Rome KS, Sela Y, Zapataro Z, Blacklow SC, Kruhlak MJ, Shi J, Aster JC, Joyce EF, Little SC, Vahedi G, Pear WS, Faryabi RB.

Mol Cell. 2019 Mar 21;73(6):1174-1190.e12. doi: 10.1016/j.molcel.2019.01.006. Epub 2019 Feb 7.

PMID:
30745086
3.

Single-cell analysis reveals fibroblast heterogeneity and myeloid-derived adipocyte progenitors in murine skin wounds.

Guerrero-Juarez CF, Dedhia PH, Jin S, Ruiz-Vega R, Ma D, Liu Y, Yamaga K, Shestova O, Gay DL, Yang Z, Kessenbrock K, Nie Q, Pear WS, Cotsarelis G, Plikus MV.

Nat Commun. 2019 Feb 8;10(1):650. doi: 10.1038/s41467-018-08247-x.

4.

Downregulating Notch counteracts KrasG12D-induced ERK activation and oxidative phosphorylation in myeloproliferative neoplasm.

Kong G, You X, Wen Z, Chang YI, Qian S, Ranheim EA, Letson C, Zhang X, Zhou Y, Liu Y, Rajagopalan A, Zhang J, Stieglitz E, Loh M, Hofmann I, Yang D, Zhong X, Padron E, Zhou L, Pear WS, Zhang J.

Leukemia. 2019 Mar;33(3):671-685. doi: 10.1038/s41375-018-0248-0. Epub 2018 Sep 11.

5.

Can genetics resolve what Notch does in HSCs?

Maillard I, Pear WS.

Blood. 2018 Apr 12;131(15):1633-1635. doi: 10.1182/blood-2018-02-829069. No abstract available.

6.

Lineage-Determining Transcription Factor TCF-1 Initiates the Epigenetic Identity of T Cells.

Johnson JL, Georgakilas G, Petrovic J, Kurachi M, Cai S, Harly C, Pear WS, Bhandoola A, Wherry EJ, Vahedi G.

Immunity. 2018 Feb 20;48(2):243-257.e10. doi: 10.1016/j.immuni.2018.01.012.

7.

MAFB enhances oncogenic Notch signaling in T cell acute lymphoblastic leukemia.

Pajcini KV, Xu L, Shao L, Petrovic J, Palasiewicz K, Ohtani Y, Bailis W, Lee C, Wertheim GB, Mani R, Muthusamy N, Li Y, Meijerink JPP, Blacklow SC, Faryabi RB, Cherry S, Pear WS.

Sci Signal. 2017 Nov 14;10(505). pii: eaam6846. doi: 10.1126/scisignal.aam6846.

8.

A B Cell Regulome Links Notch to Downstream Oncogenic Pathways in Small B Cell Lymphomas.

Ryan RJH, Petrovic J, Rausch DM, Zhou Y, Lareau CA, Kluk MJ, Christie AL, Lee WY, Tarjan DR, Guo B, Donohue LKH, Gillespie SM, Nardi V, Hochberg EP, Blacklow SC, Weinstock DM, Faryabi RB, Bernstein BE, Aster JC, Pear WS.

Cell Rep. 2017 Oct 17;21(3):784-797. doi: 10.1016/j.celrep.2017.09.066.

9.

The common oncogenomic program of NOTCH1 and NOTCH3 signaling in T-cell acute lymphoblastic leukemia.

Choi SH, Severson E, Pear WS, Liu XS, Aster JC, Blacklow SC.

PLoS One. 2017 Oct 12;12(10):e0185762. doi: 10.1371/journal.pone.0185762. eCollection 2017.

10.

Genome-wide identification and characterization of Notch transcription complex-binding sequence-paired sites in leukemia cells.

Severson E, Arnett KL, Wang H, Zang C, Taing L, Liu H, Pear WS, Shirley Liu X, Blacklow SC, Aster JC.

Sci Signal. 2017 May 2;10(477). pii: eaag1598. doi: 10.1126/scisignal.aag1598.

11.

Regeneration of fat cells from myofibroblasts during wound healing.

Plikus MV, Guerrero-Juarez CF, Ito M, Li YR, Dedhia PH, Zheng Y, Shao M, Gay DL, Ramos R, Hsi TC, Oh JW, Wang X, Ramirez A, Konopelski SE, Elzein A, Wang A, Supapannachart RJ, Lee HL, Lim CH, Nace A, Guo A, Treffeisen E, Andl T, Ramirez RN, Murad R, Offermanns S, Metzger D, Chambon P, Widgerow AD, Tuan TL, Mortazavi A, Gupta RK, Hamilton BA, Millar SE, Seale P, Pear WS, Lazar MA, Cotsarelis G.

Science. 2017 Feb 17;355(6326):748-752. doi: 10.1126/science.aai8792. Epub 2017 Jan 5.

12.

Protein Tyrosine Phosphatase PRL2 Mediates Notch and Kit Signals in Early T Cell Progenitors.

Kobayashi M, Nabinger SC, Bai Y, Yoshimoto M, Gao R, Chen S, Yao C, Dong Y, Zhang L, Rodriguez S, Yashiro-Ohtani Y, Pear WS, Carlesso N, Yoder MC, Kapur R, Kaplan MH, Daniel Lacorazza H, Zhang ZY, Liu Y.

Stem Cells. 2017 Apr;35(4):1053-1064. doi: 10.1002/stem.2559. Epub 2017 Jan 19.

13.

The Varied Roles of Notch in Cancer.

Aster JC, Pear WS, Blacklow SC.

Annu Rev Pathol. 2017 Jan 24;12:245-275. doi: 10.1146/annurev-pathol-052016-100127. Epub 2016 Dec 5. Review.

14.

High selective pressure for Notch1 mutations that induce Myc in T-cell acute lymphoblastic leukemia.

Chiang MY, Wang Q, Gormley AC, Stein SJ, Xu L, Shestova O, Aster JC, Pear WS.

Blood. 2016 Nov 3;128(18):2229-2240. Epub 2016 Sep 26.

15.

Delta/Notch-Like EGF-Related Receptor (DNER) Is Not a Notch Ligand.

Greene M, Lai Y, Pajcini K, Bailis W, Pear WS, Lancaster E.

PLoS One. 2016 Sep 13;11(9):e0161157. doi: 10.1371/journal.pone.0161157. eCollection 2016.

16.

Trib2 Suppresses Tumor Initiation in Notch-Driven T-ALL.

Stein SJ, Mack EA, Rome KS, Pajcini KV, Ohtani T, Xu L, Li Y, Meijerink JP, Faryabi RB, Pear WS.

PLoS One. 2016 May 18;11(5):e0155408. doi: 10.1371/journal.pone.0155408. eCollection 2016.

17.

Structural Basis for Substrate Selectivity of the E3 Ligase COP1.

Uljon S, Xu X, Durzynska I, Stein S, Adelmant G, Marto JA, Pear WS, Blacklow SC.

Structure. 2016 May 3;24(5):687-696. doi: 10.1016/j.str.2016.03.002. Epub 2016 Mar 31.

18.

Tribbles in normal and malignant haematopoiesis.

Stein SJ, Mack EA, Rome KS, Pear WS.

Biochem Soc Trans. 2015 Oct;43(5):1112-5. doi: 10.1042/BST20150117. Review.

19.

Tribbles at the cross-roads….

Kiss-Toth E, Velasco G, Pear WS.

Biochem Soc Trans. 2015 Oct;43(5):1049-50. doi: 10.1042/BST20150122. Review. No abstract available.

PMID:
26517921
20.

IL-1 signaling modulates activation of STAT transcription factors to antagonize retinoic acid signaling and control the TH17 cell-iTreg cell balance.

Basu R, Whitley SK, Bhaumik S, Zindl CL, Schoeb TR, Benveniste EN, Pear WS, Hatton RD, Weaver CT.

Nat Immunol. 2015 Mar;16(3):286-95. doi: 10.1038/ni.3099. Epub 2015 Feb 2.

21.

Long-range enhancer activity determines Myc sensitivity to Notch inhibitors in T cell leukemia.

Yashiro-Ohtani Y, Wang H, Zang C, Arnett KL, Bailis W, Ho Y, Knoechel B, Lanauze C, Louis L, Forsyth KS, Chen S, Chung Y, Schug J, Blobel GA, Liebhaber SA, Bernstein BE, Blacklow SC, Liu XS, Aster JC, Pear WS.

Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):E4946-53. doi: 10.1073/pnas.1407079111. Epub 2014 Nov 4.

22.

Discovery of biomarkers predictive of GSI response in triple-negative breast cancer and adenoid cystic carcinoma.

Stoeck A, Lejnine S, Truong A, Pan L, Wang H, Zang C, Yuan J, Ware C, MacLean J, Garrett-Engele PW, Kluk M, Laskey J, Haines BB, Moskaluk C, Zawel L, Fawell S, Gilliland G, Zhang T, Kremer BE, Knoechel B, Bernstein BE, Pear WS, Liu XS, Aster JC, Sathyanarayanan S.

Cancer Discov. 2014 Oct;4(10):1154-67. doi: 10.1158/2159-8290.CD-13-0830. Epub 2014 Aug 7.

23.

Identifying direct Notch transcriptional targets using the GSI-washout assay.

Bailis W, Yashiro-Ohtani Y, Pear WS.

Methods Mol Biol. 2014;1187:247-54. doi: 10.1007/978-1-4939-1139-4_19. Review.

PMID:
25053495
24.

Loss of oncogenic Notch1 with resistance to a PI3K inhibitor in T-cell leukaemia.

Dail M, Wong J, Lawrence J, O'Connor D, Nakitandwe J, Chen SC, Xu J, Lee LB, Akagi K, Li Q, Aster JC, Pear WS, Downing JR, Sampath D, Shannon K.

Nature. 2014 Sep 25;513(7519):512-6. doi: 10.1038/nature13495. Epub 2014 Jul 20.

25.

Uterine Rbpj is required for embryonic-uterine orientation and decidual remodeling via Notch pathway-independent and -dependent mechanisms.

Zhang S, Kong S, Wang B, Cheng X, Chen Y, Wu W, Wang Q, Shi J, Zhang Y, Wang S, Lu J, Lydon JP, DeMayo F, Pear WS, Han H, Lin H, Li L, Wang H, Wang YL, Li B, Chen Q, Duan E, Wang H.

Cell Res. 2014 Aug;24(8):925-42. doi: 10.1038/cr.2014.82. Epub 2014 Jun 27.

26.

The Notch1 transcriptional activation domain is required for development and reveals a novel role for Notch1 signaling in fetal hematopoietic stem cells.

Gerhardt DM, Pajcini KV, D'altri T, Tu L, Jain R, Xu L, Chen MJ, Rentschler S, Shestova O, Wertheim GB, Tobias JW, Kluk M, Wood AW, Aster JC, Gimotty PA, Epstein JA, Speck N, Bigas A, Pear WS.

Genes Dev. 2014 Mar 15;28(6):576-93. doi: 10.1101/gad.227496.113.

27.

NOTCH1-RBPJ complexes drive target gene expression through dynamic interactions with superenhancers.

Wang H, Zang C, Taing L, Arnett KL, Wong YJ, Pear WS, Blacklow SC, Liu XS, Aster JC.

Proc Natl Acad Sci U S A. 2014 Jan 14;111(2):705-10. doi: 10.1073/pnas.1315023111. Epub 2013 Dec 27.

28.

T cell development requires constraint of the myeloid regulator C/EBP-α by the Notch target and transcriptional repressor Hes1.

De Obaldia ME, Bell JJ, Wang X, Harly C, Yashiro-Ohtani Y, DeLong JH, Zlotoff DA, Sultana DA, Pear WS, Bhandoola A.

Nat Immunol. 2013 Dec;14(12):1277-84. doi: 10.1038/ni.2760. Epub 2013 Nov 3.

29.

Notch simultaneously orchestrates multiple helper T cell programs independently of cytokine signals.

Bailis W, Yashiro-Ohtani Y, Fang TC, Hatton RD, Weaver CT, Artis D, Pear WS.

Immunity. 2013 Jul 25;39(1):148-59. doi: 10.1016/j.immuni.2013.07.006.

30.

The expression of Sox17 identifies and regulates haemogenic endothelium.

Clarke RL, Yzaguirre AD, Yashiro-Ohtani Y, Bondue A, Blanpain C, Pear WS, Speck NA, Keller G.

Nat Cell Biol. 2013 May;15(5):502-10. doi: 10.1038/ncb2724. Epub 2013 Apr 21.

31.

T cell factor 1 is required for group 2 innate lymphoid cell generation.

Yang Q, Monticelli LA, Saenz SA, Chi AW, Sonnenberg GF, Tang J, De Obaldia ME, Bailis W, Bryson JL, Toscano K, Huang J, Haczku A, Pear WS, Artis D, Bhandoola A.

Immunity. 2013 Apr 18;38(4):694-704. doi: 10.1016/j.immuni.2012.12.003.

32.

Complementary genomic screens identify SERCA as a therapeutic target in NOTCH1 mutated cancer.

Roti G, Carlton A, Ross KN, Markstein M, Pajcini K, Su AH, Perrimon N, Pear WS, Kung AL, Blacklow SC, Aster JC, Stegmaier K.

Cancer Cell. 2013 Mar 18;23(3):390-405. doi: 10.1016/j.ccr.2013.01.015. Epub 2013 Feb 21.

33.

Brief report: Blockade of Notch signaling in muscle stem cells causes muscular dystrophic phenotype and impaired muscle regeneration.

Lin S, Shen H, Jin B, Gu Y, Chen Z, Cao C, Hu C, Keller C, Pear WS, Wu L.

Stem Cells. 2013 Apr;31(4):823-8. doi: 10.1002/stem.1319.

34.

Mastermind-like transcriptional co-activator-mediated Notch signaling is indispensable for maintaining conjunctival epithelial identity.

Zhang Y, Lam O, Nguyen MT, Ng G, Pear WS, Ai W, Wang IJ, Kao WW, Liu CY.

Development. 2013 Feb 1;140(3):594-605. doi: 10.1242/dev.082842.

35.

Divergent effects of supraphysiologic Notch signals on leukemia stem cells and hematopoietic stem cells.

Chiang MY, Shestova O, Xu L, Aster JC, Pear WS.

Blood. 2013 Feb 7;121(6):905-17. doi: 10.1182/blood-2012-03-416503. Epub 2012 Oct 31.

36.

Notch and PI3K: how is the road traveled?

Bailis W, Pear WS.

Blood. 2012 Aug 16;120(7):1349-50. doi: 10.1182/blood-2012-06-435099.

37.

Notch ankyrin repeat domain variation influences leukemogenesis and Myc transactivation.

Aster JC, Bodnar N, Xu L, Karnell F, Milholland JM, Maillard I, Histen G, Nam Y, Blacklow SC, Pear WS.

PLoS One. 2011;6(10):e25645. doi: 10.1371/journal.pone.0025645. Epub 2011 Oct 13.

38.

Critical roles of NOTCH1 in acute T-cell lymphoblastic leukemia.

Liu H, Chiang MY, Pear WS.

Int J Hematol. 2011 Aug;94(2):118-125. doi: 10.1007/s12185-011-0899-3. Epub 2011 Aug 5. Review.

PMID:
21814881
39.

Identification of Flt3⁺CD150⁻ myeloid progenitors in adult mouse bone marrow that harbor T lymphoid developmental potential.

Chi AW, Chavez A, Xu L, Weber BN, Shestova O, Schaffer A, Wertheim G, Pear WS, Izon D, Bhandoola A.

Blood. 2011 Sep 8;118(10):2723-32. doi: 10.1182/blood-2010-09-309989. Epub 2011 Jul 26.

40.

Genome-wide analysis reveals conserved and divergent features of Notch1/RBPJ binding in human and murine T-lymphoblastic leukemia cells.

Wang H, Zou J, Zhao B, Johannsen E, Ashworth T, Wong H, Pear WS, Schug J, Blacklow SC, Arnett KL, Bernstein BE, Kieff E, Aster JC.

Proc Natl Acad Sci U S A. 2011 Sep 6;108(36):14908-13. doi: 10.1073/pnas.1109023108. Epub 2011 Jul 7.

41.

Notch signaling in mammalian hematopoietic stem cells.

Pajcini KV, Speck NA, Pear WS.

Leukemia. 2011 Oct;25(10):1525-32. doi: 10.1038/leu.2011.127. Epub 2011 Jun 7. Review.

42.

RBP-J promotes the maturation of neuronal progenitors.

Komine O, Nagaoka M, Hiraoka Y, Hoshino M, Kawaguchi Y, Pear WS, Tanaka K.

Dev Biol. 2011 Jun 1;354(1):44-54. doi: 10.1016/j.ydbio.2011.03.020. Epub 2011 Apr 2.

43.

Hooked on Hes: a T-ALL of addiction.

Pear WS.

Immunity. 2010 Nov 24;33(5):645-7. doi: 10.1016/j.immuni.2010.11.018.

44.

Notch signalling in T-cell lymphoblastic leukaemia/lymphoma and other haematological malignancies.

Aster JC, Blacklow SC, Pear WS.

J Pathol. 2011 Jan;223(2):262-73. doi: 10.1002/path.2789. Epub 2010 Oct 21. Review.

45.

Notch dimerization is required for leukemogenesis and T-cell development.

Liu H, Chi AW, Arnett KL, Chiang MY, Xu L, Shestova O, Wang H, Li YM, Bhandoola A, Aster JC, Blacklow SC, Pear WS.

Genes Dev. 2010 Nov 1;24(21):2395-407. doi: 10.1101/gad.1975210. Epub 2010 Oct 8.

46.

Notch signaling is a critical regulator of allogeneic CD4+ T-cell responses mediating graft-versus-host disease.

Zhang Y, Sandy AR, Wang J, Radojcic V, Shan GT, Tran IT, Friedman A, Kato K, He S, Cui S, Hexner E, Frank DM, Emerson SG, Pear WS, Maillard I.

Blood. 2011 Jan 6;117(1):299-308. doi: 10.1182/blood-2010-03-271940. Epub 2010 Sep 24.

47.

Deletion-based mechanisms of Notch1 activation in T-ALL: key roles for RAG recombinase and a conserved internal translational start site in Notch1.

Ashworth TD, Pear WS, Chiang MY, Blacklow SC, Mastio J, Xu L, Kelliher M, Kastner P, Chan S, Aster JC.

Blood. 2010 Dec 16;116(25):5455-64. doi: 10.1182/blood-2010-05-286328. Epub 2010 Sep 17.

48.

Transformation by Tribbles homolog 2 (Trib2) requires both the Trib2 kinase domain and COP1 binding.

Keeshan K, Bailis W, Dedhia PH, Vega ME, Shestova O, Xu L, Toscano K, Uljon SN, Blacklow SC, Pear WS.

Blood. 2010 Dec 2;116(23):4948-57. doi: 10.1182/blood-2009-10-247361. Epub 2010 Aug 30.

49.

NOTCH1 and NOTCH3 coordinate esophageal squamous differentiation through a CSL-dependent transcriptional network.

Ohashi S, Natsuizaka M, Yashiro-Ohtani Y, Kalman RA, Nakagawa M, Wu L, Klein-Szanto AJ, Herlyn M, Diehl JA, Katz JP, Pear WS, Seykora JT, Nakagawa H.

Gastroenterology. 2010 Dec;139(6):2113-23. doi: 10.1053/j.gastro.2010.08.040. Epub 2010 Aug 27.

50.

Notch regulation of early thymocyte development.

Yashiro-Ohtani Y, Ohtani T, Pear WS.

Semin Immunol. 2010 Oct;22(5):261-9. doi: 10.1016/j.smim.2010.04.015. Epub 2010 Jul 13. Review.

PMID:
20630772

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